In 1820, J. Pelletier and J.-B. Caventou, two French pharmacist-chemists working at the Ecole de Pharmacie of Paris, extracted quinine, a new substance, from cinchona bark. We use this example to illustrate the processes which lead from a crude natural product through the isolation of an active principle to the production of a pure manufactured drug. This allows us to discuss the development of chemical analysis in relation to pharmacy, natural history, medicine and the early pharmaceutical industry. The dynamics of (...) the disciplines involved here show how organic chemistry, which was developing rapidly during these crucial years, expanded and became autonomous. Theoretical aspects and practical innovations are relevant to the scientific methods developed by the first generation of those who integrated the new chemistry into their daily work. Beyond these historical issues, this paper aims to show how a holistic approach can contribute to the debate on discovery and invention in a science that is often considered empirical. (shrink)

Science des poisons, la toxicologie est une spécialité pluridisciplinaire dont l’enseignement est dispersé entre médecine, pharmacie et chimie. Les manuels de toxicologie soulèvent des enjeux disciplinaires et éditoriaux. Une première partie montre, à travers une approche sérielle et comparative, comment la publication de manuels constitue un moyen de promouvoir et de revendiquer la reconnaissance institutionnelle d’une discipline aux contours fluctuants. Une deuxième partie présente l’histoire éditoriale du Manuel complet de médecine légale de Briand & Chaudé et les conséquences disciplinaires de (...) l’insertion d’un Traité élémentaire de chimie légale écrit par des pharmaciens-chimistes. (shrink)