Effects of undernutrition by rearing in large litters on acquisition and memory of active-avoidance learning in mice

Bulletin of the Psychonomic Society 29 (4):351-354 (1991)
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Abstract

To determine the effects of early undernutrition on learning and long-term memory, Swiss mice were cross-fostered randomly at birth to produce litter sizes of 6 and 16, thereby providing “normally nourished” and “undernourished” conditions. At 28 days of age, the pups were housed in groups of 3 and 4, with ad-lib access to food and water until testing began at 60 days of age. Each mouse received 50 active-avoidance training trials daily for 14 consecutive days. Retention testing began 14 days after the end of original training and consisted of 50 trials daily for 5 days. Overall, mice reared in large litters suffered deficits in learning but not in long-term memory.

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