Background Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial (...) clefts.Methods Using an online survey, we evaluated the experiences of 252 HCPs and 197 parents across participating cleft clinics in Ghana and Nigeria toward the return of SFs across several domains.Results Only 1.6% of the HCPs felt they had an expert understanding of when and how to incorporate genomic medicine into practice, while 50.0% agreed that all SFs should be returned to patients. About 95.4% of parents were willing to receive all the information from genetic testing (including SFs), while the majority cited physicians as their primary information source (64%).Conclusions Overall, parents and providers were aware that genetic testing could help in the clinical management of diseases. However, they cited a lack of knowledge about genomic medicine, uncertain clinical utility, and lack of available learning resources as barriers. The knowledge gained from this study will assist with developing guidelines and policies to guide providers on the return of SFs in sub-Saharan Africa and across the continent. (shrink)

This book examines the implication of Emmanuel Levinas' philosophy of ethics for the theory, criticism, and practice of human communication.

Kenneth Burke: A Dialogue of Motives employs the philosophy of ethics of Emmanuel Levinas to develop a uniquely dramatistic philosophy of ethics. Jeffrey Murray analyzes Kenneth Burke's A Grammar of Motives and A Rhetoric of Motives and offers the notion of "a dialogue of motives" as a completion of Burke's proposed trilogy and as a supplement to Burke's own tools for rhetorical criticism.

In a chapter illustrating outrageous words and criminal deeds, Valerius Maximus, the Tiberian editor of exempla, includes in his list of foreign examples reference to an impious son, Mithridates, who fought with his father over who should rule : Mitridates autem multo sceleratius, qui non cum fratre de paterno regno, sed cum ipso patre bellum de dominatione gessit. in quo qui aut homines ullos adiutores inuenerit aut deos inuocare ausus sit, † pare admiratione habet †.