Abstract
Wittgenstein's question about agency in Philosophical Investigations §621 provides a fresh way of addressing the analysis of the distinction between physical nature and human culture, featuring the artifactual, hybrid, second-natured, enlanguaged and encultured transformation of the members of Homo sapiens into selves; and a third model of the cultural between the hermeneutic and the reductive: including the cultural "penetration" of the physical, internal and external Bildung, the sui generis features of the culturally emergent, and the new unity of the human and natural sciences