DNA polymerase epsilon is a mammalian polymerase that has a tightly associated 3′→5′ exonuclease activity. Because of this readily detectable exonuclease activity, the enzyme has been regarded as a form of DNA polymerase delta, an enzyme which, together with DNA polymerase alpha, is in all probability required for the replication of chromosomal DNA. Recently, it was discovered that DNA polymerase epsilon is both catalytically and structurally distinct from DNA polymerase delta. The most striking difference between the two DNA polymerases is (...) that processive DNA synthesis by DNA polymerase delta is dependent on proliferating cell nuclear antigen (PCNA), a replication factor, while DNA polymerase epsilon is inherently processive. DNA polymerase epsilon is required at least for the repair synthesis of UV‐damaged DNA. DNA polymerases are highly conserved in eukaryotic cells. Mammalian DNA polymerases alpha, delta and epsilon are counterparts of yeast DNA polymerases I, III and II, respectively. Like DNA polymerases I and III, DNA polymerase II is also essential for the viability of cells, which suggests that DNA polymerase II (and epsilon) may play a role in DNA replication. (shrink)

This paper presents a new system of logic, LF, that is intended to be used as the foundation of the formalization of science. That is, deductive validity according to LF is to be used as the criterion for assessing what follows from the verdicts, hypotheses, or conjectures of any science. In work currently in progress, we argue for the unique suitability of LF for the formalization of logic, mathematics, syntax, and semantics. The present document specifies the language and rules of (...) LF, lays out some notational conventions, and states some basic technical facts about the system. (shrink)

Walter Benjamin pointed out the affinity of cinema and architecture, and argued unexpectedly that tbese art forms are both essentially tactile arts. The tactility of the material art of building is not difficult to grasp, but the idea that a cinematic projection could result in fundamentally tactile experience certainly meets objections. However, the philosophical as well as neurological studies ofthe past few decades in perception, emotion, and thought, as well as in artistic expressions, suggest that these two arts, or poetic (...) images at large, address ali our senses, including our synthesizing existential sense, all at once. The arts communicate through the “fiesh of the world”, to use a notion of Maurice Merleau-Ponty. The acts of perception, feeling, thinking, and memorizing cal! for the reality and sense of embodiment. We identify ourselves unknowingly with constructed architectural spaces as well as projected cinematic situations with our empathetic capacity. So, Benjamin ‘s argument could be re- -formulated: cinema and architecture are embodied atis in which the externa! and the internal are fully intertwined and fused. “The world is wholly inside, and 1 aro wholly outside myself’, as Merleau-Ponty enigmatically argues. (shrink)

This paper discusses how the association learning principle works for supporting acquisition of basic spelling and reading skills using digital game-based learning environment with the Finland-based GraphoLearn technology. This program has been designed and validated to work with early readers of different alphabetic writing systems using repetition and reinforcing connections between spoken and written units. Initially GL was developed and found effective in training children at risk of reading disorders in Finland. Today GL training has been shown to support learning (...) decoding skills among children independent of whether they face difficulties resulting from educational, social, or biological reasons. (shrink)

In our culture, intelligence, emotions and embodied intuitions continue to be seen as separate categories. The body is regarded as a medium of identity as well as social and sexual appeal, but neglected as the ground of embodied existence and silent knowledge, or the full understanding of the human condition. Prevailing educational and pedagogic practices also still separate the mental and intellectual capacities from emotions and the senses, and the multifarious dimensions of human embodiment.

Introduction -- Image in contemporary culture -- Language, thought and image -- The many faces of the image -- The anatomy of the poetic image -- The architectural image.

The idea of active power played central role in the 17th Century philosophy and science. The idea is as follows: if not prevented, bodies necessarily do certain things in virtue of their power. This kind of thought naturally arose from what might properly be called the law of persistence, according to which moving bodies continue their motion unchanged if no new external force intervenes.1 What bodies do in virtue of their power was called actions, and in terms of actions such (...) things as resistance, pressure and affections were explained. What is this active power? One of the main aims of philosophers in the 17th and 18th Centuries was to find a good answer to this question. (shrink)

This collection of essays discusses a central feature of European philosophy: the idea of a universal active power as the ultimate world-explanation.

I want to show the importance of the notion of conatus for Hobbes' political philosophy. According to Hobbes, all motion of bodies consists of elementary motions he called 'endeavors.' They are motions 'made in less space and time than can be given,' and they obey the law of persistence or inertia. A body strives to preserve its state and resist the causal power of other bodies. I call this the conatus-principle. Hobbes' argument for social contract and sovereign is based essentially (...) on this model. He proves that the natural conatus makes people strive to preserve their lives and therefore to get out of the destructive state of nature; commit to mutual contracts; keep the contracts unless some external cause otherwise determines; and establish a permanent sovereign power that Hobbes calls 'an artificial eternity of life.' All this is determined by the fundamental laws of nature, essentially, by the conatus-principle. I also show that the Prisoner's Dilemma interpretation of the Hobbesian state of nature does not represent all of the essential features of Hobbes' argument. (shrink)

This article surveys recent developments in the epistemology of modality.

This book presents a contribution to the neglected branch of history of morals in a time when virtue has been lost, and moral disorder or vacuum has ensued. The study covers a very long period from Homer and Hesiod until the twelfth century of the Common Era.

This book explores the shared experiential ground of cinema, art, and architecture. Pallasmaa carefully examines how the classic directors Alfred Hitchcock, Stanley Kubrick, Michelangelo Antonioni, and Andrei Tarkovsky used architectural imagery to create emotional states in their movies. He also explores the startling similarities between the landscapes of painting and those of movies.

The epistemology of modality has focused on metaphysical modality and, more recently, counterfactual conditionals. Knowledge of kinds of modality that are not metaphysical has so far gone largely unexplored. Yet other theoretically interesting kinds of modality, such as nomic, practical, and ‘easy’ possibility, are no less puzzling epistemologically. Could Clinton easily have won the 2016 presidential election—was it an easy possibility? Given that she didn’t in fact win the election, how, if at all, can we know whether she easily could (...) have? This paper investigates the epistemology of the broad category of ‘objective’ modality, of which metaphysical modality is a special, limiting case. It argues that the same cognitive mechanisms that are capable of producing knowledge of metaphysical modality are also capable of producing knowledge of all other objective modalities. This conclusion can be used to explain the roles of counterfactual reasoning and the imagination in the epistemology of objective modality. (shrink)

This paper examines "moderate modal skepticism", a form of skepticism about metaphysical modality defended by Peter van Inwagen in order to blunt the force of certain modal arguments in the philosophy of religion. Van Inwagen’s argument for moderate modal skepticism assumes Yablo's (1993) influential world-based epistemology of possibility. We raise two problems for this epistemology of possibility, which undermine van Inwagen's argument. We then consider how one might motivate moderate modal skepticism by relying on a different epistemology of possibility, which (...) does not face these problems: Williamson’s (2007: ch. 5) counterfactual-based epistemology. Two ways of motivating moderate modal skepticism within that framework are found unpromising. Nevertheless, we also find a way of vindicating an epistemological thesis that, while weaker than moderate modal skepticism, is strong enough to support the methodological moral van Inwagen wishes to draw. (shrink)

This article engages the anthropological assumptions underlying the apprehensions and promises associated with language in artificial intelligence (AI). First, we present the contours of two rivalling paradigms for assessing artificial language generation: a holistic-enactivist theory of language and an informational theory of language. We then introduce two language generation models – one presently in use and one more speculative: Firstly, the transformer architecture as used in current large language models, such as the GPT-series, and secondly, a model for 'autonomous machine (...) intelligence' recently proposed by Yann LeCun, which involves not only language but a sensory-motor interaction with the world. We then assess the language capacity of these models from the perspectives of the two rivalling language paradigms. Taking a holistic-enactivist stance, we then argue that there is currently no reason to assume a human-comparable language capacity in LLMs and, further, that LeCun's proposed model does not represent a significant step toward artificially generating human language because it still lacks essential features that underlie the linguistic capacity of humans. Finally, we suggest that proponents of these rivalling interpretations of LLMs should enter into a constructive dialogue and that this dialogue should continuously involve further empirical, conceptual, and theoretical research. (shrink)

Most public discussion has focused on those effects of genetic research that are considered in some way unwanted or unpleasant. For example, there has been much debate concerning the risks and the ethical appropriateness of genetic screening, gene therapy, and agricultural applications based on genetic techniques. It often claimed that genetic research may cause new problems such as genetic discrimination, stigmatization, environmental risks, or mistreatment of animals. Genes and Morality: New Essays adopts a critical attitude toward genetic research, on both (...) a theoretical and a practical level. It presents some of the most important problems in the ethics of genetic engineering, including the questions of genetic health and disease, genetic testing, responsibility for health, patenting non-human and human life, and problems related to the disclosure of genetic information. The aim of the book is to focus on real ethical and conceptual issues. Consider, for instance, the concept of genetic disease. As one of the contributors, Ingmar Pörn, writes, fear of genetic disease, or anxiety, is not itself a disease any more than fear of becoming unemployed is a disease. Alleviating such emotions is not a medical task to be discharged by drug therapy. The book also examines the philosophical foundations of these issues by discussing the most influential bioethical theories of today, including utilitarianism and principlism. (shrink)

What does God do with the “holes” or “troumatisms” that comprise the limits of our existence, that “original solitude” whereby we are confronted with the impending annihilation of all sense? Are we left enclosed in it or does God accompany us there? This essay considers to what extent Christ’s descent on Holy Saturday takes part in the extra-phenomenal “impossibility of possibility” of this original solitude. Such a consideration requires distinguishing between that “underworld” Christ descends to on the Second Day from (...) the sin that is the proper domain of “hell.” Christ descending to the underworld marks God entering our finitude so it may be transformed (Holy Saturday) rather than our faults so that we may be resurrected (Last Judgment). Philosophically, Holy Saturday, as the ab-sense and non-sense residing between Crucifixion (Good Friday) and Resurrection (Easter Sunday), exemplifies the extra-phenomenal in which nothing is manifested (phenomenology) nor signified (hermeneutics). This intermediate realm is then one in which God comes to meet us at the limit of our own finitude. (shrink)

This important collection focuses on the nature and importance of biodiversity. The concept is clarified and its intrinsic and instrumental value are discussed. Even though the term biodiversity was invented in the 1980s to promote the cause of species conservation, discussions on biological diversity go back to Plato. There are many controversies surrounding biodiversity and a few of them are examined here: What is worthy of protection or restoration and what is the acceptable level of costs? Is it permissible to (...) kill sentient animals to promote native populations? Can species be reintroduced if they have disappeared a long time ago? How should the responsibilities for biodiversity be shared? This book will be of interest to philosophers of science and biologists, but also to anyone interested in conservation and the environment. (shrink)

Can there be 'narrow' mental content, that is entirely determined by the goings-on inside the head of the thinker? This book argues not, and defends instead a thoroughgoing externalism: the entanglement of our minds with the external world runs so deep that no internal component of mentality can easily be cordoned off.

David Lewis [2] suggests that an adequate inductive method should be immodest, i.e. recommend itself as at least as accurate as any of its rivals. On this basis he works out a solution to the intricate problem of choosing among Carnap's λ-methods. Lewis himself points out certain undesirable consequences of his solution. I will argue that the solution breaks down for a more general reason than that indicated by Lewis; like other procedures for estimating degrees of belief I am familiar (...) with, it overlooks the component of lawlikeness of inductive situations. This is not to object to the requirement of immodesty; I only want to draw attention to certain assumptions which Lewis makes in deriving his equations and which seem to be unjustified. (shrink)