Two conundrums puzzle COVID‐19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID‐19 morbidity and mortality. Vaccination rates with Bacillus Calmette–Guerin, poliovirus, and other vaccines do not correlate with COVID‐19 risks, nor do COVID‐19 case or death rates correlate (...) with number of people in the population with diabetes, obesity, or adults over 65. Infant protection may be due to maternal antibodies and antiviral proteins in milk such as lactoferrin that are known to protect against coronavirus infections. Subsequent protection might then be conferred (and correlate with) rates of Haemophilus influenzae type B (Hib) (universal in infants) and pneumococcal vaccination, the latter varying widely by geography among infants, at‐risk adults, and the elderly. Also see the video abstract here https://youtu.be/GODBYRbPL00. (shrink)

This article explores medical diplomacy as a means of navigating distinct but related nation-building and internationalist projects during the Cold War. It examines how medical professionals from the Democratic Republic of Vietnam (DRV) utilized their expertise to bolster foreign relations and assert national independence. This article focuses on how three tuberculosis (TB) specialists – Đặng Đức Trạch, Phạm Ngọc Thạch and Phạm Khắc Quảng – adopted, adapted and circulated techniques of TB control, including a modified version of bacillus (...) class='Hi'>Calmette–Guérin (BCG) vaccine. Amidst these endeavours, these medical-doctors-cum-diplomats navigated various forms of internationalism while soliciting medical assistance. Their roles within the DRV's state apparatus were prominently showcased from the 1950s to the 1970s, particularly at international gatherings such as the conferences of Ministers of Health of the Socialist Countries (MOHOSC). Because of the political complexities inherent in socialist internationalism, these conferences provided a crucial platform for dialogue among socialist nations when other avenues were limited. Consequently, the DRV's medical experts cultivated goodwill and garnered political support, despite encountering mixed results in their TB control initiatives. (shrink)

If James has a latent tuberculosis infection , he is at risk of developing active tuberculosis disease but he is not yet sick. LTBI is a liminal space between health and illness. Diagnosed with LTBI, James could be conceptualised as having a liminal body. Treatments for LTBI are available, but why would a person seek treatment for a disease he does not yet have? One thing is definite: James needs to be educated about the symptoms and severity of active tuberculosis (...) disease. (shrink)

We extend recent conversation about the ethics of human challenge trials to tuberculosis (TB). TB challenge studies could accelerate vaccine development, but ethical concerns regarding risks to trial participants and third parties have been a limiting factor. We analyse the expected social value and risks of different challenge models, concluding that if a TB challenge trial has between a 10% and a 50% chance of leading to the authorisation and near-universal delivery of a more effective vaccine 3–5 years (...) earlier, then the trial would save between 26 400 and 1 100 000 lives over the next 10 years. We also identify five important ethical considerations that differentiate TB from recent human challenge trials: an exceptionally high disease burden with no highly effective vaccine; heightened third party risk following the trial, and, partly for that reason, uniquely stringent biosafety requirements for the trial; risks associated with best available TB treatments; and difficulties with TB disease detection. We argue that there is good reason to consider conducting challenge trials with attenuated strains like Bacillus Calmette-Guérin or attenuatedMycobacterium tuberculosis. (shrink)

The anti-tuberculosis BCG vaccine was conceived and developed between 1905 and 1921 at Pasteur Institutes in France. Between 1921 and A. Calmette’s death in 1933, the vaccine went through a first period of national and international production and distribution for its use in humans. In France these activities were exclusively carried out by Calmette and his collaborators at the Pasteur Institute in Paris. Initially improvised production in a small room in the cellar gave way in 1931 (...) to the construction of the spacious and magnificent ‘New laboratories for research on tuberculosis and the preparation of the BCG’ within the premises of the Pasteur Institute. Presentation and image-building of the vaccine in France insisted on the fact that the BCG was not a commercial specialty but distributed free of charge. The technical monopoly of its production nevertheless lay with the Paris Pasteur Institute and standardization of scientific proof of safety, efficacy and stability was dominated by that Institute in France. In contrast, the international production and distribution of the vaccine was entrusted and transferred, free of charge, to trustworthy laboratories outside France. Multiplication of producers and users led to an increased need for standardization. For this process the analysis distinguishes between the standardization of scientific proof concerning safety, efficacy and stability of the vaccine and standardization of its medical uses. Whereas standardization was rather successful in the inter-war period in France, the international efforts remained rather unsuccessful. Only after world war II under Scandinavian leadership and in the context of mass vaccination programs supported by the WHO and UNICEF was the international standardization effectively implemented and succeeded at least to some extend. (shrink)

Diphtheria is an acute toxin-mediated superficial infection of the respiratory tract or skin caused by the aerobic gram-positive bacillus Corynebacterium diphtheriae. The epidemiology of infection and clinical manifestations of the disease vary in different parts of the world. Historical accounts of diphtheria epidemics have been described in many parts of the world since antiquity. Developed in the late 19th century, the diphtheria antitoxin played a pivotal role in the history of public health and vaccinology prior to the advent of (...) the diphtheria-tetanus toxoids and acellular pertussis vaccine. One of the most significant demonstrations of the importance of DAT was its use in the 1925 diphtheria epidemic of Nome, Alaska. Coordinated emergency delivery of this life-saving antitoxin by dog-sled relay in the harshest of conditions has left a profound legacy in the annals of vaccinology and public health. Lead dogs Balto and Togo, and the dog-led antitoxin run of 1925 represent a dynamic illustration of the contribution made by non-human species towards mass immunization in the history of vaccinology. This unique example of cooperative interspecies fellowship and collaboration highlights the importance of the human-animal bond in the one-health initiative. (shrink)

Clinical ethics consultants often confront the most difficult clinical encounters, typically in the setting of chronically critically ill patients and surrogate decision makers. These encounters require not only analytical skills but interpersonal skills as well. In this article, I focus on an interpersonal skill absent from the American Society for Bioethics and the Humanities Task Force’s Core Competencies for Healthcare Ethics Consultation. I introduce the psychoanalytic concept of transference and argue that knowledge and use of transference phenomena are sometimes indispensable (...) for ethics consultation with surrogate decision makers. For solicitation of moral views, disclosure of relevant beliefs and values, and identification of the central ethical question—essential to assessment and analysis—cannot at times begin without recognition and working through of transference. (shrink)

Clinical ethics consultants respond to a multitude of issues, ranging from the cognitive to the emotional. As such, ethics consultants must be prepared to analyze as well as empathize. And yet, there remains a paucity of research and training on the interpersonal and emotional aspects of clinical ethics consultations—the so-called skills in “advanced ethics facilitation.” This article is a contribution to the need for further understanding and practical knowledge in the emotional aspects of ethics consultation. In particular, I draw attention (...) to defense mechanisms: what they are, why they exist, and how we might work with them in the setting of ethics consultation. (shrink)

A partir de l’étude d’un corpus de travaux de géographes en français et en anglais depuis les années 1990, l’article est consacré à la manière dont les études géographiques portant sur les espaces dits des Suds, entendus comme faisant partie des pays dominés à l’échelle mondiale, intègrent la notion de mondialisation. Le constat de la faible prise en compte des pays des Suds dans les études portant sur la mondialisation est d’abord établi. En réaction, nombre de géographes concernés ont intégré (...) cette dimension dans leurs travaux pour montrer ce qu’était la mondialisation depuis les Suds et qu’il s’agissait d’un phénomène bien réel dont ils n’étaient pas exclus. Les travaux sont souvent orientés idéologiquement, les uns développant des approches critiques de la mondialisation, dans la filiation d’études marxistes et tiers-mondistes, les autres insistant au contraire sur les conséquences bénéfiques de la mondialisation pour les pays des Suds. La plupart convergent cependant pour considérer que la mondialisation accentue les inégalités sociales et spatiales, assertion qui est ici à la fois considérée puis soumise à discussion. (shrink)

Depuis une vingtaine d'années, on assiste en France à un vaste mouvement d'initiatives féminines citoyennes que l'on peut qualifier d'espaces de médiation. Leur point commun est de créer, souvent en partenariat avec les collectivités locales, des espaces de proximité visant à résoudre les problèmes vécus au quotidien par les femmes et leurs familles. À partir d'exemples concrets, nous montrons que ces espaces de proximité sont susceptibles d'aider les femmes à acquérir une certaine autonomie à condition qu'ils reposent sur une double (...) médiation: médiation entre les pôles de l'individuel et le collectif, ce qui permet à chacune d'être reconnue dans sa singularité tout en appartenant à un collectif; médiation entre l'intérêt collectif du groupe et l'intérêt général, le groupe devenant ainsi une sorte d'intermédiaire vers la société civile.A vast movement of citizen-based initiatives led by women has emerged in France over the last twenty years or so and these can be qualified as providing mediation programmes. These projects are often run in partnership with local governments and generally have in common the fact that they are community initiatives aimed at helping women and their families solve day-to-day problems. Using real examples, we show that these community programmes can help women acquire a certain autonomy as long as they are based on a dual mediation, firstly mediation between poles of the individual and the collective and secondly mediation between the collective interest of the group and the general interest, the group thus acting as a sort of intermediary towards society as a whole. (shrink)

A history of rare archival amateur photographs and films from Nazi Germany.

The origin of Modernity is a problem often neglected in current debate, and several landmarks are often suggested, such as the new science, the Renaissance, Descartes philosophical approach or the Illustration. In this paper it is suggested that the roots of Modernity could pre-date those conventional landmarks, and could be found in the great political and cultural conflicts that occurred in Europe in the Low Middle Age.

Ivo of Chartres (1040–1115) offers a case study about how objects – ivories in particular – knitted together social relations and established kinship networks across medieval France. An active reformer amidst the Investiture Controversy, Ivo is best known today for his lively and compelling correspondence. This article, however, argues that Ivo should also be remembered for the carved ivories in his possession. At least three ivories from the late eleventh century (although two are now lost) can be associated with Ivo: (...) a comb, a set of tablets (probably a diptych), and his crosier, which is now in Florence’s Bargello Museum. Interweaving Ivo’s written reflections on the role of ivory objects in his life as reformer, bishop, politician, and friend, the essay further traces the history of Ivo’s crosier as it was passed to following generations of reform-minded canons. (shrink)

Este artículo revisa la situación de la teoría filosófica del conocimiento en la segunda mitad del siglo XX y el aporte de L. Polo a la misma. Se considera la importancia del aporte de L. Polo al realismo gnoseológico que se ha ido abriendo paso en esta época postmoderna, después de los excesos del criticismo inmanentista moderno. Se destacan dos aspectos relevantes de la teoría del conocimiento de L. Polo: a) su propuesta de una versión realista, no husserliana-cartesiana, de la (...) intencionalidad cognitiva como intencionalidad del objeto respecto a la realidad objetivada y no como relación del acto al objeto, y b) su aporte a la superación del criticismo inmenentista moderno mediante la identificación y revisión de sus orígenes tardomedievales en el representacionismo semántico de Ockham y en el representacionismo especulativo de Duns Escoto. (shrink)

It is widely accepted that the academic job market is very limited and unlikely to expand any time soon, yet enrolments in PhDs continue to rise. If the PhD is no longer preparation for academia, w...

Human beings adapt the spontaneous pace of their actions to interact with the environment. Yet, the nature of the mechanism enabling such adaptive behavior remains poorly understood. The aim of the present contribution was to examine the role of attention in motor timing using time series analysis, and a dual task paradigm. In a series of two studies, a finger-tapping task was used in sensorimotor synchronization with various tempi and motor complexity. Time series analyzes indicated that two different timing strategies (...) were used depending on the speed constraints. At slow tempi, tapping sequences were characterized by strong negative autocorrelations, suggesting the implication of cognitive predictive timing. When moving at fast and close-to-spontaneous tempi, tapping sequences were characterized by less negative autocorrelations, suggesting that timing properties emerged from body movement dynamics. The analysis of the dual-task reaction times confirmed that both the temporal and spatial constraints impacted the attentional resources allocated to the finger-tapping tasks. Overall, our work suggests that moving fast and slow involve distinct timing strategies that are characterized by contrasting attentional demands. (shrink)

Before he recognized the role of the Tradition in the Church, Newman rooted his life in the Bible, memorizing the King James Version. He commented on it throughout his life. This essay canvasses Newman’s reading of the Fourth Gospel, and brings to light the theology of the word presupposed by Newman’s interpretation of Scripture.

Résumé Le microcrédit, en Inde comme ailleurs, a été présenté ces dernières années comme un outil d’éradication de la pauvreté, permettant d’abolir des formes d’endettement informelles asservissantes, de soutenir la diffusion du capitalisme populaire et de promouvoir l’émancipation féminine. Plusieurs années de recherche en Inde rurale du Sud (Tamil Nadu) montrent que le microcrédit a surtout pour effet de renforcer une « démocratie de patronage ». La dette, sous toutes ses formes, reste un puissant moteur de paupérisation des travailleurs pauvres (...) mais aussi de construction des identités individuelles et collectives et de différentiation sociale. (shrink)

Dans la ligne de pensée de Guénon et de Schuon, constamment évoqués sinon invoqués au cours de l'ouvrage, une sérieuse investigation sur le sens de l'histoire sous l'angle de la Tradition. Poursuite d'un projet déjà instauré avec "Le véritable secret de Nostradamus" (1971), ce livre esquisse le bilan actuel où un syncrétisme inhérent à la Tradition qu'il suppose ne nuit pas au sérieux des réflexions de l'auteur.

Open peer commentary on the article “A Computational Constructivist Model as an Anticipatory Learning Mechanism for Coupled Agent–Environment Systems” by Filipo Studzinski Perotto. Upshot: Constructivist theory gives a nice high-level account of how knowledge can be autonomously developed by an agent interacting with an environment, but it fails to detail the mechanisms needed to bridge the gap between low levels of sensorimotor data and higher levels of cognition. AI workers are trying to bridge this gap, using task-specific engineering approaches, without (...) any principled theory to guide them; they could use help from psychologists. (shrink)

Au premier degré, cette étude se lit comme une réflexion sur le concept de méthode. L'examen des textes cartésiens permet de dégager les caractères de la méthode , mais surtout ce qu'on peut appeler son « esprit ». Il tient tout entier, semble-t-il, dans la découverte - qui vaut invention - de la fécondité du principe : la pensée élaborée, en effet, aperçoit d'un même mouvement l'homogénéité du principe et de la fin, d'une part, l'homologie entre la pensée et l'Être, (...) d'autre part. À un niveau plus profond, la transcendance de la méthode par rapport à ses règles conduit, dans un premier temps, à l'identifier avec la philosophie elle-même - appréhendée ici comme « commentaire de son principe » - dans un second temps à marquer, sous le rapport du modèle, la différence entre la philosophie et les sciences.As far as the literal meaning is concerned, this study can be read as a reflection on the concept of the method. The perusal of Descartes's texts allows to bring out the characteristics of the method , but especially what may be called its "spirit". It entirely lies, so it seems, in the discovery - which is as good as invention - of the potential of the principle : indeed, elaborate thought straightaway perceives the homogeneity of the principle and of the end, on the one hand, the homology between thought and Being, on the other hand. As far as the hidden meaning is concerned, the transcendence of the method with regard to its rules leads first to identify it with philosophy itself - in this instance considered as a "commentary on its principle" - subsequently to lay stress, from the point of view of the model, on the difference between philosophy and sciences. (shrink)

French end-of-life law aims at protecting patients from unreasonable treatments, but has been used to force caregivers to prolong treatments deemed unreasonable. We describe six cases (five intensi...

ABSTRACTAccording to many governments and educationalists, education should aim to develop dispositions conducive to political participation and solidarity, because democratic citizenship presupposes participation and solidarity. But there are radically different views on the nature of good citizenship. We examine the implications of this dissensus for citizenship education. Education, we contend, should involve and develop autonomy and open-mindedness. We argue that this requires a more critical approach than is possible when political participation and solidarity are conceived of as goals of education.