Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

ExcerptThis paper aims to demonstrate how political study in China contributes to and facilitates debates among Chinese and Western authors by fostering a plural understanding of political science generally, conceptually, and methodologically that goes beyond the simple dichotomization of democracy and authoritarianism. Over the last four decades (1978 to the present), Chinese political study has been shaped by two indigenized schools, among others: historical political study (lishi zhengzhi xue 历史政治学) and fieldwork political study (tianye zhengzhi xue 田野政治学). Some stimulating debates (...) have unfolded in these two narratives by simultaneously reintroducing history and reconceptualizing Chinese politics through straightforward fieldwork. These two indigenized approaches include epistemological, ontological, theoretical, and methodological aspects, and the spontaneous reconstruction of the “Chinese school” rebalances both the “scope conditions” and Chineseness of the discipline. Should these two conceivable branches not be purely descriptive, the question remains whether they represent the future trajectory of Chinese political study or merely a transient occurrence during China’s transitional stage. (shrink)

Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are deleterious for specific environments, but karyotype diversity in a population potentiates adaptive evolution. To reconcile these paradoxical observations, this review distinguishes the role of aneuploidy in cellular versus organismal evolution. (...) Further, it proposes a population genetics perspective to examine the behavior of aneuploidy on a populational versus individual level. By altering the copy number of a significant portion of the genome, aneuploidy introduces large phenotypic leaps that enable small cell populations to explore a wide phenotypic landscape, from which adaptive traits can be selected. The production of chromosome number variation can be further increased by stress‐ or mutation‐induced chromosomal instability, fueling rapid cellular adaptation. (shrink)

本书为一部当代作家系统论述玄学及在玄学理论影响下形成的中国传统文艺思想和美学思想的理论专著。.

本书为一部当代作家系统论述玄学及在玄学理论影响下形成的中国传统文艺思想和美学思想的理论专著。.

本书收录了作者有关美学的论文30篇,前后时间跨越了30多年.这些文章,有的是论述"共同美"的,有的是探讨毛泽东美学思想和中西方审美差异的;还有关于美学基本理论辨析和中国古典美学(特别是玄学美学)思想研 究的;有些文章是有关美育和语文教学美感诱发的(中等学校课堂教学的有关问题);还有一部分,专门研究悲剧的成因,震撼力问题,其中涉及到苏轼,李清照等人的悲剧个案研究.