This article focuses on the assessment of mechanistic relations with specific attention to medicine, where mechanistic models are widely employed. I first survey recent contributions in the philosophical literature on mechanistic causation, and then take issue with Federica Russo and Jon Williamson’s thesis that two types of evidence, probabilistic and mechanistic, are at stake in the health sciences. I argue instead that a distinction should be drawn between previously acquired knowledge of mechanisms and yet-to-be-discovered knowledge of mechanisms and that both (...) probabilistic evidence and manipulation are essential with respect to newly discovered mechanisms. (shrink)

This contribution claims that the two fundamental notions of causation at work in the health sciences are manipulative and mechanistic, and investigates what kinds of evidence matter for the assessment of causal relations. This article is a development of our 2007 article, ‘Plurality of Causality’, where we argue for a pluralistic account of causation with an eye to econometrics and a single medical example. The present contribution has a wider focus, and considers the notion of evidence within a whole range (...) of disciplines belonging to the health sciences. Section 1 addresses the relations between kinds of evidence and causal accounts, and it is shown how different notions of causation can be employed in various medical cases. Section 2 calls attention to issues crucial for any adequate epistemological theory of causation, such as the distinctions between types and tokens, observational and experimental regimes, explanation and prediction. Lastly, the notion of context is articulated, highlighted in its role in the assessment of causal links. All these issues are tackled in the framework of what we label a ‘bottom–up’ epistemology. (shrink)

The meaning of matter is determined by our interpretations. Even food has its own frequencies, which can be aligned with the specific notes of a musical scale. When presented with a dish we might ask not only “how does it taste?” but also “how does it sound?.” Gastrofonia is defined not as the musical accompaniment to a cooking demonstration, but the actual sound of it: music is made by food. Built upon an experiment initiated by John Cage to try to (...) make music with objects, gastrofonia examines sound as a possible connection among the visual and material arts. Combining music with taste, musician Roy Paci identified a biosonic perception of food. This chapter aims to analyze the case of gastrofonia in light of the increased scientific and artistic interest in food characterizing our contemporary society, that is, an orthorexic society where food has become a specific form of language, a communicative vehicle through which we express our identity, interests, social-ethical choices, and new concepts of art. From a sociosemiotic perspective, the gastrofonic dish is an example of a textual polyphonic discourse combining different languages, related to the five senses in a performance that becomes a form of shared communication. (shrink)

The notion of causal evidence in medicine has been the subject of wide philosophical debate in recent years. The notion of evidence has been discussed mostly in connection with Evidence Based Medicine and, more in general, with the assessment of causal nexus in medical, and especially research contexts. “Manipulative evidence” is one of the notions of causal evidence that has stimulated much debate. It has been defined in slightly different ways, attributed different relevance, and recently placed at the core of (...) Gillies’ “action-related theory of causality”, a view specifically meant to address causation in medicine. While in general sympathetic to Gillies’ account, and totally convinced of the relevance of manipulative evidence and different sorts of interventions in the biomedical sciences, we believe that some further qualifications are needed to allow the notion of manipulative evidence to better express features of medical practice. In particular, we provide some qualification of the role of “interventional evidence” proposed by Gillies, suggesting a distinction between “interventional evidence” and “evidence for interventions”. A case study from research on rare diseases is analyzed in depth and a multifaceted notion of manipulative evidence put forward that allows better understanding of what manipulations in medical contexts amount to and what their targets are. (shrink)

This paper uses a partially ordered set of syntactic categories to accommodate optionality and licensing in natural language syntax. A complex but well-studied data set pertaining to the syntax of quantifier scope and negative polarity licensing in Hungarian is used to illustrate the proposal. The presentation is geared towards both linguists and logicians. The paper highlights that the main ideas can be implemented in different grammar formalisms, and discusses in detail an implementation where the partial ordering on categories is given (...) by the derivability relation of a calculus with residuated and Galois-connected unary operators. (shrink)

ABSTRACTThe quality of medicines is generally adequately assured by manufacturers and regulatory authorities for well-resourced settings, while the implementation of existing quality standards is challenged in many low- and middle-income countries. This situation of multiple pharmaceutical standards raises the question whether it could ever be ethically justified to compromise on the quality assurance of medicines depending on what individuals, communities, or societies can afford. In this paper, we contend that ethically, any unjustified exceptions to medicines’ quality assurance represents a violation (...) of the principles of beneficence and non-maleficence. Exceptions are only acceptable in exceptional and temporary circumstances, if based on a meaningful quality risk assessment, guided by a rigorous ethical framework built on the principles of independence, technical competence, transparency, and accountability. We also discuss how such exceptional and temporary circumstances should be defined/justified.... (shrink)

Research represents an essential component of the response to infectious disease outbreaks and to other public health emergencies, whether they are localised, of international concern, or global. Research conducted in such contexts also comes with particular ethics challenges, the awareness of which has significantly grown following the Ebola outbreak in West Africa, the Zika outbreak in Latin America and the COVID-19 pandemic. These challenges include the need for implementing meaningful community engagement with the researched communities, not just to build unidirectional (...) trust towards the research team, but to achieve a genuine and mutually respectful partnership before, during and after the research. Here, we describe the real-life experience of 10 well-established research clinics in Nairobi, where a successful experience of community engagement linking prevention and care to research was interrupted during the COVID19 pandemic. We contrast this experience with the concept and processes of community engagement as described in selected scientific manuscripts and guidelines, to formulate some conclusions and recommendations. We contend that more action is needed, from research ethics committees and other key-research stakeholders, to align policies and practices with ethics guidance and with evidence-based recommendations from the academic literature, to achieve meaningful community engagement during emergency research, irrespective of the scale and location of an outbreak or public health crisis. Failure to do so, will aggravate the (postcolonial) asymmetries of power in global health and local systems. (shrink)

We define a potentialist system of ‐structures, i.e., a collection of possible worlds in the language of connected by a binary accessibility relation, achieving a potentialist account of the full background set‐theoretic universe V. The definition involves Berkeley cardinals, the strongest known large cardinal axioms, inconsistent with the Axiom of Choice. In fact, as background theory we assume just. It turns out that the propositional modal assertions which are valid at every world of our system are exactly those in the (...) modal theory. Moreover, we characterize the worlds satisfying the potentialist maximality principle, and thus the modal theory, both for assertions in the language of and for assertions in the full potentialist language. (shrink)

In this paper I argue against the received view that the anti‐nativist arguments of Book I of Locke's Essay conclusively challenge nativism. I begin by reconstructing the chief argument of Book I and its corollary arguments. I call attention to their dependence on (what I label) “the Awareness Principle”, viz., the view that there are no ideas in the mind of which the mind either isn't currently aware or hasn't been aware in the past. I then argue that the arguments' (...) dependence on this principle is question begging on two counts. Unless this principle is defended, Locke's arguments beg the question against Descartes and Leibniz because their nativism implies the denial of the Awareness Principle. And even when Locke defended the principle, his arguments remain question begging because they presuppose the empiricism they aim to prove. The disclosure of the question‐begging status of these arguments debunks a seemingly powerful way of attacking nativism. (shrink)

In the last few years, avatars have been increasingly used in treating persistent persecutory auditory verbal hallucinations. The digital representation (an avatar) of persecutory hallucinations is voiced by the therapist and engages the patient in a dialogue, progressively conceding its power and, hence, reducing the stress experienced by the patient. Such attempts at integrating digital representations and cognitive behavior therapy raise a range of philosophical questions, which this chapter tackles along two trajectories. From an epistemological standpoint, we inquire what notion (...) of mental disorder can underlie the use of avatar therapy, and how our understanding of psychiatric diseases can be affected by the implementation of such a therapy. Relatedly, from an ethical standpoint, we reflect on some of the controversial issues posed by such therapeutic strategies. Discussing selected epistemological and ethical aspects stemming from the latest relevant literature both in philosophy and in psychiatry, the chapter aims to provide a tentative evaluation of trade-offs between the promises of and the limits to this therapeutic option. (shrink)

This is a personal recollection of Lyman Tower Sargent that stresses his enormous contribution—personal and academic—to the community of utopian studies. After a brief recollection of our academic interactions, the short contribution pays homage to a “social dreamer” who is aware that utopia can be dangerous but is equally sure that it is absolutely essential if we are to survive.

Putting into question the usefulness and the adequacy of the Wave metaphor as a key to understand the complexity of the feminist movement and its history, the author critically recounts the salient nodes around which the feminist movement has discussed on the transnational level the issue of wage for housework and the nexus production/reproduction in the long 1968, critically rethinking the differences between women and the different experiences of oppression in capitalist society. In particular, the essay analyzes the way in (...) which the dichotomy redistribution/recognition has constituted an inseparable nexus in feminist reflections and has redefined the relationship between gender, class and ethnicity/race, showing the centrality of the intersections between them for the movement and feminist theory. (shrink)

After its rise, in the years of the George W. Bush Jr.’s presidency, neoconservatism seemed to collapse under the weight of its utopian ambition to dictate the new rules of the internal and international political order, to stem the conflicts and processes of disruption of the liberal order as it had been defined since the Second World War. Going through the various contributions of the monographic issue, this introduction highlights the historical and political reasons that make neoconservatism an idea whose (...) parable and movements are of great importance to understand the crisis of liberalism and the current role of the neoliberalism. (shrink)

This introduction emphasises the relevance of the theoretical feminist reflection presented by Wendy Brown in her Politics Out of History . The Italian translation of the book, which introduces Brown’s thought to the Italian public for the first time, provides the opportunity to deepen the understanding of her feminist contribution to the comprehension of the crisis of sovereignty. The book, in fact, could be investigated as a sort of link between, on the one hand, 1990s Brown’s reflection on the crisis (...) of liberal universalism, political modernity and on the gendered constructions of such concepts as State and citizenship and, on the other, her more recent analysis on the reconfiguration of power and sovereignty in the age of globalization as expressed in her 2010 Walled States, Waning Sovereignty . At the core of her reflection, a crucial role has been played by the deconstruction of the nexus freedom-power-rights that enlightens the ambiguities, the semantic ambivalences and the political-theoretical traps inherent in the linear and progressive narration of political modernity. (shrink)

i. M is positive in M . ii. M is positive (negative) in P Q iff M is positive (negative) in P . iii. M is positive (negative) in P Q iff M is positive (negative) in Q, and P denotes..

1 Recognition Device . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 Classical Categorial Grammar. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3 Classical (...) Categorial Grammar. Examples . . . . . . . . . . . . . . . . . . . . . 5 4 Logic Grammar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 5 Lambek calculus. Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 6 Lambek calculus. Semantics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 7 Lambek calculus. Advantages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 8 Derivations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 9 Residuated and Galois Connected Functions . . . . . . . . . . . . . . . . . . 14 10 Interpretation of the Constants. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 11 Nonveridical Functions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 12 Dutch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 13 Classification of NPIs in Dutch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 14 Antilicensing Relation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20.. (shrink)

Polarity Items are linguistic expressions known for being a ‘lexically controlled’ phenomenon. In this paper we show how their behavior can be implemented in a deductive system. Further- more, we point out some possible directions to recast the deductive solution into a Tree Ad- joining Grammar system. In particular, we suggest to compare the proof system developed for Multimodal Categorial Grammar (Moot & Puite, 1999) with the Partial Proof Trees proposed in (Joshi & Kulick, 1997).

In this paper we present a logical system able to compute the semantics of both declarative and interrogative sentences. Our proposed analysis takes place at both the sentential and at the discourse level. We use syntactic inference on the sentential level for declarative sentences, while the discourse level comes into play for our treatment of questions. Our formalization uses a type logic sensitive to both the syntactic and semantic properties of natural language. We will show how an account of the (...) linguistic data follows naturally from the logical relations inherent in the type logic. (shrink)

In this paper we draw some connection between the relation linking polarity items with their licensors, and the one holding between wh-phrases and weak-islands. Moreover, we briefly sketch how these relations can be modelled into Categorial Type Logic.

The article presents the first results we have obtained studying natural reasoning from a proof-theoretic perspective. In particular we focus our attention on monotonic reasoning. Our system consists of two parts: (i) A Formal Grammar – a multimodal version of classical Categorial Grammar – which while syntactically analysing linguistic expressions given as input, computes semantic information (In particular information about the monotonicity properties of the components of the input string are displayed.); (ii) A simple Natural Logic which derives (monotonicity) inferences (...) using as vehicle the parsed output. The monotonicity markers assigned in the lexicon are propagated through the proofs via a combination of the structural and the logical rules for the unary operators of Multimodal Categorial Grammar (MMCG) [Moo97]. We have chosen to work with an expressive ‘grammar logic’, in order to avoid the use of extra-logical marking devices and extra-logical structural reasoning. Having MMCG as parser, our system is able to make the derivations simply within the logic. This new approach makes the implementation of the theory an easier task. We have implemented the theoretical results, so far obtained, using Grail, a theorem prover for Categorial Grammar Logics [Moo98]. (shrink)

This article focuses on the significance of space in the display of hegemonic power in the La Scala opera house in the years 1776–1850s. More specifically, it traces the changes in the use of space from Napoleon’s attempt to “democratise” La Scala by attacking the display of hegemonic hierarchy and subverting the status quo, to the Habsburgs’ attempt to “restore” a display of hegemonic rule. The analysis of primary findings demonstrates that the space of the opera house was reshaped not (...) only physically through renovation but also by imposing rules and structuring attendance during performances. The social significance of La Scala’s theatrical space is also explored by identifying the means the Habsburg authorities used to control it as part of their response to the rise of the Risorgimento. The article thus traces the historical shifts in the political functions of space in La Scala from its early role of displaying aristocratic authority through the period of Napoleonic democratisation and finally the Hapsburgs’ restoration politics of surveillance. (shrink)

: This contribution aims to address epistemological issues at the crossroads of philosophy of science and psychiatry by reflecting on the notions of organization and resilience. Referring to the debate on the notion of “organization” and its explanatory relevance in philosophical neo-mechanistic theories, I consider how such positions hold up when tentatively applied to the mental health context. More specifically, I show how reflections on psychiatric resilience, cognitive reserve, and accommodation strategies challenge attempts to embrace a mechanistic perspective on mental (...) disorders. A deeper focus on these aspects of mental health is relevant to theoretical discussions on explanatory models as well as for clinical practice, diagnosis, and treatment. Keywords: Psychiatric resilience; Cognitive Reserve; Organization; Mechanism Il ruolo esplicativo dell’organizzazione e la resilienza psichiatrica: sfide ad un approccio meccanicistico alla malattia mentale Riassunto: Questo articolo intende discutere alcuni temi epistemologici all’incrocio tra la filosofia della scienza e la psichiatria, riflettendo sulle nozioni di organizzazione e resilienza. Muovendo dalle riflessioni sulla nozione di “organizzazione” sviluppate nell’ambito delle teorie neo-meccaniciste, e dalla difesa del suo ruolo esplicativo, il lavoro analizza la possibilità di estendere alcune posizioni relative alla spiegazione scientifica al contesto delle scienze della salute mentale. Più nello specifico, si illustra come le indagini sulla resilienza psichiatrica, la riserva cognitiva e le strategie di compensazione possano mettere in discussione i tentativi di abbracciare una prospettiva meccanicistica quando si affronta il tema del disturbo psichiatrico. Una maggiore attenzione ai suddetti filoni di ricerca può avere un impatto significativo sia sulla discussione relativa ai modelli teorici di spiegazione della malattia mentale sia sui processi clinici di diagnosi e terapia. Parole chiave: Resilienza psichiatrica; Riserva cognitiva; Organizzazione; Meccanicismo. (shrink)

Reductionism and antireductionism are among the most largely and hotly debated topics in philosophy of biology today. In this section of the volume, aiming to convey the current situation in the philosophy of the natural and life sciences, these topics are specifically addressed in Mehmet Elgin’s paper, focusing on biochemistry. Elgin strongly supports reductionism, first by claiming that the now classical argument based on multiple realizability does not entail anti-reductionism and secondly highlighting how the version of methodological reductionism that biochemistry (...) has been adopting – centered on “the principle that biological functions of biomolecules in living cells can be understood in terms of chemical and physical properties of those molecules”1 – has proved largely successful, teaching “us new knowledge about the biological systems”. Taken together, these two arguments are deemed to provide good grounds for a thorough defence of reductionism. While Elgin chooses biochemistry as his privileged standpoint on the issue, I shall dwell on the stances emerging in the health sciences. Although the health sciences are closely intertwined with – amongst others – biology and biochemistry, they also have their own peculiar features. Referring to some examples taken from different medical disciplines, I will question whether reductionism can be regarded as not only a viable, option, but as the best solution to gain new knowledge about biomedical systems. I shall suggest that considerations arising from current medical research and practice support a pluralistic approach to the topic, in which both reductionist and antireductionist stances can be accommodated in different ways. (shrink)