Despite existing federal and state law and regulation, new human subjects research scandals involving “vulnerable” populations continue to surface. Although existing oversight mechanisms were enacted to ensure voluntary informed consent for participants and institutional review board oversight of HSR, these laws and regulations do not provide any special oversight mechanisms or protections to ensure the ethical and safe inclusion of cognitively impaired adults. The absence of rules to ensure consistently ethical conduct of research involving adults who lack consent (...) capacity may either lead to exploitation of this vulnerable population or the dearth of important research into the broad range of diseases that impair cognition. In other words, while some institutions and investigators are conducting research with this group without guidance, others are taking an extremely conservative approach and are excluding these individuals from research. Without safeguards that are adequate and robust but not overly burdensome, conducting research involving this population is ethically and legally challenging. (shrink)

Clinical research with adults who are unable to provide informed consent has the potential to improve understanding and care of a number of devasting conditions. This research also has the potential to exploit some of society's most vulnerable members. Recently, a number of task forces and individual writers have proposed guidelines to ensure that such research is both possible and ethical. Yet, there is widespread disagreement over which safeguards should be adopted. In the present paper, I consider to what extent (...) these disagreements can be resolved by appeal to a general account of the interests of subjects who are unable to consent and the conditions that must be satisfied for research enrollment to constitute exploitation of their inability to make their own decisions. (shrink)

In Michael Williams' “What's So Special About Human knowledge?” he argues that the kind of knowledge characteristic of adult humans is distinctive in that it involves epistemic responsibility. In particular, when an adult human has knowledge, they have a certain kind of epistemic authority, and that to attribute knowledge to them is to grant them a certain kind of authority over the subject matter. I argue that, while it is true that when we attribute knowledge to (...) adult humans, we typically also attribute to them the relevant kind of epistemic authority, this need not be because adult humans have a distinctive kind of knowledge. Rather, it may be because adult humans are distinctive kinds of beings - beings that can have epistemic authority over the subject matter about which they know. The only thing that need be special about human knowledge is that it's had by human knowers. (shrink)

The preeminence of informed consent in human subjects protections reflects Western democratic societies' ethical and political commitments to secure each citizen against both coercive and paternalistic influences of other people. Society permits adults extensive personal discretion in choices such as where to live, what to eat, how to dress, and whether to be in research. In short, individuals are afforded extensive discretion in choosing what to do and what is in their own best interests. Informed consent to enroll (...) in research is especially important because research necessarily involves procedures such as randomization and blinding that are done to assure that the project will produce generalizable knowledge. (shrink)

The faces of both adults and children can be classified accurately by sex, even in the absence of sex‐stereotyped social cues such as hair and clothing (Wild et al., 2000). Although much is known from psychological and computational studies about the information that supports sex classification for adults' faces, children's faces have been much less studied. The purpose of the present study was to quantify and compare the information available in adults' versus children's faces for sex classification and to test (...) alternative theories of how human observers distinguish male and female faces for these different age groups. We implemented four computational/neural network models of this task that differed in terms of the age categories from which the sex classification features were derived. Two of the four strategies replicated the advantage for classifying adults' faces found in previous work. To determine which of these strategies was a better model of human performance, we compared the performance of the two models with that of human subjects at the level of individual faces. The results suggest that humans judge the sex of adults' and children's faces using feature sets derived from the appropriate face age category, rather than applying features derived from another age category or from a combination of age categories. (shrink)

Background: Walking while performing a secondary task walking) increases cognitive workload in young adults. To date, few studies have used neurophysiological measures in combination to subjective measures to assess cognitive workload during a walking task. This combined approach can provide more insights into the amount of cognitive resources in relation with the perceived mental effort involving in a walking task.Research Question: The objective was to examine cognitive workload in young adults during walking conditions varying in complexity.Methods: Twenty-five young adults performed (...) four conditions: usual walking, simple DT walking, complex DT walking and standing while subtracting. During the walking task, mean speed, cadence, stride time, stride length, and their respective coefficient of variation were recorded. Cognitive workload will be measured through changes in oxy- and deoxy-hemoglobin during walking in the dorsolateral prefrontal cortex and perceived mental demand score from NASA-TLX questionnaire.Results: In young adults, ΔHbO2 in the DLPFC increased from usual walking to both DT walking conditions and standing while subtracting condition. ΔHbO2 did not differ between the simple and complex DT and between the complex DT and standing while subtracting condition. Perceived mental demand gradually increased with walking task complexity. As expected, all mean values of gait parameters were altered according to task complexity. CV of speed, cadence and stride time were significantly higher during DT walking conditions than during usual walking whereas CV of stride length was only higher during complex DT walking than during usual walking.Significance: Young adults had greater cognitive workload in the two DT walking conditions compared to usual walking. However, only the mental demand score from NASA-TLX questionnaire discriminated simple from complex DT walking. Subjective measure provides complementary information to objective one on changes in cognitive workload during challenging walking tasks in young adults. These results may be useful to improve our understanding of cognitive workload during walking. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Human Gene TherapyMary Carrington Coutts (bio)On September 14, 1990, researchers at the U.S. National Institutes of Health (NIH) performed the first approved gene therapy procedure on a four-year-old girl named Ashanti DeSilva. Born with a rare genetic disease, severe combined immune deficiency (SCID), Ashanti lacked a healthy immune system and was extremely vulnerable to infection. Children with SCID usually develop overwhelming infections and rarely survive to adulthood; even (...) a common childhood illness like chicken pox is life-threatening. Ashanti led a cloistered existence, avoiding contact with people outside her family, remaining in the sterile environment of her home, and battling frequent illnesses with massive amounts of antibiotics.In Ashanti's gene therapy procedure, her own white blood cells were genetically modified and then infused back into her bloodstream. Laboratory tests show that the therapy has strengthened Ashanti's immune system. She no longer has recurrent colds, has been allowed to attend school, and has been immunized against whooping cough. This gene therapy procedure is not a cure, however. The genetically-treated white blood cells only survive for a few months and must then be replaced, but Ashanti's future is much brighter because of the new therapy (VI, Thompson [The First] 1993).Although this simplified description of Ashanti's gene therapy procedure sounds like a happy ending, it is little more than an optimistic chapter in a long story. The road to the first approved gene therapy procedure was rocky and fraught with controversy. The biology of human gene therapy is very complex, and there are still many techniques that need to be developed and diseases that need to be understood more fully before gene therapy is well established. The public policy debate surrounding the possible use of genetically engineered material in human subjects is equally complex. Major participants in the debate come from the fields of biology, government, law, medicine, philosophy, politics, and religion, each bringing different views to the discussion.In studying the ethics of gene therapy, one should draw a distinction between [End Page 63] therapy on somatic (non-reproductive) cells and germ (reproductive) cells. Only the germ cells carry the genes that will be passed on to the next generation. Reactions to gene therapy have varied widely. Some commentators on gene therapy object to any form of genetic manipulation, no matter how well-intentioned (VI, Rifkin 1983). Another reaction is to allow the use of somatic-cell therapy, but not to approve the use of germ-line therapy, which could have unforeseeable effects on future generations. A different stance is that, with proper regulation and safeguards, germ-line gene therapy is a logical extension of the progress made to date and that it is an ethically acceptable procedure.TechniquesTo date, 43 research protocols have been approved for somatic-cell gene therapy in the United States. The techniques employed in each protocol vary, but in general a virus is used as a "vector" to insert the desired gene into the DNA of the patient's cells, in order to compensate for a defective gene. For Ashanti's gene therapy, this technique involved obtaining white blood cells and introducing properly functioning genes into as many of the cells as possible. The normal genes were delivered through the use of a specially-engineered virus.Although similar techniques are used in germ-line gene therapy, the procedure is more difficult. There are two basic ways to perform germ-line gene therapy: (1) to treat a preimplantation embryo that carries a serious genetic defect before its implantation in the mother, which necessitates the use of in vitro fertilization techniques; or (2) to treat the germ cells (sperm or egg cells) of afflicted adults so that the genetic defects would not be passed on to their offspring, which requires the technical expertise to delete the defective gene and insert a properly functioning replacement. Because of the complexity of the procedures involved and the attendant ethical controversy, germ-line therapy is not currently performed.Candidate Diseases for Gene TherapyAt present, gene therapy is likely to be most successful in treating diseases that are caused by single-gene defects and has been approved for treating diseases such... (shrink)

My aim in this paper is to reconstruct Edmund Husserl’s views on the differences between human and animal consciousness, with particular attention to the experience of temporality.In the first section, I situate the topic of animal consciousness in the broader context of Husserl’s philosophy. Whereas this connection has been often neglected, I argue that a phenomenological analysis of non-human subjectivities is not only justified, but also essential to the Husserlian project as a whole.In the second section, I introduce (...) two notions Husserl resorts to when describing the essential difference between human and animal subjectivities, namely “strata of consciousness” and “person.” Drawing on textual evidence, I argue that Husserl does not simply see animals as excluded from the sphere of personhood. Rather, he draws a distinction between two modes of personal life, one of which is said to be unique to human adults.What holds these two modes apart, according to Husserl, is a subject’s relation to time. In the third section, I delve deeper into this topic, asking how we should understand Husserl’s claim that animals live in a “restricted temporality.” I argue that this has less to do with an inability to remember, imagine, or anticipate future events, and more with an inability to explore temporal horizons stretching before one’s birth or after one’s death. By contrast, humans gradually overcome these limitations during ontogeny, thanks to the practice of linguistic communication. This also has consequences for our capacity to engage in genuinely theoretical thought. (shrink)

Understanding the actions of others is fundamental for human social life. It builds on a grasp of the subjective intentionality behind behavior: one action comprises different things simultaneously (e.g., moving their arm, turning on the light) but which of these constitute intentional actions, in contrast to merely foreseen side-effects (e.g., increasing the electricity bill), depends on the description under which the agent represents the acts. She may be acting intentionally only under the description “turning on the light,” but did (...) not turn on the light in order to increase the electricity bill. In preregistered studies (N = 620), we asked how adults and children engage in such complex subjective action interpretation and evaluation in moral dilemmas. To capture the deep structure of subjects' representations of the intentional structures of actions, we derived “act trees” from their response patterns to questions about the acts. Results suggest that people systematically distinguish between intended main and merely foreseen side-effects in their moral and intentionality judgments, even when main and side-effects were closely related and the latter were harmful. Additional experimental conditions suggest that, when given ambiguous information, the majority of subjects assume that agents act with beneficial main intentions. This “good intention prior” was so strong that participants attributed good intentions even when the harmful action was no longer necessary to resolve the dilemma (Study 2). These methods provide promising new ways to investigate in more subtle and fine-grained ways how reasoners parse, interpret, and evaluate complex actions. (shrink)

Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher (...) scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. (shrink)

First, I introduce the concept of a “non-agential subject,” where a non-agential subject exists within an organism and has phenomenally conscious experiences in a morally significant way, but is not morally responsible for the organism's voluntary actions. Second, I argue that it's a live possibility that typical adult humans contain non-agential subjects. Finally, I argue that, if there are non-agential subjects, this has important and surprising implications for a variety of ethical issues. Accordingly, ethicists should pay more (...) attention to whether there are non-agential subjects and what their implications for ethics would be. (shrink)

We normally assume that there’s just one conscious individual per animal. Some question this, suggesting that there may be nonhuman taxonomic groups whose normal, adult members house more than one conscious subject. Call this the multitudes view (“MV)”. Our aim is methodological: we hope to understand how we might assess whether MV is true. To that end, we distinguish two strategies for counting conscious subjects: the duplication strategy and the mind-first strategy. We use human split-brain patients and (...) octopuses to illustrate the prospects and limitations of each approach, as some have argued that both sets of individuals contain multitudes. We’ll contend that while the duplication strategy is applicable to split-brain patients, it isn’t apt for octopuses. The mind-first strategy fairs better here, but there’s a catch: it requires, in a way the duplication strategy does not, numerous contentious assumptions about the nature of mentality, the individuation of minds, and consciousness to simply get off the ground. These difficulties clarify just what it would take to establish MV. (shrink)

Dual functional brain asymmetry refers to the notion that in most individuals the left cerebral hemisphere is specialized for language functions, whereas the right cerebral hemisphere is more important than the left for the perception, construction, and recall of stimuli that are difficult to verbalize. In the last twenty years there have been scattered reports of sex differences in degree of hemispheric specialization. This review provides a critical framework within which two related topics are discussed: Do meaningful sex differences in (...) verbal or spatial cerebral lateralization exist? and, if so, Is the brain of one sex more symmetrically organized than the other? Data gathered on right-handed adults are examined from clinical studies of patients with unilateral brain lesions; from dichotic listening, tachistoscopic, and sensorimotor studies of functional asymmetries in non-brain-damaged subjects; from anatomical and electrophysiological investigations, as well as from the developmental literature. Retrospective and descriptive findings predominate over prospective and experimental methodologies. Nevertheless, there is an impressive accummulation of evidence suggesting that the male brain may be more asymmetrically organized than the female brain, both for verbal and nonverbal functions. These trends are rarely found in childhood but are often significant in the mature organism. (shrink)

The goal of perception is to infer the most plausible source of sensory stimulation. Unisensory perception of temporal order, however, appears to require no inference, since the order of events can be uniquely determined from the order in which sensory signals arrive. Here we demonstrate a novel perceptual illusion that casts doubt on this intuition: in three studies (N=607) the experienced event timings are determined by causality in real-time. Adult observers viewed a simple three-item sequence ACB, which is typically (...) remembered as ABC (Bechlivanidis & Lagnado, 2016), in line with principles of causality. When asked to indicate the time at which events B and C occurred, points of subjective simultaneity shifted so that the assumed cause B appeared earlier and the assumed effect C later, despite full attention and repeated viewings. This first demonstration of causality reversing perceived temporal order cannot be explained by post-perceptual distortion, lapsed attention, or saccades. (shrink)

This chapter contains sections titled: God and I God and the Teenage I – The Theodicy Fiasco God and the Adult I – Harmful Religious Beliefs at Life's Beginning God and the Adult I – Harmful Religious Beliefs During Our Lives God and the Adult I – Harmful Religious Beliefs at Life's End Why I Speak Out Notes.

The present revolution in science and technology poses complex tasks in the sphere of management of production, tasks determined by the development of technology and technological communications. The essence of these tasks is determined primarily by objective technological and not by subjective organizational factors. The overall complexity of these tasks depends in the first place on the complexity of the development of production and not on the form of control of production adopted. The complexity of present-day production is such, however, (...) that the total mental capacity of the entire adult population would be insufficient to control it effectively. The solution of the problem lies in raising the productivity of labor in control systems, and this is impossible without employment of modern equipment, above all computers. (shrink)

The functional neural mechanisms underlying the cognitive benefits of aerobic exercise have been a subject of ongoing research in recent years. However, while most neuroimaging studies to date which examined functional neural correlates of aerobic exercise have used simple stimuli in highly controlled and artificial experimental conditions, our everyday life experiences require a much more complex and dynamic neurocognitive processing. Therefore, we have used a naturalistic complex information processing fMRI paradigm of story comprehension to investigate the role of an aerobically (...) active lifestyle in the processing of real-life cognitive-demanding situations. By employing the inter-subject correlation approach, we have identified differences in reliable stimulus-induced neural responses between groups of aerobically active and non-active cognitively intact older adults. Since cardiorespiratory fitness has previously been suggested to play a key role in the neuroprotective potential of aerobic exercise, we have investigated its dose-response relationship with regional inter-subject neural responses. We found that aerobically active lifestyle and cardiorespiratory fitness were associated with more synchronized inter-subject neural responses during story comprehension in higher order cognitive and linguistic brain regions in the prefrontal and temporo-parietal cortices. In addition, while higher regional inter-SC values were associated with higher performance on a post-listening memory task, this was not translated to a significant between-group difference in task performance. We, therefore, suggest that the modulatory potential of aerobic exercise and cardiorespiratory fitness on cognitive processing may extend beyond simple and highly controlled stimuli to situations in which the brain faces continuous real-life complex information. Additional studies incorporating other aspects of real-life situations such as naturalistic visual stimuli, everyday life decision making, and motor responses in these situations are desired to further validate the observed relationship between aerobic exercise, cardiorespiratory fitness, and complex naturalistic information processing. (shrink)

The aim was to verify the potential of holistic approaches towards the evaluation of human figure drawing. Groht-Marnat, Tharinger, Stark favour this approach, and findings seem to legitimize considerations about its diagnostic productivity. Yama, Dans-Lopez and Tarroja have identified bizarre and artistic quality criteria for drawing that have a relevant interpretative meaning. Within the study involving 525 normal adult subjects, the hypothesis of differences in personality traits and performance level produced by authors of selected types of drawings, (...) was verified. The criterium of bizarre drawing proved to be an important indicator of intellectual abilities monitored by subtests of the ISA-S test, the non-verbal CF 2A test, Decision-making test. They achieved the lowest scores in all parameters, with significance in relation to more detailed drawings. Results from IHAVEZ and DOPEN questionnaires suggest that bizarre character producers are more emotionally instable, less emotionally resilient, less anticipating, and less self-controlling, less rational, responding more intensely to problems and are less orientated towards their solution. They are more neurotic and present more psychotic experience. The main limitation is the chosen approach. Holistically evaluated drawing is rare in terms of its occurrence in a normal population. Even within the files involving several hundred participiants, it is possible to clearly classify drawing in the maximum number of tens. Diversity of the terminology and methodological ambiguity constitutes another limitation. The bizarreness itself is not interpreted clearly, rather the contrary. (shrink)

What the Doctor Didn’t Say: The Hidden Truth About Medical Research, by Jerry Menikoff , is an insightful, clear, and engaging overview of some of the ethical and legal challenges of clinical research. The book contains thoughtful discussions of legal protections for research subjects, medical malpractice law, informed consent, pediatric research, emergency research, research on decisionally incapacitated adults, payment to research subjects, and other important topics. It also makes a number of stunning revelations concerning the practice of clinical (...) research and provocative proposals for legal and policy reform. (shrink)

Recently, we proposed a fundamental subdivision of the human cortex into two complementary networks—an “extrinsic” one which deals with the external environment, and an “intrinsic” one which largely overlaps with the “default mode” system, and deals with internally oriented and endogenous mental processes. Here we tested this hypothesis by contrasting decision making under external and internally-derived conditions. Subjects were presented with an external cue, and were required to either follow an external instruction or to ignore it and follow (...) a voluntary decision process . Our results show that a well defined component of the intrinsic system—the right inferior parietal cortex—was preferentially activated during the “free-will” condition. Importantly, this activity was significantly higher than the base-line resting state. The results support a self-related role for the intrinsic system and provide clear evidence for both hemispheric and regional specialization in the human intrinsic system. (shrink)

Previously conducted structural magnetic resonance imaging (MRI) studies on the neuroanatomical correlates of mathematical abilities and competencies have a number of methodological limitations. Besides small sample sizes, the majority of these studies have employed voxel-based morphometry (VBM) – a method that, although it is easily to implement, has some major drawbacks. Taking this into account, the current study is the first to investigate in a large sample of typically developed adults the associations between mathematical abilities and variations in brain surface (...) structure by using surface-based morphometry (SBM). SBM is a method that also allows the investigation of brain morphometry by avoiding the pitfalls of VBM. Eighty-nine young adults were tested with a large battery of psychometric tests to measure mathematical competencies in four different areas: (1) simple arithmetic, (2) complex arithmetic, (3) higher-order mathematics and (4) numerical intelligence. In addition, we asked participants for their mathematics grade of their final school exam. Inside the MRI scanner, we collected high-resolution T1-weighted anatomical images from each subject. SBM analyses were performed with the computational anatomy toolbox (CAT12) and indices for cortical thickness, for cortical surface complexity, for gyrification and for sulcal depth were calculated. Further analyses revealed associations between (1) the cortical surface complexity of the right superior temporal gyrus and numerical intelligence, (2) the depth of the right central sulcus and adults’ ability to solve complex arithmetic problems and (3) the depth of the left parieto-occipital sulcus and adults’ higher-order mathematics competence. Interestingly, no relationships with previously reported brain regions were observed, thus, suggesting the importance of similar research to confirm the role of the brain regions found in this study. (shrink)

This paper highlights the evolutionary biological epistemology in Freud psychoanalytic theory. The concepts of aggressive and sexual drives are fulcrum of the psychoanalytic epistemological system, concerning the motivational/emotional roots of mental functioning. These biological roots of mental functioning, especially with regard to aggressive drive, have gradually faded away from psychoanalytic epistemology, as we show in the paper. Currently, however, Neurosciences, and in particular Affective Neuroscience (Panksepp 1998), can contribute to increase the knowledge of the biological roots of human mental (...) functioning. The motivational/emotional systems studied by Affective Neuroscience can give a new epistemological foundation to the aggressive drive concept in psychoanalytic theory. Over the course of human evolution motivational/emotional systems have assumed the role of organizers of social relationships and also of mental functioning. In this regard, among the various types of aggression (ANGER in Panksepp taxonomy 1998), that we consider in our paper is inter-male aggression, also named Dominance motivational/emotional system, which regulates social interactions between sexually mature adults. This type of aggression acts in complementary connection with FEAR motivational/emotional system, that regulate Submissive behaviour and Social defeat, the latter one of the more important stressors. The interaction between aggressiion and FEAR motivational/emotional systems gives rise to Agonistic behaviour or Dominance/Submission motivational/emotional system, as we propose in our paper. There is now a large literature that identifies in the dynamic of Agonistic behaviour one of the main factors of mental illness. When social interactions activate the Agonistic behavior, the subject can perceive himself as "destined to victory" or "destined to defeat", activating either behaviours and emotions connected to the Involuntary Defeat Strategy or Involuntary Dominant Strategy, that we can find in many types of mental disorders, e.g. mood disorders or anxiety disorders. (shrink)

Arginine vasopressin (AVP) is a powerful regulator of various social behaviors across many species. However, seemingly contradictory effects of AVP have been found in both animal and human studies, e.g., promoting aggression on one hand and facilitating social bonding on the other hand. Therefore, we hypothesize that the role of AVP in social behaviors is context-dependent. To this end, we examined the modulatory effect of AVP on male’s behavioral and neural responses to infant and adult cues. After intranasal (...) and double-blind treatment of AVP or placebo, male participants were asked to rate their subjective approaching willingness to infant and adult faces in specific contexts informed by cue words while EEG recording. Our results showed that AVP treatment increased approaching ratings to neutral and positive other-gender adult faces compared to emotional matched same-gender adult faces, and to negative girl faces compared to negative boy faces. Furthermore, compared to placebo treatment, AVP treatment induced larger N1 amplitudes to neutral cues associated with both adults and infants, whereas AVP treatment only sustained pronounced late positive potential (LPP) amplitudes to neutral cues of infants but not adults. Those findings implicate differential roles of AVP in the processing of adult- and infant-related cues and thus lend support to the context-dependent account. (shrink)

This exploratory study assessed the use of functional Near Infrared Spectroscopy (fNIRS) to examine hemodynamic response patterns during sentence processing. Four groups of participants: monolingual English children, bilingual Chinese-English children, bilingual Chinese-English adults and monolingual English adults were given an agent selection syntactic processing task. Bilingual child participants were classified as simultaneous or sequential bilinguals to examine the impact of first language, age of second-language acquisition (AoL2A), and the length of second language experience on behavioral performance and cortical activation. Participants (...) were asked to select the agent of four types of sentences: subject-verb-object (SVO), passive (PAS), subject-extracted relative clause (SR), and object-extracted relative clause (OR) adopted from the “Whatdunit” task by Montgomery et al. (2016). Semantic cues were removed by using inanimate nouns for agents and patients, which constrained participants to make decisions based on syntactic knowledge. Behavioral results showed greater accuracy for canonical SVO and SR sentence types than for noncanonical OR and PAS sentence types, which aligns with prior studies. Neuroimaging results revealed greater hemodynamic responses to relative clauses (i.e., SR and OR sentences) than to simple sentences (SVO and PAS), especially for Chinese-English bilinguals suggesting first-language transfer influencing sentence processing in English. The effects AoL2A and the length of second language experience showed no significant differences between simultaneous and sequential bilinguals or between bilingual adults and children for identifying the correct agent in each sentence. However, neuroimaging results demonstrated greater hemodynamic responses in right dorsolateral prefrontal cortex (DLPFC) and left inferior parietal lobule (IPL) in simultaneous bilinguals compared to sequential bilinguals and greater hemodynamic responses in left and right DLPFC and left IPL among bilingual adults. Different behavioral and neural hemodynamic response patterns afford new insights into the effects of syntactic knowledge on sentence processing. (shrink)

ObjectiveThis study aimed to develop a diagnostic model of multi-kinematic parameters for patients with amnestic mild cognitive impairment (aMCI).MethodIn this cross-sectional study, 94 older adults were included (33 cognitively normal, CN; and 61 aMCI). We conducted neuropsychological battery tests, such as global cognition and cognitive domains, and collected gait parameters by an inertial-sensor gait analysis system. Multivariable regression models were used to identify the potential diagnostic variables for aMCI. Receiver operating characteristic (ROC) curves were applied to assess the diagnostic accuracy (...) of kinematic parameters in discriminating aMCI from healthy subjects.ResultsMultivariable regression showed that multi-kinematic parameters were the potential diagnostic variables for aMCI. The multi-kinematic parameter model, developed using Timed Up and Go (TUG) time, stride length, toe-off/heel stride angles, one-leg standing (OLS) time, and braking force, showed areas under ROC (AUC), 0.96 [95% confidence interval (CI), 0.905–0.857]; sensitivity, 0.90; and specificity, 0.91. In contrast, a single kinematic parameter’s sensitivity was 0.26–0.95 and specificity was 0.21–0.90. Notably, the separating capacity of multi-kinematic parameters was highly similar to Montreal Cognitive Assessment (MoCA; AUC: 0.96 vs. 0.95). Compared to cognitive domain tests, the separating ability was comparable to Auditory Verbal Learning Test (AVLT) and Boston Naming Test (BNT; AUC: 0.96 vs. 0.97; AUC: 0.96 vs. 0.94).ConclusionWe developed one diagnostic model of multi-kinematic parameters for patients with aMCI in Foshan. (shrink)

The Gait Deviation Index is a multivariate measure of overall gait pathology based on 15 gait features derived from three-dimensional kinematic data. GDI aims at providing a comprehensive, easy to interpret, and clinically meaningful metric of overall gait function. It has been used as an outcome measure to study gait in several conditions: cerebral palsy, post-stroke hemiparetic gait, Duchenne muscular dystrophy, and Parkinson’s disease, among others. Nevertheless, its use in population with Spinal Cord Injury has not been studied yet. The (...) aim of the present study was to investigate the applicability of the GDI to SCI through the assessment of the relationship of the GDI with the Walking Index for Spinal Cord Injury II. 3D gait kinematics of 34 patients with incomplete SCI was obtained. Besides, 3D gait kinematics of a sample of 50 healthy volunteers was also gathered with Codamotion motion capture system. A total of 302 and 446 strides were collected. GDI was calculated for each stride and grouped for each WISCI II level. HV data were analyzed as an additional set. Normal distribution for each group was assessed with Kolmogorov-Smirnov tests. Afterward, ANOVA tests were performed between each pair of WISCI II levels to identify differences among groups. The results showed that the GDI was normally distributed across all WISCI II levels in both iSCI and HV groups. Furthermore, our results showed an increasing relationship between the GDI values and WISCI II levels in subjects with iSCI, but only discriminative in WISCI II levels 13, 19, and 20. The index successfully distinguished HV group from all the individuals with iSCI. Findings of this study indicated that the GDI is not an appropriate multivariate walking metric to represent the deviation of gait pattern in adult population with iSCI from a normal gait profile when it is compared with the levels of walking impairment described by the WISCI II. Future work should aim at defining and validating an overall gait index derived from 3D kinematic gait variables appropriate for SCI, additionally taking into account other walking ability outcome measures. (shrink)

Purpose: Studies of reactive and proactive modes of inhibitory control tend to show age-related declines and are accompanied by abnormalities in the prefrontal cortex. We explored which mode of inhibitory control would be more amenable to change and accrue greater benefits following engagement in a 4-week theater acting intervention in older adults. These gains were evaluated by performance on the AX-CPT task. We hypothesized that an increase in proactive control would relate to an increase in AY errors and a decrease (...) in BX errors. In contrast, an increase in reactive control would be associated with a decrease in AY errors, no change in AY reaction time, and an increase in BX response time. Further, we posited that an increase in behavioral proactive control would accompany greater cue versus probe activity for previously identified regions in the prefrontal cortex. In contrast, an increase in behavioral reactive control would be accompanied by greater probe activation in these identified brain areas.Materials and Methods: The participants were 179 community-dwelling adults aged 60–89 years who were on average, college-educated. Participants were pseudo-randomly assigned to either an active-experiencing acting intervention condition or the active control condition ; participant assignment was subject to time of enrollment. Participants in both groups were trained by theater-actor researchers with expertise in acting interventions. In contrast to the active control participants who attended a course on theater acting, the acting-intervention group was required to consistently deploy proactive and reactive control mechanisms. Both groups met two times/week for 75-min for 4 weeks. Participant brain-behavioral performance on the AX-CPT task was evaluated prior to and after this four-week period.Results: No intervention effects were found in favor of proactive control. Behavioral evidence in favor of reactive control was weak. Brain-related benefits to reactive control was illustrated by greater probe-activation in Brodmann areas 6 and 8, relative to controls and pre-intervention.Conclusion: We found some evidence for improvements in reactive control via brain measures, attributed to engagement in the acting intervention. (shrink)

Life history theory suggests that in risky and uncertain environments the optimal reproductive strategy is to reproduce early in order to maximize the probability of leaving any descendants at all. The fact that early menarche facilitates early reproduction provides an adaptationist rationale for our first two hypotheses: that women who experience more risky and uncertain environments early in life would have (1) earlier menarche and (2) earlier first births than women who experience less stress at an early age. Attachment theory (...) and research provide the rationale for our second two hypotheses: that the subjective early experience of risky and uncertain environments (insecurity) is (3) part of an evolved mechanism for entraining alternative reproductive strategies contingent on environmental risk and uncertainty and (4) reflected in expected lifespan. Evidence from our pilot study of 100 women attending antenatal clinics at a large metropolitan hospital is consistent with all four hypotheses: Women reporting more troubled family relations early in life had earlier menarche, earlier first birth, were more likely to identify with insecure adult attachment styles, and expected shorter lifespans. Multivariate analyses show that early stress directly affected age at menarche and first birth, affected adult attachment in interaction with expected lifespan, but had no effect on expected lifespan, where its original effect was taken over by interactions between age at menarche and adult attachment as well as age at first birth and adult attachment. We discuss our results in terms of the need to combine evolutionary and developmental perspectives and the relation between early stress in general and father absence in particular. (shrink)

The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell replacement therapy. First-in-human (...) trials, in particular, raise a number of ethical concerns including informed consent, subject recruitment and harm minimisation as well as the inherent uncertainty and risks which are involved in testing medical procedures on humans for the first time. These issues, while a feature of any human research, become more complex in the case of iPS cell therapy, given the seriousness of the potential risks, the unreliability of available animal models, the vulnerability of the target patient group, and the high stakes of such an intensely public area of science. Our paper will present a detailed case study of iPS cell replacement therapy for Parkinson's disease to highlight these broader ethical and epistemological concerns. If we accept that iPS cell technology is fraught with challenges which go far beyond merely refuting the potentiality of the stem cell line, we conclude that iPS cell research should not replace, but proceed alongside embryonic and adult somatic stem cell research to promote cross-fertilisation of knowledge and better clinical outcomes. (shrink)

ABSTRACT Dependent Origination is one of the fundamental concepts of early Buddhism. Traditionally, it is interpreted as a description of saṃsāra, the cycle of rebirth. This article offers a psychological interpretation of Dependent Origination as a model that describes how the forming unconscious of the foetus develops into the self-conscious mind of the adult human. This perspective opens new possibilities for the integration of Buddhist mind development, cognitive psychology and psychotherapy.

The present study assesses imitative ability in chimpanzees and human children. A direct comparison of these two species was conducted in an object-manipulation task. The subjects were required to copy the model stack by stacking colored blocks in the same order as the model. Four juvenile/adolescent chimpanzees failed to copy the model stack even after a long training-period. Two adult chimpanzees eventually learned to copy the model stack of two blocks. However, they failed to copy the model (...) of three blocks, and analysis of their stacking patterns revealed that they only focused on the color of the top block in the model. Human children started to copy the model of two blocks when they were two years of age and gradually increased the number of successfully copied blocks. The results from both chimpanzees and humans are discussed in terms of the social intelligence involved in object manipulation. (shrink)

As befits a French philosopher of the 1960s, Gilles Deleuze (1925-995), was famous for his antihumanism and his anti-essentialism. Humans are fully part of nature with no supernatural supplement; and essences are not the way to individuate things. That doesn’t seem to leave much room for a Deleuzean human nature, but that’s what I want to try to explore. I’ll take my clue from what he says in A Thousand Plateaus about nomads, who “reterritorialize on their power of deterritorialization.” (...) In other words, they are most at home when on the move. But this isn’t just spatial movement; we can also say that the habit of nomads is to break habits. I’ll make sense of this claim by referring to Bruce Wexler’s Brain and Culture (MIT, 2006), in particular, his claim that humans evolved for a lengthy childhood period of socially mediated neuroplasticity. Human nature on this view is such that we are individuated by our singular patterns of social – somatic interaction. And this in turn is “nomadic” in Deleuze’s sense: our nature is to be so open to our nurture that it becomes second nature. That is, we’re at home wherever home is. There’s an anti-essentialist nuance here, however. It’s children who are most “nomadic,” most plastic. Most adults drift away from nomadism and become sedentary: they want more of the same. But even here we must nuance things: what if “more of the same” means “more change”? In other words, are there adult “nomads”? I think there are. But we’ll need to discuss Deleuze’s ontology first in order to make sense of these claims. Deleuze is an interactive process philosopher: we aren't substances but processes and those processes are not individuated by properties but as singular patterns of social and somatic interaction. The embodied and the embedded aspects of our being intersect – we are bodies whose capacities form in social interaction. And it's in this intersection of the social and the somatic that subjectivity and selfhood emerge – and are sometimes attenuated and even bypassed.. (shrink)

Our ability to rapidly distinguish new from already stored information is important for behavior and decision making, but the underlying processes remain unclear. Here, we tested the hypothesis that contextual cues lead to a preselection of information and, therefore, faster recognition. Specifically, on the basis of previous modeling work, we hypothesized that recognition time depends on the amount of relevant content stored in long-term memory, i.e., set size, and we explored possible age-related changes of this relationship in older humans. In (...) our paradigm, subjects learned by heart four different word lists written in different colors. On the day of testing, a color cue indicated with a probability of 50% that a subsequent word might be from the corresponding list or from a list of new words. The old/new status of the word had to be distinguished via button press. As a main finding, we can show in a sample of n = 49 subjects, including 26 younger and 23 older humans, that response times increased linearly and logarithmically as a function of set size in both age groups. Conversely, corrected hit rates decreased as a function of set size with no statistically significant differences between both age groups. As such, our findings provide empirical evidence that contextual information can lead to a preselection of relevant information stored in long-term memory to promote efficient recognition, possibly by cyclical top-down and bottom-up processing. (shrink)

OBJECTIVES: To study whether linguistic analysis and changes in information leaflets can improve readability and understanding. DESIGN: Randomised, controlled study. Two information leaflets concerned with trials of drugs for conditions/diseases which are commonly known were modified, and the original was tested against the revised version. SETTING: Denmark. PARTICIPANTS: 235 persons in the relevant age groups. MAIN MEASURES: Readability and understanding of contents. RESULTS: Both readability and understanding of contents was improved: readability with regard to both information leaflets and understanding with (...) regard to one of the leaflets. CONCLUSION: The results show that both readability and understanding can be improved by increased attention to the linguistic features of the information. (shrink)

This study investigated the neuromodulatory effects of transspinal stimulation on soleus H-reflex excitability and electromyographic activity during stepping in humans with and without spinal cord injury. Thirteen able-bodied adults and 5 individuals with SCI participated in the study. EMG activity from both legs was determined for steps without, during, and after a single-pulse or pulse train transspinal stimulation delivered during stepping randomly at different phases of the step cycle. The soleus H-reflex was recorded in both subject groups under control conditions (...) and following single-pulse transspinal stimulation at an individualized exactly similar positive and negative conditioning-test interval. The EMG activity was decreased in both subject groups at the steps during transspinal stimulation, while intralimb and interlimb coordination were altered only in SCI subjects. At the steps immediately after transspinal stimulation, the physiological phase-dependent EMG modulation pattern remained unaffected in able-bodied subjects. The conditioned soleus H-reflex was depressed throughout the step cycle in both subject groups. Transspinal stimulation modulated depolarization of motoneurons over multiple segments, limb coordination, and soleus H-reflex excitability during assisted stepping. The soleus H-reflex depression may be the result of complex spinal inhibitory interneuronal circuits activated by transspinal stimulation and collision between orthodromic and antidromic volleys in the peripheral mixed nerve. The soleus H-reflex depression by transspinal stimulation suggests a potential application for normalization of spinal reflex excitability after SCI. (shrink)

This paper has aimed to remedy a neglect of multi-party disputes by addressing how those involved in a two-party argument may collaborate with others who are co-present. Collaboration is a complex phenomenon. In the first place, we have seen that disputes, although initially produced by two parties, do not consist simply of two sides. Rather, given one party's displayed position, stance, or claim, another party can produce opposition by simply aligning against that position or by aligning with a counterposition. This (...) means that parties can dispute a particular position for different reasons and by different means. It is therefore possible for several parties to serially oppose another's claim without achieving collaboration. A second complexity, then, is just that collaboration is a negotiated phenomenon. For example, while it is possible for an outside party to produce an uninvited alignment display that is sympathetic to an already-stated position in a two-party dispute, the party whose position it supports can agree or disagree with that display. Thus, outsiders' uninvited alignment displays that occur subsequent to those of the insiders or principals in a two-party dispute must be considered as collaboration offers, which can be accepted or rejected. But that is not the end of it, for an outside party can offer alignments that now align with a principal party's position and then, addressing a different aspect of the principal's talk, align against it. Finally, in addition to being offered, collaboration can also be solicited. A principal in a two-party dispute solicits collaboration by inviting an outsider to display an alignment favorable to inviter's own position or to participate in a joint activity that supports that stance. Such solicits can be accepted, rejected, or, again, handled in such a way as to exhibit neutrality. Argumentative collaboration, in short, is a specific, momentary, and delicate state of affairs that is also an organized, technical achievement.The fact that the subjects for this study were children has become submerged in the formal analysis of alignment structures and collaboration. Thus, following this research, two directions can be pursued. One would be to ask how children's arguments differ from those occurring among adults. A reasoned answer would be that matters of substance or content may distinguish disputes among youthful persons from those occurring among older ones, while the forms of disputing remain relatively invariant (Maynard, 1985a, 1985b). In other words, by studying multi-party disputes among first-grade children, we learn about the structure of collaboration as a generic phenomenon among at least practitioners of standard English no matter what their age. This claim can be sustained in part because the analysis presented here depends upon deriving a priori conventional relations between utterances, rather than statistical relations between variables (Coulter, 1983). We have not examined exogenous influences — which would include the age characteristics of participants — on disputes, but rather the endogenously-produced structure of argumentative discourse. Still, the claim that patterns of collaboration are generic to children and adults can be examined with further research on multi-party disputes among different age groups.Another, more radical, research orientation, would be to consider, in any social arena where the members are identified as children, how it is that such a ‘membership category’ (Sacks, 1972) is relevant. If that query is made, then research on ‘children's arguments’ would involve investigating formal practices for exhibiting the accountable category ‘children’ as much as it would mean describing the ways that disputing is done. Those who have studied children's arguments, in Pollner's (1979) terms, have treated ‘children’ as a social fact, a ‘thing,’ rather than as a socially organized meaning, or ‘ing.’To attend to the -ing of things involves a radical modification of the attitude of daily life, for it requires attending to the processes of constitution in lieu of the product thus constituted (Pollner, 1979: 253, fn. 11).In short, we have treated arguments as the important event without also seeing how it is that the category ‘children’ is constituted as a recognizable feature of and within the research setting. (shrink)

Pinch force sense plays an important role in the performance of daily finger movements, including tip, key, palmar pinch. The present study investigated the roles of pinch type in the sensation of pinch force among healthy participants in the ipsilateral force reproduction trial. This study instructed forty healthy adult subjects (20 women and 20 men) in producing reference forces at different levels [10, 30, 50% maximal voluntary isometric contraction (MVIC)] by adopting 3 pinch types (tip, key, and palmar (...) pinches) and in reproducing the above force levels with the identical hand. Our study revealed that subjects are significantly more sensitive detecting alterations of pinching forces with tip pinch but not key or palmar pinch under high forces (30 and 50% MVIC) but not at lower force levels (10% MVIC). (shrink)

In order for artificial intelligent systems to interact naturally with human users, they need to be able to learn from human instructions when actions should be imitated. Human tutoring will typically consist of action demonstrations accompanied by speech. In the following, the characteristics of human tutoring during action demonstration will be examined. A special focus will be put on the distinction between two kinds of motion events: path-oriented actions and manner-oriented actions. Such a distinction is inspired (...) by the literature pertaining to cognitive linguistics, which indicates that the human conceptual system can distinguish these two distinct types of motion. These two kinds of actions are described in language by more path-oriented or more manner-oriented utterances. In path-oriented utterances, the source, trajectory, or goal is emphasized, whereas in manner-oriented utterances the medium, velocity, or means of motion are highlighted. We examined a video corpus of adult–child interactions comprised of three age groups of children—pre-lexical, early lexical, and lexical—and two different tasks, one emphasizing manner more strongly and one emphasizing path more strongly. We analyzed the language and motion of the caregiver and the gazing behavior of the child to highlight the differences between the tutoring and the acquisition of the manner and path concepts. The results suggest that age is an important factor in the development of these action categories. The analysis of this corpus has also been exploited to develop an intelligent robotic behavior—the tutoring spotter system—able to emulate children's behaviors in a tutoring situation, with the aim of evoking in human subjects a natural and effective behavior in teaching to a robot. The findings related to the development of manner and path concepts have been used to implement new effective feedback strategies in the tutoring spotter system, which should provide improvements in human–robot interaction. (shrink)

BackgroundSeveral investigations have addressed the process of balance adaptation to external perturbations. The adaptation during unperturbed stance has received little attention. Further, whether the current sensory conditions affect the adaptation rate has not been established. We have addressed the role of vision and haptic feedback on adaptation while standing on foam.MethodsIn 22 young subjects, the analysis of geometric and spectral variables of the oscillation of the centre of feet pressure identified the effects of vision, light-touch or both in the (...) anteroposterior and mediolateral direction over 8 consecutive 90 s standing trials.ResultsAdaptation was obvious without vision and tenuous with vision. With trial repetition, path length and median frequency diminished with EC while sway area and mean level of the spectrum increased. The low- and high-frequency range of the spectrum increased and decreased in AP and ML directions, respectively. Touch compared to no-touch enhanced the rate of increase of the low-frequency power. Spectral differences in distinct sensory conditions persisted after adaptation.ConclusionBalance adaptation occurs during standing on foam. Adaptation leads to a progressive increase in the amplitude of the lowest frequencies of the spectrum and a concurrent decrease in the high-frequency range. Within this common behaviour, touch adds to its stabilising action a modest effect on the adaptation rate. Stabilisation is improved by favouring slow oscillations at the expense of sway minimisation. These findings are preliminary to investigations of balance problems in persons with sensory deficits, ageing, and peripheral or central nervous lesion. (shrink)

Bioethics committees have issued guidelines that medical interventions should be permissible only in cases of clinically verifiable disease, deformity, or injury. Furthermore, once the existence of one or more of these requirements has been proven, the proposed therapeutic procedure must reasonably be expected to result in a net benefit to the patient. As an exception to this rule, some prophylactic interventions might be performed on individuals “in their best interests” or with the aim of averting an urgent and potentially calamitous (...) public health danger. In order to invoke these exceptions, a stringent set of criteria must first be satisfied. Additionally, where the proposed prophylactic intervention is intended for children, who are unlikely to be able to provide a meaningfully informed consent, a heightened scrutiny of any such measures is required. We argue that children should not be subjected to prophylactic interventions “in their best interests” or for public health reasons when there exist effective and conservative alternative interventions, such as behavioural modification, that individuals could employ as competent adolescents or adults to avoid adverse health outcomes. Applying these criteria, we consider the specific examples of prophylactic mastectomy, immunisations, cosmetic ear surgery, and circumcision. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:IS EVERY HUMAN BEING A PERSON?* ROBERT SPAEMANN Ludwig-Maximilians-Universitat Munich, Germany I. DEFINING THE QUESTION THE PAPAL encyclical, Evangelium vitae (EV), declares solemnly that "... the direct and voluntary killing of an innocent human being is always gravely immoral" (EV 57). This unconditional ethical obligation to respect every human life is justified by reference to "the incomparable dignity of the human person." Such an unconditioned (...) claim is made upon us by the face of every human being we meet. The encyclical supports this claim of intuitive perception with two arguments. First and foremost, the claim to unconditional respect is based biblically and theologically on the recognition of the human being as the imago Dei. The human is the "image" of God. Humans, however, are not unconditioned simply taken in themselves ; merely as such, theirs is a most conditioned, finite being, which can be transformed from living to dead with hardly the lifting of a finger. And yet, such violence, while always possible for us physically, is absolutely impossible on another level. In the human being something "reveals" itself to us that is more than any finite and conditioned mode of being; thus, the term "image." In contrast to mere pictures, which are images only in an accidental sense, the human is created as image. Human being is being an image. Thus human being participates in the 'Translated by Richard Schenk, O.P. 463 464 ROBERT SPAEMAN incorruptibility of the One of whom the human is an image. Human beings are called to eternal life. The second and secondary argument is based on the consequences of not respecting the unconditioned dignity of the human being. The encyclical points out that an order of law in which the freedom from being at another's free disposition is lacking does not deserve the name of law; it is merely an organization of the power of the stronger over the weaker. In section nineteen the pope mentions a theory held by some who would acknowledge only those humans as subjects of legal rights who already manifest certain signs of personal autonomy. He also speaks of the theory of those who would "identify the dignity of the person with the capacity for explicitly verbal communication." Not included in this category are therefore the unborn, the dying, and severely impaired or senile humans; although not mentioned by the encyclical, it must be added that by this theory infants are excluded as well. In his book, Practical Ethics,1 the most influential proponent of this theory, Peter Singer, has declared outright that the life of a human infant is of less value than that of an adult pig.2 Because the encyclical argues for the most part theologically, it does not deal closely with the arguments proposed by Singer and his followers in their attempt to eliminate human rights and to claim that not all human beings are persons.3 The Holy Scriptures do not speak of "persons" as such, but simply of human beings. For revelation, humanity is one single family: all that are begotten of humans belong to this family. The conviction that even newlyborn children possess human dignity is reflected in the infancy 1 Peter Singer, Practical Ethics (Cambridge: Cambridge University Press, 1979). An expanded second edition appeared in 1993 (Cambridge University Press). 2 "A week-old baby is not a rational and self-conscious being, and there are many nonhuman animals whose rationality, self-consciousness, awareness, capacity to feel, and so on, exceed that of a human baby a week, a month, or even a year old. If the fetus does not have the same claim to life as a person, it appears that the newborn baby does not either, and the life of a newborn baby is of less value than the life of a pig, a dog, or a chimpanzee" (Singer, Practical Ethics, 122-23; in the second edition this statement appears with slight modifications on p. 169). 3 Cf. also Norbert Hoerster, Abtreibung im saekularen Staat: Argumente gegen den Paragraphen 218 (Frankfurt, 1991). IS EVERY HUMAN BEING A PERSON? 465 narratives of the Gospel, where shepherds and kings worship the child at Bethlehem. The conviction that human being begins... (shrink)

In phenomenology, theories of empathy are intimately connected with the question of how it is possible to have insight into the mind of the other person. In this article, the author wants to show why it is self-evident for us that the other person is having experiences. In order to do so, it is not enough to discuss the phenomenon of empathy with a starting point in the already constituted adult person; instead the article presents a genetic approach to (...) human development. The author thus contrasts Edith Stein’s discussion of Einfühlung (empathy), which takes its starting point in the experience of the grown-up, with Max Scheler’s discussion of Einsfühlung (feeling of oneness), where the relation between mother and infant is taken as one example. Maurice Merleau-Ponty’s discussion of the world of the infant is read as one way of developing Scheler’s theory of intersubjectivity and of Einsfühlung. This genetic approach is developed further into a phenomenological analysis of the experience of the fetus and of birth. The author argues that the analysis of the fetus highlights the distinction between knowing that another person is having experiences, and knowing the specific content of the other person’s experiences. The fetus does not experience different persons, but has a pre-subjective experience of life that includes what is later experienced as belonging to “another.” Later in life, the experience of empathy, as an experience of a specific content, can be developed from this experience. In this way empathy and Einsfühlung can be understood as complementary rather than as competing phenomena. (shrink)

Sex ratios have widely been recognized as an important link between demographic contexts and behavior because changes in the ratio shift sex-specific bargaining power in the partner market. Implicitly, the literature considers individual partner market experiences to be a function of local sex ratios. However, empirical evidence on the correspondence between subjective partner availability and local sex ratios is lacking so far. In this paper, we analyzed how closely a set of different local sex ratio measures correlates with subjective partner (...) market experiences. Linking a longitudinal German survey to population data for different entities, we used multilevel logistic regression models to explore associations between singles’ subjective partner market experiences and various operationalizations of local sex ratios. Results suggest that local sex ratios correlated only weakly with subjective partner market experiences. Adult sex ratios based on broad age brackets, including those for lower-level entities, did not significantly predict whether individuals predominantly met individuals of their own sex. More fine-grained, age-specific sex ratios prove to be better predictors of subjective partner market experiences, in particular when age hypergamy patterns were incorporated. Nevertheless, the respective associations were only significant for selected measures. In a complementary analysis, we illustrate the validity of the subjective indicator as a predictor of relationship formation. In sum, our results suggest that subjective partner availability is not adequately represented by the broad adult sex ratio measures that are frequently used in the literature. Future research should be careful not to equate local sex ratios and conscious partner market experiences. (shrink)

One emerging issue in contemporary epistemology concerns the relation between animal knowledge, which can be had by agents unable to take a view on the epistemic status of their attitudes, and reflective knowledge, which is only available to agents capable of taking such a view. Philosophers who are open to animal knowledge often presume that while many of the beliefs of human adults are formed unreflectively and thus constitute mere animal knowledge, some of them—those which become subject of explicit (...) scrutiny or are the result of a deliberative effort—may attain the status of reflective knowledge. According to Sanford Goldberg and Jonathan Matheson (2020), however, it is impossible for reflective subjects to have mere animal knowledge. If correct, their view would have a number of repercussions, perhaps most notably the vindication of a dualism about knowledge, which would frustrate attempts to provide a unified account of knowledge-attributions to human adults, very young children, and non-human animals. I discuss Goldberg and Matheson’s proposal, outline some of the ways in which it is insightful, and argue that it is ultimately unsuccessful because it neglects the inherent temporal dimension of knowledge acquisition. While the article is pitched as a reply to Goldberg and Matheson, its primary aim is to highlight significant connections between the debates on the relation between animal and reflective knowledge, propositional and doxastic justification, and the theory of epistemic defeat. (shrink)