This study aimed to establish a correlation between Education, mobility, efforts to eradicate mosquito nests (MNE), and the presence of mosquito larvae with the incidence of DHF. This analysis is a quantitative analysis performed from a case-control point of view. In 2015-2019 there were 632 patients. The large samples, the box and the control, for example, were 490 pieces. Data collection tools through questionnaires. Random sampling technique achieved. This study is quantitative analysis research with a case-control approach. The population of (...) DHF sufferers in 2015-2019 was 632 cases. Large samples as case and control amounted to 490 pieces. Data collection instruments using questionnaires. Sampling technique using a disproportionate stratified random sampling technique. There was no significant relationship between Education and the incidence of DHF cases. (P = 0.543), there is no essential relationship between population mobility and DHF events (P value = 0.860); there is a significant relationship between MNE activity and the incidence of DHF cases (P value = 0.001) with an OR of 14.20, meaning that there is a risk of 14.20 times respondents who do not do MNE activities experience DHF events compared to respondents who do MNE activities. MNE activities carried out by respondents are related to controlling the incidence of DHF cases and are at risk of experiencing DHF cases. Managing the DHF case incident program requires optimizing MNE activities through cross-program, cross-sect cooperation and empowering religious and traditional leaders. (shrink)