Maintaining intestinal homeostasis is a key prerequisite for a healthy gut. Recent evidence points out that microRNAs (miRNAs) act at the epicenter of the signaling networks regulating this process. The fine balance in the interaction between gut microbiota, intestinal epithelial cells, and the host immune system is achieved by constant transmission of signals and their precise regulation. Gut microbes extensively communicate with the host immune system and modulate host gene expression. On the other hand, sensing of gut microbiota by the (...) immune cells provides appropriate tolerant responses that facilitate the symbiotic relationships. While the role of many regulatory proteins, receptors and their signaling pathways in the regulation of the intestinal homeostasis is well documented, the involvement of non‐coding RNA molecules in this process has just emerged. This review discusses the most recent knowledge about the contribution of miRNAs in the regulation of the intestinal homeostasis. (shrink)

This paper studies the feature extraction and middle-level expression of Convolutional Neural Network convolutional layer glass broken and cracked at the scene of road traffic accident. The image pyramid is constructed and used as the input of the CNN model, and the convolutional layer road traffic accident scene glass breakage and crack characteristics at each scale in the pyramid are extracted separately, and then the depth descriptors at different image scales are extracted. In order to improve the discriminative power of (...) the depth descriptor, Hellinger kernel and Principal Component Analysis are used to perform nonlinear and linear transformations. Two aggregation strategies based on depth descriptors are proposed to form a global image representation. The classification experiment of the data set shows that Hellinger kernel, PCA transformation, and two aggregation strategies are all conducive to improving the classification accuracy. In addition, the convolutional layer road traffic accident scene glass breaking and crack feature coding can obtain better classification performance than the fully connected layer feature. We conducted dynamic impact tests on plate glass and Polyvinyl Butyral- laminated glass under different boundary conditions and studied the crack propagation and failure process of the glass under different impact speeds. The results show that there are radial cracks and circular cracks on the glass specimens under the impact load; the glass specimens show partial damage under high-speed impact and the characteristics of glass breaking and cracks at the scene of road traffic accidents; the four-frame plate glass is supported by sharp dagger-like fragments. This paper compares the energy absorption of glass specimens under different boundary conditions. The results show that the energy absorption effect of the four-point supporting glass specimen is generally stronger than that of the four-frame supporting glass. (shrink)

In this review, we provide an overview of the dynamic changes within the microbiota and its metabolites that are implicated in establishing and maintaining gastrointestinal homeostasis during various stages of microbial colonization. The gradual conversion of the gut microbiota toward a mutualistic microbial community involves replacement of pioneer gut colonizers with bacterial taxa that are characteristic for the adult gut. An important microbial signature of homeostasis in the adult gut is the prevalence and activity of a diverse spectrum of bacterial (...) species that produce beneficial metabolites through metabolic interactions between microbial groups. Deciphering these microbial signatures and their metabolites that govern short and long‐term equilibrium, as well as imbalances in host‐microbial relationships, may provide novel diagnostic tools and/or therapeutic targets for specific disorders associated with intestinal dysbiosis and loss of homeostasis. (shrink)