Abstract
Scientists need that scientific descriptions meet request methodological principles. Science knowledge is independent. Methodological principles guarantee autonomic regime of scientific investigations. Methodological principles are requirements the process of descriptive knowledge receiving as result of methodological analysis on best samples of scientific investigations, or methodological standards in history of science. There are mane principles in methodology of science: autonomic scientific investigation, competence, objectivity, expedience, systemness, verification, coherence, unity of methods, integration, differentiation, many-variation of formulizations, modernizations, diversity of chosen types of descriptions, two logical meanings – truthfulness and falseness.