Type 2 diabetes mellitus is associated with cognitive impairment in many domains. There are several pieces of evidence that changes in neuronal neuropathies and metabolism have been observed in T2DM. Structural and functional MRI shows that abnormal connections and synchronization occur in T2DM brain circuits and related networks. Neuroplasticity and energy metabolism appear to be principal effector systems, which may be related to amyloid beta deposition, although there is no unified explanation that includes the complex etiology of T2DM with cognitive (...) impairment. Herein, we assume that cognitive impairment in diabetes may lead to abnormalities in neuroplasticity and energy metabolism in the brain, and those reflected to MRI structural connectivity and functional connectivity, respectively. (shrink)

Case-cohort design is a biased sampling method. Due to its cost-effective and theoretical significance, this design has extensive application value in many large cohort studies. The case-cohort data includes a subcohort sampled randomly from the entire cohort and all the failed subjects outside the subcohort. In this paper, the adjustment for the distorted covariates is considered to case-cohort data in Cox’s model. According to the existing adjustable methods of distorted covariates for linear and nonlinear models, we propose estimating the distorting (...) functions by nonparametrically regressing the distorted covariates on the distorting factors; then, the estimators for the parameters are obtained using the estimated covariates. The proof of consistency and being asymptotically normal is completed. For calculating the maximum likelihood estimates of the regression coefficients subject in Cox’s model, a minorization-maximization algorithm is developed. Simulation studies are performed to compare the estimations with the covariates undistorted, distorted, and adjusted to illustrate the proposed methods. (shrink)

Ben shu de zhu yao nei rong shi chan shu zhe xue de te shu de li lun xing zhi he du te de huo dong fang shi,Bing tong guo ju ti lun zheng zhe xue dui gou cheng si xiang de ji ben xin nian,Ji ben luo ji,Ji ben fang shi,Ji ben guan nian,Zhe xue li nian de qian ti pi pan,Zhan xian zhe xue fa zhan de zi wo pi pan de huo li he yong bu ku (...) jie de li lun kong jian. (shrink)

This study examined the relationship between two types of mathematical flexibility – potential flexibility, which indicates individuals’ knowledge of multiple strategies and strategy efficiency, and practical flexibility, which refers to individuals’ flexible performances when solving math problems. Both types of flexibility were assessed in the domain of linear equation solving. Furthermore, two types of beliefs – self-efficacy and use of flexible cognition – were investigated as potential moderators between potential and practical flexibility. 121 8th grade students from China took part (...) in this study. Results indicate that potential flexibility positively predicted practical flexibility. Additionally, self-efficacy and use of flexible cognition might moderate the relationship between these two types of flexibility, suggesting that potential flexibility may lead to different degrees of practical flexibility depending on different levels of beliefs. Implications of these findings for research on mathematical flexibility and for educational practice are discussed. (shrink)

The no-wait flow-shop scheduling problem with sequence-dependent setup times and release times is a typical NP-hard problem. This paper proposes an enhanced differential evolution algorithm with several fast evaluating strategies, namely, DE_FES, to minimize the total weighted tardiness objective for the NFSP with SSTs and RTs. In the proposed DE_FES, the DE-based search is adopted to perform global search for obtaining the promising regions or solutions in solution space, and a fast local search combined with three presented strategies is designed (...) to execute exploitation from these obtained regions. Test results and comparisons with two effective meta-heuristics show the effectiveness and robustness of DE_FES. (shrink)

本書以「全新」的方式探討了一個「古老」並曾一度被「埋沒」且慣於「視而不見」的問題。 本書是「歷史」與「當代」衝擊和交匯的產物。無論「馬克思主義」這一「非哲學理論」曾以何種緣故歸入「哲學研究」，從實際的結果看，它很少被以「純粹哲學」的形式進行探討。從蘇東到東亞，從英美到歐陸，對其觀點的 研究、理解、評價與反思無不時常受到上至「國際政治」下到「經濟生活」等方方面面實踐的影響。在此意義，關於「馬克思主義」的「實踐效用」，不論是「積極的」或是「消極的」，不論是「已有定論」還是「一筆爛賬」， 人們已經說了太多，其中唯獨缺少純粹獨立的「理論反思」。 同時，「馬克思主義」在「中國」的命運，也隨時代的變遷經歷了數次「脫胎換骨」的改變。「馬克思主義哲學化」這一共產意識形態的「陳舊規制」撞見改革開放後（至少曾經一度）日益「學術化」的中國學界，會擦出怎樣的 火花？對此，具有真正「知識分子」品格的幾代中國學人已經交出了自己的答卷。本書代表了與此一脈相承的創新研究，從中可見「九零世代」的年輕學子如何以「純粹哲學」的方式，以「馬克思主義的基本命題」為對象，展開 無愧於「良心」與「真理」的獨立思考。.

L’amitié connaît un regain de faveur dans la Chine ancienne à partir des Song, avec l’attractivité sans précédent du système des examens mandarinaux dans les milieux savants. Mais quoi de plus éloigné, en apparence, du rapport égalitaire auquel nous associons l’amitié que le système foncièrement hiérarchisant que sont les examens? Le cas de la session de 1057 offre une vue exceptionnelle sur les possibilités du déploiement de l’amitié dans un contexte de sociabilité très hiérarchisée, à travers les rapports de l’examinateur (...) en chef Ouyang Xiu 歐陽修 (1007-1072), d’un des sous-examinateurs Mei Yaochen 梅堯臣 (1002-1060) et d’un jeune lauréat, Su Shi 蘇軾 (1037-1101). En croisant les perspectives de l’histoire littéraire, de l’histoire politique et de l’histoire administrative, nous nous demandons d’abord comment les échanges poétiques ont pu créer un cadre amical parmi les examinateurs dans un contexte institutionnel inévitablement tendu, et finalement favoriser une action commune. Nous nous interrogeons ensuite sur les circonstances qui ont permis à l’amitié déjà ancienne de Ouyang Xiu et Mei Yaochen de s’approfondir à la faveur d’un échange poétique, et dans quelle mesure le prestige de cet échange a pu accroître le renom de Mei Yaochen. Quant aux lettres de remerciement de Su Shi, nous examinons comment a pu se créer à travers elles une « affinité élective » entre les deux examinateurs et le jeune lauréat. (shrink)

Resumen: El teatro chino tiene sus orígenes en formas primitivas de canto y danza, y desde entonces ha evolucionado hasta convertirse en una forma artística integral con una rica historia. Se considera una de las tres culturas dramáticas más antiguas, junto con la griega y la sánscrita de la India. Las distintas naciones tienen culturas diferentes con características nacionales únicas, mientras que los conceptos filosóficos personalizados desempeñan un papel destacado en la formación de la cultura. La ciencia, la literatura, el (...) arte, la educación, etc. que pertenecen a la categoría cultural están todos guiados e influenciados por pensamientos filosóficos, y el arte dramático es igual. Este artículo discute y analiza los pensamientos filosóficos que subyacen a la cultura dramática tradicional china. (shrink)

Brain imaging studies have consistently shown subgenual Anterior Cingulate Cortical (sgACC) involvement in emotion processing. COMT Val158 and Met158 polymorphisms may influence such emotional brain processes in specific ways. Given that resting-state fMRI (rsfMRI) may increase our understanding on brain functioning, we integrated genetic and rsfMRI data and focused on sgACC functional connections. No studies have yet investigated the influence of the COMT Val158Met polymorphism (rs4680) on sgACC resting-state functional connectivity (rsFC) in healthy individuals. A homogeneous group of sixty-one Caucasian (...) right-handed healthy female university students, all within the same age range, underwent rsfMRI. Compared to Met158 homozygotes, Val158 allele carriers displayed significantly stronger rsFC between the sgACC and the left parahippocampal gyrus, ventromedial parts of the inferior frontal gyrus, and the nucleus accumbens (NAc). On the other hand, compared to Val158 homozygotes, we found in Met158 allele carriers stronger sgACC rsFC with the medial frontal gyrus, more in particular the anterior parts of the medial orbitofrontal cortex. Although we did not use emotional or cognitive tasks, our sgACC rsFC results point to possible distinct differences in emotional and cognitive processes between Val158 and Met158 allele carriers. However, the exact nature of these directions remains to be determined. (shrink)

以现代性批判为切入点来研究马克思思想。该书全面、完整、细致地勾勒出马克思现代性批判思想,阐释了这一思想在当代的重要意义.

Der vorliegende Aufsatz entwickelt die These, dass Arbeitsteilung ein wesentliches Medium ist, um gesellschaftliche Verachtung zu organisieren und zu mobilisieren. Er tut dies im Ausgang und im Rückgriff auf Simone Weil. Ihre Überlegungen zu Arbeit und Arbeitsteilung erlauben es, einen Brückenschlag zwischen zwei aktuellen Forschungssträngen zu schlagen, die in der Regel nebeneinanderher laufen: die sozialphilosophische Diskussion um das Verhältnis von Anerkennung und Arbeit auf der einen Seite und die Debatte zur Frage bedeutungsvoller Arbeit (meaningful work) in der Politischen Philosophie auf (...) der anderen Seite. Simone Weil erlaubt es, beide Debatten zu bereichern und zu verknüpfen. Ihre Reflexion auf das Phänomen Arbeitsteilung bereichert die sozialphilosophische Diskussion, indem sie zeigt, dass Arbeit nicht nur ein Medium gesellschaftlicher Anerkennungsprozesse ist bzw. sein kann, sondern auch ein Mittel gesellschaftlicher Verachtungsprozesse (Teil 1). Zugleich fordert sie, dass Arbeit so gestaltet wird, dass die Tätigen darin Autonomie erfahren können. Ihre diesbezüglichen Überlegungen ergänzen die Debatte in der Politischen Philosophie, in der ebenfalls auf das Kriterium der Autonomie zurückgegriffen wird, um bestimmen zu können, was „meaningful work“ ist (Teil 2). Am Ende des Aufsatzes werden die wesentlichen Ergebnisse kurz zusammengefasst und die weiterführende Frage aufgeworfen, inwiefern sich mit diesen Überlegungen an das normative Projekt einer verachtungsfreien Gesellschaft angeknüpft werden kann, das Avishai Margalit mit seinem Buch „The Decent Society“ einst skizziert hat. (shrink)

本书“以人为主”，有意召回近几十年史学中逐渐隐去的具体的“人”，使人与事更紧密地结合，就人论事，就事说理，在立说者和接受者的辩难和互动之中，展现思想者怎样思想，以及特定思想观念的发展进程。全书涉及的多 为菁英读书人，但也包括相对边缘的“知识青年”。既关注天下、国家、世界、民族主义、革命、共和等近代史上的关键词，也探讨读书人关于中外文化融合与文化主体性的思考，并梳理一些重要学人的学术走向、治学风格和研 究方法。希望呈现近代经典淡出之后，社会无所指引之时，读书人有着怎样的困惑，及其因应与努力。.

PurposeTo investigate spontaneous brain activity in patients with dry eye and healthy control using the fractional amplitude of low frequency fluctuation technique with the aim of elucidating the relationship between the clinical symptoms of DE and changes in brain function.Material and MethodsA total of 28 patients with DE and 28 matched healthy volunteers were enrolled. Resting-state functional magnetic resonance imaging scans were performed in both groups. Then all subjects were required to complete a comprehensive Hospital Anxiety and Depression Scale. Receiver (...) operating characteristic curve analysis was used to evaluate the differences in fALFF values between the two groups and their diagnostic value. Linear correlations between HADS and fALFF values in different brain regions of DE patients were analyzed using the Pearson correlation coefficient.ResultsPatients with DE had significantly higher fALFF values in the left calcarine sulcus than the HC group, while fALFF values in the bilateral middle frontal gyrus and right MFG/right inferior frontal gyrus were significantly lower in DE patients than in HC group. fALFF values had a high diagnostic value for differentiating patients with DE from the HC group. Right MFG and right MFG/IFG were significantly correlated with HADS values.ConclusionOur study found that DE mainly involved functional disorders in the brain areas of the left CS, bilateral MFG and right MFG/right IFG, which helped us to find possible clinical features of DE disease and reflected the potential pathological mechanism of DE. (shrink)

勞思光、牟宗三、葛瑞漢、華靄仁、安樂哲， 探究當代孟學家學術理解之差異， 透過思想省察及文獻分析等方式，重釋及廓清《孟子》研究的爭議性課題。 中國儒家經典《孟子》，向來被研究得最廣泛、透澈卻又似乎未能獲致研究者共同認定的一致性成果。由於研究者的學養背景相異，援引的哲學路數不同，使得《孟子》研究呈現出理解上的莫衷一是及多元歧見的情況。 本書針對當代學者有關《孟子》研究的爭議性課題，試圖透過思想史的省察及文獻分析等方式予以廓清與重釋。首先，作者立基於《孟子》的歷史發展脈絡，並掌握經典文獻語義及架構價值。其次，藉由學術研究成績斐然的勞思 光先生與當代新儒家的重要代表人物牟宗三先生，對於《孟子》詮釋的差異性作比較與省思，深刻觸及了儒家哲學的內在問題。接著，探究葛瑞漢、華靄仁以及安樂哲三位漢學家，何以因為迥異的思維而產生不同的學術理解。最 後，疏理傳統與當代及西方詮釋孟學所引發的爭議。全書既省察當代孟學詮釋，並對比其論述脈絡，是一本孟學及儒學研究者必備專書。.

本書從思想史脈絡的溯源，立足在孟學發展史上之歷史關鍵點，以宋／清孟學發展轉折切入，以朱熹／戴震做為研究對象，探究二家思想的關聯性，並從西方詮釋學的新視野研究兩家詮釋殊異之因；透過朱熹與戴震二位理學大家 ，釐清由宋至清的孟學系譜，勾勒出孟學何以能從宋明理學「向內體證理路」轉而趨向清代義理「向外道德實踐」的不同蘊趣。【秀威資訊科技股份有限公司製作】.

La “política de adaptación” se trataba de una manera pacífica en la difusión de las doctrinas de Dios. Sin embargo, esta estrategia no significó un consenso entre todos los misioneros en el Oriente. En el caso de China, la Evangelización se encontraba con enormes dificultades en la etapa inicial del proceso, entre los motivos principales, se encontraba la dificultad del idioma chino, la singularidad de la cultura autóctona, la filosofía confuciana arraigada y el poder absolutamente centrista. Los misioneros jesuitas que (...) llegaron a la tierra de Ming en los siglos XVI y XVII, desempeñaron un papel pionero en las comunicaciones científicas entre China y el Occidente. En este sentido, se puede decir que la historia de la misión jesuita de China durante la dinastía Ming está estrechamente vinculada con el origen de los estudios chinos en Europa. (shrink)

本书阐述了党政干部职业道德建设的重大意义,对党政干部的基本道德规范进行了详尽的论述,同时指出了党政干部职业道德培养和教育的途径和方法。.

本书探讨了元代儒学学派与诗文流派之间的互动关系。全书分为上下两编，上编为总论部分，对南宋金元时期学术变迁与派别分化、学术与诗文的联动、理学门派传承与诗文流派的生成加以宏观性论述；同时重点考察了许衡与元 代中州文派、刘因与元代北方文派、许谦与元代金华文派、李齐贤与元代高丽文派等的儒学承传和文学创作。下编为考证部分，汇辑了元代高丽士人李齐贤研究资料，并考撰了“元代中朝（韩）越日间文学活动编年”。.