Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and that are also widely applied in biomedical research, interrupt mitochondrial proteostasis and physiology in animals ranging from round worms, fruit flies, and mice to human cell lines. Importantly, plant chloroplasts, like their mitochondria, are also under certain conditions vulnerable to these and other antibiotics that are leached into our environment. Together these endosymbiotic organelles are not only essential for cellular and organismal homeostasis stricto sensu, but (...) also have an important role to play in the sustainability of our ecosystem as they maintain the delicate balance between autotrophs and heterotrophs, which fix and utilize energy, respectively. Therefore, stricter policies on antibiotic usage are absolutely required as their use in research confounds experimental outcomes, and their uncontrolled applications in medicine and agriculture pose a significant threat to a balanced ecosystem and the well‐being of these endosymbionts that are essential to sustain health.Also watch theVideo Abstract. (shrink)

仁斎にとっての「学問」とは、世界の見え方を刷新させるものである。そして、そのような「学問」の道を開いたのが孔子であった。.

Some understand forgiveness as a normative power. Here we raise an objection to such views. They cannot explain certain instances when forgiveness is beyond our grasp. A victim of a wrong, despite thinking forgiveness is the right thing to do, and wishing she could forgive, may find herself unable to do so. No good explanation of this impossibility, consistent with forgiveness being a normative power, is available.

Here I distinguish two things jurisprudence might take itself to explain. A theory of law can be either concept-first or practice-first. Concept-first theories investigate the concept we implicitly deploy to label some things as law and not others. Practice-first theories investigate directly, and uncover interesting features of, a particular social practice. That practice could be, for instance, the practice of lawyers and officials which prevails in the United States. I identify Hershovitz's Law Is a Moral Practice with a practice-first approach. (...) Then I elaborate on the distinction and show that a practice-first approach is more defensible than many assume. Finally, I argue a practice-first approach rules out predictive theories of law. (shrink)

Since 2016, my embodied avatar performance (EAP) has explored healing rituals and life review at the intersection of arts, health and virtual reality (VR) for a variety of individuals, including older adults and cancer patients. EAP established a format in which the avatar mirrors the participant’s behaviours and speech, facing them during the life review process. The aspect of mirroring and facing is crucial in EAP for facilitating engagement, embodiment and empathy and a symbiotic relationship between avatar and human. This (...) article outlines the symbiosis between humans and avatars within the EAP process, focusing on the interactions where participants face and mirror their avatars. The avatars are presented as if participants are looking into a mirror. As the avatars face the participants and mimic their movements, they create an illusion similar to seeing one’s reflection in a virtual setting. The article discusses a range of mirroring aspects, including virtual mirrors in VR, echoing techniques in drama and movement therapy, and broader concepts like empathy, embodiment, we-ness and the Korean emotional concept of Cheong. Early EAP avatars, especially in the case of technical failures, will be discussed as examples. (shrink)

Demonstrates the uniqueness of Hume as an Enlightenment thinker, illustrating how his 'spirit of scepticism' often leads him into seemingly paradoxical positions. This book will be of interest to Hume scholars, intellectual historians of 17th- to 19th-century Europe and those interested in the Enlightenment more widely.

It is generally assumed that in early modern Britain, chivalry—allegedly typified by the Crusades—was considered a negative or even ridiculous ideology until its rehabilitation by the pre-Romantic movement. However, this paper argues that Hume and other Scottish Enlightenment thinkers had already shown a deep interest in its historical role and influence on modern civilization. That Hume shared a broad interest in chivalry with contemporary philosophers does not undermine the novelty of his thought on this topic. In fact, the pioneering and (...) unique aspects of his contributions can be clarified by setting them in context. (shrink)

The significance of Hume's positive attitude towards luxury might have been overemphasized by his commentators. In fact, arguments in favor of "moderate" luxury had already been entertained before the emergence of Hume's position. Therefore to argue that Hume's argument entailed the defense of moderate luxury is not to identify in it anything particularly unique. Thus, the first aim of this paper is to clarify the nature of Hume's contribution to the ongoing luxury debates. This does not consist merely of an (...) assertion of the compatibility of moral virtue with the enjoyment of luxury, but lies rather in Hume's emphasis on two aspects of the beneficial interaction between morality and luxury. First, the historical process of the introduction of luxury is regarded by Hume as fostering new morals peculiar to the commercial age; and secondly, the enjoyment of luxury is seen as a condition favorable to the maintenance of morals. The second aim of this paper is to shed some new light on an aspect of Hume's thought that, so far, has been relatively neglected, namely, his distinction between "innocent" and "vicious" forms of luxury, as well as his acknowledgement of the possibility of the emergence of the latter, as well as the former, in the modern commercial world. However, this does not necessarily lead us to a more pessimistic interpretation of Hume's view of luxury than those accepted thus far; only to the awareness of how difficult and delicate, in Hume's view, is the maintenance of the balance between the interlinked concepts of industry, knowledge, and humanity. (shrink)

Perspectivalism is a popular way to understand legal obligations. That there is a legal obligation, on this view, is equivalent to there being a moral obligation from the legal perspective. But Adam Perry argues that perspectivalism cannot account for arguments going from legal premisses to a factual conclusion. Take, for instance, the premisses (i) only those over 18 have a legal right to vote and (ii) Sarah has a legal right to vote. Seemingly we should be able to arrive at (...) the valid conclusion that Sarah is over 18. Perry says perspectivalism cannot explain the validity of this conclusion. We show that it can. So his objection – that perspectivalism cannot make sense of an important feature of legal argumentation – fails. Along the way, our discussion reveals an important lesson: those who endorse perspectivalism must take care to ensure that all parts of a legal argument, both premisses and conclusions, are true according to the legal perspective. (shrink)

BackgroundTo explore how self-disclosure leads to post-traumatic growth in adults who have experienced traumatic events, this study identified the relationship between self-disclosure and post-traumatic growth in Korean adults. We examined a parallel multiple mediating model for this relationship.MethodsParticipants were 318 Korean male and female adult participants aged 20 years or older who had experienced trauma. We measured deliberate rumination, positive social responses, and the meaning of life as mediating variables.ResultsThe results revealed that the study variables positively correlated with PTG. Self-disclosure (...) was positively correlated with deliberate rumination, positive social responses, and meaning of life. In the multiple mediating model, deliberate rumination, positive social responses, and meaning of life mediated the relationship between self-disclosure and PTG.ConclusionSelf-disclosure, deliberate rumination, positive social responses, and meaning of life play an important role in the growth of adults who have experienced traumatic events. The findings of this study should provide valuable information for future research and for mental health professionals who want to promote the PTG of their clients. (shrink)

In the biographies of David Hume, Horace Walpole’s name has been memorialised as the author of a forged letter assuming the identity of the King of Prussia. However, in the letter, Walpole’s scorn was directed against not only Rousseau, but also other French philosophes and, possibly, even Hume. Walpole drew a line between himself and the ‘pedants and pretended philosophers’, although he sometimes blurred the distinction between the two by considering an author or ‘man of letters’ synonymous with a ‘philosopher’. (...) Walpole broached his lifelong stricture on modern pretentious philosophers to Hume in one of his letters, just after the Concise Account was published. Walpole’s thorough contempt for French philosophers appeared to Hume as a Rousseauian, anti-philosophical stance. In his reply, Hume attempted to advocate his thesis of intellectual improvement and moral cultivation. Meanwhile, in another letter written around the same time, Hume kept away from Turgot’s sanguine view of human progress. The distance that Walpole maintains between himself and the philosophers—through the Hume-Rousseau affair—casts a long shadow on his evaluations of Hume and his historical works, and leads to their differing assessments of the standpoint of philosophers in the age of lumières. (shrink)

「士農工商は天下を治めるたすけとなる」―江戸期、都市化・経済化の流動的な波の中で、人々の生のつながりの公共的意義を説いた梅岩。広範な影響を及ぼしたその心学は、人々に希望を与え、世界のすべての存在が共に 幸福になることをめざす創造的・運動的な営みであった。.

1. Hōriron -- 2. Hōshisō -- 3. Jitteihō no kiso riron.

Car driving is supported by perceptual, cognitive, and motor skills trained through continuous daily practice. One of the skills that characterize experienced drivers is to detect changes in the driving environment and then flexibly switch their driving modes in response to the changes. Previous functional neuroimaging studies on motor control investigated the mechanisms underlying behaviors adaptive to changes in control properties or parameters of experimental devices such as a computer mouse or a joystick. The switching of multiple internal models mainly (...) engages adaptive behaviors and underlies the interplay between the cerebellum and frontoparietal network regions as the neural process. However, it remains unclear whether the neural mechanisms identified in previous motor control studies also underlie practical driving behaviors. In the current study, we measure functional magnetic resonance imaging activities while participants control a realistic driving simulator inside the MRI scanner. Here, the accelerator sensitivity of a virtual car is abruptly changed, requiring participants to respond to this change flexibly to maintain stable driving. We first compare brain activities before and after the sensitivity change. As a result, sensorimotor areas, including the left cerebellum, increase their activities after the sensitivity change. Moreover, after the change, activity significantly increases in the inferior parietal lobe and dorsolateral prefrontal cortex, parts of the FPN regions. By contrast, the posterior cingulate cortex, a part of the default mode network, deactivates after the sensitivity change. Our results suggest that the neural bases found in previous experimental studies can serve as the foundation of adaptive driving behaviors. At the same time, this study also highlights the unique contribution of non-motor regions to addressing the high cognitive demands of driving. (shrink)

Skateboarding has been a hallmark of adolescent experience in suburban America ever since its beginning in the 1950s. Skateboarding has become an underground subculture, providing the youth population a novel outlet for self-expression and independence. Transworld Skateboarding magazine displays the ideological characteristic of the skateboard movement through their unique populist syntext, distinctive signification system, and extensive textual convergence. However, while expressing adolescent resistance against homogeneity, the magazine also reflects the influence of popular culture on skateboarders. This idiosyncrasy of Transworld Skateboarding (...) magazine reflects popular culture’s constant struggle between the need for hegemonic provision and resistance of mainstream conformity. (shrink)

Purpose The purpose of this study is to understand the nature and characteristics of legal movie download services and to explore the factors that influence user acceptance of the services. Design/methodology/approach The authors analyzed the three aspects of legal movie download services and empirically examined how they affect the potential users’ behavioral intent to adopt the services based on the theory of reasoned action. An online survey of 142 respondents about a real legal movie download services, currently operated by a (...) major online service provider, was conducted. Findings Perceived playfulness and perceived usefulness had statistically significant effects on attitude. The relationships between subjective norms and its influencers are validated for moral judgment as well as risk aversion. The influence of price consciousness and past experience on behavioral intent to adopt the service are both supported. In the TRA model, attitude and subjective norms had statistically significant influence on behavioral intent to adopt the services. Originality/value The authors contribute to extending the literature on online pirating behavior from the different perspective, i.e. adoption of new legal alternatives. The study shows that the specific boundary conditions, i.e. hedonic attribute of information systems and existence of illegal alternatives, would generate the different results from the theories and previous literature. (shrink)