BackgroundPublic health guidelines have recommended that elective medical procedures, including deep brain stimulation surgery for Parkinson’s disease, should not be scheduled during the coronavirus pandemic to prevent further virus spread and overload on health care systems. However, delaying DBS surgery for PD may not be in the best interest of individual patients and is not called for in regions where virus spread is under control and inpatient facilities are not overloaded.MethodsWe administered a newly developed phone questionnaire to 20 consecutive patients (...) with PD who received DBS surgery in Ruijin Hospital in Shanghai during the COVID-19 pandemic. The questionnaire was designed to gather the patients’ experiences and perceptions on the impact of COVID-19 on their everyday activities and access to medical care.ResultsMost of the patients felt confident about the preventive measures taken by the government and hospitals, and they have changed their daily living activities accordingly. Moreover, a large majority of patients felt confident obtaining access to regular and COVID-19-related health care services if needed. Routine clinical referral, sense of security in the hospital during the outbreak, and poor control of PD symptoms were the three main reasons given by patients for seeking DBS surgery during the COVID-19 pandemic.ConclusionThe COVID-19 pandemic has considerably impacted medical care and patients’ lives but elective procedures, such as DBS surgery for PD, do not need to be rescheduled when the health care system is not overloaded and adequate public health regulations are in place. (shrink)

This paper addresses the robust stabilization problem for a class of stochastic Markovian jump systems with distributed delays. The systems under consideration involve Brownian motion, Markov chains, distributed delays, and parameter uncertainties. By an appropriate Lyapunov–Krasovskii functional, the novel delay-dependent stabilization criterion for the stochastic Markovian jump systems is derived in terms of linear matrix inequalities. When given linear matrix inequalities are feasible, an explicit expression of the desired state feedback controller is given. The designed controller, based on the obtained (...) criterion, ensures asymptotically stable in the mean square sense of the resulting closed-loop system. The convenience of the design is greatly enhanced due to the existence of an adjustable parameter in the controller. Finally, a numerical example is exploited to demonstrate the effectiveness of the developed theory. (shrink)

Objective: To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation (DBS) on motor function in Parkinson’s disease (PD).Methods: We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna (GPi) DBS, and 18 underwent bilateral subthalamic nucleus (STN) DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part (MDS UPDRS-III) was assessed before (...) surgery and at the last follow-up in different medication and stimulation conditions, respectively.Results: Pearson’s correlation analysis revealed a positive correlation between preoperative L-dopa challenge responsiveness and GPi-DBS responsiveness on the total score (R2 = 0.283, p = 0.016) but not on the non-tremor total score (R2 = 0.158, p = 0.083) of MDS UPDRS-III. Such correlation remained significant (R2′ = 0.332, p = 0.010) after controlling for age at the time of surgery as confounding factor by partial correlation analysis. The preoperative L-dopa challenge responsiveness was significantly correlated with the tremor-controlling outcome of GPi-DBS (R2 = 0.390, p = 0.003). In contrast, we found a positive correlation between preoperative L-dopa challenge responsiveness and STN-DBS responsiveness on the non-tremor total score (R2 = 0.290, p = 0.021), but not on the total score (R2 = 0.130, p = 0.141) of MDS UPDRS-III. The partial correlation analysis further demonstrated that the predictive value of preoperative L-dopa challenge responsiveness on the non-tremor motor outcome of STN-DBS was eliminated (R2′ = 0.120, p = 0.174) after controlling for age at the time of surgery as confounding factor.Interpretation: The short-term predictive value of preoperative response to the L-dopa challenge test for the motor outcome of GPi-DBS in PD was systematically described. Our findings suggest: (1) a solid therapeutic effect of GPi-DBS in treating L-dopa-responsive tremors; (2) a negative effect of age at the time of surgery on motor outcomes of STN-DBS, (3) a possible preference of STN- to GPi-DBS in L-dopa-resistant tremor control, and (4) a possible preference of GPi- to STN-DBS in elderly PD patients who have a satisfactory dopamine response. (shrink)

In the traditional case, the uncertainty of the ambient temperature measured by the experiential distributed sensor is considered. In this paper, a model based on the moving least square method in the fusion algorithm is proposed to study the optimal monitoring point of the sensor in the greenhouse and determine the most suitable installation position of the sensor in the greenhouse to improve the control effect of the temperature control device of the system. MATLAB simulation software is used to simulate (...) each working condition of the greenhouse. Temperature data measured at 15 locations in the greenhouse were used to evaluate all possible combinations of monitoring locations and to estimate the optimal location for indoor temperature sensors. Compared with the traditional method, the error is reduced to 0.373, and the data are more accurate. (shrink)

Background: Contact heat evoked potentials is used to diagnose small fiber neuropathy. We established the normal values of CHEPs parameters in Chinese adults, optimized the test technique, and determined its reproducibility.Methods: We recruited 151 healthy adults. CHEPs was performed on the right forearm to determine the optimal number of stimuli, and then conducted at different sites to establish normal values, determine the effects of demographic characteristics and baseline temperature, and assess the short- and long-term reproducibility. N2 latency/height varied with age (...) and sex, while P2 latency/height and N2–P2 amplitude varied with age. The optimal number of stimuli was three.Results: N2 latency/height and P2 latency/height decreased and N2–P2 amplitude and visual analog scale score increased with increased baseline temperature. CHEPs parameters did not differ with time.Conclusion: We established normal CHEPs values in Chinese adults. We found that CHEPs parameters changed with baseline temperature and that the short- and long-term test reproducibility were satisfactory. (shrink)

v. 1. Tan suo zhe dao lu de tan suo -- v. 2. Lukaqi yu Makesi -- v. 3. Makesi zhu yi zhe xue ji ben wen ti yan jiu -- v. 4. Makesi zhu yi zhe xue jing dian wen xian yan jiu.

Music classification is conducive to online music retrieval, but the current music classification model finds it difficult to accurately identify various types of music, which makes the classification effect of the current music classification model poor. In order to improve the accuracy of music classification, a music classification model based on multifeature fusion and machine learning algorithm is proposed. First, we obtain the music signal, and then extract various features from the classification of the music signal, and use machine learning (...) algorithms to describe the type of music signal and the relationship between the features. The music classifier and deep belief network machine learning models in shallow logistic regression are established, respectively. Experiments were designed for these two models to verify the applicability of the model for music classification. By comparing the experimental results, it is found that the classification accuracy of the deep confidence network model is higher than that of the logistic regression model, but the number of iterations needed for its accuracy to converge is also higher than that of the logistic regression model. Compared with other current music classification models, this model reduces the time of constructing music classifier, speeds up the speed of music classification, and can identify various types of music with high precision. The accuracy of music classification is obviously improved, which verifies the superiority of this music classification model. (shrink)

This research synthesizes social exchange, organizational culture, and social identity theories to explore the boundary conditions of the relationship between high-performance work systems and employee organizational citizenship behavior. In particular, it draws on the China-specific management context. In this country, in spite of the wide use of a long-term-oriented and loose-control-focused Western-styled strategic human resource management model, a short-term-focused and tight-control-oriented error aversion culture is still popular. The study uses multi-source individual-level survey data in a large state-owned enterprise to test (...) the hypotheses. It is found that employee-experienced, Western-styled high-performance work systems positively impact a China-specific employee’s organizational citizenship behavior, and the—joint—moderation effects of employee-perceived error aversion culture and organizational identification are significant. The research findings deepen the understanding of the HRM-OCB relationship by demonstrating that culture and identity can jointly adjust the effects of HRM on OCB. The findings also challenge an established argument in the HRM-OCB literature that compatibility between employees’ personalities and organizational values – organizational identification – can enhance OCB. (shrink)

BackgroundPrevious studies on voxel-based morphometry have found that there were gray matter alterations in patients with hepatic encephalopathy. However, the reported results were inconsistent and lack a quantitative review. Therefore, this study aims for a quantitative meta-analysis of VBM analysis on patients with HE.MethodsThe studies in our meta-analysis were collected from Pubmed, Web of Science, and Embase, which were published from January 1947 to October 2021. The seed-based d mapping method was applied to quantitatively estimate the regional gray matter abnormalities (...) in patients with HE. A meta-regression analysis was applied to evaluate the relationship between plasma ammonia and gray matter alteration.ResultsThere were nine studies, with sixteen datasets consisting of 333 participants with HE and 429 healthy controls. The pooled and subgroup meta-analyses showed an increase in gray matter volume in the bilateral thalamus and the calcarine fissure but a decrease in the GMV in the bilateral insula, the basal ganglia, the anterior cingulate gyrus, and the cerebellum. The meta-regression showed that plasma ammonia was positively associated with the GMV in the left thalamus but was negatively associated with the GMV in the cerebellum and the bilateral striatum.ConclusionGray matter volume in patients with HE largely varied and could be affected by plasma ammonia. The findings of this study could help us to better understand the pathophysiology of cognitive dysfunction in patients with HE. (shrink)