Extant evidence suggests that the two self-conscious emotions pride and guilt guide people's behavior in the context of self-control dilemmas. Pride and guilt are both outcomes of and antecedents to how people resolve self-control dilemmas. However, evidence on how pride and guilt motivate individuals to exert self-control is inconsistent. Based on the Expectancy Value Theory, we propose a conceptual framework to predict when and how pride and guilt can lead to increased or decreased self-control. One particularly important factor is the (...) relatedness of the past and focal dilemmas: whether pride or guilt arises from a success or failure to exercise self-control in a domain related or unrelated to a focal self-control dilemma may determine people's motivation to exert self-control. (shrink)

Precise spatiotemporal control of gene expression during normal development and cell differentiation is achieved by the combined action of proximal (promoters) and distal (enhancers) cis‐regulatory elements. Recent studies have reported that a subset of promoters, termed Epromoters, works also as enhancers to regulate distal genes. This new paradigm opened novel questions regarding the complexity of our genome and raises the possibility that genetic variation within Epromoters has pleiotropic effects on various physiological and pathological traits by differentially impacting multiple proximal and (...) distal genes. Here, we discuss the different observations pointing to an important role of Epromoters in the regulatory landscape and summarize the evidence supporting a pleiotropic impact of these elements in disease. We further hypothesize that Epromoter might represent a major contributor to phenotypic variation and disease. (shrink)

Volume 20, Issue 7, July 2020, Page W12-W14.