“Actionability” is a key concept in precision oncology. Its precise definition, however, remains contested. This article undertakes a philosophical analysis of “actionability” to aid in conceptual clarification. We map distinct concepts of actionability, arguing that each is best understood as a contextually objective category articulated to mitigate risk of “conceptual slippage.” We defend “interactive pluralism,” acknowledging the need for distinct concepts but also for conceptual interaction in practice. This article thus offers insights for both practitioners and philosophers, clarifying approaches to (...) actionability for scientists and clinicians and serving as a case study to test competing views on scientific pluralism. (shrink)

In non-causal explanations, some non-causal facts (such as mathematical, modal or metaphysical) are used to explain some physical facts. However, precisely because these explanations abstract away from causal facts, they face two challenges: 1) it is not clear why would one rather than the other non-causal explanantia be relevant for the explanandum; and 2) why would standing in a particular explanatory relation (e.g., “counterfactual dependence”, “constraint”, “entailment”, “constitution”, “grounding”, and so on), and not in some other, be explanatory. I develop (...) an explanatory relevance account which is based on erotetic constraints and show how it addresses these two challenges. (shrink)

Philosophers of science have come to accept that contextual values can play unavoidable and desirable roles in science. This has raised concerns about the need to distinguish legitimate and illegitimate value influences in scientific inquiry. I discuss here four such concerns: epistemic distortion, value imposition, undermining of public trust in science, and the use of objectionable values. I contend that preserving epistemic integrity and avoiding value imposition provide good reasons to attempt to distinguish between legitimate and illegitimate influences of values (...) in science. However, the trust and the objectionable values concerns constitute no good reason for demarcation criteria. (shrink)

There is a major debate as to whether there are non-causal mathematical explanations of physical facts that show how the facts under question arise from a degree of mathematical necessity considered stronger than that of contingent causal laws. We focus on Marc Lange’s account of distinctively mathematical explanations to argue that purported mathematical explanations are essentially causal explanations in disguise and are no different from ordinary applications of mathematics. This is because these explanations work not by appealing to what the (...) world must be like as a matter of mathematical necessity but by appealing to various contingent causal facts. (shrink)

We focus on a neglected aspect of scientific theory choice: how the selection of theories affects epistemic values. Building on Kuhn, we provide a general characterization of the feedback-loop dynamic between theories and values in theory choice as analogous to the relationship between organisms and the environment in niche construction. We argue that understanding theory choice as niche construction can explain how certain values acquire more weight and a specific application over time, and how resistance to scientific change can, therefore, (...) arise. We illustrate our picture by looking at the Mendelian–biometrician controversy. (shrink)

Scientists and philosophers alike debate whether various systems such as plants and bacteria exercise cognition. One strategy for resolving such debates is to ground claims about nonhuman cognition in evidence from mathematical models of cognitive capacities. In this article, I show that proponents of this strategy face two major challenges: demarcating phenomenological models from process models and overcoming underdetermination by model fit. I argue that even if the demarcation problem is resolved, fitting a process model to behavioral data is, on (...) its own, not strong evidence for any cognitive process, let alone processes shared with humans. (shrink)

Recent developments in generalized probability theory have renewed a debate about whether regularity (i.e., the constraint that only logical contradictions get assigned probability 0) should be a necessary feature of both chances and credences. Crucial to this debate, however, are some mathematical facts regarding the interplay between the existence of regular generalized probability measures and various cardinality assumptions. We improve on several known results in the literature regarding the existence of regular generalized probability measures. In particular, we give necessary and (...) sufficient conditions for the existence of regular generalized probability measures defined on the whole powerset of any sample space. (shrink)

This paper investigates the question of how subjective probability should relate to binary belief. We propose new distance minimization methods, and develop epistemic decision-theoretic accounts. Both approaches can be shown to get “close” to the truth: the first one by getting “close” to a given probability, and the second by getting expectedly “close” to the truth. More specifically, we study distance minimization with a refined notion of Bregman divergence and expected utility maximization with strict proper scores. Our main results reveal (...) that the two ways to get “close” to the truth can coincide. (shrink)

Historians have shown that philosophical discussions about the implications of relativity significantly shaped the development of European philosophy of science in the 1920s. Yet little is known about American debates from this period. This paper maps the first responses to Einstein’s theory in three U.S. philosophy journals and situates these papers within the local intellectual climate. We argue that these discussions (1) stimulated the development of a distinctly American branch of philosophy of science and (2) paved the way for the (...) logical empiricists, who emigrated to the United States in the years before World War II. (shrink)

Our thinking often uses rich memories of particular past events. Yet frequently we would do better to use other forms of memory. I show that existing accounts of the function of episodic memory cannot account for such cases, then develop an account which can. Roughly: rich representations of particular past events are required for Unrestricted Learning, learning which is not limited in how much of the world’s complexity it can capture; and episodic memory’s selection for Unrestricted Learning could explain its (...) ubiquitous (and often inappropriate) use for other tasks. This proposal suggests many avenues for further empirical and computational research. (shrink)

Teleosemantic theories aim to naturalize mental representation through the use of functions, typically based on past selection processes. However, the historical dependence of these theories has faced severe criticism, leading some philosophers to develop ahistorical alternatives. -/- This paper presents a new dilemma for all ahistorical teleosemantic theories, focusing in particular on the theories proposed by Timothy Schroeder and Bence Nanay. These theories require certain dispositions in the producers or consumers of mental representations. But the appeal to dispositions puts the (...) proponents in an undesirable position: mental content is either overly dependent on current circumstances or ultimately dependent on historical factors. (shrink)

I discuss a contemporary solution to the dynamic problem of old evidence (POE), as proposed by Sprenger. Sprenger’s solution combines the Garber–Jeffrey–Niiniluoto (GJN) approach with Howson’s suggestion of counterfactually removing the old evidence from scientists’ belief systems. I argue that in the dynamic POE, the challenge is to explain how an insight under beliefs in which the old evidence E is known increased the credence of a scientific hypothesis. Therefore, Sprenger’s counterfactual solution, in which E has been artificially removed, does (...) not resolve the problem. I consider several potential responses. (shrink)

In light of recent criticisms by Woodward (2017) and Rescorla (2018), we examine the relationship between mechanistic explanation and phenomenological laws. We disambiguate several uses of the phrase “phenomenological law” and show how a mechanistic theory of explanation sorts them into those that are and are not explanatory. We also distinguish the problem of phenomenological laws from arguments about the explanatory power of purely phenomenal models, showing that Woodward and Rescorla conflate these problems. Finally, we argue that the temptation to (...) pit mechanistic and interventionist theories of explanation against one another occludes important and scientifically relevant research questions. (shrink)

Microaggressions are hypothesized to play a causal role in undesirable population effects such as racial health gaps, but the mechanisms through which this occurs are not yet well understood. I call inquiry about these mechanisms the “explanatory project.” I suggest that the explanatory project has been hindered by microaggression concepts tailored to be applicable under conditions of lived uncertainty, rather than to facilitate understanding of structural causes. I defend a pluralist, structural account of microaggressions from arguments by Regina Rini that, (...) while appropriate for ethical projects, do not apply to the explanatory project. (shrink)

Transdisciplinary research knits together knowledge from diverse epistemic communities in addressing social-environmental challenges, such as biodiversity loss, climate crises, food insecurity, and public health. This paper reflects on the roles of philosophy of science in transdisciplinary research while focusing on Indigenous and other subaltern forms of knowledge. We offer a critical assessment of demarcationist approaches in philosophy of science and outline a constructive alternative of transdisciplinary philosophy of science. While a demarcationist focus obscures the complex relations between epistemic communities, transdisciplinary (...) philosophy of science provides resources for meeting epistemic and political challenges of collaborative knowledge production. (shrink)

I defend a novel account of scientific progress centred around justification. Science progresses, on this account, where there is a change in justification. I consider three options for explicating this notion of change in justification. This account of scientific progress dispels with a condition for scientific progress that requires accumulation of truth or truthlikeness, and it emphasises the social nature of scientific justification.

This paper advances the development of a phylogeny-based psychology in which cognitive ability types are individuated as characters in the evolutionary biological sense. I explain the character concept and its utility in addressing (or dissolving) conceptual problems arising from discoveries of cognitive abilities across a wide range of species. I use the examples of stereopsis in the praying mantis, internal cell-to-cell signaling in plants, and episodic memory in scrub jays to show how anthropocentric cognitive ability types can be reformulated into (...) cognitive characters, thereby promoting the integration of psychology with other sciences of evolved traits. (shrink)

Scientific hedges are communicative devices used to qualify and weaken scientific claims. Gregor Betz has argued—unconvincingly, we think—that hedging can rescue the value-free ideal for science. Nevertheless, Betz is onto something when he suggests there are political principles that recommend scientists hedge public-facing claims. In this article, we recast this suggestion using the notion of public justification. We formulate and reject a Rawlsian argument that locates the justification for hedging in its ability to forge consensus. On our alternative proposal, hedging (...) is often justified because it renders scientific claims as publicly accessible reasons. (shrink)

Scientists have the epistemic responsibility of producing knowledge. They also have the social responsibility of aligning their research with the needs and values of various societal stakeholders. Individual scientists may be left with no guidance on how to prioritise and carry these different responsibilities. As I will argue, however, the responsibilities of science can be harmonised at the collective level. Drawing from debates in moral philosophy, I will propose a theory of the collective responsibilities of science that accounts for the (...) internal diversity of research groups and for their different responsibilities. (shrink)