Abstract
This paper examines the challenges to critical realism posed by the ways in which the original postmodern sensibility has transformed into various forms of anti-humanism, trans-humanism, and post-humanism. These transformations, largely growing out of poststructuralism, are reinforced by developments in psychology and computer science but also incorporate a new turn toward ontology in alternate forms of realism such as Object-Oriented-Ontology. This paper identifies what is new and what is old in these trends and argues that, while there is something to be learned from them, some of which implicitly and even explicitly borrow from CR, the humanist orientation of CR continues to deserve defense.