ABSTRACT There is growing concern about the reuse and exportation of biological materials (human tissues) for use in research worldwide. Most discussions about samples have taken place in developed countries, where genetic manipulation techniques have greatly advanced in recent years. There is very little discussion in developing countries, although collaborative research with institutions from developed countries is on the increase. The study sought to identify and describe ethical issues arising in the storage, reuse and exportation of samples in a developing (...) country. Research protocols presented to two Ethics Review Committees in Kenya during a period of two years were reviewed. A record was made of the protocol title, sample collected, request for storage, reuse or exportation and whether or not subject consent was sought. The findings indicated that about 25% out of the 388 protocols sought permission for reuse and only half of those actually informed subjects of the contemplated re‐use. Less than 20% requested storage and again, about half of them sought consent from subjects. There is an indication that investigators do not see the need to seek consent for storage, reuse and exportation of samples. It is proposed that these issues should be addressed through policy interventions at both the national and global levels. (shrink)

Background. The increased number of clinical trials taking place in developing countries and the complexity of trial protocols mandate that local ethics review committees reviewing them have the capacity to ensure that they are conducted to the highest ethical standards.Methods. The Kenya AIDS Vaccine Initiative Institute of Clinical Research and the Kenyan National Council for Science and Technology embarked on an exercise to enhance the capacity of ERCs in Kenya to review such protocols. This process involved conducting an audit of (...) all ERCs in the country, and performing training needs assessments to identify knowledge and capacity gaps. Information obtained was used to develop training materials for ERC members at workshops conducted in different parts of the country.Results. Five accredited and 13 non-accredited ERCs were identified. Four of the accredited ERCs were located in the capital city of Kenya, Nairobi. The most common challenges cited by participants during the needs assessments were excess workload, and a lack of co-ordination and/or communication between the ERCs. Subsequently, 140 ERC members from 17 institutions across the country were trained as follows: 36 from institutions in the western part of Kenya, 38 from institutions in the south-eastern coastal region, 38 from the eastern region and 44 from Nairobi.Conclusion. The KAVI-ICR and the NCST have developed training modules for training ERC members in Kenya and are in the process of developing a manual to train members. The Kenyan experience may be used to enhance the capacity of ERCs in the East African region. (shrink)

Graham Harman describes the allure of art as the tension and fusion of a real object to sensual qualities so that it makes it seem that the inwardness of reality is opened to us. Yet real objects are withdrawn; how are we aware of their fusion? Since Harman’s ontology mandates that contact between real objects occurs only through sensual objects, this essay explores the idea that art’s allure must be a tension between sensual objects that draw the experiencer to believe, (...) or alieve, they are in contact with the withdrawn real. By looking at the examples in representational painting and sleight of hand magic, we see that ontographic art objects use at least four, carefully separated sensual objects to produce their aesthetic effect. The conclusion summarises allure as a sensual object process, speculates on art’s dialetheic confusion of sensual and real objects giving an enduring allure to idealism, and notes potential motifs of an infra-realist resistance. (shrink)

This paper examines explore the issues of intergenerational equity raised by climate change. A number of different reasons have been suggested as to why current generations may legitimately favor devoting resources to contemporaries rather than to future generations. These - either individually or jointly - challenge the case for combating climate change. In this paper, I distinguish between three different kinds of reason for favoring contemporaries. I argue that none of these arguments is persuasive. My answer in each case appeals (...) to the concept of human rights. It maintains that a human rights-centered perspective to climate change enables us to address each of these reasons. (shrink)

In this paper I use philosophical accounts on the relationship between trust and knowledge in science to apprehend this relationship on the Web. I argue that trust and knowledge are fundamentally entangled in our epistemic practices. Yet despite this fundamental entanglement, we do not trust blindly. Instead we make use of knowledge to rationally place or withdraw trust. We use knowledge about the sources of epistemic content as well as general background knowledge to assess epistemic claims. Hence, although we may (...) have a default to trust, we remain and should remain epistemically vigilant; we look out and need to look out for signs of insincerity and dishonesty in our attempts to know. A fundamental requirement for such vigilance is transparency: in order to critically assess epistemic agents, content and processes, we need to be able to access and address them. On the Web, this request for transparency becomes particularly pressing if (a) trust is placed in unknown human epistemic agents and (b) if it is placed in non-human agents, such as algorithms. I give examples of the entanglement between knowledge and trust on the Web and draw conclusions about the forms of transparency needed in such systems to support epistemically vigilant behaviour, which empowers users to become responsible and accountable knowers. (shrink)

According to the Contingency Theory of Laws, if there are possible worlds in which it is a law that all Fs are G, there are also possible F-containing worlds in which it is not. I argue here that the theory is forced to accept the possibility of nomic inversion: i.e. pairs of properties that have their actual nomic roles swapped in some possible world. Such inversions cannot be ruled out on grounds of logical or metaphysical inconsistency, and therefore – since (...) nomic inversion is counterintuitive – the Contingency Theory is undermined. (shrink)

The task of axiomatizing physical theories has attracted, in recent years, some interest among both empirical scientists and logicians. However, the axiomatizations produced by either one of these two groups seldom appear satisfactory to the members of the other. It is the purpose of this paper to develop an approach that will satisfy the criteria of both, hence permit us to construct axiomatizations that will meet simultaneously the standards and needs of logicians and of empirical scientists.

For each k 1, let Γk be the countable universal homogeneous k-hypergraph. In this paper, we shall classify the closed permutation groups G such that Aut G Sym. In particular, we shall show that there exist only finitely many such groups G for each k 1. We shall also show that each of the associated reducts of Γk is homogeneous with respect to a finite relational language.

The molecular clock hypothesis remains controversial more than a quarter of a century after it was first proposed. A variety of approaches have been applied to testing the molecular clock in mammals. In many of these studies apparent refutation of the molecular clock has based on false assumptions about the pattern of mammalian evolution. With a few exceptions there now appears to be little evidence for variation in the rate of molecular evolution among mammalian lineages, although comparison of more genes (...) and proteins among a greater variety of mammalian orders is needed before a definitive conclusion can be reached on the issue. (shrink)

Unconscious stimuli can influence participants’ motor behavior but also more complex mental processes. Recent research has gradually extended the limits of effects of unconscious stimuli. One field of research where such limits have been proposed is spatial cueing, where exogenous automatic shifts of attention have been distinguished from endogenous controlled processes which govern voluntary shifts of attention. Previous evidence suggests unconscious effects on mechanisms of exogenous shifts of attention. Here, we applied a cue-priming paradigm to a spatial cueing task with (...) arbitrary cues by centrally presenting a masked symmetrical prime before every cue stimulus. We found priming effects on response times in target discrimination tasks with the typical dynamic of cue-priming effects indicating that central symmetrical stimuli which have been associated with endogenous orienting can modulate shifts of spatial attention even when they are masked. Prime–Cue Congruency effects of perceptual dissimilar prime and cue stimuli suggest that these effects cannot be entirely reduced to perceptual repetition priming of cue processing. In addition, priming effects did not differ between participants with good and poor prime recognition performance consistent with the view that unconscious stimulus features have access to processes of endogenous shifts of attention. (shrink)

How can we equalize opportunities while respecting people’s freedom? According to a view that I call libertarian resourcism, people’s fair shares of resources should normally take the form of uncon...

Global policy transfer has become increasingly popular in recent years, and one recent example of such policy transfer is the England–China Teacher Exchange, which was initiated in 2014 with the explicit aim of raising attainment in maths in English primary schools by trialling concepts used in Shanghai schools, Shanghai rising to the top of the PISA rankings in 2009. However, as this paper will argue this is an overly simplistic attempt to transfer a policy between two wholly different contexts, the (...) lack of success of the policy seen in the very limited impact on student attainment in the participating schools. Whilst such policy transfer has increasingly taken place in the context of isomorphism and global pressures to adopt policy from high performing education systems, it is argued that policy needs to be explicitly reconsidered in terms of the local context it is being imported into if it is to be embedded in an effective manner, as well as rooted firmly in research. It is also argued that the England–China Teacher Exchange reflects a broader ideological focus in coalition government policy on the marketisation of education alongside the PISA rankings, rather any wider consideration of how this particular policy would drive up standards. (shrink)

In this article we study how reported speech markers are used as procedural resources in a laboratory based parapsychology experiment to investigate forms of anomalous communication, such as extrasensory perception. In particular, we focus on how specific activities in a key part of the experiment are mediated by the use of `you said' formulations which project that whatever is said next is a paraphrase or a verbatim report of what the recipient had said earlier. We identify two uses of reported (...) speech markers. First, they are used in utterances that initiate some form of repair, such as correction or clarification. Second, they cluster in sequential locations that mark, after a temporary suspension, the resumption of key activities in the experiment. In this we hope to contribute to the study of the institutional properties of reported speech. We conclude by discussing the ways in which broader cultural understandings of the inferential force of `you said' formulations inform their use in this institutional setting, and reflecting on the significance of these findings for parapsychological investigation of anomalous communication in this setting. (shrink)

It is widely believed that science is in the business of finding out what the world is really like. The philosophical version of this belief is scientific realism -- a doctrine about science that tells us that we ought to believe that the best theories in science are true, and that the world is occupied with the objects that those theories contain. If scientific realism was not correct, the argument goes, the incredible success of science would be a miracle. The (...) best explanation for the success of science however, is not that it is a miracle, but that scientific theories are true. This argument is an instance of inference to the best explanation, or IBE. Skeptics have questioned why scientific success must imply its truth given that there are so many abandoned, false scientific theories in the history of science that were nevertheless successful. One of the controversies in the debate between scientific realists and anti-realists surrounds the legitimacy of reasoning in accordance with IBE. Realists need IBE to be a justified and reliable guide to truth. In this compilation thesis, I address various questions related to IBE and scientific realism. Paper 1 argues that scientific realism without IBE loses too much of its epistemic optimism, and that it in some contexts even becomes more pessimistic than the most prominent rival philosophical doctrine about science -- constructive empiricism. To avoid deflating realism, I argue, a defense of IBE is necessary. Paper 2 addresses whether methodological similarities between science and metaphysics force scientific realists to also be realists with respect to metaphysics. If IBE is legitimate, it should not only be valid in science, but also in metaphysics, effectively inflating the ontology that scientific realists are rationally bound to accept. I argue against this conclusion. Paper 3 offers a proof of concept regarding a novel way to justify inferences to unobservable objects. Paper 4 establishes a novel critique of non-probabilistic versions of IBE in scientific realism. (shrink)

Causal queries about singular cases, which inquire whether specific events were causally connected, are prevalent in daily life and important in professional disciplines such as the law, medicine, or engineering. Because causal links cannot be directly observed, singular causation judgments require an assessment of whether a co‐occurrence of two events c and e was causal or simply coincidental. How can this decision be made? Building on previous work by Cheng and Novick (2005) and Stephan and Waldmann (2018), we propose a (...) computational model that combines information about the causal strengths of the potential causes with information about their temporal relations to derive answers to singular causation queries. The relative causal strengths of the potential cause factors are relevant because weak causes are more likely to fail to generate effects than strong causes. But even a strong cause factor does not necessarily need to be causal in a singular case because it could have been preempted by an alternative cause. We here show how information about causal strength and about two different temporal parameters, the potential causes' onset times and their causal latencies, can be formalized and integrated into a computational account of singular causation. Four experiments are presented in which we tested the validity of the model. The results showed that people integrate the different types of information as predicted by the new model. (shrink)

This article explores the ideas on narrative identity of two promi-nent French philosophers, Jean-Paul Sartre and Pierre Bourdieu. Both independently describe what they call the “biographical illu-sion,” the idea that the events of life are not structured in the same way as they are presented in stories such as biographies. Sartre and Bourdieu both argue against a common conception of narrative identity. Interestingly, however, Bourdieu presents his notion in part as a critique of Sartre’s ideas about identity. By investigating their (...) similarities and differences, light is shed on the debate con-cerning criticism of the classical notion of subjectivity in contempo-rary thought. Cet article explore les idées sur l’identité narrative de deux philo-sophes français éminents, Jean-Paul Sartre et Pierre Bourdieu. Tous deux ont décrit indépendamment ce qu’ils appelaient « l’illusion biographique », l’idée que les événements de la vie ne sont pas structurés de la même manière qu’ils sont présentés dans des récits tels que les biographies. Sartre et Bourdieu s’opposent tous deux à une conception courante de l’identité narrative. Cependant, il est intéressant de noter que Bourdieu présente sa notion en partie comme une critique des idées de Sartre sur l’identité. En examinant leurs similitudes et différences, un éclairage est apporté sur le dé-bat concernant la critique de la notion classique de subjectivité dans la pensée contemporaine. (shrink)

This article begins from the premise that, in contemporary conditions of immense cultural, social and ethnic diversity, a just and stable political order must be one in which all citizens are able to enjoy due recognition. In order to determine what form such a politics of recognition must take in practice, the article focuses on the case of Northern Ireland. More specifically, it examines the principle of ‘parity of esteem’ which forms the keystone of the Belfast Agreement of 1998. A (...) detailed examination of this idea is conducted by developing a contrast between it and an alternative principle of ‘due recognition’. It is contended that, despite initial impressions, parity of esteem and due recognition are not direct rivals since they aim to occupy different places in a politics of recognition. To be specific, while the former describes a vertical relationship between state and citizen, the latter depicts a horizontal relationship between citizens themselves. Building on this analysis, it is claimed that this examination of the principle of parity of esteem reveals something interesting and important both about the specific case of Northern Ireland and about the necessary features of a politics of recognition in general. (shrink)