BackgroundInnovations in technology have contributed to rapid changes in the way that modern biomedical research is carried out. Researchers are increasingly required to endorse adaptive and flexible approaches to accommodate these innovations and comply with ethical, legal and regulatory requirements. This paper explores how Dynamic Consent may provide solutions to address challenges encountered when researchers invite individuals to participate in research and follow them up over time in a continuously changing environment.MethodsAn interdisciplinary workshop jointly organised by the University of Oxford (...) and the COST Action CHIP ME gathered clinicians, researchers, ethicists, lawyers, research participants and patient representatives to discuss experiences of using Dynamic Consent, and how such use may facilitate the conduct of specific research tasks. The data collected during the workshop were analysed using a content analysis approach.ResultsDynamic Consent can provide practical, sustainable and future-proof solutions to challenges related to participant recruitment, the attainment of informed consent, participant retention and consent management, and may bring economic efficiencies.ConclusionsDynamic Consent offers opportunities for ongoing communication between researchers and research participants that can positively impact research. Dynamic Consent supports inter-sector, cross-border approaches and large scale data-sharing. Whilst it is relatively easy to set up and maintain, its implementation will require that researchers re-consider their relationship with research participants and adopt new procedures. (shrink)

Mobile health applications (‘health apps’) that promise the user to help her with some aspect of her health are very popular: for-profit apps such as MyFitnessPal, Fitbit, or Headspace have tens of millions of users each. For-profit health apps are designed and run as optimization systems. One would expect that these health apps aim to optimize the health of the user, but in reality they aim to optimize user engagement and, in effect, conversion. This is problematic, I argue, because digital (...) health environments that aim to optimize user engagement risk being manipulative. To develop this argument, I first provide a brief analysis of the underlying business models and the resulting designs of the digital environments provided by popular for-profit health apps. In a second step, I present a concept of manipulation that can help analyze digital environments such as health apps. In the last part of the article, I use my concept of manipulation to analyze the manipulative potential of for-profit health apps. Although for-profit health can certainly empower their users, the conditions for empowerment also largely overlap with the conditions for manipulation. As a result, we should be cautious when embracing the empowerment discourse surrounding health apps. An additional aim of this article is to contribute to the rapidly growing literature on digital choice architectures and the ethics of influencing behavior through such choice architectures. I take health apps to be a paradigmatic example of digital choice architectures that give rise to ethical questions, so my analysis of the manipulative potential of health apps can also inform the larger literature on digital choice architectures. (shrink)

The food supply is complicated and consumers are increasingly calling for labeling on food to be more informative. In particular, consumers are asking for the labeling of food derived from genetically modified organisms based on health, safety, and environmental concerns. At issue is whether the labels that are sought would accurately provide the information desired. The present study examined consumer perceptions of health, safety and the environment for foods labeled organic, natural, fat free or low fat, GMO, or non-GMO. Findings (...) indicated that respondents consistently believed that foods labeled GMO are less healthy, safe and environmentally-friendly compared to all other labels. These results suggest that labels mean something to consumers, but that a disconnect may exist between the meaning associated with the label and the scientific consensus for GMO food. These findings may provide insight for the development of labels that provide information that consumers seek. (shrink)

Personalized medicine aims to tailor disease prevention, diagnosis, and treatment to individuals on the basis of their genes, lifestyle and environments. Patient and interest organizations may potentially play an important role in the realization of PM. This paper investigates the views and perspectives on PM of a variety of PIOs. Semi-structured telephone interviews were conducted among leading representatives of 13 PIOs located in Europe and North-America. The data collected were analysed using a conventional content analysis approach. The PIO representatives supported (...) the realization of PM but feared that many financial, structural and organizational challenges may delay its realization. They encouraged strategies to modernize drug licencing mechanisms, develop research and data sharing infrastructures, and educate patients and health care professionals in PM. Notably, they emphasized the importance of developing PM in an equitable way and taking into consideration the patients’ needs, values and personal situation. Despite varying levels of awareness regarding PM, the PIO representatives expressed willingness to engage in the PM agenda and recommended that PIOs work closely with policy-makers to design PM in a way that truly addresses the needs and concerns of patients. PIOs have the potential to become central drivers of the PM agenda. Collaborations should be further developed between PIOs, researchers, drug developers and health care authorities. (shrink)

[1] Man and spirit: the speculative philosophers.--[2] Man and man: the social philosophers.--[3] Man and the state: the political philosophers.--[4] Man and the universe: the philosophers of science.

In this commentary, we ask when rationalization is most likely to occur and to not occur, and about where to expect, and how to measure, its benefits.

Journal of Philosophy of Education, EarlyView.

-- jild-i 2. Hānrī Birgsūn / Sayyid ʻAbd Allāh Anvār ; Zīgmūnd Firūyd / Duktur Maḥmūd Ṣināʻī ; Ālfrid Nūrs̲ Vāythid / Aḥmad Ārām ; Sir Ārtūr Sitānlī Idīngtūn / Muḥammad Ḥusayn Tamaddun ; Sir Jayms Jīnz / Abū Ṭālib Ṣārimī ; Anshtayn / Duktur Jināb.

[1] Man and spirit: the speculative philosophers.--[2] Man and man: the social philosophers.--[3] Man and the state: the political philosophers.--[4] Man and the universe: the philosophers of science.

The 'business judgement rule ' requires corporate directors only to act with honesty and reasonable care in the interest of shareholders. A stronger ' fiduciary ' duty is required where one party requires protection from another. This paper argues that where corporations take risks with the environment, directors are fiduciaries. Stakeholders are in that case the general public, future generations and other species, which have not voluntarily accepted risk and cannot limit liability. Recognition of fiduciary duty in such cases is (...) consistent with recent trends in the law of equity. It would require all economic activities to move from open to closed systems. (shrink)

This chapter explores how Friedrich Nietzsche’s work The Anti-Christ inspired not only an unexpected charitable reading of Jesus’s life and thought in the New Testament, but also an unlikely sense of “holy envy.” The topic of Jesus is very tricky for Jews. The legacy of Christian anti-Judaism provides the hermeneutical lens for how Jews may interpret the life and teachings of Jesus in the New Testament. Incorporating aspects of Jesus’s life and teachings into a Jewish religious way of engaging the (...) world, or even just appreciating them, can be an anathema to classical and many forms of modern Jewish thought. Sax explores the irony and power of how Nietzsche’s Jesus could inspire a contemporary Jewish thinker to admire and connect to the Jesus of the New Testament. (shrink)

Jild-i 1: Muntakhab-i ās̲ār-i: Sant Agūstīn, tarjumah-ʼi Muḥammad Taqī Bahrāmī Ḥarrān; Tūmās Akvīnās, tarjumah-ʼi Manūchihr Buzurgmihr; Bārūkh Ispīnūzā, tarjumah-ʼi Abū Ṭālib Ṣārimī; Bilz Pāskāl, tarjumah-ʼi Ḥusayn Kasmāʼī, va muntakhabātī az: Ūpānīshādhā, Dimāpādā, Sūrāngāmāsūtrā, Bhāgavat Gītāyā tarjumah-ʼi Riz̤ā Ṣaddūqī --.