Abstract
In the second half of the 18th century the voices criticizing the concept of simple substances as proposed by Leibniz and Wolff became increasingly louder. In response, Kant altered his theory of substances as first proposed in the 1750s. So for example, while his notion of substance in the Monadologia physica is simple and not merely in space, but fills space entirely, the Kantian position in the 1760s and early 1770s is quite different. This essay examines the solution Kant offers in his Inaugural Dissertation for the problems raised by critics of simple substances. It shows how Kant removes substance from space and consequently from the empirical world and makes it into a concept of the understanding which leads to the knowledge of simple substances by employment of the pure understanding.