Over 80% of the genes in the E. coli chromosome express fewer than a hundred copies each of their protein products per cell. It is argued here that transcription of these genes is neither constitutive nor regulated by protein factors, but rather, induced by the act of replication. The utility of such replication‐induced (RI) transcription to the temporal regulation of synthesis of determinate quantities of low copy number (LCN) proteins is described. It is suggested that RI transcription may be necessitated, (...) as well as facilitated, by the folding of the bacterial chromosome into a compact nucleoid. Mechanistic aspects of the induction of transcription by replication are discussed with respect to the modulation of transcriptional initiation by negative supercoiling effects, promoter methylation status and derepression. It is shown that RI transcription offers plausible explanations for the constancy of the C period of the E. coli cell cycle and the remarkable conservation of gene order in the chromosomes of enteric bacteria. Some experimental tests of the hypothesis are proposed. (shrink)

Transcription and DNA supercoiling are known to be linked by a cause‐effect relationship that operates in both directions. It is proposed here that this two‐way relationship may be exploited by the E. coli genome to facilitate constitutive transcription of supercoil‐sensitive genes by polymerase batteries made up of uniformly spaced RNA polymerase elongation complexes. Specifically, it is argued that (1) polymerases transcribing DNA in tandem cooperate to relax each other's transcription‐driven positive supercoils; and (2) negative supercoils driven upstream by elongation complexes (...) tend to be ‘harnessed’ and used to cooperatively (and periodically) initiate fresh transcription from promoters. Harnessing of transcription‐driven negative supercoils is thought to be achieved through the erection of protein barriers to the rotational upstream propagation of supercoils from transcription events. The possible relevance of such cooperation amongst polymerases to the activation of transcription by DNA‐binding protein factors is emphasized. Some testable predictions are made and implications are discussed. (shrink)

Articles on Vedanta school of philosophy.

Metaphysical Meditations is a beloved classic book of the great yoga master, Paramhansa Yogananda (1893-1952), author of Autobiography of a Yogi. First published in 1932, then revised in 1952, this version of Metaphysical Meditations is faithful to the original writing of Yogananda, with all his deep inspiration, uniquely and eloquently expressed. He makes spiritual wisdom seem both natural and accessible to all readers. God and our higher Self become "the nearest of the near, and the dearest of the dear." His (...) words in this book remain with us, loved and remembered, reverberating within our hearts and minds, reassuring us with love and strength. At the bedside, by the meditation altar, and while traveling-one can choose no greater companion than Metaphysical Meditations. Contains poems and prayers written by Yogananda. (shrink)

We propose that hyper‐inflammation (HYPi) is a ‘‘runaway’’ consequence of acute inflammation (ACUi) that arises more easily (and also abates less easily) in those who host a pre‐existing chronic inflammation (CHRi), because (i) most factors involved in generating an ACUi to limit viral proliferation are already present when there is an underlying CHRi, and also because (ii) anti‐inflammatory (AI) mechanisms for the abatement of ACUi (following containment of viral proliferation) are suppressed and desensitized where there is an underlying CHRi, with (...) this causing the ACUi to spiral into a HYPi. Stress, pollution, diet, and gut microbiomes (alterable in weeks through dietary changes) have an intimate and bidirectional cause‐effect relationship with CHRi. We propose that avoidance of CHRi‐promoting foods and adoption of CHRi‐suppressing foods could reduce susceptibility to HYPi, in Covid‐19 and in other viral diseases, such as influenza, which are characterized by episodic and unpredictable HYPi. (shrink)

An interfaith perspective on meditation discusses such aspects of the practice as its spiritual foundations, the benefits of energy-building exercises and affirmations, techniques for effective prayer, and ways to measure inner practice.

One Seit Platon (mit dem Spott von Diogenes) über Kant ist die Fundamentalfrage "Was ist der Mensch?" bis heute nicht nur von der Philosophie (als regina scientiarum), sondern von der Wissenschaft überhaupt nicht beantwortet. Phänomenologisch hat der Mensch a posteriori physische (somatische), psychische(perceptio, emotio, cognitio), mentale (logische), spirituelle (conscientia, volitio, actio) "Sphären". Ontologisch in Kontext von to ti en einai (Aristoteles) sollte der Mensch a priori ein "Programm" (Information) vor der Kosmogonie haben. Der (Neo‐) Positivismus (z.B. Hume bis Carnap, Russel*; (...) * Nobel Laureate) verwirft Fragen der Metaphysik als Scheinprobleme. Damit bleibt das Menschen‐Wesen in Kontext von Postulaten, wie res cogitans (Descartes), Monaden(Leibniz), "Gott, Freiheit, Unsterblichkeit", Seligkeit und (moralischer) Vollkommenheit (Kant), absoluter Geist (Hegel) in der theologischen Dimension. Antwort könnte eine zukünftige (holistisch‐multidimensionale) philosophische theoretische und Experimentaltheologie (kontrollierbare Beobachtung) durch weitere Forschung geben, in Kontext (bzw. Existenz) von A. Physikotheologie bzw. (a) höhere (als drei) geometrische/physikalische Dimensionen (Hilbert, Riemann /Friedmann, Minkowski, Schmutzer), (b) Paralleluniversen (z.B. L. Randall), (c) Quantentheorie/‐philosophie (Planck*, u.a.), (d) Gravitations‐/Relativitätstheorie (Newton/Einstein*), (e) Vakuumenergie (Sato), etc. B. ChemoBiotheologie bzw. "psychischen" (Fechner) und "spezifischen" (Joh. Müller) Energien,"biologischem Feld" (Gurwitsch), künstlicher Biogenese (Oparin, Fox, Urey*, u.a.; 32 Fragen von John Bernal). C. Psychotheologie bzw. parapsychische Phänomene (Carrel*, Richet*/France, Rhinne/USA, Vassilev, Bechterew/Russia, etc.). D. Religionstheologie: (über‐) Bewußtsein, übersinnliche, immaterielle, supraphysikalische Phänomene (Sri Aurobindo, Dalai Lama*, Konfuzius/Laotse, Gopi Krishna, Papst Benedikt, Paramahansa Yogananda, Sri Yogendra, etc.)und ihre physiologische Begründung (Anand/Chinna, Kasamatsu/Hirai, Ornstein, Pauli*, von Weizsäcker, etc.). Damit hängt die ontologische Frage nach dem MenschenWesen mit der Lösung des Problemkomplexes "Gott Geist/Seele Mensch Natur" zusammen. (shrink)

Many of us think that we just aren't enough. Not good enough, not pretty enough, not rich enough, and not happy enough. But just because we think something doesn't mean it's true. You are more than you think you are teaches you how to revise your belief system, fulfill your deepest dreams and desires, and create an epic, successful, and inspiring life. Unlocking your True Self is the key to new levels of joy, beauty, and peace. But what is the (...) True Self, and how can you realize its infinite potential? In this easy-to-read book, Kimberly Snyder answers these questions and shows you how to tap into this unstoppable force to transform every aspect of your life for the better. Drawing inspiration from the teachings of the great guru Paramahansa Yogananda along with personal stories and the latest scientific research, Kimberly offers simple exercises, potent ancient practices, and in-depth meditations to help you overcome negative beliefs and see yourself as you truly are--a goddess, a warrior, a lover, and a creator of your extraordinary destiny" -- Back cover. (shrink)

"Mystical Prayers of Poetic Beauty" - In the tradition of the great lyric mystics of all religions, Paramahansa Yogananda's "Whispers from Eternity" offers a window on the devotional experience of ecstasy. Sharing prayers and affirmations directly inspired by his high state of God-communion, this beloved spiritual master helps modern seekers achieve their own mystical relationship with the Divine. Now with a contemporary new look, these universal prayers and prose poems offer daily inspiration for seekers of all faiths. A uniquely (...) devotional offering in the spirit of Yogananda's best-selling "Metaphysical Meditations," this popular collection will inspire a new legion of readers seeking a nonsectarian, experiential relationship with God. (shrink)