Results for 'PRDM'

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    PRDM proteins: Important players in differentiation and disease.Cathrine K. Fog, Giorgio G. Galli & Anders H. Lund - 2012 - Bioessays 34 (1):50-60.
    The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co‐factors or, more speculatively, confer methylation of non‐histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, (...)
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