Abstract
This essay contextualizes the apostle Paul’s pivotal missionary residence in Ephesus, giving particular attention to the intriguing confrontation between Paul’s associates and devotees of the cult of Ephesian Artemis. The essay begins by examining aspects of the city of Ephesus and its residents that presented Paul both with unique challenges and unique evangelical opportunities. Specific attention is given to the shift in Paul’s locus of evangelism, from the Ephesian synagogue to residential house churches. This is followed by an exploration of the Ephesians’ distinctive adoration of Artemis. Finally, the dramatic clash between Christians and pagans in the Ephesian amphitheatre is scrutinized, with emphasis placed on the people involved and implications for the first century expansion of the Christian Church.