Discovering Control Mechanisms: The Controllers of Dynein

Philosophy of Science 89 (5):1145-1154 (2022)
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Abstract

Most accounts of mechanism discovery have focused on mechanisms that perform the work required to produce a phenomenon. These mechanisms are often subject to regulation by control mechanisms. Using the example of the molecular motor dynein, this paper examines one process by which such control mechanisms are discovered—the process by which researchers, after identifying additional components required to produce the phenomenon but not directly involved in the work of producing that phenomenon, investigate both how these components act on the original mechanism and how they do so in response to measurements of conditions relevant to the operation of the controlled mechanism.

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William Bechtel
University of California, San Diego

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Constraint-based reasoning in cell biology: on the explanatory role of context.Karl S. Matlin & Sara Green - 2024 - History and Philosophy of the Life Sciences 46 (3):1-26.

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