Amyloid fibril formation plays a central role in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer and Parkinson diseases. Transient prefibrillar oligomers forming during the aggregation process, exhibiting a small size and a large hydrophobic surface, can aberrantly interact with a number of molecular targets on neurons, including the lipid bilayer of plasma membranes, resulting in a fatal outcome for the cells. By contrast, the mature fibrils, despite presenting generally a high hydrophobic surface, are endowed with a low (...) diffusion rate and poorly penetrate the interior of the lipid bilayer. However, increasing evidence shows that both intracellular α‐synuclein fibrils, as well and as extracellular amyloid‐β and β2‐microglobulin fibrils, can release oligomers over time that quickly diffuse to reach the membrane of the neighboring cells. The persistent leakage of harmful oligomers from fibrils triggers an ongoing cascade of events resulting in a sustained injury to neurons and glia and also provides aggregates with the ability to cross biological membranes and diffuse between cells or cellular compartments. (shrink)

Cognitive penetration of perception, broadly understood, is the influence that the cognitive system has on a perceptual system. The paper shows a form of cognitive penetration in the visual system which I call ‘architectural’. Architectural cognitive penetration is the process whereby the behaviour or the structure of the perceptual system is influenced by the cognitive system, which consequently may have an impact on the content of the perceptual experience. I scrutinize a study in perceptual learning that provides empirical evidence that (...) cognitive influences in the visual system produce neural reorganization in the primary visual cortex. The type of cognitive penetration can be synchronic and diachronic. (shrink)

Il volume offre una riflessione sulle forme di esperienza musicale della contemporaneità e di un passato che spazia dalla prima età moderna alla fine del ventesimo secolo. Queste possono essere riportate a un concetto ampliato di mediazione musicale che non si applica soltanto all’esperienza “mediatizzata” della musica, proposta da dischi, film, trasmissioni radio e televisive, piattaforme di archiviazione web e social media, ma anche a un concerto dal vivo, a un’installazione, a una partitura a stampa e a un manoscritto musicale (...) miniato. Saggi di Cecchi, Borio, Albert, Bratus, Borghetti, Garda, Sala, Senici, Calabretto, Varon, Corbella, Soldani, Giuggioli, Meandri e Aldeni. (shrink)

The article aims at showing how far the technologies of audiovisual registration affect not only the ontology of images but also our sense of realism in politics and history. As argue Jacques Derrida and Bernard Stiegler, historical events have become “tele-events” after the birth of these technologies. Our handling with images has changed accordingly. As argues Pietro Montani, we no longer consider them as “copies” of real objects but rather as “occasions” for initiating processes of “validation” of history. Hannah Arendt’s (...) opposition between the ancient concept of history being based on praxis and the modern concept of history as “fabrication” (poiesis) of the humankind must be therefore reconsidered. History is rather the negotiation between these two attitudes (praxis and poiesis): cinema might be one of the exemplary sources of this negotiation, as epitomized by the documentary work in the audiovisual archives conducted by Esfir Shub (1927) and Harun Farocki (1992). Representation (Louis Martin) becomes thus a dynamical power of imagination dealing with historical and political reality; consequently, the “ideal spectator”, just as the “ideal reader” for novels (Umberto Eco), is charged with a new task of actualizing the sense of images with regard to their historical and political references. (shrink)

The essay reconsiders Wolfgang Iser’s phenomenology of reading, taken as a possible non reductionist answer to the neuroscientific theories of literature. By emphasizing the aesthetic nature of reading, thanks also to Hans Robert Jauss’ contribution, the idea of a ‘reader’s imagination’ emerges here, as a specific and unique power which allows not only the access to the world of the literary text, but opens also new spheres for the understanding and exploration of the real world. In shorts, it is concerned (...) with the constitution of a special cognitive-emotional pattern, which depends on the building of what Iser considers as the reader’s «artificial habitats», through the interaction with the text. (shrink)

Il saggio propone una lettura estetica del documentario contemporaneo, considerato dal punto di vista delle pratiche intermediali.

Fino a una quindicina di anni fa, l’idea di una connessione forte tra l’estetica da una parte e l’intermedialità e l’interattività dall’altra non sarebbe stata probabilmente pensata nei termini in cui essa emerge nei contributi qui presentati. Di interattività si sarebbe presumibilmente parlato a partire dagli esperimenti di arte interattiva e di incontro tra arte e video: una forma di interazione tutta compresa all’interno di un discorso sulle pratiche artistiche, poco o nulla aperto al conf...

The article considers the nature of series as a narrative, focusing especially on its chronotope, i.e. its spatiotemporal coordinates. The concept of chronotope can be applied at at least two different levels of the interpretation of a narrative: the real world of reception and the expressive form of narration. The impact of series entails both aspects. It is for this reason that series, once on television then on the internet, represented a revolutionary turn in the modern experience of storytelling. Series (...) are therefore bound to the progressive spread of a new form of sociality known as a digital “total mobilisation”. Since the era of TV series up to the emergence of web series, seriality has been able to regulate the increase of interaction in the use of visual devices. Series play the role of a dietetical regulator, which designs the spectators’ attention. An artistic, i.e. experimental, exploitation of this new form of storytelling is possible when one considers the emergence of a new narrative genre, which we propose to call the “short form”. (shrink)

This article compares two philosophers who have a different theoretical origin: respectively, Arthur C. Danto and Jean-François Lyotard. Both of them are interested in the revolutionary character of Andy Warhol’s art. Danto as well as Lyotard argues that Warhol conceives the work of art as a machine: according to the former, it is a philosophical machine; according to the latter, it is a consumerist machine. Nonetheless, the two hypotheses converge on judging Warhol’s art as a turn in the history of (...) art and its relationship to the world. According to Danto, who follows Hegel here, Warhol at the same time interprets and transcends the 1960s and their Zeitgeist. But paradoxically, Warhol’s historical gesture, epitomized by his work Brillo Box, initiates the age of the “end of art”. According to Lyotard, on the contrary, Warhol represents the end of the critical power of modern art, to which the sublime alone can remediate. The two perspectives converge in the idea that the investigation of repetition is the very center of Warhol’s art. Art has now become the pivot of the Western capitalism and consumerist society. Warhol actually explores the different forms and modes of repetition (commodities, icons, symbols) and, in this way, anticipates the confrontation of contemporary art with the “finite infinite” represented by the media world. (shrink)

Cognitive and affective penetration of perception refers to the influence that higher mental states such as beliefs and emotions have on perceptual systems. Psychological and neuroscientific studies appear to show that these states modulate the visual system at the visuomotor, attentional, and late levels of processing. However, empirical evidence showing that similar consequences occur in early stages of visual processing seems to be scarce. In this paper, I argue that psychological evidence does not seem to be either sufficient or necessary (...) to argue in favour of or against the cognitive penetration of perception in either late or early vision. In order to do that we need to have recourse to brain imaging techniques. Thus, I introduce a neuroscientific study and argue that it seems to provide well-grounded evidence for the cognitive penetration of early vision in face perception. I also examine and reject alternative explanations to my conclusion. (shrink)

Il saggio tratta dell'estetica di John Dewey dal punto di vista della sua teoria dell'esperienza, mettendola in relazione con la filosofia critica di Kant.

La Critique de la faculté de juger ne relève pas seulement d’une théorie esthétique, pour originelle qu’elle puisse être. Elle met surtout en œuvre un nouveau discours philosophique. La critique de la métaphysique y est reconsidérée d’une manière positive, comme une réflexion sur la donation de sens à la croisée entre principes généraux et expériences contingentes. Le philosophe italien Emilio Garroni a développé ce nouveau point de vue sur le troisième Critique, en soutenant que, dans cette Critique, Kant a formulé (...) une nouvelle forme de « libre schématisme », et en même temps la primauté de ce schématisme par rapport au « schématisme objectif » de la Critique de la raison pure. De manière générale, il partage l’idée que le schématisme représente le lieu théorique où Kant développe implicitement sa théorie sémantique. Lisant, comme Garroni, Kant après Wittgenstein, nous posons alors la question : qu’est-ce qu’une forme de vie après le langage? (shrink)

Il saggio propone una ricognizione nell'estetica dei media contemporanei.

The article focuses on the possibility of reconsidering the relationship existing between monstrosity and sublime in the light of Jean-François Lyotard’s interpretation of the Kantian sublime. Sublime and monstrosity unveil a system of analogies and differences, which can depict the aesthetic experience mediated by mass media, rather than by art. The lack of form and the sometimes obscene drift, which are typical of media experience, configure indeed a sensibility that oscillates between the ascension to sublime heights and the emergence of (...) monsters. (shrink)

Il libro di Nicola Perullo – una raccolta di sei saggi già pubblicati su varie riviste e presentati ora in forma rielaborata – suscita interesse sia per l’ampiezza della tematica, sia per l’originalità di una prospettiva che si presenta al tempo stesso come antifondazionalista e realista. La possibilità di filosofare tenendo insieme i presupposti, che potrebbero apparire prima facie divergenti, antifondazionalista e realista è mostrata dall’Autore sulla scorta di una lettura incrociata di Wit...

The paper is concerned with arguing the existence of a relationship between the enactive theory of perception and aesthetics. One of the leading figures in the theory of enactment, Alva Noe, pointed out that the works of art constitute one of the keys to understand how perception and cognition realize their enactment onto reality. Art objects are, in fact, a very peculiar case of artefacts since they are considered as being able to quicken the living beings’ organization in their interaction (...) to the world. Do they create a different atmosphere? Do they “furnish” the surrounding habitat with new meanings? The paper argues that these are, of course, fundamental elements in the art’s action onto reality. As far as the subjective enactment of perception is concerned, together with power in designing life organization, art has arguably another original functions, that of building new “environs” where experience can meet reality under a different light and thus prepare the field for other creative contributions, both cultural and technological. (shrink)

v. 1. Presentazione de Biagia Catanzaro Gligora -- v. 2. Logica, totalità-reale e realtà -- v. 3. Anima e coscienza.

Through a direct reference to Louis Marin’s theory of the visual representation, in the article some filmic and non-filmic images (Biblical episodes, paintings, tapestry, movies and digital images) are analysed as they all display the character of a screen. The convergence between visual representations and screens is then generalized in order to show that, at least during Western Modernity, image vision often functioned as an absorption into a screen space, where the spectator was not only able to reorganize his optical (...) experience, but was also empowered, through the relationship established with the figures in the representation, to act and display his/her agency, desires and claims. Considered as screens, images show thus the coincidence between an aesthetic and a political experience, where the spectator is not a passive consumer, but an actor on the stage. (shrink)

The article examines the use of the concept of mimesis in Adorno’s notes towards a theory of musical performance. In trying to idiosyncratically define the latter as “reproduction”, Adorno relied on a framework elaborating on concepts introduced by Arnold Schoenberg, Hugo Riemann and Walter Benjamin – a framework that the article discusses insofar as it deals with the problem of mimesis. Specific attention is devoted to the relation between Benjamin’s essays on language and translation and Adorno’s theory of notation, that (...) soon became the crucial aspect of his theory of reproduction. Given the shortcomings of Adorno’s theory, which in the end did not achieve its goals, the article proposes to capitalize on his terminology while at the same time rethinking his framework in the light of recent musicological paradigms for the study of musical performance. On the whole, the article shows that it was Adorno’s philosophical assumptions – in particular the theses of music’s non-intentionality and of its non-similarity to language – that prevented him from convincingly theorizing musical performance, and suggests an alternative framework for future research. (shrink)

John Dewey puts aesthetic experience at the center of his reflection on art and beauty, reconsidering it dynamically. Nowadays, this view opened the path to somaesthetics, a term coined by Richard Shusterman, and aesthetic anthropology. Here, it is argued that the contribution of pragmatist aesthetics could be further developed by exploring its analogies with techno-aesthetics, a paradigm proposed by French philosopher Gilbert Simondon in the early 1980s. Art occupies accordingly a special place within the different forms of aesthetic experience, being (...) considered as a way of experimenting the impact of new technologies in the human experience. It is a process by which technologies create ‘devices’ for experimenting perception and reflection: namely, ways of reconstructing the nature of the human mind in-between body and technology, and by means of their interaction. Cinema reconsidered after Dewey’s fellow George H. Mead, offers an exemplary case as both artistic and technological devices. (shrink)

The use of robots in therapy for children with autism spectrum disorder raises issues concerning the ethical and social acceptability of this technology and, more generally, about human–robot interaction. However, usually philosophical papers on the ethics of human–robot-interaction do not take into account stakeholders’ views; yet it is important to involve stakeholders in order to render the research responsive to concerns within the autism and autism therapy community. To support responsible research and innovation in this field, this paper identifies a (...) range of ethical, social and therapeutic concerns, and presents and discusses the results of an exploratory survey that investigated these issues and explored stakeholders’ expectations about this kind of therapy. We conclude that although in general stakeholders approve of using robots in therapy for children with ASD, it is wise to avoid replacing therapists by robots and to develop and use robots that have what we call supervised autonomy. This is likely to create more trust among stakeholders and improve the quality of the therapy. Moreover, our research suggests that issues concerning the appearance of the robot need to be adequately dealt with by the researchers and therapists. For instance, our survey suggests that zoomorphic robots may be less problematic than robots that look too much like humans. (shrink)

In Portugal, research productivity is nowadays essential for the positive assessment of academics, research units and study programmes. Academic inbreeding has been highlighted in the literature as one of the factors influencing research productivity. This paper tests the hypothesis that inbreeding is detrimental for research productivity, measured through the number of publications listed in Scopus. The study resorts to a database provided by the national Agency for Assessment and Accreditation of Higher Education, which comprises all academics teaching in all Portuguese (...) institutions in the academic year 2015/2016. The sample selected for the analysis contains all academics with a PhD in Sociology. The study uses a special regression model for the analysis: the negative binomial logit hurdle. This was necessary given the large amount of academics with no publications or citations in Scopus, which were the dependent variables to assess research performance. The analysis provides separate results for the probability of inbred academics of having no papers/citations, and for the probability of producing more papers/citations than the non-inbred. Findings suggest that academic inbreeding, defined at the institutional level, has no negative effect on research productivity, contrary to what was expected. However, when defined at the national level, academic inbreeding is detrimental for the recognition and the impact of research: academics with a foreign PhD are more likely to have citations compared to academics who obtained their PhD in Portugal. A tendency was also noted that inbreeding might be more detrimental to research productivity in faculties of Economics than in Social Sciences and Humanities. (shrink)

Anne Conway’s philosophy has been categorized as “vitalism,” “vital monism,” “spiritualism,” “monistic spiritualism,” “immaterial vitalism,” and “antimaterialism.” While there is no doubt that she is a monist and a vitalist, problems arise with the categories of “spiritualism,” “immaterial vitalism,” and “antimaterialism.” Conway conceives of created substances as gross and fixed spirit, or rarefied and volatile matter. While interpreters agree that Conway’s “spirit” shares characteristics traditionally attributed to matter (e.g., extension, divisibility, impenetrability), and that she is critical of Henry More’s immaterial (...) spirit, Conway’s spirit is still conceived as an immaterial soul-like or mind-like entity. I argue that Conway’s vitalism is material, and is best understood in the tradition of Renaissance vital naturalism. First, Conway does not criticize materialism per se, only mechanical materialism, which characterizes matter as lifeless. Her vitalism has to be materialistic in some sense, since only God is an immaterial substance. Second, Conway’s conceptions of matter and spirit, the language she uses, and the fact that she attributes thinking to extended, divisible, and impenetrable substances all place her within the tradition of Renaissance vital naturalism, wherein Bernardino Telesio, Tommaso Campanella, and Francis Bacon used “spirit” to account for all natural processes. (shrink)

Social cooperation often relies on individuals’ spontaneous norm obedience when there is no punishment for violation or reward for compliance. However, people do not consistently follow pro-social norms. Previous studies have suggested that an individual’s tendency toward norm conformity is affected by empirical information (i.e., what others did or would do in a similar situation) as well as by normative information (i.e., what others think one ought to do). Yet little is known about whether people have an intrinsic desire to (...) obtain norm-revealing information. In this paper, we use a dictator game to investigate whether dictators actively seek norm-revealing information and, if so, whether they prefer to get empirical or normative information. Our data show that although the majority of dictators choose to view free information before making decisions, they are equally likely to choose empirical or normative information. However, a large majority (more than 80%) of dictators are not willing to incur even a very small cost for getting information. Our findings help to understand why norm compliance is context-dependent, and highlight the importance of making norm-revealing information salient in order to promote conformity. (shrink)

Atores com distintas perspectivas educacionais têm utilizado, cada vez mais, o vocábulo autonomia de acordo com os seus interesses. Objetivamos com este artigo, que é uma revisão de literatura, discutir sobre a autonomia a partir de enfoques da Filosofia, da Psicologia e da Sociologia. As contribuições de autores como Rousseau, Kant, Freud, Adorno, Agamben, Piaget, Kamii, Martins, Freire, Barguil, dentre outros, enriquecem uma leitura interdisciplinar da complexa relação entre autonomia e Educação. Concluímos que a autonomia não é uma característica do (...) sujeito, mas uma prática indispensável para o seu desenvolvimento individual e social, bem como para fortalecer o processo democrático. (shrink)

Background: In the present study, we aimed to better investigate attention system profile of Parkinson's disease-Mild Cognitive Impairment patients and to determine if specific attentional deficits are associated with 123I-FP-CIT SPECT.Methods: A total of 44 de novo drug-naïve PD patients [ with normal cognition and 17 with MCI ], 23 MCI patients and 23 individuals with subjective cognitive impairment were recruited at the Clinical Neurology Unit of Santa Chiara hospital. They were assessed by a wide neuropsychological battery, including Visual Search (...) Test measuring selective attention. Performances among groups were compared by non-parametric tests. Further, Spearman's rank correlations were performed to explore the association between neuropsychological variables and 123I-FP-CIT SPECT data in PD subgroup.Results: PD-MCI patients performed worse on VST than patients with PD-NC, patients with MCI and individuals with SCI. The performance of PD-MCI patients on VST significantly correlated with caudate nucleus 123I-FP-CIT SPECT uptake, whereas a negative correlation between such test and 123I-FP-CIT SPECT uptake in the left putamen was found in PD-NC patients.Conclusions: We suggest that selective attention deficit might be a trigger of cognitive decay in de novo PD-MCI patients. The VST should be routinely used to detect attentional deficits in hospital clinical practice, in the light of its closely association with dopamine depletion of basal ganglia in mildly impaired PD patients. (shrink)

Resenha do livro “O Arsenal da Democracia”, de Claude-Jean Bertrand, Bauru, 2002.

The article discusses how the emergence of the term "minor" in Brazilian society, from the mid-nineteenth century, forged mainly by the practice of legal and medical discourse, outlined a path of institutionalization for poor children; first, in the post-abolition period of enslavement until the thirties of the last century and, later, until the period of democratization of Brazil, considering the promulgation of the Federal Constitution of 1988. The analysis for the proposed periods was based on the concept of disciplinary power (...) and biopower, both coined by Foucault. Furthermore, the emergence of the black child was discussed, based on its status as a citizen child, contained in the Federal Constitution of 1988, and in the Statute of the Child and Adolescent created in the 1990s. From this period up to the present day, the text deals with the new devices created by the Brazilian State, which have ensured unequal conditions for black children and mainly promoted the increase of homicides among them.The analysis of the last period presented was based on the concept of “necropolitics,” developed by Achille Mbembe. Finally, we defend the principle that another childhood for black child will only be possible through a becoming-other, a new opening of the world and, above all, a decolonization of childhood for children belonging to the black ethnic-racial group. (shrink)