As one of the main competencies, professionalism is to be taught and evaluated during the residency period. The aim of this research is to investigate the professionalism perception among medical residents of Tabriz University of Medical Sciences. This cross-sectional study was conducted in 2017 using Persian Professionalism Questionnaire American Board of Internal Medicine (American Board of Internal Medicine). Probability proportional to size sampling was used to recruit the participants (n = 250). Data analysis was done using SPSS24 through descriptive and (...) analytical statistics. The mean age of residents was 33.28 (SD = 5.56). About 46% of residents were not familiar with professionalism. Mean of perceived professionalism score by the residents was to be 6.85 (of 10) ± 1.52. Honor/Integrity dimension with a score of 7.53 ± 2.1 had the highest mean, while professional excellence with a score of 6.2 ± 1.43 had the lowest mean. No statistically significant relationship was observed between residents’ demographic characteristics and perceived professionalism. Medical residents’ professionalism perception was not at an acceptable level. It is necessary to spread the concept of professionalism in the form of formal and informal training programs to promote residents’ professional behaviors. Moreover, it was experienced that peer to peer observation could be used to assess professionalism in the working environment. (shrink)