Paying Human Subjects in Research: Where are We, How Did We Get Here, and Now What?

Journal of Law, Medicine and Ethics 39 (3):543-558 (2011)
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Abstract

On November 14, 1996, an in-depth report on the recruiting and testing practices of Lilly Pharmaceuticals appeared in the Wall Street Journal. Laurie Cohen reported that most pharmaceutical companies had difficulty recruiting healthy subjects to participate in testing of “untried and potentially dangerous” drugs. These companies often had to pay subjects up to $250 a day to ensure adequate enrollment, and some even gave referral bonuses to doctors who sent potential subjects their way. Cohen then exposed how Lilly was able to keep costs down: by recruiting homeless alcoholics to serve as research guinea pigs. “In many ways,” Cohen reported, “the practice is mutually beneficial. For Lilly, it is efficient and limits the risk that subjects will sue if harmed by an experiment or divulge particulars of a drug.” And the subjects “get several weeks or months of free room and board, and in interviews they express voluble gratitude for what they often call easy money.”

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References found in this work

Inducement in Research.Martin Wilkinson & Andrew Moore - 1997 - Bioethics 11 (5):373-389.
Ending Concerns about Undue Inducement.Ezekiel J. Emanuel - 2004 - Journal of Law, Medicine and Ethics 32 (1):100-105.

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