The work that helped to determine Paul Feyerabend's fame and notoriety, Against Method,stemmed from Imre Lakatos's challenge: "In 1970 Imre cornered me at a party. 'Paul,' he said, 'you have such strange ideas.

Clement of Alexandria’s Quis dives salvetur is the first text of Christian literature expressly devoted to the problem of the relationship between wealth and poverty. Clement’s discourse clarifies how he considers the Scriptures as the basis of all pedagogy, inasmuch as they are normative in themselves and esteemed for the absolute value in them that transcends any contingency related to temporal, cultural, historical or sociological situations. This article offers a study of the reception of the Old Testament and New Testament (...) in Clement’s work, focusing on a particular scriptural text, Mk 10:17-31, that is primary and foundational for all of his thought. (shrink)

According to a growing trend in theoretical neuroscience, the human perceptual system is akin to a Bayesian machine. The aim of this article is to clearly articulate the claims that perception can be considered Bayesian inference and that the brain can be considered a Bayesian machine, some of the epistemological challenges to these claims; and some of the implications of these claims. We address two questions: (i) How are Bayesian models used in theoretical neuroscience? (ii) From the use of Bayesian (...) models in theoretical neuroscience, have we learned or can we hope to learn that perception is Bayesian inference or that the brain is a Bayesian machine? From actual practice in theoretical neuroscience, we argue for three claims. First, currently Bayesian models do not provide mechanistic explanations; instead they are useful devices for predicting and systematizing observational statements about people's performances in a variety of perceptual tasks. That is, currently we should have an instrumentalist attitude towards Bayesian models in neuroscience. Second, the inference typically drawn from Bayesian behavioural performance in a variety of perceptual tasks to underlying Bayesian mechanisms should be understood within the three-level framework laid out by David Marr ( [1982] ). Third, we can hope to learn that perception is Bayesian inference or that the brain is a Bayesian machine to the extent that Bayesian models will prove successful in yielding secure and informative predictions of both subjects' perceptual performance and features of the underlying neural mechanisms. (shrink)

Science and philosophy both express, and attempt to quench, the distinctively human thirst for knowledge. Today, their mutual relationship has become one of conflict or indifference rather than cooperation. At the same time, scientists and philosophers alike have moved away from at least some of our ordinary beliefs. But what can scientific and philosophical theories tell us about the world, in isolation from each other? And to what extent does a sophisticated investigation into the nature of things force us to (...) question commonsense beliefs? This book defends a form of naturalism which preserves the autonomy of metaphysics – the part of philosophy that aims to uncover the fundamental features of reality - while also keeping science centre stage. The proposed methodological perspective allows one to seek the right equilibrium between science, metaphysics and common sense. This is illustrated via three case studies, which provide a clear discussion of key philosophical issues. (shrink)

Soundness Arguments for the consistency of a (mathematical) theory S aim to show that S is consistent by first showing or employing the fact that S is sound, i.e., that all theorems of S are true. Although soundness arguments are virtually unanimously accepted as valid and sound for most of our accepted theories, philosophers disagree about their epistemic value, i.e., about whether such arguments can be employed to improve our epistemic situation concerning questions of consistency. This article provides a (partial) (...) negative answer to this question and argues that soundness arguments cannot be employed to justify their conclusion. Additionally, soundness arguments are unconvincing; they cannot be employed to overcome reasonable open-mindedness about their conclusion. (shrink)

In this article, we will firstly explore the concept of connected design; secondly, we will explain how environments can be understood as interfaces for knowledge; and thirdly, we will expose the characteristics and objectives of the project Wired Book & Electronic Margin, which is part of a larger project called Universal Margin, as an example of connective design. Lastly, we will show the benefits of contextualizing information and transforming the world into a connected and lively real-time library, to underline how (...) connected design can facilitate a bottom-up construction of knowledge. (shrink)

Altruism and Groups Many animals display altruistic behaviour (=df behaviour that benefits conspecifics more that the agent). Until the 1950s this was explained as good for the group if not the individual. (Ardrey, Wynne-Edwards, lemmings.) BUT won’t groups of altruists always be invaded by selfish animals?

Chinese and English. Half title also in Chinese characters: T°ien chu shih i. Bibliography: 473-482. Includes index.

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status is unclear. Also (...) unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

In recent work, the interrelated questions of whether there is a fundamental level to reality, whether ontological dependence must have an ultimate ground, and whether the monist thesis should be endorsed that the whole universe is ontologically prior to its parts have been explored with renewed interest. Jonathan Schaffer has provided arguments in favour of 'priority monism' in a series of articles (2003, 2004, 2007a, 2007b, forthcoming). In this paper, these arguments are analysed, and it is claimed that they are (...) not compelling: in particular, the possibility that there is no ultimate level of basic entities that compose everything else is on a par with the possibility of infinite 'upward' complexity. The idea that we must, at any rate, postulate an ontologically fundamental level for methodological reasons ( Cameron 2008 ) is also discussed and found unconvincing: all things considered, there may be good reasons for endorsing 'metaphysical infinitism'. In any event, a higher degree of caution in formulating metaphysical claims than found in the extant literature appears advisable. (shrink)

Some naturalistic philosophers of mind subscribing to the predictive processing theory of mind have adopted a realist attitude towards the results of Bayesian cognitive science. In this paper, we argue that this realist attitude is unwarranted. The Bayesian research program in cognitive science does not possess special epistemic virtues over alternative approaches for explaining mental phenomena involving uncertainty. In particular, the Bayesian approach is not simpler, more unifying, or more rational than alternatives. It is also contentious that the Bayesian approach (...) is overall better supported by the empirical evidence. So, to develop philosophical theories of mind on the basis of a realist interpretation of results from Bayesian cognitive science is unwarranted. Naturalistic philosophers of mind should instead adopt an anti-realist attitude towards these results and remain agnostic as to whether Bayesian models are true. For continuing on with an exclusive focus and praise of Bayes within debates about the predictive processing theory will impede progress in philosophical understanding of scientific practice in computational cognitive science as well as of the architecture of the mind. (shrink)

As innovations in the field of vascular composite allotransplantation (VCA) progress, whole-eye transplantation (WET) is poised to transition from non-human mammalian models to living human recipients. Present treatment options for vision loss are generally considered suboptimal, and attendant concerns ranging from aesthetics and prosthesis maintenance to social stigma may be mitigated by WET. Potential benefits to WET recipients may also include partial vision restoration, psychosocial benefits related to identity and social integration, improvements in physical comfort and function, and reduced surgical (...) risk associated with a biologic eye compared to a prosthesis. Perioperative and postoperative risks of WET are expected to be comparable to those of facial transplantation (FT), and may be similarly mitigated by immunosuppressive protocols, adequate psychosocial support, and a thorough selection process for both the recipient and donor. To minimize the risks associated with immunosuppressive medications, the first attempts in human recipients will likely be performed in conjunction with a FT. If first-in-human attempts at combined FT-WET prove successful and the biologic eye survives, this opens the door for further advancement in the field of vision restoration by means of a viable surgical option. This analysis integrates recent innovations in WET research with the existing discourse on the ethics of surgical innovation and offers preliminary guidance to VCA programs considering undertaking WET in human recipients. (shrink)

Despite the impressive amount of financial resources invested in carrying out large-scale brain simulations, it is controversial what the payoffs are of pursuing this project. The present paper argues that in some cases, from designing, building, and running a large-scale neural simulation, scientists acquire useful knowledge about the computational performance of the simulating system, rather than about the neurobiological system represented in the simulation. What this means, why it is not a trivial lesson, and how it advances the literature on (...) the epistemology of computer simulation are the three preoccupations addressed by the paper. (shrink)

In this article, which is assembled from interviews, the main issues of in silico medicine, present and future, are discussed by three scientists who are directly involved in the implementation and development of in silico techniques.

What are the conditions for holding each other responsible for the actions we take? What is moral blame and how does it function? Can we hold ourselves morally responsible for actions that depend on situational influences? Can growing up in unfortunate circumstances be a reason to suspend our blame attitudes? These are some of the questions that have characterized the contemporary debate on moral responsibility. Building on the reflections on responsibility proposed by Peter Strawson, the author reconstructs some attempts in (...) contemporary English-language moral philosophy to answer them. At the centre of inquiry there are the socalled "practices of moral responsibility", which divide two shores: the description of moral agents as natural agents and the normative expectations that generate reciprocal claims about respectful behavior. (shrink)

Normative positions are sometimes illustrated in diagrams, in particular in didactic contexts. Traditional examples are the Aristotelian polygons of opposition for deontic modalities (squares, triangles, hexagons, etc.), and the Hohfeldian squares for obligative and potestative concepts. Relying on previous work, we show that Hohfeld’s framework can be used as a basis for developing several Aristotelian polygons and more complex diagrams. Then, we illustrate how logical theories of increasing strength can be built based on these diagrams, and how those theories enable (...) us to determine in a computably efficient way whether a set of normative positions can be derived from another set of normative positions. (shrink)

How should we understand the claim that people comply with social norms because they possess the right kinds of beliefs and preferences? I answer this question by considering two approaches to what it is to believe (and prefer), namely: representationalism and dispositionalism. I argue for a variety of representationalism, viz. neural representationalism. Neural representationalism is the conjunction of two claims. First, what it is essential to have beliefs and preferences is to have certain neural representations. Second, neural representations are often (...) necessary to adequately explain behaviour. After having canvassed one promising way to understand what neural representations could be, I argue that the appeal to beliefs and preferences in explanations of paradigmatic cases of norm compliance should be understood as an appeal to neural representations. (shrink)

Causal reductionism is the widespread assumption that there is no room for additional causes once we have accounted for all elementary mechanisms within a system. Due to its intuitive appeal, causal reductionism is prevalent in neuroscience: once all neurons have been caused to fire or not to fire, it seems that causally there is nothing left to be accounted for. Here, we argue that these reductionist intuitions are based on an implicit, unexamined notion of causation that conflates causation with prediction. (...) By means of a simple model organism, we demonstrate that causal reductionism cannot provide a complete and coherent account of ‘what caused what’. To that end, we outline an explicit, operational approach to analyzing causal structures. (shrink)

This article offers a limited defense of metaphysical “infinitism,” the view that there are, or might be, infinite chains of ontological dependence. According to a widespread presupposition, there must be an ultimate ground of being—most likely, a plurality of fundamental atoms. Contrary to this view, this article shows that metaphysical infinitism is internally coherent. In particular, a parallel with the debate concerning infinitism about epistemic justification is suggested, and an “emergence model” of being is put forward. According to the emergence (...) model, the being of any given entity gradually arises out of an infinite series of progressively less dependent entities—it is not wholly transmitted, as it were, from a basic, ungrounded level to all the dependent ones in a step-by-step fashion. Some objections are considered and rebutted. (shrink)

This paper is about metaphysical ‘infinitism’, the view that there are, or could be, infinite chains of ontological dependence. Its main aim is to show that, contrary to widespread opinion, metaphysical infinitism is a coherent position. On the basis of this, it is then additionally argued that metaphysical infinitism need not fare worse than the more canonical ‘foundationalist’ alternatives when it comes to formulating metaphysical explanations. In the course of the discussion, a rather unexplored parallel with the debate concerning infinitism (...) about justification is suggested. (shrink)

Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n (...) = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. (shrink)

In this work we provide an analysis of some issues arising with geometrical representations of a family of deontic and potestative relations that can be classified as Hohfeldian modalities, traditionally illustrated on two diagrams, the Hohfeldian squares. Our main target is the lack of symmetry to be found in various formal accounts by drawing analogies with the square of opposition for alethic modalities. We argue that one should rather rely on an analogy with the alethic hexagon of opposition and exploit (...) the notions of contingency and absoluteness in order to restore the symmetry of Hohfeldian modalities in accordance to the diagrams presented by Hohfeld. Interestingly, the investigation unveils three potestative squares defined at different levels of granularity (force, outcome and change) and allows us to further elaborate on the connections between deontic and potestative relations. (shrink)

The present paper discusses different approaches to metaphysics and defends a specific, non-deflationary approach that nevertheless qualifies as scientifically-grounded and, consequently, as acceptable from the naturalistic viewpoint. By critically assessing some recent work on science and metaphysics, we argue that such a sophisticated form of naturalism, which preserves the autonomy of metaphysics as an a priori enterprise yet pays due attention to the indications coming from our best science, is not only workable but recommended.

Cultural traits are those phenotypic traits whose development depends on social learning. These include practices, skills, beliefs, desires, values, and artefacts. The distribution of cultural traits in the human species changes over time. But this is not enough to show that culture evolves. That depends on the mechanisms of change. In the cultural realm, one can often observe something similar to biology’s ‘descent with modification’: cultural traits are sometimes modified, their modifications are sometimes retained and passed on to others through (...) social learning, until new modifications are added. In this way, new modifications are piled on top of old modifications, generating cumulative change. But, again, this is not enough to show that culture evolves. For culture to evolve, cumulative change must be the result of hidden-hand mechanisms similar to those that explain cumulative biological change. If cumulative cultural change cannot be explained in these terms, the analogy between cultural change and biological evolution is unhelpful. The best known biological mechanism is natural selection. There are reasons to think that cultural change is at least sometimes due to natural-selection-like mechanisms. The adaptive fit often found between cultural traits and the environment has in many cases been built gradually and in a way that involves natural selection operating at the cultural level. The parallel with morphological adaptation is compelling. No complete and universally accepted account of natural-selectionlike processes operating at the cultural level exists at this stage. But at least three kinds of processes seem possible. (shrink)

This paper introduces a new framework, based on the notion of compatibility space, obtained by adding a primitive incompatibility relation to a state space in the sense of Fine. The key idea inspiring the framework is to modify Fine's truthmaker semantics by taking the notion of incompatibility as primitive, and use it to define other notions. We discuss some interesting features of the framework and explore its advantages over the standard framework of state spaces. We review some applications of the (...) framework, including proofs of soundness and completeness theorems for a number of logics, one way to use compatibility states to mirror Kripke frames, and an exploration of a way to use the new framework to provide truthmaking clauses for modal formulas. (shrink)

This paper discusses the issue of the identity and individuality (or lack thereof) of quantum mechanical particles. It first reconstructs, on the basis of the extant literature, a general argument in favour of the conclusion that such particles are not individual objects. Then, it critically assesses each one of the argument’s premises. The upshot is that, in fact, there is no compelling reason for believing that quantum particles are not individual objects.

In the United States, the crisis broke out in 2008 launched a public debate on the decline of the middle class with peculiar historical references: from the Great Depression and the New Deal to the globalization of the Nineties, through the fractures imposed by the social movements of the Sixties and the neo-liberal turn of the Eighties. In the light of a debate in which the middle class emerges as an indisputable keyword of the American political cultures, the essay points (...) out the historical origin of the fetish of middle class by showing the role that US social sciences have had in the making of the middle class as an ideological notion at the very foundation of the American century. Released by its fetish, middle class emerges as a historical category that allows to trace the formation of the liberal order and its transition to the neoliberal order, to point to the crisis and transformation of capitalism and the American state, to identify the frontier beyond which their historical legitimacy is missing. (shrink)

Until now studies on the historical development of atomic spectroscopy have focused on three main aspects-its first applications as a method of chemical analysis, the formulation of spectral laws , and the rise of the old quantum theory. These developments of spectroscopy were based on the same assumption: the invariance of the atomic spectrum after fixing the chemical element . This paper shows that running alongside these lines of research there was another, no less important area of study based on (...) the negation of this assumption. The focus of these latter studies was the behaviour of atomic spectra as a function of different working conditions. English astrophysicist Sir Norman Lockyer played a central role in this research. While studying the effect of temperature on spectral lines and comparing stellar spectra with laboratory spectra, he discovered a new class of spectral lines . In an attempt to explain the origin of these lines, Lockyer, at the beginning of 1897 , hypothesized the 'dissociation' of the chemical elements into simplified forms of matter, named proto-elements. Lockyer's studies are mentioned by Thomson in the paper which introduces the corpuscle for the first time. In this paper we have tried to reconstruct the history of Lockyer's proto-elements and highlight the links between them and Thomson's corpuscle. Our analysis has shown that not only the famous studies on discharges in rarefied gases but also Lockyer's stellar spectroscopy played an important role in the work of J. J. Thomson, convincing him that the atom was complex and divisible. (shrink)