The conserved ribosomal protein uS3 in eukaryotes has long been known as one of the essential components of the small (40S) ribosomal subunit, which is involved in the structure of the 40S mRNA entry pore, ensuring the functioning of the 40S subunit during translation initiation. Besides, uS3, being outside the ribosome, is engaged in various cellular processes related to DNA repair, NF‐kB signaling pathway and regulation of apoptosis. This review is devoted to recent data opening new horizons in understanding the (...) roles of uS3 in such processes as the assembly and maturation of 40S subunits, ensuring proper structure of 48S pre‐initiation complexes, regulation of initiation and ribosome‐based RNA quality control pathways. Besides, we summarize novel results on the participation of the protein in processes beyond translation and consider biomedical implications of previously known and recently found extra‐ribosomal functions of uS3, primarily, in oncogenesis. (shrink)

In this paper we introduce a new type of nets with bounded types of distributed resources . Linear Logic to describe the behaviour of BR-nets is defined. It is based on Girard's Linear Logic but captures not only consumption of resources but their presence as well. Theorem of soundness and completeness of the proposed axiomatization is proved and the complexity of the provability problem is established for the general case and some particular ones.

It is now clear that two prominent nuclear domains, interchromatin granule clusters (IGCs) and Cajal bodies (CBs), contribute to the highly ordered organization of the extrachromosomal space of the cell nucleus. These functional domains represent structurally stable but highly dynamic nuclear organelles enriched in factors that are required for different nuclear activities, especially RNA biogenesis. IGCs are considered to be the main sites for storage, assembly, and/or recycling of the essential spliceosome components. CBs are involved in the biogenesis of several (...) classes of small RNPs as well as the modification of newly assembled small nuclear RNA. We have summarized data on the molecular composition, structure, and functional roles of IGCs and CBs in the nuclei of mammalian somatic cells and oocytes of some animals with a special focus on insects. We have focused on similarities and differences between the IGCs and CBs of oocytes and the well‐studied CBs and IGCs of cultured mammalian somatic cells. We have shown the heterogeneous character of oocyte IGCs and CBs, both in structure and molecular content. We have also demonstrated the unique capacity of oocytes to form close structural interactions between IGC and CB components. We proposed to consider these joint structures as integrated entities, sharing the features of both IGCs and CBs. (shrink)

The fact that modern artists are turning toward science and the latest technologies—robotics, information technology, biomedicine—forces us to reformulate our concept of art. One need only imagine...

The purpose of the study is to reveal the main actions of the major central banks during the COVID - 19 pandemic and their main impact on the world stock markets. The scientific novelty consists in identifying the key results of the impact of the pandemic in general and the restrictive measures of national governments, in particular, on the dynamics of the state of the stock markets of the world, namely, the level of decline in the main stock indexes of (...) the S &P 500, Dow Jones and NASDAQ. The measures taken by the central banks of the United States, Japan, England and other developed and developing countries of the world to provide financial assistance to commercial banks and other financial organizations related to the purchase of government bonds at a "zero" rate, targeting the yield of government bonds, reducing key rates and other measures are summarized. It is indicated that the influx of new private investors provided a great help to the stock market, for which many Central Banks introduced special programs and preferences. As a result, the main measures taken by the Central Bank of the Russian Federation to stabilize the financial situation in the country and the domestic stock market, in particular, are summarized. (shrink)

By the end of the 20th century educational issues had become of global character due to the fact, that it is education that makes the basis for the social dimensions of the 21st century. The importance of educational issues can be explained by the post-industrial society being oriented at rising the significance of information and knowledge as being the main resources for the society development, at the priority of intellectual activities, resulting in changing the roleand place of education in the (...) society, at turning education into the strategically important sphere of our lives. (shrink)

The article is devoted to understanding a healthy lifestyle in old age, significant limitations and differences that arise with age and redefine many basic ideas about health. The article begins by identifying basic ideas about healthy aging, which are questioned and clarified through an analytical analysis of dense interviews (the author’s terminology for qualitative interviews, the closest analogue of which in the Russian-speaking environment is in-depth interviews) with old people. Field work took place in the Republic of Khakassia in three (...) cities: Abakan, Chernogorsk and Abaza. A total of 12 interviews were conducted with older people receiving long-term care services. Based on the received narratives, five conditions accompanying aging were identified: living in illness; accepting limitations; loneliness; support and withdrawal from others; emotional depression. Through a critical understanding of the life world of aging, four signs of a healthy lifestyle in old age are identified: attention to the old man, the need for the old man, the value of aging and the presence of a goal in life for the old man. Modern social policy in Russia is based on only one component of “attention to the elderly” (although other components are also declared by law), through the organization of long-term care, the development and implementation of rehabilitation means, and the creation of an accessible environment. But the most important elements remain the formation of the need for the old man among significant loved ones (relatives and others), joint agreement, the formation of goal-setting in the old man in life and the promotion of the value of aging as such. The article proposes an agenda for further research to more accurately shape domestic policies in the field of aging. (shrink)

The paper deals with the need for new methods in foreign language teaching to students of non-linguistic universities. The article presents a strategy to optimize the foreign language lesson. As an example an algorithm with authentic technical text in German is considered. It makes possible to change the work with foreign language text. It is proposed to substitute the standard tasks to the practice-oriented, which purpose is to teach students to understand the text.

This article deals with the question of the interrelation between two papers, both called, in short, “Onomatodoxy”, dedicated to the doctrine of Name-glorification (Imiaslavie, Onomatodoxy), both of which were created in line with the Neo-Patristic movement in the Russian philosophy of the Silver Age. One of these papers is by Alexei Losev and the other by Pavel Florensky. In my opinion, there are sufficient grounds to state that Losev’s “Onomatodoxy” was written either after Florensky created his own “Onomatodoxy”, i.e., after (...) November 1922, or, at the earliest, after Florensky started to give clandestine lectures about Onomatodoxy in Moscow (where Losev lived), i.e., not earlier than spring 1921. Therefore, Losev’s article “Onomatodoxy” could have been intended for the religious-philosophical collection of articles planned for publishing by Yaschenko in 1922 in Berlin. (shrink)

Summary This paper presents a new argument against the widely accepted view that Eratosthenes and some other Greek authors of the pre-Roman period measured distances in special stades that were much shorter than the ‚common‘ stade of 185 m attested by the majority of sources.

Summary Historians of science have neglected early modern natural philosophers' varied attitudes to the history of philosophy, often preferring to use loose labels such as ?Epicureanism? to describe the survival of ancient doctrines. This is methodologically inappropriate: reifying such philosophical movements tells us little about the complex ways in which early modern natural philosophers approached the history of their own discipline. As this article shows, a central figure of early modern natural philosophy, Robert Boyle, invested great intellectual energy into his (...) depiction of the history of philosophy. Boyle's historical worldview was mediated through an array of textual traditions: classical, patristic, humanist and contemporary. Drawing extensively on his manuscript notes, this is examined for three topics. First, from his turn to natural philosophy in the late 1640s, Boyle combined a sceptical attitude towards philosophy's potential ? stemming from humanist historicisations of the ?speculative? heritage of Greek philosophy ? with a belief in natural philosophy's efficacy as a spiritual exercise, as performed by ancient ?priests of nature?. Second, Boyle's attitude to the history of matter theory was far more complex than any simple comparison with ?ancient atomism? can convey. Unlike many of his contemporaries, Boyle held Epicurus to be a speculative and reductionist philosopher, leading him to posit a different lineage for a non-reductionist corpuscularianism which depended on exploitation of non-standard historiographical traditions. Appreciating this allows us to make an intervention in the ongoing debate about the relationship between corpuscularianism, chymistry and experiment in Boyle's philosophy. Third, Boyle's historicisation of supposedly anthropomorphic philosophies in his famous Free Enquiry (1686) exploited recent theological historiography, most importantly Samuel Parker's combination of the history of idolatry with the history of Greek philosophy, which itself relied on developments in continental sacred history. It was this historicisation, rather than any philosophical realities, which led to the positing of the mechanical philosophy as more compatible than Aristotelianism with Christian doctrine. (shrink)

This article attempts to develop a theoretical approach to exploration of the environment, of intra-environmental information processes and mutually determinative relationships, and mode of being. Relying on the theoretical postulates of Gregory Bateson, the information theory of Claude Shannon, the concept of predictive processing, and Nikolai Ladovsky’s principle of economy of perception in architecture, the author seeks to show that the environment can act as an alternative mode to the subject for organizing experience. This interpretation of the concept of environment (...) can serve as a foundation for constructing an optics of inquiry that is not human-centric but at the same time could remain an optics of human inquiry. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN 3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is (...) asserted, d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT 4 . Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a –order (truth order) and d –order (falsity order) coincide with first-degree entailment. Finally logic with two kinds of operations ( a –connectives and d –connectives) and consequence relation defined via a –ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

The paper deals with the enactivist approach to the problem of consciousness. The problem of consciousness is the problem of naturalistic explanation of phenomenal aspects of our experience. According to classical cognitive science, we can explain all mental states as functional, representational states. Many philosophers disagree with this view. They demonstrate that phenomenal qualities of conscious states cannot be understood in terms of mental representations. Contemporary debates about the nature of phenomenal qualities are the debates between representationalists and anti-representationalists. The (...) arguments proposed by anti-representationalists demonstrate the insufficiency of classical representational approach. But it doesn't mean that we should accept the existence of qualia - special nonrepresentational phenomenal properties. It is possible to defend representationalism by reconsidering the nature of mental representations. This article examines the transformation of the concept of mental representation in cognitive science over the last few decades. It demonstrates that the notion of representation in action discussed in enactivist theories can help us to provide the foundation for naturalistic understanding of conscious experience. (shrink)

The Catholic polemicist John Sergeant published three major works of philosophy towards the end of his literary career, The Method to Science (1696), Solid Philosophy (1697) and Metaphysics (1700). They were highly critical of what Sergeant saw as the idea-grounded epistemology of the Cartesians and John Locke, whom he labelled 'ideists'. Previous scholars have interpreted Sergeant's texts as manifestations of his lifelong obsession with certainty, as initially developed in his Restoration polemics against Anglican divines. Using a previously neglected autobiographical letter, (...) it is demonstrated that Sergeant's intentions were very different. Like Edward Stillingfleet and other critics, Sergeant saw Locke's philosophy as inspiring contemporary heterodoxy. The article identifies the specific channels by which Sergeant saw Lockeanism seeping into irreligion. Moreover, unlike Locke's Anglican critics, Sergeant resorted not to polemical accusations, but to abstract philosophy. This must also be explained contextually: Sergeant wished his works to become textbooks at the universities, concerned as he was by the pedagogical impact of the Essay. A premise of this article is that reception history is less useful for elucidating on the meaning of the received text than for telling us something about the intentions of the receiver, and about the intellectual culture in which the process of reception occurs. With this in mind, the article finishes by recontextualizing Sergeant's works within a broader narrative: his was an attempt to reassert the place of philosophy as a propaedeutic to theology in an age when such a conception of philosophy's social role was coming under intense scrutiny. (shrink)

This article discusses the “event” in Merab Mamardashvili’s philosophy. The roots of the post-secular interpretation of the event are traced back to Sören Kierkegaard’s concept of “the moment”, which is posited within a non-classical understanding of temporality and historicity of cognition. The concept of the “event” is also explored in the broader context of non-classical and post-secular Western philosophy of the twentieth century, especially in the works of Martin Heidegger and Jean-Luc Marion, who both belong to the phenomenological tradition. The (...) concept of the event in Mamardashvili’s philosophy is explored as one relative to analogous conceptualizations of the event in a post-secular context. (shrink)

We explore a possibility of generalization of classical truth values by distinguishing between their ontological and epistemic aspects and combining these aspects within a joint semantical framework. The outcome is four generalized classical truth values implemented by Cartesian product of two sets of classical truth values, where each generalized value comprises both ontological and epistemic components. This allows one to define two unary twin connectives that can be called “semi-classical negations”. Each of these negations deals only with one of the (...) above mentioned components, and they may be of use for a logical reconstruction of argumentative reasoning. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is asserted, (...) d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT4. Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a–order and d–order coincide with first-degree entailment. Finally logic with two kinds of operations and consequence relation defined via a–ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

This book is a philosophical study of two major thinkers who span the period of late antiquity: Plotinus, who establishes many of the central themes for later debate and establishes strategies of argument and interpretation, and Proclus, who develops a grand philosophical synthesis and provides original insights into a number of important problems regarding being and thinking, matter and evil.

In this paper we continue the study of Girard's Linear Logic and introduce a new Linear Logic with modalities. Our logic describes not only the consumption, but also the presence of resources. We introduce a new semantics and a new calculus for this logic. In contrast to the results of Lincoln [7] and Kanovich [4] about the NP-completeness of the problem of the construction of a proof for a given sequent in the multiplicative fragment of Girard's Linear Logic, we present (...) here a non-exponential algorithm to construct a proof for a given sequent and a given point of a given model in our Linear Logic. (shrink)

The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, (...) together with the implications of their association for the structure of the chromatin fibre. (shrink)

This article is devoted to a critical analysis of neuropsychoanalysis, an interdisciplinary field that emerged at the end of the 20th century and set itself the task of combining neuroscience with the psychoanalytic approach. The author draws attention to the conceptual gaps of this ambitious undertaking. The main gap is argued to be the insufficient attention paid to the psychophysical problem (or mind-body problem), which ends up overlooking the fundamental difference between brain and psychic / mental reality, and attempts to (...) derive the principles of functioning of the latter from the observations of brain activity. This, in turn, leads to further problems: the problem of translation and search for a correspondence between psychoanalytic theory based on a thick observation of the subject's mental activity and the conceptual tools of neurosciences. What percentage of loss of meaning in this translation can be recognized as acceptable and what remains of psychoanalysis as a result of such a procedure? Another problem is related to the intersubjective symbolic nature of human desire, which cannot be deduced from observations of brain physiology. Finally, the author draws attention to the fact that neurosciences - and neuropsychoanalysis is no exception here - are already initially interwoven into social and cultural space, making them easy victims of contemporary- sometimes implicit - ideological attitudes. The article concludes with a call for greater reflexivity regarding neuropsychoanalysis on the part of both interested parties - psychoanalysts and neuroscientists. (shrink)

Collected writings on Plato’s unwritten teachings.

The article critically addresses Boris Groys’ interpretation of photographs by Alexandre Kojève. In 2012, Groys organized the exhibition After History: Alexandre Kojève as a Photographer, which intended to demonstrate the “posthistorical” dimension in Kojève’s artistic output. The article questions the adequacy of that perspective, given the somewhat tendentious curatorial presentation of the photos as showing an empty, dehumanized world. Considering the aesthetic and ontological aspects of the analysis of visual images that were central to Kojève’s brief account of his 1920 (...) visit to the Borghese Gallery in Rome and to his 1936 article on Kandinsky, Groys’ reading of Kojève’s photographic stance is subject to revision. The notion of aura, as proposed by Walter Benjamin, is operative in a comparative treatment of the photos by Kojève and Eugène Atget. (shrink)

A conception of an information system has been introduced by Pawlak. The study has been continued in works of Pawlak and Orlowska and in works of Vakarelov. They had proposed some basic relations and had constructed a formal system of a modal logic that describes the relations and some of their Boolean combinations. Our work is devoted to a generalization of this approach. A class of relation systems and a complete calculus construction method for these systems are proposed. As a (...) corollary of our main result, our paper contains a solution of a Vakarelov's problem: how to construct a formal system that describes all the Boolean combinations of the basic relations. (shrink)

This article examines the role of primary ethnographic materials – of field notes, letters and photographs – and even of the shelves and bookcases – in building accounts of the human condition. We trace the lives of incomplete and not-yet-found manuscripts, which have been treated as representative of whole archives, as well as closely held convictions and ideas in the history of anthropology. In so doing, we employ the notion of a ‘proxy’, or a set of signs and images which (...) point the audience in particular directions, without determining their overall destination. Our research is based on a few episodes from the histories of paper and digital copies of manuscripts and photographs of the anthropological couple Sergei and Elizabeth Shirokogoroff, who conducted ethnographic, linguistic and some archaeological research, first on the borderlands between China and Russia, and then later within China. We aim to show the complexity and social and intellectual vibrancy of their ethnographic field archives, which have been scattered across countries, institutions and personal collections. We conclude by suggesting that engaging anthropologically with field archives enables us to approach existing perspectives on archives in a new way, viewing them not as containers of catalogued information, but as entanglements reflecting social relations in local communities, the trajectories of ethnographers, and the aspirations of scholars asking questions today. (shrink)

I detect a specific attitude to Byzantium (“the Byzantine Enlightenment”) in Ivan Kireevsky’ Slavophile article “On the Character of Enlightenment in Europe” (1852). I qualify this attitude as Byzantinocentrism. I take that as a focal point and, against this background, consider the image of Byzantium in Kireevsky and some thinkers of his social circle. It allows me to trace the most important lines of attitudes to Byzantium in the Russian historiosophical literature and opinion journalism of the nineteenth century. I detect (...) two opposite lines in perceiving Byzantium in Kireevsky’s early social circle: the anti- and pro-Byzantine ones. The first line goes back to an anti-Byzantine message, characteristic of the epoch of Enlightenment. It found its manifestation in G. W. F. Hegel’s Lectures on the Philosophy of History. I point to the traces of the implicit polemics with Hegel’s anti-byzantinism in Kireevsky and identify the context of these polemics in Arist Kunick. As well, I outline how these lines worked in Pyotr Chaadaev and Alexander Pushkin. Then I distinguish between how the image of Byzantium was presented, first, in Kireevsky’s earlier Slavophile article “On the Character of Enlightenment in Europe” and, second, in his last article “On the Necessity and Possibility of the new Foundations for Philosophy” (1856). In the latter article, which sees Byzantium as bipolar, I find another view on Byzantium. I suggest that this view on Byzantium as a bipolar entity goes back to Alexey Khomyakov’s Semiramis. My point is that this difference in the views on Byzantium is paradigmatic and it reflects a division that was present in the Russian Slavophile-conservative milieu of that time. I suggest that this division stands behind another division within the same milieu, which was politically oriented, the one in relation to the Greek-Bulgarian ecclesiastical question. I analyze how both monopolar (Byzantinocentric) and bipolar views on Byzantium were reflected in the Greek-Bulgarian question as it was considered by Alexey Khomyakov and Terty Filippov. I find a context for developing Kireevsky’s attitude towards Byzantium in François Guizot’s historiosophic scheme as well. (shrink)

The subject of this study is a set of alleged contradictions in the development of artificial intelligence, pursued in order to achieve their overcoming. Philosophical anthropology contains the potential to analyze complex interactions, to articulate the problems that arise between artificial intelligence and humans. The philosophical and anthropological analysis of artificial intelligence is aimed at understanding this human phenomenon, human presence and its experience. The article is an attempt to identify and outline the trajectories for the possible resolution of the (...) contradiction in the development of artificial intelligence, the analysis of the parameters proposed by philosophical anthropology to solve their problems in the modern socio-cultural situation. The relevance of the proposed problem arises in the fact that artificial intelligence qualitatively changes the existence of a person, and in philosophical anthropology there is a potential to outline the prospects for the development of artificial intelligence, while preserving the languid human in a person. To study this perspective is very important in society. The novelty of the topic raised in the article is the analysis of solving the problems of artificial intelligence from the standpoint of philosophical anthropology, in the articulation of contradictions in the development of artificial intelligence, in the search for solutions to overcome these contradictions. Philosophical anthropology provides tools for a balanced decision on the development of artificial intelligence, the degree of its impact on human existence. (shrink)

This article analyzes the extended mind hypothesis that has been discussed during the past two decades following the article “The Extended Mind” by Andy Clark and David Chalmers. It examines the position of active externalism and notes the shortcomings of the arguments supporting this position as proposed by Clark and Chalmers. It is demonstrated that the cultural-historical psychology developed by Vygotsky represents an alternative means of substantiating the extended mind hypothesis. Interpreting Vygotsky’s position as “active social externalism,” the author contrasts (...) Vygotsky’s theory with the active externalism of Clark and Chalmers, as well as with the classical externalism advocated by Putnam and Burge, showing the advantage of Vygotsky’s approach. This advantage has been seen in the ability of Vygotsky’s active social externalism to avoid the problems faced by other externalist approaches to explaining the mind. (shrink)

Martin Mulsow's Knowledge Lost is a magnificent contribution to early modern intellectual history and the history of knowledge. In the hope of stimulating further discussion, this article asks several questions, most of them circling around one meta question: have we perhaps overly caricatured early modern ‘orthodoxy’, and underestimated the plurality of its intellectual output?.