Galvanic vestibular stimulation is a non-invasive method of electrically stimulating the vestibular system. We investigated whether the application of GVS can alter the learning of new functional mobility and manual control tasks and whether learning can be retained following GVS application. In a between-subjects experiment design, 36 healthy subjects performed repeated trials, capturing the learning of either a functional mobility task, navigating an obstacle course on a compliant surface with degraded visual cues or a manual control task, using a joystick (...) to null self-roll tilt against a pseudo-random disturbance while seated in the dark. In the “learning” phase of trials, bilateral, bipolar GVS was applied continuously. The GVS waveform also differed between subjects in each task group: white noisy galvanic vestibular stimulation at 0.3 mA high-level random GVS at 0.7 mA, or with the absence of stimulation. Following the “learning” trials, all subjects were blindly transitioned to sham GVS, upon which they immediately completed another series of trials to assess any aftereffects. In the functional mobility task, we found nGVS significantly improved task learning. Further, improvements in learning the functional mobility task with nGVS were retained, even once the GVS application was stopped. The benefits in learning with nGVS were not observed in the manual control task. High level GVS tended to inhibit learning in both tasks, but not significantly so. Even once the high-level stimulation was stopped, the impaired performance remained. Improvements in learning with nGVS may be due to increased information throughput resulting from stochastic resonance. The benefit of nGVS for functional mobility, but not manual control nulling, may be due to the multisensory, strategic, motor coordination, or spatial awareness aspects of the former task. Learning improvements with nGVS have the potential to benefit individuals who perform functional mobility tasks, such as astronauts, firefighters, high performance athletes, and soldiers. (shrink)

Israel Scheffler is the pre-eminent philosopher of education in the English-speaking world today. This volume collects seventeen original, invited papers on Scheffler's philosophy of education by scholars from around the world. The papers address the wide range of topics that Scheffler's work in philosophy of education has addressed, including the aims of education, cognition and emotion, teaching, the language of education, science education, moral education, religious education, and human potential. Each paper is followed by a response from Scheffler himself. (...) The collection is essential reading for anyone concerned with contemporary scholarship in philosophy of education, or with the place of this singularly important author in it. (shrink)

La noción de interpretación desarrollada en el racionalismo crítico de Karl R. Popper muestra atributos específicos que la distinguen de modo sustancial de la interpretación constitutiva de la experiencia que tanto N. R. Hanson como Th. Kuhn defienden en sus respectivas propuestas. Se muestra que la interpretación del modelo popperia-no queda atrapada en una epistemología de corte empirista que la separa de modo radical de toda hermenéutica filosófica.

In this article I defend a form of classical possibilism with an actualist foundation. As a matter of fact, I believe that this position is more in keeping with the classical metaphysical tradition. According to this form of possibilism, I construe possible objects as possible non-existing objects of an existing producing power. Consequently, they are nothing vis-à -vis the modality of their own actual being, although they do exist with regard to the modality of the producing power’s being. The actualist (...) requirement prescribed by the Frege-Quinean criterion of the quantification domain is thus fulfilled; indeed, really possible objects are not actual objects, but their possibility is actual. (shrink)

Bohmian mechanics represents the universe as a set of paths with a probability measure defined on it. The way in which a mathematical model of this kind can explain the observed phenomena of the universe is examined in general. It is shown that the explanation does not make use of the full probability measure, but rather of a suitable set function deriving from it, which defines relative typicality between single-time cylinder sets. Such a set function can also be derived directly (...) from the standard quantum formalism, without the need of an underlying probability measure. The key concept for this derivation is the quantum typicality rule, which can be considered as a generalization of the Born rule. The result is a new formulation of quantum mechanics, in which particles follow definite trajectories, but which is based only on the standard formalism of quantum mechanics. (shrink)

In the following article, I introduce three forms of spirituality elucidated by Santayana in his Reason in Religion, viz. the Fanatical, the Rational, and the Mystical. First, I explore what kinds of spiritual practices and ideologies are considered fanatical or devoted to escaping worldliness via establishing a single, essentially arbitrary, interest. Second, I explore what kinds of spiritual practices and ideologies are considered mystical or devoted to escaping worldliness via abstention and surrender. Third, I explore what kinds of spiritual practices (...) and ideologies are considered rational or devoted to escaping worldliness via seeking “a rational advance over it”. Finally, I use these forms to demonstrate the unity between Santayana’s earlier works with his later works, to clarify Santayana’s notion of a Union with The Good, and to explore similarities and differences between the Life of Reason and Realms of Being. (shrink)

In recent years numerous attempts have been made by analytic philosophers to naturalize various different domains of philosophical inquiry. All of these attempts have had the common goal of rendering these areas of philosophy amenable to empirical methods, with the intention of securing for them the supposedly objective status and broad intellectual appeal currently associated with such approaches. This volume brings together internationally recognised analytic philosophers, including Alvin Plantinga, Peter van Inwagen and Robert Audi, to question the project of naturalism. (...) The articles investigate what it means to naturalize a domain of philosophical inquiry and look at how this applies to the various sub-disciplines of philosophy including epistemology, metaphysics and the philosophy of the mind. The issue of whether naturalism is desirable is raised and the contributors take seriously the possibility that excellent analytic philosophy can be undertaken without naturalization. Controversial and thought-provoking, Analytic Philosophy Without Naturalism examines interesting and contentious methodological issues in analytic philosophy and explores the connections between philosophy and science. (shrink)

Graphical AbstractPheomelanogenesis may have evolved as an excretory mechanism to remove excess cysteine, and in humans this might potentially confer a greater ability to avoid disease such as Parkinson's and Alzheimer's disease, in which excess cysteine is a contributory cause.

An Introduction to Proof Theory provides an accessible introduction to the theory of proofs, with details of proofs worked out and examples and exercises to aid the reader's understanding. It also serves as a companion to reading the original pathbreaking articles by Gerhard Gentzen. The first half covers topics in structural proof theory, including the Gödel-Gentzen translation of classical into intuitionistic logic, natural deduction and the normalization theorems, the sequent calculus, including cut-elimination and mid-sequent theorems, and various applications of these (...) results. The second half examines ordinal proof theory, specifically Gentzen's consistency proof for first-order Peano Arithmetic. The theory of ordinal notations and other elements of ordinal theory are developed from scratch, and no knowledge of set theory is presumed. The proof methods needed to establish proof-theoretic results, especially proof by induction, are introduced in stages throughout the text. Mancosu, Galvan, and Zach's introduction will provide a solid foundation for those looking to understand this central area of mathematical logic and the philosophy of mathematics. (shrink)

The paper studies two formal schemes related to -completeness.LetS be a suitable formal theory containing primitive recursive arithmetic and letT be a formal extension ofS. Denoted by (a), (b) and (c), respectively, are the following three propositions (where (x) is a formula with the only free variable x): (a) (for anyn) ( T (n)), (b) T x Pr T (–(x)–) and (c) T x(x) (the notational conventions are those of Smoryski [3]). The aim of this paper is to examine the (...) meaning of the schemes which result from the formalizations, over the base theoryS, of the implications (b) (c) and (a) (b), where ranges over all formulae. The analysis yields two results overS : 1. the schema corresponding to (b) (c) is equivalent to ¬Cons T and 2. the schema corresponding to (a) (b) is not consistent with 1-CON T. The former result follows from a simple adaptation of the -incompleteness proof; the second is new and is based on a particular application of the diagonalization lemma. (shrink)

Three decades ago, interactions between evolutionary biology and physiology gave rise to evolutionary physiology. This caused comparative physiologists to improve their research methods by incorporating evolutionary thinking. Simultaneously, evolutionary biologists began focusing more on physiological mechanisms that may help to explain constraints on and trade‐offs during microevolutionary processes, as well as macroevolutionary patterns in physiological diversity. Here we argue that evolutionary physiology has yet to reach its full potential, and propose new avenues that may lead to unexpected advances. Viewing physiological (...) adaptations in wild animals as potential solutions to human diseases offers enormous possibilities for biomedicine. New evidence of epigenetic modifications as mechanisms of phenotypic plasticity that regulate physiological traits may also arise in coming years, which may also represent an overlooked enhancer of adaptation via natural selection to explain physiological evolution. Synergistic interactions at these intersections and other areas will lead to a novel understanding of organismal biology. (shrink)

This article explains how Henri de Lubac contributed during the 20th century to the renewal of contemporary theology, and sustains the thesis that Lubac played a decisive role in the area of interreligious dialogue.

This paper discusses Aristotle's references to a ζῷον in his Poetics (1450b34–51a4 and 1459a20) and evaluates their implications. The usual interpretation, ‘living creature’ or ‘animal’, is one-sided, because the word ζῷον is Aristotle's paradigm of homonymy, applying as it does to both the human being and the drawing (Cat. 1a1–6). After an examination of the two passages containing such references and their contexts, other passages by Aristotle and earlier writers (Plato, Alcidamas and Gorgias) that may shed light on the issue (...) are analysed. The conclusion reflects on the relevance of the interpretation as ‘figure’ for the premises and purpose of the Poetics. (shrink)

Mechanisms occurring at the atomic level are now known to drive processes essential for life, as revealed by quantum effects on biochemical reactions. Some macroscopic characteristics of organisms may thus show an atomic imprint, which may be transferred across organisms and affect their evolution. This possibility is considered here for the first time, with the aim of elucidating the appearance of an animal innovation with an unclear evolutionary origin: migratory behaviour. This trait may be mediated by a radical pair (RP) (...) mechanism in the retinal flavoprotein cryptochrome, providing essential magnetic orientation for migration. Isotopes may affect the performance of quantum processes through their nuclear spin. Here, we consider a simple model and then apply the standard open quantum system approach to the spin dynamics of cryptochrome RP. We changed the spin quantum number (I) and g‐factor of hydrogen and nitrogen isotopes to investigate their effect on RP's yield and magnetic sensitivity. Strong differences arose between isotopes with I = 1 and I = 1/2 in their contribution to cryptochrome magnetic sensitivity, particularly regarding Earth's magnetic field strengths (25–65 µT). In most cases, isotopic substitution improved RP's magnetic sensitivity. Migratory behaviour may thus have been favoured in animals with certain isotopic compositions of cryptochrome. (shrink)

_Worlds of Truth: A Philosophy of Knowledge_ explicates and builds upon a half century of philosophical work by the noted philosopher Israel Scheffler. Propounds a new doctrine of _plurealism_ which maintains the existence of multiple real worlds Offers a defense of absolute truth, which denies certainty and eschews absolutism, and defends systematic relativity, objectivity, and fallibilism Emphasizes a wide range of pragmatic interests: epistemology and scientific development, cognition and emotion, science and ethics, ritual and culture, and art and science.

Brutus wanted to kill Caesar. He believed that Caesar was an ordinary mortal, and that, given this, stabbing him (by which we mean plunging a knife into his heart) was a way of killing him. He thought that he could stab Caesar, for he remembered that he had a knife and saw that Caesar was standing next to him on his left, in the Forum. So Brutus was motivated to stab the man to his left. He did so, thereby killing (...) Caesar. (shrink)

In the wake of the Scientific Revolution, the late seventeenth and eighteenth centuries saw the complete demolition of traditional structures of authority, scientific thought, and belief by the new philosophy and the philosophes, including Voltaire, Diderot, and Rousseau. The Radical Enlightenment played a part in this revolutionary process, which effectively overthrew all justification for monarchy, aristocracy, and ecclesiastical power, as well as man's dominance over woman, theological dominance of education, and slavery. Despite the present day interest in the revolutions of (...) the eighteenth century, the origins and rise of the Radical Enlightenment have received limited scholarly attention. The greatest obstacle to the movement finding its proper place in modern historical writing is its international scope: the Racial Enlightenment was not French, British, German, Italian, Jewish or Dutch, but all of these at the same time. In this wide-ranging volume, Jonathan Israel offers a novel interpretation of the Radical Enlightenment down to La Mettie and Diderot, two of its key exponents. Particular emphasis is placed on the pivotal role of Spinoza and the widespread underground international philosophical movement known before 1750 as Spinozism. (shrink)