In this paper we address the interrelated questions of why and how certain features of an organism’s environment become meaningful to it. We make the case that knowing the biology is essential to understanding the foundation of meaning-making in organisms. We employ Miguel Nicolelis et al’s seminal research on the mammalian somatosensory system to enrich our own concept of brain-objects as the neurobiological intermediary between the environment and the consequent organismic behavior. In the final section, we explain how brain-objects advance (...) the ongoing discussion of what constitutes a biosemiotic system. In general, this paper acknowledges Marcello Barbieri’s call for biology to make room for meaning, and makes a contribution to that end. (shrink)

The strong continuity thesis postulates that the properties of mind are an enriched version of the properties of life, and thus that life and mind differ in degree and not kind. A philosophical problem for this view is the ostensive discontinuity between humans and other animals in virtue of our use of symbols—particularly the presumption that the symbolic nature of human cognition bears no relation to the basic properties of life. In this paper, we make the case that a genuine (...) account of strong continuity requires the identification of some sort of correlate of symbol-use in basic life properties. Our strategy is three-fold: 1) we argue that examples of proto-symbolism in simple living systems would be consistent with an evolutionary trajectory that ultimately produced symbolic cognition in humans; 2) we introduce Gordon Tomkins’ biological notion of ‘symbol’ as something that represents to the organism a feature of its environment that is significant to its survival; and 3) we employ this biological understanding of symbol-use to suggest that the symbolic nature of human cognition can be understood as an enriched version of the basic symbolic properties of life, thus preserving life-mind continuity in this context. (shrink)

This article introduces the symposium “Toward a Philosophy of Blockchain,” which provides a philosophical contemplation of blockchain technology, the digital ledger software underlying cryptocurrencies such as bitcoin, for the secure transfer of money, assets, and information via the Internet without needing a third-party intermediary. The symposium offers philosophical scholarship on a new topic, blockchain technology, from a variety of perspectives. The philosophical themes discussed include mathematical models of reality, signification, and the sociopolitical institutions that structure human life and interaction. The (...) symposium also investigates the metaphilosophical theme of how to create a philosophy of anything, specifically a new topic such as blockchain technology. Repeated themes are identified, in all areas of philosophical inquiry, and conceptual resources are elaborated to contribute to a philosophical understanding of blockchain technology. Thus, philosophy as a metaphilosophical approach is shown to be able to provide an understanding of the conceptual, theoretical, and foundational dimensions of novelty and emergence in the world, with a particular focus on blockchain technology. (shrink)

Philosophers attracted to the republican ideal of freedom as nondomination sometimes offer the thought that a state concerned to promote this ideal would be more committed to economic justice than a liberal state pursuing freedom as noninterference. The republican commitment to economic justice is more demanding and its provisions are more substantial. These philosophers overstate republican redistributive commitments. The state need only provide a basic set of capabilities in order to achieve the republican goal, and concerns about domination in society (...) better support a sufficiency aim in redistributive policy. (shrink)

This research examines the practice of cryonics and provides empirical evidence for an improved understanding of the motivations and attitudes of participants. Cryonics is the freezing of a person who has died of a disease in hopes of restoring life at some future time when a cure may be available. So far, about 300 people have been cryopreserved, and an additional 1200 have enrolled in such programs. The current work has three vectors. First, the results of a worldwide cryonics survey (...) carried out as part of this research are discussed. Second, a theoretical model is developed from the survey results to propose a Theory of Cryonic Life Extension which explains an individual’s decision to select cryopreservation. Third, the most distinctive survey result, a conceptualization of personal identity malleability, is extended with a philosophical formulation. Personal identity is found to be emergent, not fundamental, and thus may continue to evolve in concept and application, particularly in the longer time frames implicated by cryonics. The potential consequences of this work are that the conceptual norms materializing in the cryonics community could be forerunners of wider societal trends of how humans understand themselves as subjects in an era increasingly configured by science and technology. (shrink)

Despite the increasing amount of literature on the legal and political questions triggered by a commitment to liberty of conscience, an explanation of the normative significance of conscience remains elusive. We argue that the few attempts to address this fail to capture the reasons people have to respect the consciences of others. We offer an alternative account that utilizes the resources of the contractualist tradition in moral philosophy to explain why conscience matters.

In addition to recognizing the connection between aesthetic judgment and mindfulness to better understand the continuity between humans and nonhuman animals, a shift of the discussion of the origins of mind to the origins of mindfulness ...

What is artificial life? Much has been said about this interesting collection of efforts to artificially simulate and synthesize lifelike behavior and processes, yet we are far from having a robust philosophical understanding of just what Alifers are doing and why it ought to interest philosophers of science, and philosophers of biology in particular. In this paper, I first provide three introductory examples from the particular subset of artificial life I focus on, known as ‘soft Alife’ (s-Alife), and follow up (...) with a more in-depth review of the Avida program, which serves as my case study of s-Alife. Next, I review three well-known accounts of thought experiments, and then offer my own synthesized account, to make the argument that s-Alife functions as thought experimentation in biology. I draw a comparison between the methodology of the thought-experimental world that yields real-world results, and the s-Alife research that informs our understanding of natural life. I conclude that the insights provided by s-Alife research have the potential to fundamentally alter our understanding of the nature of organic life and thus deserve the attention of both philosophers and natural scientists. (shrink)

The aim of this paper is to explore the development of brain-computer interfacing and cloudminds as possible future scenarios. I describe potential applications such as selling unused brain processing cycles and the blockchaining of personality functions. The possibility of ubiquitous brain-computer interfaces that are continuously connected to the Internet suggests interesting options for our future selves. Questions about what it is to be human; the nature of our current existence and interaction with reality; and how things might be different could (...) become more prominent. I examine speculative future scenarios such as digital selves and cloudmind collaborations. Applications could be adopted in tiers of advancing complexity and risk; starting with health tracking; followed by information seeking and entertainment; and finally; self-actualization. By linking brains to the Internet; BCIs could allow individuals to be more highly connectable not just to communications networks but also to other minds; and thus could enable participation in new kinds of collective applications such as a cloudmind. A cloudmind is the concept of multiple individual minds joined together to pursue a collaborative goal such as problem solving; idea generation; creative expression; or entertainment. The prospect of cloudminds raises questions about individual versus collective personhood. Some of the necessary conditions for individuals to feel comfortable in joining a cloudmind include privacy; security; reversibility; and retention of personal identity. Blockchain technology might be employed to orchestrate the security; automation; coordination; and credit-assignation requirements of cloudmind collaborations. (shrink)

John Hare has proposed “prescriptive realism” in an attempt to stake out a middle-ground position in the twentieth century Anglo-American debates concerning metaethics between substantive moral realists and antirealist-expressivists. The account is supposed to preserve both the normativity and objectivity of moral judgments. Hare defends a version of divine command theory. The proposal succeeds in establishing the middle-ground position Hare intended. However, I argue that prescriptive realism can be strengthened in an interesting way.

Considering the mutual benefits of blockchain and transhumanism, this essay proposes crypto cloudminds as a safe mechanism by which the human mind might transcend its unitary limitations by permissioning partial resources to join a multi-party mind in a cloud-based environment. Cloudminds could have diverse purposes including problem solving, learning, experience, exploration, innovation, artistic expression, and other personal development activities. Crypto cloudminds could be multicurrency, operating with payment remuneration, security, and ideas as the denominations of measure. For thriving in the future, (...) mind node peers could enter “Yes-and” Payment Channels with one another for collaborative idea development. For surviving in the future, good-player behavior could be game-theoretically enforced with the simultaneous privacy-transparency property of blockchains, together with the immutable peer-confirmed consensus algorithm and audit-log checks and balances system. Overall, blockchains might serve as an institutional technology that is the basis for treaties and progress in a multi-species society of human, algorithm, and machine, guiding the way to positive transhuman futures. (shrink)

Linda Zagzebski’s recent account of the role of emotion in the structure of moral judgments aims to reconcile the role of affect in these judgments with moral cognitivism. The account is implausible because it is based on a problematic analysis of what it is to express a moral attitude and because it makes making a moral judgment unduly difficult. I suggest a way to reconcile Zagzebski’s intuitions about moral judgments that does not encounter these two problems.

A good Christian can be a good liberal, and perhaps should be, because liberalism is the political theory most consistent with the biblical mandate concerning the role of the state and its officers. The argument for this is made in terms that any good Christian should find acceptable, and then two policy implications are briefly discussed.

Constructive theories usually have interesting metamathematical properties where explicit witnesses can be extracted from proofs of existential sentences. For relational theories, probably the most natural of these is the existence property, EP, sometimes referred to as the set existence property. This states that whenever ϕϕ is provable, there is a formula χχ such that ϕ∧χϕ∧χ is provable. It has been known since the 80s that EP holds for some intuitionistic set theories and yet fails for IZF. Despite this, it has (...) remained open until now whether EP holds for the most well known constructive set theory, CZF. In this paper we show that EP fails for CZF. (shrink)

This chapter contains sections titled: Rationality and Paradigm Shifts Incommensurable Paradigms and Holism.

We define a class of higher inductive types that can be constructed in the category of sets under the assumptions of Zermelo‐Fraenkel set theory without the axiom of choice or the existence of uncountable regular cardinals. This class includes the example of unordered trees of any arity.

This study focused on the state-level implementation of the Common Core English Language Arts (CC-ELA) standards and the implications for state education department personnel in social studies. Researchers employed a mixed methods approach to data collection and analysis asking the following research questions: (1) How do state-level social studies coordinators understand the obligations and implications of the CC-ELA standards for social studies? and (2) What benefits and challenges do they anticipate the CC-ELA standards offer to social studies educators? Findings from (...) the survey and interviews offer a glimpse into the thinking of social studies coordinators. The findings clustered around four assertions: (1) Coordinators were generally supportive of the CC-ELA standards, (2) CC-ELA is changing the way social studies is enacted at the state level, (3) Coordinators were cautiously optimistic about the impact of CC-ELA on elementary social studies, and (4) Coordinators were consistently positive about the impact of CC-ELA on secondary social studies. The positive views of the CC-ELA standards, however, appeared to do little to mitigate the challenge that the state coordinators face as they translate the standards and teach them to social studies teachers across their states. (shrink)

By using instrumentation initially designed for counting white blood cells, sperm counts have been utilized by clinicians since 1929, particularly to evaluate cases of suspected infertility. Although this basic biological parameter might be assumed to be stable over time, several studies over the past 20 years have suggested a decline in sperm count or density. The most controversial of these analyses was published in 1992. A flood of criticism followed this analysis of 61 studies that found a 50% decline in (...) sperm density between 1938 and 1990. Critics suggested that historical methods (of counting sperm or conducting studies) were variable and unreliable, differing from modern methods both qualitatively and quantitatively. To address this issue we analyzed these studies for trends in counting methods or their variability. We found neither. Alternative analyses produced some differences in trend estimates, but statistical factors alone could not account for the total decline in sperm density. We reviewed study populations to identify trends in population characteristics, such as abstinence time, that might explain the decline. However, controlling analytically for such factors only increased the rate of decline. We conclude that historical data on sperm density, despite large random error, are surprisingly reliable. Nonetheless, understanding causes of temporal and geographic differences in sperm density must await contemporary data. BioEssays 21:614–621, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

The paper investigates different ways to understand the claim that non-cognitivist theories of morality are incoherent. According to the claim, this is so because, on one theory of truth, non-cognitivists are not able to deny objective truth to moral judgments without taking a substantive normative position. I argue that emotivism is not self-defeating in this way. The charge of incoherence actually only amounts to a claim that emotivism is incompatible with deflationary truth, but this claim is based upon a mistake. (...) It relies upon a problematic understanding of both emotivism and the deflationary theory of truth. (shrink)

Clathrin‐mediated endocytosis is a major route for the retrieval of plasma‐membrane cargoes, and defects of this process can cause catastrophic human dysfunctions. However, the processes governing how a clathrin‐coated profile (ccp) is initiated are still murky. Despite an ever‐growing cast of molecules proposed as triggers of ccp nucleation and increasingly sophisticated bioimaging techniques examining clathrin‐mediated endocytosis, it is yet unknown if ccp formation is governed by a universal mechanism. A recent paper by Cocucci et al. has tracked single‐molecule events to (...) identify that stable accumulation of ccps requires the near‐simultaneous arrival of two AP2 adaptors bridged by one clathrin triskelion. This commentary examines the role of AP2 in cargo‐mediated endocytosis in the light of recent advances in biophotonics, chemical inhibitors and genetics, examines the claims of other molecules to be the initiators of ccp formation and proposes future directions in research into this topic.Editor's suggested further reading in BioEssays: The evolution of dynamin to regulate clathrin‐mediated endocytosis AbstractClathrin‐mediated endocytosis: What works for small, also works for big Abstract. (shrink)

The Baptist pastor John Gill believed the doctrine of eternal generation was vital to the Christian faith. While he firmly held to the doctrine of eternal generation, counting it as indispensable for grounding distinctions between the persons within the Godhead, he denied that the divine essence is communicated in generation. Generation, for Gill, entailed only the begetting of persons, and spoke to the ordering and personal relations between the Trinitarian Persons. As the second Person, the Son is from the Father, (...) but as God, he is of himself. This understanding of eternal generation flowed from Gill’s commitment to the aseity of all the divine Persons. According to Gill, each of the divine Persons fully possesses the essence without any communication of essence and without respect to their ordered subsistence. Each person equally, fully, and eternally partakes of the divine essence of himself. Gill’s affirmation of eternal generation was strengthened and elaborated by his understanding of the Son as the divine Word. Gill’s understanding of the Son as the divine Word incorporated the analogy of the mind, which was further understood by other Scriptural images and was further apprehended by the Son’s identification as Wisdom. Gill understood these analogies and names as mutually defining for understanding the nature of the Son of God. The central theological implications of this divine name, namely, the Son’s deity, eternality, and distinct personality, were all based on Gill’s reading of Scripture, most notably in the Gospel of John. (shrink)

This paper utilizes the framework of Karl Popper’s 3-world ontology to make the case that forensic science is a specialized coding system that establishes meaningful connections between the world of biology and the world of human society . Forensic science is a cross-disciplinary endeavor that uses scientific methods to determine what transpired in a crime so the legal system can determine how to prosecute the offender. On a Popperian analysis of forensic science, world 1 consists of evidence gathered at the (...) crime scene, which enables investigators to develop a detailed reconstruction of the incident for consideration under the legal and ethical codes of society, which are products of world 3. Understanding forensic science in this way serves two purposes: first, it extends Marcello Barbieri’s code biology into the realm of philosophical considerations in science, law and ethics; and second, it situates forensic science within the larger context of debates in contemporary philosophy of science. (shrink)

There is a long liberal political tradition of marshalling arguments aimed at convincing Christians that distinctively Christian reasons for issuing coercive laws are not sufficient to justify those laws. In the first part of this paper I argue that the two most popular of these arguments, attributable to Locke, will not reliably convince committed biblical Christians, nor, probably, should they. In the second part I argue that even if the Lockean arguments fail, committed biblical Christians should think that God has (...) authorized the state only to fill the same general role that political liberals have identified for it. (shrink)

Gerald Dworkin’s overlooked defense of legal moralism attempts to undermine the traditional liberal case for a principled distinction between behavior that is immoral and criminal and behavior that is immoral but not criminal. According to Dworkin, his argument for legal moralism “depends upon a plausible idea of what making moral judgments involves.” The idea Dworkin has in mind here is a metaethical principle that many have connected to morality/reasons internalism. I agree with Dworkin that this is a plausible principle, but (...) I argue that some of the best reasons for accepting it actually work against his enforcement thesis. I propose a principled distinction between the immoral-and-criminal and the immoral-but-not-criminal, and argue that a principle at least very much like it must be correct if the metaethical principle Dworkin avows is correct. (shrink)

While most Christians have come to accept that there should be no attempt on the part of the state to coerce strict matters of conscience, many actively support the state coercively interfering with certain modes of conduct that violate God’s moral law. The development of this stance occurred during the seventeenth century English toleration debates. Then, tolerationists argued that there should be toleration for dissenting Protestant denominations, and eventually for Catholics, heretics, and atheists, too. But very few strict biblical Christians, (...) even today, endorse extending legal toleration, for example, to homosexual conduct or same-sex marriage. Two strategies, attributable to Locke, fail to support this asymmetry between religious error and the characteristic types of ‘Christian immorality’. I draw on arguments from the toleration debates to show that the boundaries of legal toleration should be extended to include these violations of divine moral law, and that strict biblical Christians should agree. (shrink)

This chapter contains sections titled: Looking Back Looking Forward Namaste From the Individual to the Universal Yoga in Schools Furthering the Case for Yoga in Schools Specific, Additional Options Worth Considering Conclusion.