This paper explores the epistemology of extrapolation from model organisms to humans in molecular medicine. We take into account two common views on the issue, the homology view and the disanalogy view. In response to both interpretations, we argue that the foundational basis of extrapolations cannot simply be provided by homology and that relevant disanalogies can, thanks to the techniques of molecular biology, be experimentally controlled and exploited to allow useful and reliable extrapolations. The case of "humanised mice" in the (...) context of cancer stem cell research provides evidence of how animal models can be construed to approximate bona fide causal analogue models of human diseases. To supplement this view we show how the epistemology of model organisms needs to take into account the engineering side of molecular medicine. Model organisms are often manipulated to create analogies or remove disanalogies with the target system. We maintain that highlighting this feature is fundamental to explain what warrants extrapolation in the search for the molecular causes of disease. (shrink)

Nella storia della metafisica è stato un grande problema come chiarire l’idea della coincidentia oppositorum (la coincidenza degli opposti) di Cusano, il quale è riconosciuto comunque da Cassirer come il primo epistemologo del pensiero moderno, in particolare come colui che ha saputo conquistare l’infinito alla mente umana. Dopo alcuni secoli, ha avuto una grande importanza una idea simile a quella di Cusano, la dialettica di Hegel, la quale aggiunge una negazione ad una prima frase negata per ottenere una sintesi in (...) termini generali. Ma poi queste idee sono state sempre meno seguite, eccetto che nel XX secolo da un filosofo non accademico, Lanza del Vasto che ha criticato Hegel e si è ricondotto a Cusano. Nello scritto esamino questa tematica mediante gli strumenti recentemente forniti dalla logica matematica, già verificati sugli scritti di altri scienziati; essi sono capaci di distinguere con precisione che cosa, negli scritti di uno studioso, è un passaggio logico formale e che cosa è una semplice illazione, derivata dalla conoscenza comune o dalla sua creatività; e se è un passaggio logico, decidere di che tipo di logica è. Per mezzo di questo metodo formale, i) presento alcune caratteristiche del ragionare di Cusano; ii) critico il metodo di Hegel; il risultato si accorda con la analisi critica di Hegel che Lanza del Vasto ha compiuto in maniera intuitva; iii) dimostro che la relazione tra Cusano e Lanza del Vasto è più forte di quanto dichiara quest’ultimo; iv) suggerisco una spiegazione della coincidentia oppositorum, chiarendo che la novità di ragionare in logica non classica è stata così innovativa che il tentativo di Cusano di precisarne il metodo è risultato in una scorciatoia, non errata ma valida solo in alcune situazioni; mentre è stato deviante il tentativo di Hegel; Lanza del Vasto, che ha portato un contributo al metodo di Cusano, si è comunque reso conto che occorreva arrivare a formalizzare un nuovo tipo di logica, che oggi risulta essere quella non classica. In definitiva, occorre attribuire a Cusano il merito di aver suggerito una nuova maniera di razionalità logica, quella capace di ragionare in logica non classica e di averne dato, sia pure in maniera imprecisa ed oscura, una prima formalizzazione. (shrink)

I characterize Bishop's constructive mathematics as an alternative to classical mathematics, which makes use of the actual infinity. From the history an accurate investigation of past physical theories I obtianed some ones - mainly Lazare Carnot's mechanics and Sadi Carnot's thermodynamics - which are alternative to the dominant theories - e.g. Newtopn's mechanics. The way to link together mathematics to theoretical physics is generalized and some general considerations, in particualr on the geoemtry in theoretical physics, are obtained.that.

Normal.dotm 0 0 1 135 770 111111 6 1 945 12.0 0 false 14 18 pt 18 pt 0 0 false false false Normal.dotm 0 0 1 161 922 111111 7 1 1132 12.0 0 false 14 18 pt 18 pt 0 0 false false false Eles são há muito conhecidas algumas suposições sobre a relação entre a assimetria do cérebro e/ou indecisão hemisférica funcional que, por vezes, caracteriza os indivíduos canhotos e distúrbios de aprendizagem específicas. Até hoje, no entanto, (...) essas teorias não encontrei muitas confirmações em estudos da neurociência e da psicologia experimental. Em outros aspectos, se olharmos para as evidências experimentais em distúrbio específico de linguagem, ou observação em sala de aula de crianças com distúrbio específico de aprendizagem, ou seja, as experiências empíricas descritas por professores do ensino fundamental, Essa relação parece ser bastante óbvio. Através da aplicação de um questionário estruturado a uma amostra de professores do ensino fundamental italianos, neste estudo, tentamos documentar se há uma maior incidência de dislexia, discalculia e disgrafia em crianças canhotos. Palavras-chave : dislexia, discalculia, disgrafia, assimetria cerebral, canhotismo. (shrink)

I prove that the three basic propositions of Vasiliev's paraconsistent logic have a semantic interpretation by means of the intuitionist logic. The interpèretation is confirmed by amens of the da Costa's model of Vasiliev's paraconsistent logic.

La philosophie de l’animalité chez Heidegger et Merleau-PontyLe présent essai est une tentative de réflexion à partir de l’oeuvre de Merleau-Ponty sur le problème anthropologique: comment penser l’humain dans son rapport ontologique avec l’animal sans retomber dans les dichotomies traditionnelles du spiritualisme et du naturalisme ou de la philosophie et de la non-philosophie, dans lesquelles la pensée contemporaine, en particulier la pensée heideggerienne, est restée à notre avis enfermée. L’originalité théorique de l’approche merleau-pontienne à l’égard de la thématique de la (...) différence anthropologique consiste dans le fait de vouloir repenser la vie, humaine et non humaine, au-delà des dichotomies classiques anthropologico-métaphysiques de la matière et de l’esprit, de l’instinct et de la raison, de la nature et de l’histoire, et ainsi de suite. Par conséquent, ce que nous proposons ici est de repenser la philosophie de l’animalité capable de rendre compte de la spécificité de l’humain sur la base d’une proximité ontologique inédite avec l’animal, comprise comme élément central de l’ontologie de la nature que Merleau-Ponty tentait d’élaborer dans les dernières années de sa vie. Une tâche qui, sans doute, plus qu’un aboutissement théoriques, pourrait être l’indice d’une série de problèmes que la philosophie, grâce avant tout à la contribution fondamentale de Merleau-Ponty, pourrait enfin affronter de manière radicale.The Philosophy of Animality in Heidegger and Merleau-PontyBased on Merleau-Ponty’s work, the present essay attempts to reflect on the anthropological problem: how to conceive the human in its ontological relation withthe animal – without falling back into the traditional dichotomies of spiritualism and naturalism or philosophy and non-philosophy, in which contemporary thought, in particular Heidegger’s thought, has remained, in our opinion, confined. The theoretical originality of Merleau-Ponty’s approach in regard to the thematic of anthropological difference consists in the fact of wanting to rethink life – both human and non-human life – beyond the classic anthropologico-metaphysical dichotomies of matter and spirit, of instinct and reason, nature and history, and so forth. As a result, what we propose here is to rethink the philosophy of animality in a way that is capable of accounting for the specificity of the human on the basis of a new ontological proximity with the animal. We understand this new ontological proximity as the central element of the ontology of nature that Merleau-Ponty attempts to elaborate in the last years of his life. No doubt, this is a task which, being more than a theoretical result, could be the index of a series of problems that philosophy, thanks above all to Merleau-Ponty’s fundamental contribution, can finally confront in a radical manner. (shrink)

This volume presents the results of the research PRIN project “Perception, performativity, and cognitive sciences”, which has been financed by MIUR over the three years period 2016–2019 and carried out by a team of academics: Antonino Pennisi, Vittorio Gallese, Ruggero Eugeni, Claudio Paolucci, Pietro Montani, Marco Mazzone, Franco Lo Piparo, Guglielmo Tamburrini. During 2017 Nunzio Allocca has joined the roman unity, while Marco Carapezza joined the unity of Palermo. All the news about the state of research and the scientific (...) initiatives involving our research group are available on the web and described in 2/2017 of “Reti Saperi Linguaggi. Italian Journal of Cognitive Sciences”. (shrink)

. Each predicate of the Aristotelian square of opposition includes the word “is”. Through a twofold interpretation of this word the square includes both classical logic and non-classical logic. All theses embodied by the square of opposition are preserved by the new interpretation, except for contradictories, which are substituted by incommensurabilities. Indeed, the new interpretation of the square of opposition concerns the relationships among entire theories, each represented by means of a characteristic predicate. A generalization of the square of opposition (...) is achieved by not adjoining, according to two Leibniz’ suggestions about human mind, one more choice about the kind of infinity; i.e., a choice which was unknown by Greek’s culture, but which played a decisive role for the birth and then the development of modern science. This essential innovation of modern scientific culture explains why in modern times the Aristotelian square of opposition was disregarded. (shrink)

In my contribution, I discuss the important role of moral anthropological questions in the development of Schiller’s theoretical thought. I underline the fact that Schiller’s philosophical questions in Jena are much closer to those he confronted in Stuttgart – much closer than is considered to be the case in contemporary Schiller scholarship. I show how this continuity becomes evident when we take into consideration the moral anthropological topics that continued to interest Schiller throughout his life. To ground my argument, I (...) show that the concept of the“whole human being” (i. e. the concept of a human considered in its entirety, as both sensible and rational) constitutes the continuous characteristic of Schiller’s philosophical considerations. (shrink)

The paper discusses the identity-building power and motivational force of patriotism. The basic idea underlying the discussion is that far from being a mere irrational and destructive force, patriotism is an expression of ‘existing human social identity.’ Thus, it argues that rather than dismissing patriotism altogether as an undesirable and/or irrational phenomenon, we need to understand how to discriminate between alternative forms of patriotism while investigating what constitutional reforms might be required to support those forms of patriotic identification that are (...) morally desirable. I argue that to flourish, desirable forms of patriotism (what I call Ethical Patriotism) require a political milieu where forms of subsidiarity, functional representation and local participation combine to produce a more democratic and decentralized system of governance. Applied to a post-national polity like the EU, this conclusion invites to rethink the European constitutional project so as to make it less elitist and more open to influence and participation from below. Keywords: cosmopolitanism; communitarianism; identity; nationalism; governance; Europe (Published: 4 December 2009) Citation: Ethics & Global Politics, Vol. 2, No. 4, 2009, pp. 321–348. DOI: 10.3402/egp.v2i4.2002. (shrink)

Nous pourrions, d?une formule générale, avancer que selon le médecin psychiatre et philosophe Ludwig Binswanger, l?action de la psychothérapie vise à aider le malade à recouvrer quelque chose de la mobilité de son existence au sein des structures, volontiers qualifiées d?existentiales ou de transcendantales, ou encore a priori , de l?être-au-monde et de l?être-avec-autrui. Je m?attacherai à montrer ici que la capacité à endurer l?indéter­mination inhérente à l?ouverture des possibles, à se porter depuis l?au-delà des préfigurations de l?avenir, est comme (...) la condition de l?historicisation de l? ipse , d?une traversée des conditions destinales de l?existence, une traversée de la passivité, commerce dialectique avec elle mais sans telos glorieux. Pâtir l?indétermination pour élaborer sa passivité. Chacun sait que du côté de la philosophie, l??uvre de Binswanger a reçu ses principales impulsions, après l?étude précoce de Kant 1 , de la phéno­ménologie, en particulier celle de Husserl, et de l?analytique existen­tiale de Heidegger. Chez chacun de ceux-ci, Binswanger a cherché les moyens de décrire la mondanéisation du monde dans l?expérience normale et, sur la base des résultats acquis avec ces seuls moyens descriptifs, de mettre au jour les Umwandlungen , les modifications, les « flexions » de l?existence au cours des expériences morbides de ses patients. Encore faut-il voir, si nous. (shrink)

The essays collected in this volume explore the ethical issues raised by the process and substance of policy-making, and discuss whether it is reasonable to expect ethical standards in public affairs.

The social research about group decision-making in the human societies has received recent contributions from studies reached in the field of ethology and Game theory. Comparative data revealed the adoption of symbolic systems for vote expression and the consensus achievement in other social species. The wide diffusion of the voting procedure—as a sign of an ecological rationality– in species with different social organizations and cognitive levels, requires a new interpretation of the consensus issue assuming a new evolutionary biopolitical perspective, for (...) the survey of the sociality and in particular of the effects of linguistic rationality on the human group decision-making. (shrink)

European Journal of Philosophy, Volume 29, Issue 4, Page 795-810, December 2021.

Quel est le rôle de Galilée dans la naissance séculaire de la science moderne? Je réponds à la question ci-dessus à la lumière de deux nouveaux éléments. Dès le xvie siècle, Nicolas de Cues, quoiqu’il ne pratiquât pas la science expérimentale, a anticipé une partie substantielle de la révolution copernicienne et de la naissance de la méthodologie galiléenne. Le deuxième élément est l’introduction d’une nouvelle conception des fondements de la science ; ils sont définis comme constitués de trois dialectiques. Après (...) cette définition, la naissance de la science moderne correspond à un très long processus historique qui se conclut à notre époque. Sur cette longue période, Galilée ne fut pas seulement le premier à recourir à une méthodologie scientifique, mais aussi presque le seul à jamais avoir été conscient de l’ampleur des enjeux intellectuels de l’entreprise scientifique. (shrink)

Mindfulness can be understood as the mental ability to focus on the direct and immediate perception or monitoring of the present moment with a state of open and nonjudgmental awareness. Descriptions of mindfulness and methods for cultivating it originated in eastern spiritual traditions. These suggest that mindfulness can be developed through meditation practice to increase positive qualities such as awareness, insight, wisdom, and compassion. In this article we focus on the relationships between mindfulness, with associated meditation practices, and the cognitive (...) neuroscience of attention and awareness. Mindful awareness is related to distributed attention, phenomenal consciousness, and momentary self-awareness, as characterized by recent findings in cognitive psychology and neuroscience as well as in influential consciousness models. Finally, we outline an integrated neurocognitive model of mindfulness, attention, and awareness, with a key role of prefrontal cortex. (shrink)

This article uses the Historia Lausiaca of Palladius (cc. 33-34) to identify in a monastic and ecclesiastical community some verbal, psychological and physical violence that reflects what today would be framed as bullying.

The A. compares the psalmus contra partem Donati, written by Augustin about 394, with the anonymous psalmus responsorius from a papyrus preserved in the Benedictine abbey in Montserrat, near Barcelona, under the shelf mark P.Monts.Roca inv. 128-178, dating maybe to the mid-IV century AD, from which only the strophes from A to L are complete. Particularly, he focuses on four lines before the acrostic strophes, whose reading is very controversial, and whose prosody he presents as different from the common one, (...) restoring it fully to its function of hypopsalma: Páter qui ómnia régis péto / Chrísti nós sciás herédes / Chrístus uérbo nátus pér quem pópulús est líberátus. (shrink)