Abstract

Graphical AbstractIn neurons, teneurins and latrophilins form a juxtacrine unit that originated in the earliest metazoans. The ‘teneurin C-terminal associated peptide’ (TCAP) regulates mitochondrial function to coordinate energy usage in surrounding cells. TCAP inhibits stress-related actions of corticotropin-releasing factor (CRF) in the central nervous system and may underlie the etiology of some affective disorders. More details can be found in article number 2000039 by David A. Lovejoy and David W. Hogg. Cover image by Mia Husic.