The LIM domain kinases (LIMKs) are important actin cytoskeleton regulators. These proteins, LIMK1 and LIMK2, are nodes downstream of Rho GTPases and are the key enzymes that phosphorylate cofilin/actin depolymerization factors to regulate filament severing. They therefore perform an essential role in cascades that control actin depolymerization. Signaling of the LIMKs is carefully regulated by numerous inter‐ and intra‐molecular mechanisms. In this review, we discuss recent findings that improve the understanding of LIM domain kinase regulation mechanisms. We also provide an (...) up‐to‐date review of the role of the LIM domain kinases, their architectural features, how activity is impacted by other proteins, and the implications of these findings for human health and disease. (shrink)

Worldwide interest in understanding art and creative practices as valid forms of knowledge production has led to the establishment of research-creation as an interdisciplinary academic field in the last twenty years in Canada as elsewhere. Its establishment relates to a growing interest in critical making and technological innovation and to the legacies of feminism(s) and its critique of the power dynamics of knowledge production within academia. This article outlines a series of interactive projects that bring visibility to Latin American women (...) in art, science and technology and speculates on the legacies of feminism(s) in the emergence of research-creation. The four projects discussed build on each other and explore re-mediation, re-activation and re-enactment as part of a collaborative feminist research-creation methodology. I theorize their potential to activate political memory by highlighting how these three approaches to creation share a preoccupation for revisiting the past through repetition, iteration and the facilitation of intergenerational encounters among humans, non-humans and across media and technologies. While discussing the feminist orientation of these approaches, I suggest a critique of dominant modes of knowledge production that have obscured the contributions of Latin American women and offer four research-creation interventions in the media arts archive. (shrink)

Physical and mental training are associated with positive effects on executive functions throughout the lifespan. However, evidence of the benefits of combined physical and mental regimes over a sedentary lifestyle remain sparse. The goal of this study was to investigate potential mechanisms, from a source-resolved event-related-potential perspective, that could explain how practicing long-term physical and mental exercise can benefit neural processing during the execution of an attention switching task. Fifty-three healthy community volunteers who self-reported long-term practice of Tai Chi, meditation (...) + exercise, simple aerobics, or a sedentary lifestyle, aged 47.8 ± 14.6 were included in this analysis. All participants undertook high-density electroencephalography recording during a switch paradigm. Our results indicate that people who practice physical and mental exercise perform better in a task-switching paradigm. Our analysis revealed an additive effect of the combined practice of physical and mental exercise over physical exercise only. In addition, we confirmed the participation of frontal, parietal and cingulate areas as generators of event-related-potential components commonly associated to the performance of switch tasks. Particularly, the N2-like component of the parietal and frontal domains showed significantly greater amplitudes in the exercise and mental training groups compared with aerobics and sedentary groups. Furthermore, we showed better performance associated with greater N2-like amplitudes. Our multivariate analysis revealed that activity type was the most relevant factor to explain the difference between groups, with an important influence of age, and body mass index, and with small effects of educational years, cardiovascular capacity, and sex. These results suggest that chronic combined physical and mental training may confer significant benefits to executive function in normally aging adults, probably through more efficient early attentional processing. Future experimental studies are needed to confirm our results and understand the mechanisms on parieto-frontal networks that contribute to the cognitive improvement associated with practicing combined mental and aerobic exercise, while carefully controlling confounding factors, such as age and body mass index. (shrink)

This paper is a contribution to the study of equality-free logic, that is, first-order logic without equality. We mainly devote ourselves to the study of algebraic characterizations of its relation of elementary equivalence by providing some Keisler-Shelah type ultrapower theorems and an Ehrenfeucht-Fraïssé type theorem. We also give characterizations of elementary classes in equality-free logic. As a by-product we characterize the sentences that are logically equivalent to an equality-free one.

Der vorliegende Aufsatz stellt das Erbe der Kantischen Theorie der Konstitutions- und Regulationsleistung der Erfahrung – die Analytik der Grundsätze – dar, das unserer Auffassung nach zur Begründung der rein spekulativen Philosophie Hegels führt. In diesem Zusammenhang werden einerseits die transzendental-konstitutiven Grundsätze – Axiome der Anschauung und Antizipationen der Wahrnehmung – und andererseits die transzendental-regulativen Grundsätze – Analogien der Erfahrung und Postulate des empirischen Denkens überhaupt – als grundlegendes Material der Exegese benutzt. Als Resultat der Deutung erscheint das Problem des (...) Doppel-Verhältnisses zwischen Erfahrung und Verstandesgrundsätzen. Ein solches Verhältnis entfaltet sich nicht nur als die erfahrungsmäßige Verwirklichung der Grundsätze, sondern auch als die grundsätzliche Ermöglichung der Erfahrung. Der notwendige Charakter der Wahrheit in transzendentaler Hinsicht begründet sich dabei durch die allgemeine Beziehung der transzendentalen Grundsätze des reinen Verstandes zur Gesamtheit der Erfahrung. Es wird die These vertreten, dass die Auffassung der Natur – d.h. die das Dasein der Erscheinungen in der Zeit ermöglichende Einheit – das Hauptvermächtnis Kants für den Deutschen Idealismus im Allgemeinen und für Hegels Philosophie im Besonderen darstellt. (shrink)

Research into artificial intelligence has increased significantly in recent years. However, the fundamental question of what intelligence is and how it works remains open to some extent. Traditional definitions of intelligence are broad and lack clarity regarding its nature and mechanisms. The nature of consciousness is another matter that has been widely explored with multiple theories but for which we do not have a final agreed theory, especially in terms of its relation to intelligence. In this work, we present a (...) preliminary theory of the nature of intelligence and its working mechanisms. We contrast it against observations to show that our theory is consistent with observed reality. We also use our theory of intelligence to offer a theory on the nature of consciousness, as well as its relation to human understanding and intent. We then show that our theories can be consistent with the theory of evolution. Similarly, we explore examples of how our theory applies to specific cases to show its consistency across applications. Lastly, we outline how our theory can pave the way towards artificial general intelligence. Our theory is unproven. (shrink)

This paper presents an example of a supersimple nonlow theory and characterizes its independence relation.

Empirical research in bioethics has developed rapidly over the past decade, but has largely eschewed the use of technology-driven methodologies. We propose “design bioethics” as an area of conjoined theoretical and methodological innovation in the field, working across bioethics, health sciences and human-centred technological design. We demonstrate the potential of digital tools, particularly purpose-built digital games, to align with theoretical frameworks in bioethics for empirical research, integrating context, narrative and embodiment in moral decision-making. Purpose-built digital tools can engender situated engagement (...) with bioethical questions; can achieve such engagement at scale; and can access groups traditionally under-represented in bioethics research and theory. If developed and used with appropriate rigor, tools motivated by “design bioethics” could offer unique insights into new and familiar normative and empirical issues in the field. (shrink)

Fomentar la educación abierta inclusiva es responsabilidad de todos. Se presenta el diseño instruccional de un libro electrónico para el desarrollo de competencias de información y alfabetización digital. Está enfocado a personas con deficiencia visual. Se utiliza el modelo ADDIE y los principios de Diseño Universal para el Aprendizaje. Se realizó una hoja de ruta para la definición de aspectos iniciales. Como trabajo futuro se contempla desarrollar el libro y compartirlo como recurso educativo abierto con licencia Creative Commons BY-SA para (...) fomentar su reutilización. Se sugiere medir el desarrollo de otras competencias a partir de su uso. (shrink)

This paper explores the functional role of noise in synthetic biology and its relation to the concept of randomness. Ongoing developments in the field of synthetic biology are pursuing the re-organisation and control of biological components to make functional devices. This paper addresses the distinction between noise and randomness in reference to the functional relationships that each may play in the evolution of living and/or synthetic systems. The differentiation between noise and randomness in its constructive role, that is, between noise (...) as a perturbation in routine behaviours and noise as a source of variability that cells may exploit, indicates the need for a clarification and rectification of the conflicting uses of the notion of noise in the studies of the so-called noise biology. (shrink)

A pesar de que los historiadores han considerado frecuentemente que el conocimiento histórico moderno surge como contraparte a la filosofía de la historia y el positivismo, en la idea tradicional de narración la herencia de la filosofía dialéctica de Hegel es recurrente: en ambos casos, el devenir de la auto-constitución del ser determina el método de conocimiento. Hegel afirma que las fases de la lógica no son solamente condiciones trascendentales que hacen posible la experiencia, sino etapas en la auto-determinación del (...) Espíritu. Ranke sostiene que la narración es el método histórico apropiado debido a que la historia misma posee una estructura narrativa. Desde la década de 1970, esta idea de narración experimenta una crisis. Nuestra hipótesis es que las perspectivas predominantes de este concepto utilizadas actualmente por historiadores y teóricos de la historia corresponden a las principales posturas del pensamiento filosófico contemporáneo: la narración como modelo analítico, la narración como competencias del discurso práctico, la narración como mecanismo de legitimación, la narración sin estructura y la narración como necesidad transcultural. Despite the fact that historians have often considered that modern historical knowledge originates in opposition to philosophy of history and positivism, in the traditional idea of narration the inheritance of Hegel's dialectical philosophy is recurrent: in both cases, the becoming of the self-constitution of the Being determines the knowledge method. Hegel asseverates that phases of logic are not only transcendental conditions that make possible the experience, but stages in the self-determination of Spirit. Ranke affirms that narration is the historical appropriate method due to the fact that the history itself possesses a narrative structure. Since 1970's, this idea of narration undergoes a crisis. Our hypothesis is that the prevalent perspectives of this concept, used at present by historians and theorists of history, correspond to the principal positions of contemporary philosophical thought: narration as an analytic model, narration as condition of practical discourse, narration as a function of legitimation, narration without structure. (shrink)

En el siguiente artículo se analiza "Hopeful Monsters or, The Unfulfilled Figure in Hayden White´s Conceptual System", donde Kellner demuestra que la teoría de la figuralidad está latente desde el inicio de la teoría de Hayden White. Además, aplica el análisis figural a la propia obra de White afirmando que la teoría de los tropos será cumplimentada por el emplotment que, a su vez, será cumplimentado por el figuralismo. Luego se sigue el desarrollo de Kellner que muestra que en los (...) pasajes de White hay dos usos diferentes del concepto de unfulfillment: una noción de incumplimiento como figura que no llegó a su máxima potencia y una noción de incumplimiento como lo sublime indecible. Se examina específicamente la cuestión judía, asumiendo la misma como una figura incumplida y se rescatan las contribuciones del romanticismo y del iluminismo a su cumplimentación. Por último, se realizan algunas críticas a la insistencia de Kellner en el papel post teológico del figuralismo y al lugar del incumplimiento ligado a lo sublime como trascendiendo lo histórico. ARK: ark:/s18537960/eimr/sd31. (shrink)

History textbooks in Chile are characterized by exposing an adult-centered historical narrative that invisibilizes the participation of boys and girls, since they have traditionally focused on describing the political exploits carried out by elite adult men in national and western history. To evidence this problem, in this qualitative, exploratory and interpretive research, critical literacy is used to analyze the texts and images of four textbooks published between 2016 and 2019 by SM and Santillana publishers. From these manuals, thematic units related (...) to Ancient Rome and Greece, colonial Chile, and European history of the 19th and 20th centuries were selected because they have the most relevant evidence to examine the subject. It is concluded that the analyzed discourses show that infants are marginalized social actors in history or are represented from the adult-centered paradigm as dependent and subordinate subjects to the adult world. Faced with this scenario, the importance of prioritizing children’s perspectives in the study of history and in the problematization of historical contents taught in the classroom is emphasized. (shrink)

Resumen: Se ensaya la tesis de que no habiendo innovación sin tradición, la filosofía opera en un espacio en tensión entre estos dos polos. Se comienza trazando un recorrido por las distintas precomprensiones de la naturaleza y el conocimiento en la Antigüedad y en la Modernidad como esquemas del contraste entre tradición e innovación; a continuación, se acude a Ortega y Gasset y a Heidegger para precisar en qué consiste la innovación en filosofía y para explicitar su conexión con y (...) dependencia de la tradición; por último, se propone explorar la innovación educativa de la filosofía como, siguiendo a Odo Marquard, descarga compensatoria de la sobrecarga innovativa. Palabras clave: innovación, tradición, Ortega y Gasset, Heidegger, Marquard. English title: Philosophy as unloading of innovation overloadAbstract: This paper claims that insofar as there is no innovation without tradition, philosophy operates in a space of tension between those two poles. I begin by sketching different pre-understandings of nature and knowledge in Antiquity and Modernity as schemas of the contrast between tradition and innovation. I then resort to Ortega y Gasset and Heidegger to specify what innovation consists of in philosophy and to explain its connection with and dependence on tradition. I finally propose to understand, following Odo Marquard, educative innovation in philosophy as a compensatory unloading of innovation overload. Keywords: innovation, tradition, Ortega y Gasset, Heidegger, Marquard. (shrink)

I) Metaphysics of evidence, which most conspicuous expression is the Cartesian mathesis universalis, looks for the urgent and necessary, the fundament or foundation of things, which is regarded as independent of the form and accesible whithout asumptions to knowledge: rhetoric is the dispensable qualitas of philosophy. II) Vico¿s way of thinking, in opposition to that view, could be considered as its retorsion: by reveling its hidden presuppositions, refuses them. III) Vico¿s tropology, by proposing the tropical univocity, makes a rhetoric philosophy (...) and a philosophical rhetoric: rhetoric is the indispensable quidditas of philosophy. I) La metafísica de la evidencia, cuya más conspicua expresión es la mathesis universalis cartesiana, busca lo apremiante y necesario, el fundamento o fondo de las cosas, el cual se entiende independiente de la forma y alcanzable por un pensamiento sin supuestos: la retórica es la prescindible qualitas de la filosofía. II) La de Vico, por contra, puede considerarse como una retorsión de esa postura filosófica: al contribuir a desvelar sus supuestos ocultos, los niega. III) La tropología viquiana, al proponer la univocidad de los tropos, hace de la filosofía retórica y de la retórica filosofía: la retórica es la imprescindible quidditas de la filosofía . (shrink)

En el siguiente trabajo, se analiza el desarrollo histórico del verbo meter, particularmente sus usos auxiliares como construcción incoativa y causativa. El objetivo consiste en establecer un contraste entre las variedades americana y peninsular; esta última, representada por la investigación de Comer. Para el contraste de variedades dialectales, se seleccionan cuatro criterios de análisis: la fijación sintáctica, la incorporación sintáctica, la animacidad del sujeto y la dinamicidad del infinitivo. En este sentido, el estudio se apoya en la teoría de la (...) gramaticalización y en la gramática de construcciones. Los datos analizados han sido extraídos de corpus históricos como el CORDE y CORDIAM. Como conclusión, se describe que el uso americano del verbo meter evidencia un mayor grado de gramaticalización en cuanto al grado de fijación formal y a la incorporación sintáctica, en tanto que el uso peninsular está más gramaticalizado en relación con la animacidad del sujeto y la dinamicidad del infinitivo. Además, se ofrece evidencia en favor de un mayor conservadurismo sintáctico del español americano. (shrink)

El objetivo de esta reseña es presentar un libro que reflexiona acerca de los procesos históricos de constitución de la identidad masculina y femenina, buscando explicaciones posibles para la desigualdad de género y la dominación sexista que se ha evidenciado a lo largo de la historia y en distintas sociedades.

Abstract:In this article, we present a pragmatic approach to neuroethics, referring back to John Dewey and his articulation of the “common good” and its discovery through systematic methods. Pragmatic neuroethics bridges philosophy and social sciences and, at a very basic level, considers that ethics is not dissociable from lived experiences and everyday moral choices. We reflect on the integration between empirical methods and normative questions, using as our platform recent bioethical and neuropsychological research into moral cognition, action, and experience. Finally, (...) we present the protocol of a study concerning teenagers’ morality in everyday life, discussing our epistemological choices as an example of a pragmatic approach in empirical ethics. We hope that this article conveys that even though the scope of neuroethics is broad, it is important not to move too far from the real life encounters that give rise to moral questions in the first place. (shrink)

This paper re-evaluates the role that Plato confers to pleasure in the "Philebus." According to leading interpretations, Plato there downplays the role of pleasure, or indeed rejects hedonism altogether. Thus, scholars such as D. Frede have taken the "mixed life" of pleasure and intelligence initially submitted in the "Philebus" to be conceded by Socrates only as a remedial good, second to a life of neutral condition, where one would experience no pleasure and pain. Even more strongly, scholars such as Irwin (...) have seen the "Philebus'" arguments against false pleasures as an actual attack on hedonism, showing -- in Irwin's words -- "why maximization of pleasure cannot be a reasonable policy for the best life." Against these claims, I argue that the mixed life of pleasure and intelligence is presented in the "Philebus" as a first best and not just as a second best for humans, and that, accordingly, Socrates proposes to incorporate -- rather than reject -- pleasure as one of the intrinsically desirable aspects of the happy life. Thus, I offer alternative readings of controversial passages that have given rise to the prevalent interpretation criticized here, and advance positive evidence that at least some pleasures are seen by Plato as inherently good. In addition, I demonstrate that Plato's arguments against false pleasures do not by themselves constitute an attack on hedonism. Rather, they can be seen as a strategy to show the hedonist that, in order to be a maximal, or even a consistent, hedonist, he should go for true, and not fake pleasures, if after all pleasure is the object of his pursuit. But, since this cannot be achieved without intelligence, then the mixed life of pleasure and intelligence is to be accepted even by hedonist themselves. (shrink)

Although a great deal has been written on Plato's ethics, his cosmology has not received so much attention in recent times and its importance for his ethical thought has remained underexplored. By offering accounts of Timaeus, Philebus, Politicus and Laws X, the book reveals a strongly symbiotic relation between the cosmic and human sphere. It is argued that in his late period Plato presents a picture of an organic universe, endowed with structure and intrinsic value, which both urges our respect (...) and calls for our responsible intervention. Humans are thus seen as citizens of a university that can provide a context for their flourishing even in the absence of good political institutions. The book sheds light on many intricate metaphysical issues in late Plato and brings out the close connections between his cosmology and the development of his ethics. (shrink)

RESUMEN El objetivo de este trabajo es mostrar que la relación de Rorty con la tradición filosófica presenta muchos más matices de los que su reputación podría hacer creer. Se confrontan dos hechos: de un lado, el propósito rortiano de superar la tradición; de otro, la necesidad de la tradición para mantener la conversación, interés principal de la filosofía para Rorty. Por tanto, la relación de Rorty con la tradición es ambigua. Ahora bien, esa ambigüedad puede verse como no contradictoria: (...) Rorty no pretendió tanto ofrecer una argumentación alternativa a la de la tradición cuanto una alternativa a la argumentación de la tradición. Así, más que romper con la tradición, Rorty, a su modo, le da una oportunidad. ABSTRACT The aim of this paper is to show that Rorty’s relationship with philosophical tradition has more nuances of meaning than his reputation might suggest. Two opposite facts are considered: on the one hand, Rorty’s intention to overcome tradition; on the other hand, the fact that there cannot be conversation, the main interest of philosophy for Rorty, without tradition. Rorty’s relationship to the philosophical tradition is, thus, ambiguous. Nevertheless, this ambiguity can be seen as not inconsistent. One reason might explain this fact: rather than an alternative argumentation to the traditional one, Rorty offered an alternative to the traditional argumentation. Therefore it makes more sense to read Rorty as giving the tradition a break rather than breaking with the tradition. (shrink)

La Pedagogía para la Paz en Colombia se brinda desde enfoques diseñados para promover valores como la paz, la convivencia pacífica y la justicia social, buscando cambiar actitudes y formas de relacionamiento para prevenir la violencia. Implica crear y fortalecer espacios de conciliación, promover el perdón, la reconciliación y abordar aspectos como la resolución de conflictos desde edades tempranas. Escuchar y valorar las narrativas de las víctimas del conflicto armado en el hecho victimizante de la desaparición forzada, es esencial para (...) construir una paz duradera, promoviendo el reconocimiento, la comprensión en la comunidad. La Pedagogía para la Paz implica un desafío para trabajar y construir un mundo libre de miedo, violencia, opresión, promoviendo la justicia, la dignidad y el amor por la humanidad. (shrink)

El artículo muestra que el hombre obtiene las especies inteligibles a partir de lo sensible por la acción del intelecto agente. También, que en el juicio se da un paso desde las especies hacia la cosa, hecho posible a causa de un contacto espiritual que es la intencionalidad intelectiva, que trasciende las especies. Ese contacto con la cosa ocurre gracias a la información de los sentidos por el intelecto. En esta vida, toda elevación del alma a lo puramente espiritual se (...) da a partir del conocimiento sensible. Pero es posible dicha elevación porque la mente participa de la Verdad eterna, como se hace patente en la inmaterialidad de los conceptos y en la formación de los principios naturales del entendimiento. (shrink)

El autor fantasea una lectura de la ciencia nueva como gaya ciencia imaginando que su metaforología casi común responde al problema del nihilismo: introducir sentido en un mundo caracterizado por la ausencia de Dios.

Reseña de / Review of: New Vico Studies, 11, 1993.

O presente artigo quer encontrar um modo de pensar a filosofia a partir de uma escrita marcada pelo que vamos seguir entendendo como “pessoas”. Jacques Derrida será o norte teórico desse texto, ao que ele próprio traz em linhas muito precisas ao longo de sua obra em torno da expressão “digno de seu nome”. Se há dignidade ou se algo detém uma dignidade e por ela um nome, se a palavra dignidade [Würdigkeit] ainda nos remete, como em Kant, à noção (...) incondicional de “pessoa” e se ela pode nesse registo e, como veremos, ser estendida ao todo-outro e ainda assim inscrever uma “majestade”, é dessa forma que a expressão “digno de seu nome” atravessa a obra de Derrida quando ele inicia um incansável trabalho com a palavra, especialmente em seus escritos tardios, cuja significação não é mais objetável. (shrink)

La atención en la obra rortiana a la retórica como tal es mínima, por no decir nula. No hay en Rorty una Filosofía de la Retórica en el sentido objetivo del genitivo. Sin embargo, al romper explícitamente «el espejo de la naturaleza», Rorty está rompiendo implícitamente aquello que posibilitaba el divorcio entre la filosofía y la retórica. De hecho, el propósito de este ensayo es explicitar ese implícito presentando la filosofía rortiana como una Filosofía de la Retórica en el sentido (...) subjetivo del genitivo, es decir, como una Retórica de la Filosofía o una Retórica filosófica. (shrink)