Abstract
This article reflects on the radical change in the meaning and role of the economy in relation to processes of subjectivation, and to the social and political bond. The genealogy of the theological-economic paradigm, accompanying the development of the theological-political, highlights how the meaning of economy cannot be exhausted in economy strictly defined, but rather fulfils the role of the logic of government. On this path, the turn towards the bio-economic production of lives is marked by a marginalizing perspective that replaces the centrality of needs with desire, only so as then to rule desire through rational choice.