There is growing interest in the effect of sound on visual motion perception. One model involves the illusion created when two identical objects moving towards each other on a two-dimensional visual display can be seen to either bounce off or stream through each other. Previous studies show that the large bias normally seen toward the streaming percept can be modulated by the presentation of an auditory event at the moment of coincidence. However, no reports to date provide sufficient evidence to (...) indicate whether the sound bounce-inducing effect is due to a perceptual binding process or merely to an explicit inference resulting from the transient auditory stimulus resembling a physical collision of two objects. In the present study, we used a novel experimental design in which a subliminal sound was presented either 150 ms before, at, or 150 ms after the moment of coincidence of two disks moving towards each other. The results showed that there was an increased perception of bouncing when the subliminal sound was presented at or 150 ms after the moment of coincidence compared to when no sound was presented. These findings provide the first empirical demonstration that activation of the human auditory system without reaching consciousness affects the perception of an ambiguous visual motion display. (shrink)

Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion‐dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? (...) Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. If future studies can demonstrate that PRG4 is a potent inflammatory mediator, this will change current paradigms in the musculoskeletal and ophthalmological fields regarding the how the inflammatory microenvironment is regulated in these tissues and potentially others. (shrink)

Here we question the mechanisms underlying the emergence of the feeling of control that can be modulated even when the feeling of being the author of one’s own action is intact. With a haptic robot, participants made series of vertical pointing actions on a virtual surface, which was sometimes postponed by a small temporal delay (15 or 65 ms). Subjects then evaluated their subjective feeling of control. Results showed that after temporal distortions, the hand-trajectories were adapted effectively but that the (...) feeling of control decreased significantly. This was observed even in the case of subliminal distortions for which subjects did not consciously detect the presence of a distortion. Our findings suggest that both supraliminal and subliminal temporal distortions that occur within a healthy perceptual–motor system impact the conscious experience of the feeling of control of self-initiated motor actions. (shrink)

Ciencia y lógica de mundos posibles indaga en un aspecto negativo de la visión positivista de la historia del pensamiento. Según esta interpretación, determinante dentro del pensamiento contemporáneo, existe una oposición irredimible entre la metodología del conocimiento científico y la metafísica. El estudio de los supuestos ontológicos de la epistemología aristotélica y de la nueva metodología galileana evidencia, sin embargo, que históricamente la ciencia moderna no nace en oposición a la metafísica, sino que surge a partir de una concepción metafísica (...) determinada. Resulta imposible comprender a fondo el fenómeno de la revolución galileana sin tener en cuenta los aportes lógicos de pensadores medievales que tuvieron una actitud crítica frente a las implicaciones ontológicas de la epistemología aristotélica. Con el advenimiento del idealismo trascendental - a diferencia de Descartes, Leibniz o Newton - la filosofía se separa de la ciencia experimental. Esto se debe a que con Kant la filosofía se aleja de la postura filosófica de los origenes de la ciencia moderna, y retorna a una concepción de la naturaleza en cierto modo similar a la aristotélica. Así mismo, la interpretación propuesta en el manifiesto del Círculo de Viena con respecto a algunas de las revoluciones científicas de los siglos XIX y XX, supone que la ciencia moderna se ha desarrollado en la dirección señalada por la concepción metafísica del mundo que se encuentra en el origen de la revolución galileana. (shrink)

Trough an analysis of change based in the logical laws of Contradiction and of Excluded Middle, it's possible to demonstrate that the existence of the total state of the world at the present instant does not derive directly from the states of the world of any previous instant.

S'il n'est pas un véritable juriste, Rousseau ne s'en est pas moins intéressé à de nombreux problèmes juridiques, du droit public romain au droit de la famille. La réflexion historique occupe également une place importante dans son oeuvre. Ce sont ces aspects moins connus de la pensée de Rousseau jurisconsulte et historien qui sont abordés dans ce volume, considérant aussi le rayonnement du citoyen de Genève dans l'histoire intellectuelle et politique occidentale. Inspirateur des révolutionnaires français, utilisé plus que compris, récupéré (...) par les uns, dénoncé par les autres, Rousseau a eu une influence sur nombre de penseurs politiques et de législateurs constitutionnels. Le présent ouvrage invite ainsi à suivre la trace de cette influence pour restituer à sa pensée politique la singularité comme l'ampleur de sa place dans l'histoire. (shrink)