Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Stolz, Ärger, Angst, Neid - das ganze Spektrum der Gefühle wird philosophischen Einzelanalysen unterzogen. Ausgehend von der Alltagserfahrung stehen die gemeinsamen Merkmale und die Differenzen der einzelnen Gefühle im Vordergrund. Dabei wird Bezug genommen auf die Philosophiegeschichte und aktuelle philosophische Kontroversen. Nicht nur Struktur und Gehalt der Gefühle, sondern auch ihre leibliche Erfahrung werden betrachtet. Ein einmaliges Nachschlagewerk für Philosophen und Psychologen.

Johann Gottfried Herder (1744-1803) gilt weithin als Autor des literarischen Sturm und Drang bzw. der philosophischen und theologischen Spataufklarung. Dass er jedoch auf vielen Gebieten die Klassische Deutsche Philosophie massgeblich beeinflusste, wird eher selten in den Blick genommen. Der Band untersucht dieses sowohl kritische als auch affirmative Rezeptionsverhaltnis Kants, Schellings, Schlegels, Humboldts oder Hegels zu Herder auf den Gebieten der Geschichtsphilosophie, der Metaphysik, der Ethik und Politik sowie der Asthetik und Anthropologie. - Mit Beitragen von Andreas Arndt, Manfred Baum, Christoph (...) Binkelmann, Martin Bondeli, Nigel De Souza, Stefan Greif, Andree Hahmann, Cornelia Klinger, Christian Krijnen, Stephan Nachtsheim, Angelica Nuzzo, Ludger Roth, Gideon Stiening, Violetta Stolz und Gunter Zoller. (shrink)

Philosophers of music often appeal to intuition to defend ontological theories of musical works. This practice is worrisome as it is rather unclear just how widely shared are the intuitions that philosophers appeal to. In this paper, I will first offer a brief overview of the debate over the ontology of musical works. I will argue that this debate is driven by a conflict between two seemingly plausible intuitions—the repeatability intuition and the creatability intuition—both of which may be defended on (...) the grounds that they are reflective of our actual musical practices. The problem facing philosophers within this debate is that there is no clear way to determine which of the two conflicting intuitions is more reflective of our musical practices. Finally, I offer discussion of an experimental study that was designed to test participants' intuitions regarding the repeatability of musical works. The evidence presented there suggests that the participants broadly accept the repeatability of musical works, but in a much narrower way than philosophers would likely accept. (shrink)

One of the major developments in cancer research in recent years has been the construction of models that treat cancer as a cellular population subject to natural selection. We expand on this idea, drawing upon multilevel selection theory. Cancer is best understood in our view from a multilevel perspective, as both a by-product of selection at other levels of organization, and as subject to selection at several levels of organization. Cancer is a by-product in two senses. First, cancer cells co-opt (...) signaling pathways that are otherwise adaptive at the organismic level. Second, cancer is also a by-product of features distinctive to the metazoan lineage: cellular plasticity and modularity. Applying the multilevel perspective in this way permits one to explain transitions in complexity and individuality in cancer progression. Our argument is a reply to Germain’s scepticism towards the explanatory relevance of natural selection for cancer. The extent to which cancer fulfills the conditions for being a paradigmatic Darwinian population depends on the scale of analysis, and the details of the purported selective scenario. Taking a multilevel perspective clarifies some of the complexities surrounding how to best understand the relevance of evolutionary thinking in cancer progression. (shrink)

We often know what we are judging, what we are deciding, what problem we are trying to solve. We know not only the contents of our judgements, decidings and tryings; we also know that it is judgement, decision and attempted problem-solving in which we are engaged. How do we know these things?

Visual experience is shaped by a number of factors that are independent of the external objects that we perceive—factors like lighting, angle of view, and the sensitivities of photoreceptors in the retina. This paper seeks to catalog, analyze, and explain the fluctuations in visual phenomenology that are due to such factors.

The most arresting aspect of the Scottish Enlightenment is its conception of commercial society as a distinct and distinctive social formation. Christopher Berry explains why Enlightenment thinkers considered commercial society to be wealthier and freer than earlier forms, and charts the contemporary debates and tensions between Enlightenment thinkers that this idea raised. The book analyses the full range of literature on the subject, from key works like Adam Smith's 'Wealth of Nations', David Hume's 'Essays and Treatises on Several Subjects' (...) and Adam Ferguson's 'Essay on the History of Civil Society' to lesser-known works such as Robert Wallace's 'Dissertation on Numbers of Mankind'. (shrink)

This chapter contains section titled: Feeble Versions Robust Versions The Body View Who's Who? The Soul View The Reincarnation View Is There an Afterlife? Might I Live On?

Explaining Auschwitz and Hiroshima: History Writing and the Second World War, 1945?1990. By R. J. B. Bosworth (London and New York: Routledge, 1993) xv + 260 pps. £40.00 cloth.

Ethics & Behavior, Volume 21, Issue 5, Page 428-430, September-October 2011.

This chapter contains sections titled: Introduction Doubts About Libertarianism Obligations Conclusions References Further reading.

The craftworker is considered to be an exemplar of attention to quality, service to the public, personal satisfaction and the embodiment of tradition. The teacher as craftworker can safely be seen as one of the three archetypes of the teacher described briefly in Chapter 4. Furthermore, it is perhaps the default conception of the teacher in recent philosophical treatments of the nature of teacher's work. This conception is examined and criticised.

Throughout history, war seems to have had an iron grip on humanity. In this short book, internationally renowned philosopher of war, Christopher Coker, challenges the view that war is an idea that we can cash in for an even better one - peace. War, he argues, is central to the human condition; it is part of the evolutionary inheritance which has allowed us to survive and thrive. New technologies and new geopolitical battles may transform the face and purpose of (...) war in the 21st century, but our capacity for war remains undiminished. The inconvenient truth is that we will not see the end of war until it exhausts its own evolutionary possibilities. (shrink)

Anna Vaninskaya's Fantasies of Time and Death: Dunsany, Eddison, Tolkien brings together three major writers of fantasy and studies their treatment of temporality and mortality. This book is about our ongoing conversation regarding time and death and the unique ability for fantasy to tackle these biggest of subjects. If writers have long envisioned time as a river and death as the sea, for instance, what Vaninskaya's new book discusses is how fantasy allows us, through the use of impossible creations and (...) new metaphors, to imagine new ways of understanding our ontological trap. The genre attempts to try to see the world as one of the gods creating it, or to understand time as the eternal burden of the elves; we may... (shrink)

Appealing to reason rather than religious belief, this book is the most comprehensive case against the choice of abortion yet published. This updated edition of The Ethics of Abortion critically evaluates all the major grounds for denying fetal personhood, including the views of those who defend not only abortion but also post-birth abortion. It also provides several (non-theological) justifications for the conclusion that all human beings, including those in utero, should be respected as persons. This book also critiques the view (...) that abortion is not wrong even if the human fetus is a person. The Ethics of Abortion examines hard cases for those who are prolife, such as abortion in cases of rape or in order to save the mother's life, as well as hard cases for defenders of abortion, such as sex selection abortion and the rationale for being "personally opposed" but publically supportive of abortion. It concludes with a discussion of whether artificial wombs might end the abortion debate. Answering the arguments of defenders of abortion, this book provides reasoned justification for the view that all intentional abortions are ethically wrong and that doctors and nurses who object to abortion should not be forced to act against their consciences. Updates and Revisions to the Second Edition include: --A response to Alberto Giubilini's and Francesca Minerva's now famous 2012 article, "After-Birth Abortion" in the Journal of Medical Ethics--Responses to new defenses of Judith Jarvis Thomson's violinist argument--The addition of a new chapter on gradualist views of fetal moral worth, including Jeff McMahan's Time-Relative Interest Account--The addition of a new chapter on the conscience protection for health care workers who are opposed to abortion--Responses to many critiques of the first edition, including those made by Donald Marquis, David DeGrazia, and William E. May. (shrink)

Quentin Skinner has enduringly insisted that a past text cannot be ‘understood’ without the reader knowing something about its historical and linguistic context. But since the 1970s he has been attacked on this central point of all his work by authors maintaining that the text itself is the fundamental guide to the author’s intention, and that a separate study of the context cannot tell the historian anything that the text itself could not. Mark Bevir has spent much of the last (...) 20 years repeating a similar counter-argument. Although ‘study the linguistic context’ might be a useful heuristic maxim, Bevir says, it does not express a necessary or sufficient condition for understanding. But Skinner is right, and one of the figures he has consistently identified as a formative inspiration, R. G. Collingwood, has already (in his work of the 1930s) shown why. What Collingwood calls his ‘logic of question and answer’ explains why the historian cannot answer his characteristic ‘intention’ question about past texts without knowing the context of problems to which authors think they are offering solutions. The study of context is neither ‘prior’ (as Bevir incorrectly supposes) nor ‘separate’ (as Skinner inaccurately says), but it is, as Skinner maintains, nevertheless impossible to grasp an author’s intention without it. This ‘logic of question and answer’ also explains why, in history, dismissing the study of context is in fact a pre-judgement of evidence yet unseen. (shrink)

It is widely believed that many of the competing accounts of scientific explanation have ramifications which are relevant to the scientific realism debate. I claim that the two issues are orthogonal. For definiteness, I consider Cartwright's argument that causal explanations secure belief in theoretical entities. In Section I, van Fraassen's anti-realism is reviewed; I argue that this anti-realism is, prima facie, consistent with a causal account of explanation. Section II reviews Cartwright's arguments. In Section III, it is argued that causal (...) explanations do not license the sort of inferences to theoretical entities that would embarass the anti-realist. Section IV examines the epistemic commitments involved in accepting a causal explanation. Section V presents my conclusions: contra Cartwright, the anti-realist may incorporate a causal account of explanation into his vision of science in an entirely natural way. (shrink)

Oocyte cryopreservation, or ‘egg freezing,’ is the practice of preserving unfertilised oocytes for later fertilisation. This practice allows women to extend their reproductive years. In 2014, Facebook and Apple announced that they would subsidise their female employees’ elective — or ‘social’ — use of egg freezing so that these women can more easily reconcile the demands of career and family life. This announcement engendered controversy and moral debate. Given that social egg freezing is becoming more popular, ethical and empirical analyses (...) are warranted. Here, I utilise content analysis to examine media messages in advertising for SEF. I conclude that many fertility clinics engage in biased advertising — i.e. they advertise the service persuasively, not informatively, emphasising indirect benefits while minimising risks and the low chance of successfully bringing a child to term. As advertising for medical services has been shown to influence the use of those services, advertising for SEF should emphasise clear and easily interpretable statistics about success rate, usage rate, cost, and risk. (shrink)

During the 1940s in America, as medicine became more research-focused, medical researcher heroes were described as devotedly pursuing miraculous medicine. At the same time, Hollywood thrived, and films were an effective means to help build the myth of the physician hero. Cinematic techniques, rather than only the narrative, of four films, Dr. Arrowsmith, The Story of Louis Pasteur, Dr. Ehrlich’s Magic Bullet, and Dr. Jekyll and Mr. Hyde, are discussed to understand how they helped construct the image of the physician (...) hero, both in terms of what they were and what they were not. (shrink)

Many commentators have accused Aquinas of committing either a formal or an informal fallacy in his Third Way argument. I believe it is possible to revise the Third Way argument so as to avoid such errors. I here present a revision of the first part of the Third Way that is (a) immune to the objections most commonly raised against it, (b) consonant with the basic tenets of Thomism, and (c) plausible from a contemporary point of view.

In this article, I highlight systemic oppression related to identity construction and ontological performativity. I introduce the concept of inter-relationality as a discursive tool that builds upon intersectionality, feminist theology, and quantum entanglement theory. For a case study, I recount my experience observing sex-trafficked boys in Thailand in order to demonstrate the analytical model I present. My chief analytical guiding principle in the treatment of the case study is the way masculinity operates to re-enforce oppression. I propose queering masculinity using (...) an inter-relational perspective for the purpose of de-constructing oppressive systems and replacing them with liberative ones. (shrink)

In this article, I will elucidate the Indian government’s two primary discourses concerning yoga since 2014 as right-wing Hindu Nationalist Prime Minister Narendra Modi and his Hindu Nationalist political party, the Bharatiya Janata Party, have interacted with both international and domestic audiences. These discourses can be broadly grouped into two categories, or what I refer to as Modi and the BJP’s “double discourse”: Yoga as a global soft power solution to counter the Global North’s climate change privilege on the international (...) stage and Yoga as biopower for the advancement of India’s depressed economy on the domestic front. Relying on yoga’s polyvalent character, Modi and the BJP are able to frame yoga in these two particular ways—which together signal their commitment to neoliberal economic ideology—by drawing from historical and contemporaneous precedents which I also outline in the article. I conclude with a brief visit to the preparations for the BJP’s 2019 International Day of Yoga, where this double discourse becomes most evident in the two divergent themes announced for the event. (shrink)