Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Montaigne Among the Moderns: Receptions of the “Essais”Patrick HenryMontaigne Among the Moderns: Receptions of the “Essais,” by Dudley M. Marchi; xiii & 334 pp. Providence, Rhode Island: Berghahn Books, 1994, $49.95.This ambitious project is not a study of the Essais per se, but rather an analysis of their receptions from the seventeenth century to the present. Written by a comparativist with access to German, French, and English literature (...) and philosophy, it deals with authors from diverse backgrounds and time periods and pays careful attention throughout both to intertextuality and to the particular “horizons-of-experience” in which the Essais were received. “Reception” here does not mean some un-Mont aigne-like passive acceptance, but rather the assimilation and reactivation of the essayist’s concept of literature, writerly project, and theories of reading and writing in the works of later writers, mainly “premodernists” (Emerson and Nietzsche), “high modernists” (Pater and Woolf), and “postmodernists” (Butor, Chaillou, Sollers). In the most general sense, what Montaigne shares with all these authors is the need to make central in the form and substance of his work the paradox of a rupture with the pa st and its simultaneous continuation. Here modernism is less a period concept than a recurring literary phenomenon whereby the essayist not only influences the moderns and the postmoderns but is one of them. This enables us, finally, to perceive in the Essais a dialogical process that resists closure and reenacts the literary and philosophical debates of our own historical situation.Chapter One schematizes the history of the receptions of the Essais in France from 1580 to 1950 focusing mainly on the stylistic and religious readings of major figures in French literature. While much of this has already been done, Marchi syn thesizes well, makes his own original points, and offers us exceedingly interesting pages on the essayist’s covenant daughter and most active literary executrix, Marie le Jars de Gournay. Throughout he depicts how the shifting nature of the Essais’ textuality (their “hermeneutic undecidability” [p. 74]) allows them to assume various identities in the minds of different interpreters through the ages, thus problematizing the very act of reception and granting the reader a role in the production of me aning.The next chapters constitute the most original parts of the study and analyze the reception of the Essais in the works of Emerson, Nietzsche, Pater, Woolf, Butor, Chaillou, and Sollers. In Emerson and Nietzsche, we find reactivated the Montaig nean dialogue between the unique self and cultural tradition. Emerson read the Essais in the Cotton translation and wrote about Montaigne in Representative Men but only relied on the essayist to help him reach his own intellectual independen ce, finally moving from a more ego-centered position to the security of past models and rejecting skepticism in favor of dialectical resolution. Nietzsche read Montaigne in the original and knew him through Emerson. Marchi finds “an active inter textual Montaignean dimension” (p. 124) [End Page 140] in Nietzsche’s work and underscores their mutual preoccupation with radical skepticism, self-cultivation, self-portraiture, mutability, the instability of language, and the crisis of representa tion. He discovers two sides to Nietzsche’s reception of the Essais: the Apollonian “Socrantic optimism” and the Dionysian “libertine transgression” (p. 165) and indicates how the essayist’s concreteness and acceptance of human limitations tempered respectively Nietzsche’s propensity toward abstract metaphysics and Schopenhaurean pessimism.The third chapter unveils the aesthetic and thematic elements of the Essais in the critical and creative works of Pater and Woolf who went beyond the philosophical essaying of Emerson and Nietzsche, were the first to extend aspects of the E ssais in narrative works since Marie de Gournay, and created Montaigne the modernist “by insisting on the qualities of his textuality most akin to their own” (p. 186). The most interesting pages here delineate, on the one hand, Pater’s failed attempt to reconcile the religion of Pascal and the aesthetics of Montaigne and the essayist’s presence in Pater’s Gaston de Latour and, on the other, Woolf’s Montaigne-like essayistic techniques of weighing probabilities, suspending dogmatic judgment, and breaking of narrative sequentiality and her concomitant assimilation... (shrink)

Utopia repeatedly sets forth the rhetorical strategy of using pleasant and healing words to “enter” or “flow” or “steal into” fortresses of hardened opinion and custom without arousing warlike passions to keep them out. An important part of this strategy is the creation of a character who denounces major instances and causes of injustice but who nonetheless supports war and other means of force at the expense of law in rectifying that injustice; another part of the strategy is the creation (...) of a character and a plot that embody the “indirect” rhetorical approach aimed primarily at long-term persuasion needed to improve laws and institutions. (shrink)

Le mérite le plus patent de Zur Kritik der Gewalt de Benjamin consiste à défaire toute représentation innocente de la violence et de ses usages, toute compréhension de la violence qui n’y verrait que l’innocuité d’un moyen neutre légitimé, ou pas, par les fins qu’il vise, les intérêts qu’il sert ou les classes qui le mobilisent. « Dans cette perspective, la violence est un produit naturel, en quelque sorte un matériau brut dont l’utilisation ne pose aucun problème ». S’interroger sur (...) la viole... (shrink)

This study ascertained reports of assent (affirmative agreement) and permission (agreement by an adult fully capable of being informed) in 114 children's research articles in 1990 in Child Development (CD), Journal of Consulting and Clinical Psychology (JCCP), Journal of Pediatric Psychology, and Journal of Clinical Child Psychology. Of the research projects, 43% failed to specify permission, and 68.5% failed to specify assent. JCCP reported assent significantly more than CD. Assent was reported significantly more in research with older children than with (...) younger children. This lack of sensitivity to assent and permission suggests that many authors, reviewers, and editors consider reporting assent and permission unessential. We recommend specifying assent and permission in all manuscripts, highlighting children's research issues in graduate training, and using specific safeguards when conducting research with children. (shrink)

Danielle Cohen-Levinas (DCL) : Qu’est-ce qui se trouve pour Rosenzweig définitivement achevé après la guerre? C’est par cette question à bien des égards brutale, que j’aimerais entrer avec vous dans l’œuvre de Franz Rosenzweig, une œuvre complexe, qui déplace les interprétations hégéliennes de l’histoire, mais qui toutefois reste encore confidentielle, confinée à quelques cercles de savants, érudits, ou intellectuels qui ont trouvé chez ce philosophe un « agir » de la philosophie. Que ma pre...

La philosophie politique, dans sa tradition dominante, prend essentiellement en vue la possibilité d’une continuité plus ou moins harmonieuse entre personne et société, entre individu et communauté – que ce soit dans la figure du contrat, de l’association, du transfert de forces ou dans celle de l’universalité concrète de l’État. La pensée du politique autorisée par l’éthique de Levinas frappe de discontinuité les formes et les instances d’homogénéisation ou de dialectisation qui découlent de ce modèle. Elle propose une pensée de (...) l’altérité comme interruption radicale mais fragile des totalisations et des autonomisations de la politique. Dans le contraste entre visage et personne, entre proximité duelle et multiplicité des tiers, dans l’équivoque même de la personne, dans l’inspiration de la société et de la politique par ce qui vient avant elles, une pensée de la Justice s’esquisse, originale et profonde. (shrink)

Nuclear waste is ethically contentious, concerning institutional trust, community engagement and the role nuclear plays in different sociotechnical configurations of energy futures. Using Q-methodology with a diverse UK-based stakeholder group, we find three emergent discourses: a) ‘Managing a distrustful public’, b) ‘Fair and democratic nuclear waste decision-making’, and c) ‘Putting the experts in control’. Although multi-stakeholder support is expressed for geological disposal of wastes, disagreements arise toward the ethics of nuclear-powered energy futures and for community decision-making roles. We recommend that (...) policy authorities must first strengthen community withdrawal rights, and second, renew deliberative democratic decision-making mechanisms within energy policy strategy. (shrink)

On a charge of murder or manslaughter it must be shown that the person killed was one who was in being. It is neither murder nor manslaughter to kill an unborn child while still in its mother’s womb although it may be the statutory offences of child destruction or abortion. If however the child is born alive and afterwards dies by reason of an unlawful act done to it in the mother’s womb or in the process of birth, the person (...) who committed that act is guilty of murder or manslaughter according to the intent with which the act is done. [Halsbury’s LAWS OF ENGLAND, 4th ed. reissue, Vol. 11 (1). London: Butterworths, 1990.]. (shrink)

Esse livro reúne os textos críticos dispersos de Gérard Lebrun sobre a filosofia crítica de um dos maiores filósofos do idealismo alemão,Immanuel Kant, tornando-os agora acessíveis à maioria do público, que não tem o hábito de consultar revistas especializadas em filosofia.

The concept of a technical frontier in branches of experimental measurement, such as the resolution of the microscope, angular measure and time telling, has been around for more than 60 years. The purpose of this brief paper is to identify the technical frontier operating on the achromatic astronomical telescope, where a limiting factor of the resolution of fine detail was the quality of the optical glass available. The achromatically corrected objective is formed from two kinds of glass, the common crown (...) glass and the heavy clear flint glass or lead glass. This last was difficult to make homogeneous, that is without regions of different density, and therefore different refraction and dispersion. Unusually, optical glass had to pass a second frontier, this time placed on the whole glass industry by the English Government in the form of excise duty, administered with a bureaucratic efficiency that effectively stopped, in around 1800, the making of optical glass suitable for the serious astronomical telescopes. The result of the tax imposition was to delay the English production of improved optical glass for more than 80 years. (shrink)

Dans son article de 1915 sur l'inconscient, Freud pose la question suivante: « Nous disions qu'il y avait des représentations conscientes et des représentations inconscientes; mais y a-t-il aussi des motions pulsion-nelles, des sentiments, des sensations inconscients, ou bien, dans leur cas, de telles alliances de mots sont-elles dénuées de sens?».

Papers presented at a conference held in University College, Galway, in June 1993.

Cet essai se situe sur le terrain de la théologie pour relever l’usage qu’elle en fait comme clef du langage sur Dieu. A ce titre, l’analogie déborde et dépasse le domaine de la logique et de l’épistémologie pour servir une pensée non seulement spéculative, mais encore spirituelle et mystique. Son emploi en théologie traduit l’aspect intellectuel d’une attitude d’abord existentielle et croyante où l’homme se reconnaît comme créature distante de son Créateur, mais surtout en tant que nature raisonnable, comme fait (...) à l’image de Dieu et appelé à la dignité de fils du Dieu Père. La réflexion sur l’analogie nous introduit ainsi inévitablement dans le domaine de l’image dont l’homme ne porte la marque qu’en raison de sa participation à l’image parfaite de Dieu qu’est son Verbe. Si l’analogie suggère la distance entre les termes transcendant et immanent qu’elle relie, ne reviendrait-il pas à l’image d’effectuer leur rapprochement ? S’appuyant sur la théologie de S. Thomas, l’enquête de G. Rémy traite de l’analogie comme outil conceptuel indispensable au discours sur Dieu et le mystère trinitaire ; le relais sera pris par la notion d’image appliquée à l’homme mais dont l’archétype est le Christ.This essay is situated in the area of theology to note how analogy is used as a key to language about God. As such, analogy goes beyond and transcends the domain of logic and epistemology to serve not only speculative but even spiritual and mystical reflection. Its use in theology translates the intellectual aspect of an attitude at first existential and believing, in which man recognizes himself as a creature distant from his Creator, but, above all, as a reasonable nature made in the image of God and called to dignity as the son of God the Father. This reflection on analogy inevitably leads us into the domain of the image, of which man carries only the mark by reason of his participation to the perfect image of God who is his Word. If analogy suggests the distance between the transcendent and immanent terms that it connects, is it not the role of the image to bring them close to each other? Relying on the theology of St. Thomas, the inquiry of G. Remy treats analogy as a conceptual tool that is indispensable to the discourse on God and the Trinitarian mystery. It is relayed by the notion of image applied to man, of which the archetype is Christ. (shrink)

Een theologisch betoog van de gereformeerde Kamper hoogleraar in (o.a.) de Ethiek.

I am going to begin, as all philosophers do, by going back to the ancient Greeks, and then taking a quick tour of the present day, before returning to the ancient Greeks again. Let us begin with the so-called quarrel between philosophy and poetry–what was the reason for this? Well, philosophy was invented at a particular point in time, and in relation to poetry, it was a newcomer. When philosophy was invented it found another intellectual enterprise already in possession of (...) the field, and that enterprise was poetry, primarily Homer and Hesiod. Plato, in trying to make intellectual space for philosophy, made so much space that he risked pushing poetry out of the field altogether as an intellectual enterprise. Plato assumes that poetry and philosophy are competitors in the same business; he can then be seen as attempting to make a hostile take-over bid. (shrink)