BackgroundFinancial interactions between pharmaceutical companies and physicians lead to conflicts of interest. This study examines the extent and trends of non-research payments made by pharmaceutical companies to board-certified allergists in Japan between 2016 and 2020.MethodsA retrospective analysis of disclosed payment data from pharmaceutical companies affiliated with the Japanese Pharmaceutical Manufacturers Association was conducted. The study focused on non-research payments for lecturing, consulting, and manuscript drafting made to board-certified allergists from 2016 to 2020. We performed descriptive analyses on payment data. Trends (...) were analyzed using generalized estimating equation models.ResultsOf the 3,943 board-certified allergists, 2,398 (60.8%) received non-research payments totaling $43.4 million over five years. Lecturing fees comprised 85.7% ($37.2 million) of the total payment amounts. For allergists who received at least one payment, the median amount per allergist was $3,106 (interquartile range: $966 – $12,124), in contrast to a mean of $18,092 (standard deviation: $49,233) over the five-year span. The top 1% and 10% of these allergists accounted for 20.8% and 68.8% of all non-research payments, respectively. The annual payment amounts significantly increased by 7.2% annual increase (95% CI: 4.4 – 10.0%, p < 0.001) each year until 2019, but saw a significant decrease in 2020 amid the COVID-19 pandemic.ConclusionThe majority of allergists received non-research payments, with a notable concentration among a small group. Payments increased annually until the pandemic’s onset, which coincided with a substantial decrease. Further research is needed to explore the implications of these financial interactions on clinical practice and patient care in Japan. (shrink)

The Christian philosopher Muto Kazuo contributed substantially to the predominantly Buddhist “Kyoto School of Philosophy.” Through critical exchange with its representatives, he opened up new perceptions of Christian faith, enabled mutual understanding between Buddhism and Christianity, and challenged the Western dialectical method.

Fuzzy logic has become an important tool for a number of different applications ranging from the control of engineering systems to artificial intelligence. In this concise introduction, the author presents a succinct guide to the basic ideas of fuzzy logic, fuzzy sets, fuzzy relations, and fuzzy reasoning, and shows how they may be applied. The book culminates in a chapter which describes fuzzy logic control: the design of intelligent control systems using fuzzy if-then rules which make use of human knowledge (...) and experience to behave in a manner similar to a human controller. Throughout, the level of mathematical knowledge required is kept basic and the concepts are illustrated with numerous diagrams to aid in comprehension. As a result, all those curious to know more about fuzzy concepts and their real-world application will find this a good place to start. (shrink)

京都を知る，アルゴリズムを知る。アルゴリズムとはそもそも，何か物事を行うときの“具体的手順”のことである。私たちは日々，意識するかしないかに関わらず，次々とアルゴリズムの設計をしながら生活をしている。 本書は，岩間一雄教授が京都の町を題材にアルゴリズムの思考を伝える，読み物的手法をとった数学書である。読者はその奥深い世界へと誘われてゆくだろう。 巻末には本書で取り上げた京都関連の名所・行事などの索引があり，逆引きで読んでいくことができる。 【目次】 1．斜め横断 2．アイドルタイム 3．人事部長の悩み 4．チームワーク 5．神様との勝負 6．アルゴリズムからメカニズムへ 7．一番でなくとも 8．千年に1回も起こらない 9．自分のページランクを上げたい 10．対話のアルゴリズム 11．ビットコインの素晴らしさ 12．P対NP問題：ノーベル賞以上？ 13．アルゴリズムから見た進化論.

日本古来の神々の色、陰陽五行説の色、武将たちに愛された色、雅な平安の色、粋な大江戸の色彩から、昭和の流行色まで、ビジュアルで辿る日本の色を探る旅。.

解きやすい離散最適化問題に対して統一的な枠組を与える「離散凸解析」の全体像を平易に解説.