This study analyses the performance and market timing of US socially responsible (SR) mutual funds in relation to business cycle regime shifts and different grouping criteria: Ethical strategy focus, SR attributes scores and Morningstar category. Different methodologies are applied and results highlight the importance of considering specific benchmarks related to the investment style in evaluating the SR fund performance. Our results show that, in aggregate, the abnormal performance of SR funds is negative and significant in expansion periods, but no significant (...) differences are found in recession periods. When specific benchmarks are considered, performance improves in recession periods, particularly for environmental funds, those with high SR attributes scores, and funds from the nine Morningstar style box categories. Market timing of SR funds takes positive values and is partially significant. Previous evidence of negative timing after a recent financial crisis vanishes when specific benchmarks are considered. For comparative purposes the performance of conventional US mutual funds is also analysed. There are no significant differences between the performance of SR and conventional mutual funds when a fair comparison is made within the same style categories. When all the SR funds are considered, they underperform conventional funds in expansion sub‐periods, but in recession sub‐periods they perform better, although the differences observed are not significant. (shrink)

The great powers of regeneration shown by freshwater planarians, capable of regenerating a complete organism from any tiny body fragment, have attracted the interest of scientists throughout history. In 1814, Dalyell concluded that planarians could “almost be called immortal under the edge of the knife”. Equally impressive is the developmental plasticity of these platyhelminthes, including continuous growth and fission (asexual reproduction) in well‐fed organisms, and shrinkage (degrowth) during prolonged starvation. The source of their morphological plasticity and regenerative capability is a (...) stable population of totipotent stem cells—“neoblasts”; this is the only cell type in the adult that has mitotic activity and differentiates into all cell types. This cellular feature is unique to planarians in the Bilateria clade. Over the last fifteen years, molecular studies have begun to reveal the role of developmental genes in regeneration, although it would be premature to propose a molecular model for planarian regeneration. Genomic and proteomic data are essential in answering some of the fundamental questions concerning this remarkable morphological plasticity. Such information should also pave the way to understanding the genetic pathways associated with metazoan somatic stem‐cell regulation and pattern formation. BioEssays 28: 546–559, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

One of the most pleasurable aspects of video games is their ability to induce immersive experiences. However, there appears to be a tentative conceptualization of what an immersive experience is. In this short review, we specifically focus on the terms of flow and immersion, as they are the most widely used and applied definitions in the video game literature, whilst their differences remain disputable. We critically review the concepts separately and proceed with a comparison on their proposed differences. We conclude (...) that immersion and flow do not substantially differ in current studies and that more evidence is needed to justify their separation. (shrink)

In this open access book, the Community of Practice led by the VPH Institute, the Avicenna Alliance, and the In Silico World consortium has brought together 138 experts in In Silico Trials working in academia, the medical industry, regulatory bodies, hospitals, and consulting firms. Through a consensus process, these experts produced the first attempt to define some Good Simulation Practices on how to develop, evaluate, and use In Silico Trials. Good Simulation Practice constitutes an indispensable guide for anyone who is (...) planning to engage at any title with In Silico Trials. (shrink)

Medium-sized language communities face competition between local and global languages such as Spanish, Russian, French and, above all, English. The various regions of Spain where Catalan is spoken, Denmark, the Czech Republic, and Lithuania show how their medium-sized languages (a term used to distinguish them as much from minority codes as from more widely-spoken codes) coexist alongside or struggle with their big brothers in multilingual families. This comparative analysis offers unique insight into language contact in present-day Europe.

The history of Sephardic Judaism, from the late Middle Age to Modernity, and its diatribes against Christianity, which claims to be its theological resolution and, therefore, considers it abolished time, points out the direction of theological, philosophical and even political thought, which crystallize in the evolution of modern Judaism itself and in philosophical schools that are breeding grounds for a given materialism, the fullest systematic culmination of which is the work of Amsterdam-born, Sephardic Jew Benedictus de Espinosa.

During the Italian campaigns of the French Revolutionary Wars (1796–1801), several epidemic outbreaks sparked acrimonious aetiological debates: were the fevers spread by soldiers and prisoners of war, or produced by environmental factors? This debate was not only a scientific issue, but also a political one, for causation was linked to accountability. Looking at a series of medical investigations written by French military practitioners, this paper argues that theories of contagion were used by civilians to accuse the army of spreading disease, (...) in what I describe as an “aetiology of blame.” Likewise, military officials attempted to absolve themselves of responsibility for the spread of disease by focusing on unwholesome environments, depicting diseases as unavoidable fatalities. Military doctors thus supported French imperial endeavours by obscuring the army's responsibility for the spread of diseases, putting forward aetiologies of fate and blaming individual behaviour. Even when they did not radically dismiss contagionist perspectives, military practitioners insisted on a wide range of pathogenic causes. Their discourses were in line with medical theories of the time, but they downplayed the responsibility of the army for the spread of diseases, which they depicted as a factor among others. Military doctors were thus not always involved in the direct and deliberate production of ignorance, but they did sustain controversies and uncertainty. (shrink)

El análisis de los fundamentos conceptuales de lo político en la obra de Aristóteles exige una contextualización etimológica, histórica y filosófica de sus términos clave y vincularlo al marco general del sistema ontológico aristotélico. Desde esa plataforma, es posible abordar el patrón teórico propuesto, principalmente, en los libros I y III de la Política, para medir el grado de desviación o de aproximación con respecto a la línea vectorial teleológica de lo político: el gobierno correcto con vistas al bien común, (...) así como su aplicación para un diagnóstico preciso de los fenómenos políticos de la Historia y de nuestros días. (shrink)

El objetivo del presente trabajo es especular sobre los factores que pueden llevar a un posible retorno del Estado en general y del Estado de Bienestar en particular, después de la etapa neoliberal que podría haberse cerrado con las crisis contemporáneas. Se trata de ver si la tendencia hacia el “Estado mínimo” se ha revertido, cosa que ya pudo haberse iniciado a finales del siglo XX, e incluso si el conjunto de crisis mundiales acaecidas a principios del XXI no habrán (...) acelerado tal tendencia. De todos modos, podría darse el caso de un retorno del Estado pero con un planteamiento sobre el Estado de Bienestar bien diferente del que tuvieron los que, a finales del siglo XIX y principios del XX, comenzaron a implantarlo en países centrales. (shrink)

Higiene escolar y profilaxis didáctica. El fin de la escuela pública en la era de la pandemia.

The intellectual hegemony of Catholicism in the general understanding of teaching throughout the Middle Ages suffers a rollover in the beginning of Modernity. The enquiry on the philosophical foundations and demarcation criteria of these confronted theories allows us to measure its real essence, the description of which could be established by taking into consideration Tomist pedagogy as the paradigm to which Comenius’ and Rousseau’s pedagogy is opposed.

No debe exagerarse la intensidad del poder a escala mundial. El presente trabajo explora las limitaciones del poder mundial tanto en el sentido de estar detentado por una potencia hegemónica, es decir, los Estados Unidos de América, como en el sentido de países centrales en cuanto opuestos a los periféricos. En el caso de los Estados Unidos, se presentan algunas debilidades que se derivan de sus aparentes fortalezas, en especial en el campo militar, económico, político y cultural, haciendo énfasis en (...) las limitaciones que resultan de su enorme capacidad de acumular información. Se citan otros autores que anuncian la decadencia de esa hegemonía. Por otro lado, se discute el carácter más pluralista del poder mundial en contra de las visiones derivadas de la consideración de la hegemonía o el imperio. El hecho es que hay otros estados que detentan poder a escala mundial junto a multinacionales y, especialmente, las clases sociales a escala mundial. En este último caso, la “clase alta” está relativamente bien organizada a escala mundial, aunque de manera contradictoria mientras que la “clase baja” está claramente desorganizada al tiempo que inclinada a los sentimientos nacionalistas o locales. Como conclusión, se presenta una visión más “taoísta” del poder mundial. (shrink)

Los recientes movimientos sociales (desde las “primaveras árabes” a Occupy Wall Street, pasando por los “indignados” europeos o los estudiantes latinoamericanos) pueden entenderse mejor, sin negar sus componentes locales, si se perciben como alternativas producidas dentro de la lógica del sistema capitalista. A ello se añade la actual coyuntura de inseguridades producidas por la crisis visible desde 2008, que agudiza los motivos de protesta. Ésta, sin embargo, no es mayoritaria, y sus integrantes se plantean -con dificultad- objetivos y medios, al (...) tiempo que oscilan entre la búsqueda de cambios en el sistema y su generalización hacia un cambio de sistema. (shrink)

This study examined health professionals’ (HPs) experience, beliefs and attitudes towards brain death (BD) and two types of donation after circulatory death (DCD)—controlled and uncontrolled DCD. Five hundred and eighty-seven HPs likely to be involved in the process of organ procurement were interviewed in 14 hospitals with transplant programs in France, Spain and the US. Three potential donation scenarios—BD, uncontrolled DCD and controlled DCD—were presented to study subjects during individual face-to-face interviews. Our study has two main findings: (1) In the (...) context of organ procurement, HPs believe that BD is a more reliable standard for determining death than circulatory death, and (2) While the vast majority of HPs consider it morally acceptable to retrieve organs from brain-dead donors, retrieving organs from DCD patients is much more controversial. We offer the following possible explanations. DCD introduces new conditions that deviate from standard medical practice, allow procurement of organs when donors’ loss of circulatory function could be reversed, and raises questions about “death” as a unified concept. Our results suggest that, for many HPs, these concerns seem related in part to the fact that a rigorous brain examination is neither clinically performed nor legally required in DCD. Their discomfort could also come from a belief that irreversible loss of circulatory function has not been adequately demonstrated. If DCD protocols are to achieve their full potential for increasing organ supply, the sources of HPs’ discomfort must be further identified and addressed. (shrink)

This paper deals with the history of “pathogenic environments,” understood as places, regions, or environments whose characteristics are considered to be the origin of diseases in the human beings. While some specific environments were almost universally considered noxious, some others had a different trajectory. Crowded and poorly-ventilated premises as well as tropical regions were perceived as “the most unhealthy spots in the world.” However, the progressive “medicalisation” of hospitals transformed what were previously considered to be hellholes into therapeutic places. This (...) does not mean that iatrogenic diseases disappeared, but that hospitals tended to be seen in a more positive way. Similarly, European colonial expansion changed medical perspectives on tropical regions. Western physicians became increasingly convinced not only that could they prepare Europeans for long travel, but also that they could shape foreign environments. For instance, the perception of the Caribbean climate gradually changed “from deadly to healthy” from the middle of the 19th century onwards. Changes in perceptions could thus follow scientific progress, but also arise from political agendas and stigmatising narratives. Victims of the harmful influences of a pathogenic environment were often presented as responsible for their fate. For instance, some were accused of not carrying out the instructions delivered by the administrative or medical authorities. The process of (un)making pathogenic environments thus offers privileged access to the understanding of the relationship between health and environment. This paper provides situated accounts of how some places or regions came to be perceived as pathogenic or ceased to be so. It explores avenues of research, such as the study of lay perspectives on health and environment, the dangers of travel itself, and the connection between environmental health and military medicine. (shrink)

El Gobierno de España y el Banco Internacional de Reconstrucción y Fomento (BIRF) firmaron en 1971 un Proyecto de colaboración con el objetivo de mejorar el nivel de la investigación agraria mediante tres estrategias fundamentales: a) reestructuración del Instituto Nacional de Investigaciones Agrarias (INIA) para crear Centros especializados por cultivos con ámbito de actuación nacional, b) cambio en la planificación y gestión de la investigación mediante la creación de Programas Nacionales por cultivos y c) formación de 200 investigadores en laboratorios (...) internacionales de prestigio en temas prioritarios para las investigaciones a realizar en los Centros. El presupuesto global del Proyecto fue de 28,2 millones de dólares (equivalentes a unos 204 millones de euros actuales), de los que el BIRF aportó 12,7 millones de dólares en forma de crédito. El proyecto cumplió todos los objetivos fundamentales previstos y provocó un cambio importante en la calidad y orientación de la investigación agraria española, que ha tenido una elevada repercusión científica y socioeconómica, especialmente debido al programa de formación, ya que los otros logros se diluyeron como consecuencia de las transferencias del INIA a las Comunidades Autónomas. (shrink)

From the 1660s onwards, France tried to establish itself as a leading maritime and colonial power. The first French East India Company allowed a decisive penetration into the Indian Ocean, while the foundation of the Rochefort arsenal was the starting point of a great shipbuilding effort. The archives of the State Secretariat of the French Navy, ports, and learned societies, as well as printed scholarly literature, testify to an increasing mobilisation around the health of the “gens de mer.” Most of (...) the actors involved in this reflection, whether doctors or surgeons, naval officers or engineers, scholars or inventors, agreed in associating seamen's diseases with the poor air quality prevailing within ships. The environment of seafarers was thus definitely regarded as harmful. However, the atmosphere of a ship was also seen through the possibility to reshape it and reduce its dangerousness, with adapted behaviours, careful maintenance, or technical solutions. This was crucial to ensure the circulation of human beings and goods across the French overseas empire, but also to defend it from the threats associated with the major conflicts of the second half of the 18th century. This article highlights how environments regarded as “pathogenic” were conceived and reshaped during the second half of the early modern period in France, using the example of naval hygiene. It examines the strategies designed and implemented to combat the “noxious” air of French ships, in particular through the regulations introduced since the end of the 17th century, and considers how this issue has stimulated the search for technological solutions. (shrink)

Simple idealized models seem to provide more understanding than opaque, complex, and hyper-realistic models. However, an increasing number of scientists are going in the opposite direction by utilizing opaque machine learning models to make predictions and draw inferences, suggesting that scientists are opting for models that have less potential for understanding. Are scientists trading understanding for some other epistemic or pragmatic good when they choose a machine learning model? Or are the assumptions behind why minimal models provide understanding misguided? In (...) this paper, using the case of deep neural networks, I argue that it is not the complexity or black box nature of a model that limits how much understanding the model provides. Instead, it is a lack of scientific and empirical evidence supporting the link that connects a model to the target phenomenon that primarily prohibits understanding. (shrink)

Emily Brady provides a systematic account of aesthetics in relation to the natural environment, offering a critical understanding of what aesthetic appreciation ...

Standpoint theorists have long been clear that marginalization does not make better understanding a given. They have been less clear, though, that social dominance does not make ignorance a given. Indeed, many standpoint theorists have implicitly committed themselves to what I call the strong epistemic disadvantage thesis. According to this thesis, there are strong, substantive limits on what the socially dominant can know about oppression that they do not personally experience. I argue that this thesis is not just implausible but (...) politically pernicious; it is an excuse for ignorance and silence that stifles our ability to address many injustices. Moreover, I argue that if we are to avoid lending support to the SEDT while working within a standpoint theory framework, we must hold that the socially dominant can achieve marginalized standpoints. So, we must hold that men can achieve feminist standpoints, that white women (and men) can achieve black feminist standpoints, and so on. (shrink)

In The Sublime in Modern Philosophy: Aesthetics, Ethics, and Nature, Emily Brady takes a fresh look at the sublime and shows why it endures as a meaningful concept in contemporary philosophy. In a reassessment of historical approaches, the first part of the book identifies the scope and value of the sublime in eighteenth-century philosophy, nineteenth-century philosophy and Romanticism, and early wilderness aesthetics. The second part examines the sublime's contemporary significance through its relationship to the arts; its position with respect to (...) other aesthetic categories involving mixed or negative emotions, such as tragedy; and its place in environmental aesthetics and ethics. Far from being an outmoded concept, Brady argues that the sublime is a distinctive aesthetic category which reveals an important, if sometimes challenging, aesthetic-moral relationship with the natural world. (shrink)

The laws of nature have come a long way since the time of Newton: quantum mechanics and relativity have given us good reasons to take seriously the possibility of laws which may be non-local, atemporal, ‘all-at-once,’ retrocausal, or in some other way not well-suited to the standard dynamical time evolution paradigm. Laws of this kind can be accommodated within a Humean approach to lawhood, but many extant non-Humean approaches face significant challenges when we try to apply them to laws outside (...) the time evolution picture. Thus for proponents of non-Humean approaches to lawhood there is a clear need for a novel non-Humean account which is capable of accommodating these sorts of laws. In this paper we propose such an account, characterizing lawhood in terms of constraints, which are understood as a form of modal structure. We demonstrate that our proposed realist account can indeed accommodate a large variety of laws outside the time evolution paradigm, and describe some possible applications to important philosophical problems. (shrink)

Dementia patients in the moderate-late stage of the disease can, and often do, express different preferences than they did at the onset of their condition. The received view in the philosophical literature argues that advance directives which prioritize the patient’s preferences at onset ought to be given decisive moral weight in medical decision-making. Clinical practice, on the other hand, favors giving moral weight to the preferences expressed by dementia patients after onset. The purpose of this article is to show that (...) the received view in the philosophical literature is inadequate and is out of touch with real clinical practice. I argue that having dementia is a cognitive transformative experience and that preference changes which result from this are legitimate and ought to be given moral weight in medical decision-making. This argument ought to encourage us to reduce our confidence in the moral weight of advance directives for dementia patients. (shrink)

Esta investigación tiene como objetivo principal reflexionar sobre la efectividad de las aplicaciones de arqueología virtual en públicos escolares para la comprensión y el aprendizaje del patrimonio arqueológico con el fin de aprehender de qué manera las tecnologías, como la Realidad Aumentada y la Realidad Virtual, pueden aportar un valor añadido a las propuestas educativas realizadas por museos y sitios arqueológicos que no cuentan con esta inclusión. El análisis exploratorio del caso se realiza en el Museo del Mar de Santa (...) Pola (España) que ha desarrollado este tipo de aplicaciones en el yacimiento arqueológico romano que gestiona, el Portus Ilicitanus. (shrink)

There is an undeniable tendency to dismiss women’s sexual assault allegations out of hand. However, this tendency is not monolithic—allegations that black men have raped white women are often met with deadly seriousness. I argue that contemporary rape culture is characterized by the interplay between rape myths that minimize rape, and myths that catastrophize rape. Together, these two sets of rape myths distort the epistemic resources that people use when assessing rape allegations. These distortions result in the unjust exoneration of (...) people we cannot conceive of as monstrous, while making it too easy to believe that some marginalized people could be rapists. I also argue that rape myths enable a novel kind of epistemic injustice. This injustice concerns how our assessments of trustworthiness and our assessments of plausibility interact. I argue that rape myths can result in runaway credibility deflations that can explain both why people fail to believe most women, and also why people may unjustly believe false allegations that white women have been raped by black men. (shrink)

Social epistemologists should be well-equipped to explain and evaluate the growing vulnerabilities associated with filter bubbles, echo chambers, and group polarization in social media. However, almost all social epistemology has been built for social contexts that involve merely a speaker-hearer dyad. Filter bubbles, echo chambers, and group polarization all presuppose much larger and more complex network structures. In this paper, we lay the groundwork for a properly social epistemology that gives the role and structure of networks their due. In particular, (...) we formally define epistemic constructs that quantify the structural epistemic position of each node within an interconnected network. We argue for the epistemic value of a structure that we call the (m,k)-observer. We then present empirical evidence that (m,k)-observers are rare in social media discussions of controversial topics, which suggests that people suffer from serious problems of epistemic vulnerability. We conclude by arguing that social epistemologists and computer scientists should work together to develop minimal interventions that improve the structure of epistemic networks. (shrink)

Viewed this way, the texts yield striking examples of language and notation that are irreducibly ambiguous and productive because they are ambiguous.

El artículo analiza las condiciones y el proceso en el que se aprobó en 1986 la Ley de Fomento y Coordinación General de la Investigación Científica y el Desarrollo Tecnológico y las principales aportaciones de la Ley a la construcción de un Sistema Científico- Técnico. Se analizan igualmente los cambios en el propio Sistema Científico-Técnico y en los contextos políticos, económico y sociales que se han producido en los veinte años de vigencia de la Ley, así como las tendencias en (...) los cambios en los marcos regulatorios de la I+D en los países más desarrollados. Finalmente se proponen algunas bases sobre las que construir unos marcos legales y normativos para el futuro desarrollo de la I+D en España. (shrink)

What is time? This is one of the most fundamental questions we can ask. Emily Thomas explores how a new theory of time emerged in the seventeenth century. The 'absolute' theory of time held that it is independent of material bodies or human minds, so even if nothing else existed there would be time.

Under what conditions does machine learning (ML) model opacity inhibit the possibility of explaining and understanding phenomena? In this article, I argue that nonepistemic values give shape to the ML opacity problem even if we keep researcher interests fixed. Treating ML models as an instance of doing model-based science to explain and understand phenomena reveals that there is (i) an external opacity problem, where the presence of inductive risk imposes higher standards on externally validating models, and (ii) an internal opacity (...) problem, where greater inductive risk demands a higher level of transparency regarding the inferences the model makes. (shrink)

Experiments are commonly thought to have epistemic privilege over simulations. Two ideas underpin this belief: first, experiments generate greater inferential power than simulations, and second, simulations cannot surprise us the way experiments can. In this article I argue that neither of these claims is true of experiments versus simulations in general. We should give up the common practice of resting in-principle judgments about the epistemic value of cases of scientific inquiry on whether we classify those cases as experiments or simulations, (...) per se. To the extent that either methodology puts researchers in a privileged epistemic position, this is context sensitive. (shrink)

What kinds of issues does the global crisis of climate change present to aesthetics, and how will they challenge the field to respond? This paper argues that a new research agenda is needed for aesthetics with respect to global climate change (GCC) and outlines a set of foundational issues which are especially pressing: (1) attention to environments that have been neglected by philosophers, for example, the cryosphere and aerosphere; (2) negative aesthetics of environment, in order to grasp aesthetic experiences, meanings, (...) and dis/values in light of the catastrophic effects of GCC; (3) bringing intergenerational thinking into aesthetics through concepts of temporality and ‘future aesthetics’ (4) understanding the relationship between aesthetic and ethical values as they arise in regard to GCC. (shrink)

Because idealizations frequently advance scientific understanding, many claim that falsehoods play an epistemic role. In this paper, we argue that these positions greatly overstate idealiza...

Explainable AI (xAI) methods are important for establishing trust in using black-box models. However, recent criticism has mounted against current xAI methods that they disagree, are necessarily false, and can be manipulated, which has started to undermine the deployment of black-box models. Rudin (2019) goes so far as to say that we should stop using black-box models altogether in high-stakes cases because xAI explanations ‘must be wrong’. However, strict fidelity to the truth is historically not a desideratum in science. Idealizations (...) – the intentional distortions introduced to scientific theories and models – are commonplace in the natural sciences and are seen as a successful scientific tool. Thus, it is not falsehood qua falsehood that is the issue. In this paper, I outline the need for xAI research to engage in idealization evaluation. Drawing on the use of idealizations in the natural sciences and philosophy of science, I introduce a novel framework for evaluating whether xAI methods engage in successful idealizations or deceptive explanations (SIDEs). SIDEs evaluates whether the limitations of xAI methods, and the distortions that they introduce, can be part of a successful idealization or are indeed deceptive distortions as critics suggest. I discuss the role that existing research can play in idealization evaluation and where innovation is necessary. Through a qualitative analysis we find that leading feature importance methods and counterfactual explanations are subject to idealization failure and suggest remedies for ameliorating idealization failure. (shrink)

I argue that ML models used in science function as highly idealized toy models. If we treat ML models as a type of highly idealized toy model, then we can deploy standard representational and epistemic strategies from the toy model literature to explain why ML models can still provide epistemic success despite their lack of similarity to their targets.

Recently there have emerged an assortment of theorems relating to the ‘absoluteness of emerged events,’ and these results have sometimes been used to argue that quantum mechanics may involve some kind of metaphysically radical non-absoluteness, such as relationalism or perspectivalism. However, in our view a close examination of these theorems fails to convincingly support such possibilities. In this paper we argue that the Wigner’s friend paradox, the theorem of Bong et al and the theorem of Lawrence et al are all (...) best understood as demonstrating that if quantum mechanics is universal, and if certain auxiliary assumptions hold, then the world inevitably includes various forms of ‘disaccord,’ but this need not be interpreted in a metaphysically radical way; meanwhile, the theorem of Ormrod and Barrett is best understood either as an argument for an interpretation allowing multiple outcomes per observer, such as the Everett approach, or as a proof that quantum mechanics cannot be universal in the sense relevant for this theorem. We also argue that these theorems taken together suggest interesting possibilities for a different kind of relational approach in which _interaction_ states are relativized whilst observed events are absolute, and we show that although something like ‘retrocausality’ might be needed to make such an approach work, this would be a very special kind of retrocausality which would evade a number of common objections against retrocausality. We conclude that the non-absoluteness theorems may have a significant role to play in helping converge towards an acceptable solution to the measurement problem. (shrink)