In the past decade, there has been an increase in genomic research and biobanking activities in Africa. Research initiatives such as the Human Heredity and Health in Africa Consortium are contributing to the development of scientific capacity and infrastructure to support these studies on the continent. Despite this growth, genomic research and biobanking have raised important ethical challenges for key research stakeholders, including members of research ethics committees. One of these is the limited ethical and regulatory frameworks to guide the (...) review and conduct of genomic studies, particularly in Africa. This paper is a reflection on a series of consultative activities with research ethics committees in Africa which informed the development of an ethics and governance framework for best practices in genomic research and biobanking in Africa. The paper highlights the engagement process and the lessoned learned. (shrink)

The rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.

To begin with, there is a conceptual necessity implied in the very concept of cause itself, and in all concepts that have a causal element; and this definitional "must," far from being conventional or arbitrary, reflects the natural necessity of those physical systems which in fact constitute the nature of our universe. The conceptual necessity of the concept of cause can be pointed up in the following way. Assume that we have good reason for saying at to that f, g, (...) h, and i are jointly sufficient to E and hence C of E. What would we say at t1 if f, g, h, and i occurred but not E? We would clearly not say then, or ever, that while ordinarily these conditions are jointly sufficient for E, this time they were not; rather we would say that somehow we were mistaken in thinking that f, g, h, and i at t1 were identical with f, g, h, and i at t0. We might have been mistaken in either of two ways. We might have mis-identified one of the conditions at t1, erroneously thinking, say, that p was an f; or one or more of the conditions might have had its nature altered, losing some capacity or power it once had. In either case, we would withdraw the claim at t1 that C was the cause of E. Since we would withdraw the use of C at t1 and would never admit that f, g, h, and i at any t, if genuine instances of f, g, h, and i, would not produce E, we are clearly using C in such a way that actually producing E is part of its meaning. On the assumption that the conditions are genuinely the same, it follows, so to speak, from the principle of identity that they must produce the same effect. (shrink)

Implicit in the scottish tradition is a metaphilosophy of commonsense which deserves as much attention as that recently given to scottish presentative realism and agent causality. The author articulates this metaphilosophy by (a) sketching a systematic metaphilosophy of commonsense, (b) considering to what extent thomas reid fits this pattern, And (c) deciding to what extent asa mahan, One of the ablest of the american realists, Fits it. The result is a characterization of a coherent scottish metaphilosophy still worthy of consideration. (...) He also explores the question whether the metaphilosophy that emerges from (b) and (c) is part of an ongoing tradition. It has been suggested that there are important similarities between the scottish view and g e moore's concept of analysis. While he agrees that there are analogies he stresses the disanalogies as more enlightening about the nature of both. (shrink)

The justification of a wholly non-Humean conceptual scheme, based upon the idea of enduring individuals with powers, rests in part on the success of such a scheme in resolving the problems bequeathed to us by the Humean tradition and in part must be achieved by a careful construction of the metaphysics of the new scheme itself. By this we mean a thorough exposition of the meaning and interrelations of the concepts of the new scheme. It is to the latter task (...) that we turn in this paper, being satisfied that the power of the scheme to give a rational account of science has been shown, and that its effectiveness in resolving the Humean problems and dilemmas has been amply demonstrated. (shrink)

There are a standard number of replies to the riddle of induction, none of which has gained ascendency. It seems that a new approach is needed that concedes less to the Humean dialectic. Humeans, both traditional and contemporary, unwittingly play on the ambiguity of the phrase "change in the course of nature," and that is why `C· ∼ E' appears to be self-consistent, though in fact it is not. I provide an analysis of 'cause' and 'natural necessity' which gives inductive (...) inference that internal warrant we assume it to have in ordinary and scientific thinking and rebut in advance contemporary Humean objections based on the erroneous assumption that 'x is necessary' and 'x is a priori' are materially equivalent. (shrink)

HAMILTON WORRIED THAT THERE WERE REPRESENTATIVE ELEMENTS\nIN REID'S EPISTEMOLOGY, WHILE J S MILL FLATLY CHARACTERIZED\nTHE SCOT AS A REPRESENTATIVE REALIST. I ARGUE THAT HAMILTON\nAND MILL WERE MISTAKEN AND THAT THEIR MISTAKES AROSE FROM\nAN INSUFFICIENT UNDERSTANDING AND APPRECIATION OF THE\nNATIVISTIC ELEMENTS OF THE UNDERSTANDING INTRODUCED BY\nREID; AND TO INSUFFICIENT AWARENESS OF REID'S\nCHARACTERIZATION OF PERCEPTION AS ACTIVE IN CONTRAST TO\nBRITISH EMPIRICIST RELIANCE ON A PASSIVELY GIVEN EPISTEMIC\nBASE. REID REJECTED EVERY VARIETY OF THE "MESSENGER"\nTHEORY.

IN the recent past there has been a resurgence of interest in the work of Thomas Reid; several new editions of his work have appeared as well as a series of articles concerning various aspects of his systematic philosophy. Interest has generalized to the whole Scottish tradition, including numerous figures in the history of American philosophy who were deeply influenced by Reid and Dugald Stewart. In addition, several recent and contemporary philosophers have used Reid's epistemic views as a point of (...) departure in developing their own adverbial theories of sensing and appearing. Others have used Reid's theory of agency in formulating their own views on freedom and responsibility. (shrink)

Probability and Frequency. Aristotle frequently used the concept of probability, but apparently he did not make any persistent effort to clarify or analyze it. His description of a fortiori argument in The Topics, e.g., depends upon “the more or less likely or probable,” but he does not explore this notion. In The Rhetoric, where he applies himself to a puzzle about probability which the Sophists had advanced, he comes closer to an analysis of probability. Aristotle quotes Agathon, One might perchance (...) say this was probable—That things improbable oft will hap to men, and elaborates thusly: “For what is improbable does happen [often], and therefore it is probable that improbable things will happen. Granted this, one might argue that ‘what is improbable is probable.’ “ Aristotle believes that one can avoid this imposture by distinguishing between “general” and “specific” probability, and apparently intends by the former the statistical sense of frequent occurrence; but he does not establish what he might mean by the probability of an individual event and so leaves the notion of “specific probability” unclear. (shrink)

Most philosophers of science nowadays hold a network or postulational view of the meaning of theoretical words. However, there are many nuances to this view, and after explicitly separating them, we show what we take to be wrong with each one. While we reject the postulational view we do not defend its traditional alternatives either; rather we show the pointlessness of insisting on a single source for the meaning of theoretical words. We also point out the shortcomings of Carnap's newest (...) meaning criterion which depends upon a network view. But, again, we suggest not only that this new rendition of the criterion is faulty but also that there is something misguided about any search at all for such a criterion. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:(P)rescription Narratives: Feminist Medical Fiction and the Failure of American Censorship. by Stephanie Peebles TaveraEtta M. MaddenStephanie Peebles Tavera. (P)rescription Narratives: Feminist Medical Fiction and the Failure of American Censorship. Edinburgh: Edinburgh University Press, 2022. Hardback, xii + 220 pp. ISBN 978-1-4744-9319-2.Utopian Studies readers first saw Stephanie Peebles Tavera’s work in print in her 2018 essay on reproductive health in Charlotte Perkins Gilman’s Herland. More recently, in (P)rescription (...) Narratives, she gives readers a view of the much broader historical scope of her scholarship in literary and cultural studies. Tavera’s analysis of what she labels “feminist medical fiction” considers not only novels and short stories but also literary reviews, dramas, and documentary films, many of which will be unfamiliar to readers of utopian and dystopian literature. Yet the book contextualizes the ways in which these works capture the “utopian possibilities” of women writers who pushed for breaking the boundaries of the dystopian strictures of embodied life. The literary works “rescript” what had been prescribed by others as “normalized behavior,” from the latter-nineteenth century through the Progressive Era (5, 37). As Tavera illustrates through her detailed analysis, these women’s narratives provide “interventions that... interrupt the dissemination of false [End Page 612] narratives of the female body” and “alter the course of cultural development toward greater inclusivity” (5).To establish the temporal boundaries for the project, Tavera emphasizes the Comstock Law, established in 1873, and the death of its author Anthony Comstock in 1915. While Comstock’s work often has been understood as restricting pornography, she explains the Comstock Law as more than merely that. Comstock sought to control what he and others saw as sexual deviation, which included birth control in any form. Tavera also bookends the project with lawsuits associated with Victoria Woodhull and Margaret Sanger, both women who advocated for abortion and birth control as means of allowing women to avoid the strictures over their bodies. Additionally, she explains, Comstock’s racism caused him to completely overlook Black women, ironically allowing a space in which Black women’s feminist medical fiction especially rescripts “normalized behavior” (37)—a topic she pursues in two parts of the book.The book follows a roughly chronological path as it examines four topics related to women’s health, brilliantly organized into “(p)rescriptions,” indicated by Rx, rather than chapters with numbers. Rx1, “Crip Medicine,” illustrates how authors such as Charlotte Perkins Gilman pointed to the socially constructed status of “hysteria” in a patriarchal culture that saw women as deviant by nature. Instead, these authors advocated for a more holistic examination of women’s health, impacted by the environments in which they lived. Drawing from Lyman Tower Sargent’s widely accepted view of utopianism as dreaming of a place “considerably better than the society in which the author lived,” she underscores “the utopian impulse underlies much of the work of feminist medical fiction” (39). In particular, writers of feminist medical fiction were “driven by failure.”Perhaps most familiar to illustrate this point is Gilman’s work, such as “The Yellow Wallpaper,” which illustrated how the culture failed certain characters. The narrator of that story suffers postpartum depression and is made worse by Dr. S. Weir Mitchell’s rest cure. Consequently, Gilman proceeded to write other works, such as Moving the Mountain (1911) and then Herland (1915), which push readers to envision “alternative societies” without such destructive patriarchal medical practices (39). But Tavera also explains how Louisa May Alcott’s Eight Cousins, or the Aunt-Hill (1875) critiques contemporary culture by providing a “domestic utopia” in the female domain of Aunt-Hill, wherein the male Dr. Alec Campbell demonstrates “a better way... of caring for the female body” (55). And another key example is Rebecca Harding [End Page 613] Davis’s Kitty’s Choice: A Story of Berrytown (1875). Berrytown is described as “the Utopia in actual laths, orchards, and bushel-measures of the advance guard of the reform party in the United States” (qtd. in Tavera 55). Through its two physicians, Dr. Muller and Dr. McCall, who represent homeopathic and allopathic practitioners, readers see that the society... (shrink)

Irregularity is fundamental to both Wright's and Peirce's positions but they interpret it in radically different ways. The occurrence of things by absolute chance, Peirce's tychism, is his explanation of irregularity; chance, for him, is ontologically irre- ducible--"an objective reality, operative in the cosmos." Wright, on the other hand, interpreted irregularity as a function of causal complexity; it does not constitute an abridgement of causality but only an abridgement of our knowledge of it.

While I do not accept any current analysis of theoretical terms I also reject certain criticisms of them. Specifically, I reject the criticism that the paradoxes of material implication and the counterfactual problem eliminate the explicit definition view; and I also reject the criticism that explicitly defined theoretical terms do not refer to anything which "really exists" or do not have "excess meaning." I do argue, however, that the explicit definition view confuses and conflates the concepts of criterion and meaning (...) analysis. I also defend reduction sentences against the counterfactual difficulty, but show, too, how this view is already logically committed to the network or postulational view of meaning. Finally, I show how the concept of reduction sentences confuses in several ways the concepts of criterion and meaning analysis--although not in quite the same way as explicit definitions do. (shrink)

In July 2020, the H3Africa Ethics and Community Engagement (E&CE) Working Group organised a webinar with ethics committee members and biomedical researchers from various African institutions throughout the Continent to discuss the issue of whether and how biological samples for scientific research may be accessed by commercial entities when broad consents obtained for the samples are silent. 128 people including Research Ethics Committee members (10), H3Africa researchers (46) including members of the E&CE working group, biomedical researchers not associated with H3Africa (...) (27), representatives from the National Institutes of Health (16) and 10 other participants attended the webinar and shared their views. Several major themes emerged during the webinar, with the topics of broad versus explicit informed consent, defining commercial use, legacy samples and benefit sharing prevailing in the discussion. This report describes the consensus concerns and recommendations raised during the meeting and will be informative for future research on ethical considerations for genomic research in the African research context. (shrink)

Professor Boring is best known for his work in the history of psychology and for good reason: his History of Experimental Psychology and his Sensation and Perception in the History of Experimental Psychology are truly impressive works. However, he has also written numerous articles in the philosophy of science, the psychology of scientific discovery, and the sociology of scientific production, but unfortunately this material has not heretofore been readily accessible. This deficiency, however, has been corrected efficiently by the recent publication (...) of Boring's History, Psychology, and Science: Selected Papers, edited by Robert I. Watson and Donald T. Campbell. The essays in this book represent the whole range of Boring's interests and make essential reading for any serious student of the philosophy of science. Of especial value to philosophers are the essays listed under the titles “The Scientific Method” and “The Mind-Body Problem.” Since the groupings overlap, however, the following essays in other categories are also crucial: “The Nature and History of Experimental Control,” “William James and the Psychology of the Present,” and “The Influence of Evolutionary Theory Upon American Psychological Thought.” All of these essays are interesting but the ones on operationism and theory in psychology, and the one on evolutionary notions in American psychology, are classics and worth very careful consideration and comment. (shrink)