The importance of drug‐metabolizing enzymes in developing mammals has been recently reevaluated in view of the activities and potential inducibilities of these enzymes. The role of endogenous factors raises the question of whether there is a positive regulation of the expression of drug‐metabolizing enzymes by hormones. In humans, among the different isoenzymes of cytochrome P‐450 described in adult liver, only one is absent in 20‐week‐old fetuses. Epoxide hydrolase and glutathione S‐transferases are active while UDP‐glucuronidation develops postnatally. The consequence of this (...) asynchronous rise of activities is briefly discussed. (shrink)

"Based on the reading of the only twelfth-century manuscript of the Enigma extant, Charleville MS. 114, and an examination of the fifteenth-century manuscript Uppsala C. 79." Revision of the editor's thesis, Catholic University of America, 1971, presented under title: The enigma fidei of William of Saint Thierry, a translation and commentary. Bibliography: p. 119-120.

Le mot anagogia, « anagogie » serait une mauvaise traduction latine du grec a. L'équivalent latin serait, selon les philologues, sursumductio. D'abord conçue comme un voyage, l'anagogie prendra le sens d'ascension, de montée. Le mot anagogie est plus fréquemment employé pour désigner le quatrième sens de l'Écriture, le terme s'inscrit dans l'histoire de l'exégèse sacrée et plus généralement de l'herméneutique.Les études qui composent cet ouvrage (sur l'obscénité, Alfred Jarry, Georges Bataille, René Daumal, Pierre Klossowski, Maurice Blanchot, Pierre Guyotat, Jean-Noël Vuarnet (...) ou Platon) traitent, de près ou de loin, de cette ascension, souvent entendue ici comme transgression : l'esprit sursoit aux limites de la matière, dont il ne s'émancipe jamais totalement, dans un mouvement vers le sommet (mort, rire divin, « communication », révélation, soleil). (shrink)

Formal topology aims at developing general topology in intuitionistic and predicative mathematics. Many classical results of general topology have been already brought into the realm of constructive mathematics by using formal topology and also new light on basic topological notions was gained with this approach which allows distinction which are not expressible in classical topology. Here we give a systematic exposition of one of the main tools in formal topology: inductive generation. In fact, many formal topologies can be presented in (...) a predicative way by an inductive generation and thus their properties can be proved inductively. We show however that some natural complete Heyting algebra cannot be inductively defined. (shrink)

Thierry Patrice, 57 ans, médecin, nommé professeur à 32 ans, Lauréat de la Faculté, est internationalement connu pour ses travaux concernant l'action de la lumière sur les tissus vivant en cancérologie. Il a reçu plusieurs Prix pour l'étude du rôle de l'oxygène dans différentes maladies, dont le diabète, mais aussi lors du vieillissement.

Presenting a series of historical portraits of Bantu, Thierry Secretan recounts his investigation into the compounds that housed the black labor of the gold mines of the Rand, around Johannesburg. The use of a « pass » to control the black miners prefigured the apartheid system. From 1904 to 1939,Alfred Martin Duggan-Cronin, an Irish guard at one of the compounds, began to photograph the different kind of people doing the hard labor in the mines. The results were some 7200 (...) exposures and working prints, on 13 /18 cm negatives. Hundreds of enlargements were exhibited from 1925 onward in a gallery in his own home in Kimberley. These photographs were rediscovered in 1998 by Thierry Secretan, who is still attempting to save them front slow destruction: they constitute an extraordinary catalogue of the Bantu cultures. (shrink)

Etudier le probleme de la personne, c'est s'interesser a un probleme qui traverse a peu pres tous les domaines de la philosophie, depuis la psychologie jusqu'a la theologie en passant par l'ethique et par le droit, mais dont le denominateur commun est la definition du soi-meme. Etudier ce probleme chez Maimonide, c'est voir comment un philosophe juif du Moyen-Age pouvait elaborer une representation coherente de l'homme en s'appuyant a la fois sur la pensee greco-arabe et sur la tradition hebraique. Ce (...) livre espere contribuer a une meilleure comprehension d'un philosophe dont on a trop souvent fragmente la pensee, apparemment dechiree entre des sources contradictoires. En fait, Maimonide a su developper un dialogue critique entre deux heritages qui demeurent aux fondements de la civilisation occidentale. C'est ce qui donne a sa pensee son caractere eminemment actuel. (shrink)

Valorising the biocultural heritage of common goods could enable peasant farmers to achieve socially and economically inclusive sustainability. Increasingly appreciated by consumers, peasant heritage products offer small farmers promising opportunities for economic, social and territorial development. Identifying the obstacles and levers of this complex, multi-scale and multi-stakeholder objective requires an integrative framework. We applied the panarchy conceptual framework to two cases of participatory research with small quinoa producers: a local fair in Chile and quinoa export production in Bolivia. In both (...) cases, the “commoning” process was crucial both to bring stakeholders together inside their communities and to gain outside recognition for their production and thus achieve social and economic inclusion. Despite the differences in scale, the local fair and the export market shared a similar marketing strategy based on short value chains promoting quality products with high identity value. In these dynamics of biocultural heritage valorisation, the panarchical approach revealed the central place as well as the vulnerability of the community territory. As a place of both anchoring and opening, the community territory is the privileged space where autonomous and consensual control over the governance of common biocultural resources can be exercised. (shrink)

We present a manuscript of Paul Lorenzen that provides a proof of consistency for elementary number theory as an application of the construction of the free countably complete pseudocomplemented semilattice over a preordered set. This manuscript rests in the Oskar-Becker-Nachlass at the Philosophisches Archiv of Universität Konstanz, file OB 5-3b-5. It has probably been written between March and May 1944. We also compare this proof to Gentzen's and Novikov's, and provide a translation of the manuscript.

In this interview, Anne Fagot-Largeault discusses with Thierry Bardini her recollections of the life and work of French philosopher Gilbert Simondon (1924–1989). The discussion covers Simondon’s theory of individuation and considers its influences on contemporary thinkers such as Gilles Deleuze and François Laruelle. Fagot-Largeault situates Simondon’s thinking within the broader context of 20th-century biological research and the development of life sciences. Informed by her personal association and experiences working with Simondon, her reminiscences shed light on the unique character of (...) Simondon as a person and as a thinker. (shrink)

The present paper examines how discursive representations and emotive constructions underpin an argumentative dynamic that emerges from apparently non-argumentative statements, like those found in newspaper headlines. Our data comes from Greek broadsheet newspapers in the polarized context of the Greek crisis. First, we outline an analytic synergy that scrutinizes representational meaning and the semiotization of emotions in headlines. We then move towards the reconstruction of the inferential passage, contained in the headlines, that unites the implicit standpoint with its supporting argument.

L'oeuvre et la pensée de Henry David Thoreau (1817-1862) semblent devoir éternellement se résumer à ses cieux textes les plus célèbres, Walden ou la vie dans les bois et La Désobéissance civile, occultant un parcours riche et complexe. Chantre de la liberté individuelle, engagé activement dans la lutte contre l'esclavage, il ne fut pas cet ermite vivant clans sa cabane retirée au bord d'un lac, dans la forêt, bien qu'il entretînt une relation panthéiste avec la Nature. Inlassable arpenteur de sa (...) région, autour de Concord, en Nouvelle-Angleterre, il vécut de son métier de géomètre qui lui permit de s'adonner à l'observation de la faune et de la flore. Nourri de littérature classique et de philosophie orientale, éternel célibataire aux nombreuses amitiés masculines et féminines, brillant conférencier, il concentre en lui cette indépendance intemporelle et cet appel du Wild qui constituent l'âme de la nation américaine. Au risque d'écorner l'image d'Epinal que s'est faite de lui la postérité, cette biographie se propose de révéler les aspects les moins connus de la vie du grand écrivain, qui tint son Journal pendant un quart de siècle. Loin d'en souffrir, l'image de Thoreau se trouve au contraire rehaussée par cet éclairage nouveau. (shrink)

In the wake of recent attempts at alternate history (Bowler 2013), this paper suggests several avenues for a pluralistic approach to Charles Darwin and his role in the history of evolutionary theory. We examine in what sense Darwin could be described as a major driver of theoretical change in the history of biology. First, this paper examines how Darwin influenced the future of biological science: not merely by stating the fact of evolution or by bringing evidence for it; but by (...) discovering natural selection, and giving it pre-eminence over any other mechanism for evolution; and also by proposing a masterful and quite unique synthesis of many scientific fields. Contrasting Darwin’s views with those of A.R. Wallace, I conclude that “natural selection” is clearly an original contribution, that it had no forerunners or co-discoverers, and could barely have appeared after Darwin conceived of it. This specificity of Darwin’s contribution is an invitation to be strongly presentist (Loison 2016) and to adopt only weak counter-factuals. In contrast, there are possible ways to use strong counter-factuals as attempts to “pluralize” the history of biological theory: i.e. imagine new possible avenues for the development of evolutionary biology. The idea that evolution was a theory “in the air” suggests that evolutionary theory could have developed in a world without Darwin, especially if we accept to delete not only “Darwin” but “England”. France and Germany are examined as possible countries where evolutionary ideas would have thrived even with no contribution from the English scientists. Finally, the paper suggests another counter-factual hypothesis: deleting not Darwin and his Origin but the Darwin Industry itself. This may allow us to read the Origin of Species with fresh eyes and to discover Darwin’s life-long interest in variation and its laws, as many of his early readers did. (shrink)

Thierry Meynard examines how the Jesuits in China came to understand the Confucian tradition, and how they offered the first complete translation of the Lunyu in the West, in the Confucius Sinarum Philosophus.

'The Matrix Project' comprises two contexts, namely photographic work of architect Thierry Lagrange and the self-reflective trajectory that he developed during his doctorate at KULeuven. Lagrange's practice-based research developed to an autonomous artistic project, in which he studied the signification and nature of observation within a creative process. Through his multifaceted practice as an architect, photographer and researcher, Lagrange developed 'The Matrix Method'; a method that stimulates creativity within different contexts and can be implemented for example in art education. (...) For the Matrix Project, 25 years' worth of photographs was entered into a context of research and presents a new perspective on different ways of seeing in our present visual culture. (shrink)

The use of Next Generation Sequencing such as Whole Genome Sequencing is a promising step towards a better understanding and treatment of neurological diseases. WGS can result into unexpected information, and information with uncertain clinical significance. In the context of a Genome Canada project on ‘Personalized Medicine in the Treatment of Epilepsy’, we intended to address these challenges surveying neurologists’ opinions about the type of results that should be returned, and their professional responsibility toward recontacting patients regarding new discovered mutations. (...) Potential participants were contacted through professional organizations or direct invitations. A total of 204 neurologists were recruited. Fifty nine percent indicated that to be conveyed, WGS results should have a demonstrated clinical utility for diagnosis, prognosis or treatment. Yet, 41% deemed appropriate to return results without clinical utility, when they could impact patients’ reproductive decisions, or on patients’ request. Current use of targeted genetic testing and age of patients influenced respondents’ answers. Respondents stated that analysis of genomics data resulting from WGS should be limited to the genes likely to be relevant for the patient’s specific medical condition, so as to limit IFs. Respondents felt responsible to recontact patients and inform them about newly discovered mutations related to the medical condition that triggered the test for as long as they are following up on the patient. Finally, 53.5% of the respondents felt responsible to recontact and inform patients of clinically significant, newly discovered IFs. Our results show the importance of formulating professional guidelines sensitive to the various – and sometimes opposite – viewpoints that may prevail within a same community of practice, as well as flexible so as to be attuned to the characteristics of the neurological conditions that triggered a WGS. (shrink)

This paper assesses the problem of the possible tension between development and environmental protection, especially for developing countries. Some leaders of these countries like Jacob Zuma claim for example that poor countries should only join the fight against climate change if it does not compromise their economic development, thus suggesting that environmental protection is more often than not an obstacle to economic development. I argue that this argument is if not misleading, at least incomplete because it does not take the (...) diversity of environmental protection seriously and reduces development to economic development. In fact, some aspects of environmental protection may clearly clash with some kinds of economic development. In that line, when countries are still very poor, their economic development should take priority over some ecological-friendly policies. But this is only one side of the truth. The other side of the truth is that some ecologically-friendly policies can also make poor countries richer, more democratic and fairer. (shrink)

Les premiers travaux d’histoire du sport sont à peu près contemporains des premières initiatives en faveur d’une histoire des femmes au début des années 1970. Dans ces conditions, le constat d’une antériorité des travaux nord-américains sur l’histoire du sport féminin dans les années 1980 puis, ultérieurement, sur l’histoire du sport et du genre, ne saurait véritablement surprendre, États-Unis et Canada étant en l’occurrence des nations doublement pionnières en matière d’histoire du sport et...

Une analyse de la dimension egoiste de la personnalite de Montaigne, prise dans un sens moral, qui romprait avec la traditionnelle emprise de la sphere publique sur le prive, posant les jalons d'une pensee liberale. Il confronte la pensee du philosophe a celle d'Habermas, d'Arendt, de Derrida et de Rand pour en devoiler l'heritage.

continent. 2.3 (2012): 224–228 Introduction Jamie Allen Thierry Geoffroy’s conceptual, event- and environment-based art practice has generated over two-decades of definitional activity around what he terms “format art.” The works re-galvanize the energies of a syndicatable, open and atmospheric arrangement, of varying specifics dependent on context, participants and environment. With formats like the Emergency Room, Biennalist, and the Critical Run, Geoffroy endeavors to imbricate art and artist in the most exigent and current of social, political and mediatised spectacles. The (...) result seems to plant us at a triangulation of the configurations proposed by Alan Kaprow, Andrea Fraser and Alan Abel. Geoffroy plays up a guileless innocence (at times sporting the “Naive Blue Helmet”) as he interviews spectactors at the 2012 dOCUMENTA13 exhibitions in Kassel, Germany. What he evokes is a declamation of the appropriative, unenthusiastic, cool inclinations of the mainstream art festival, the profligate biennial (triennial, quadrennial, etc.) circuit and national and global ideological cultural-engines. In propositional artifacts, definitional articles and direct transmissions from Geoffroy’s Emergency Room field office at dOCUMENTA13, the masking of an emergency is here questioned: Can an art show like dOCUMENTA be dangerous? —JA Is dOCUMENTA designed to make people cry about something and not make them see something else? Is the contemporary a distraction from the present? Can art in delay have any impact with today? Do we learn anything by seeing art shows reflecting on history? Could 860,000 visitors have been intoxicated by an apathic gaze than keep them away from reacting? Why is dOCUMENTA proud of having recieve no critic? Why is proximity less important? Why was dOCUMENTA in Kabul? Can weapons designed to kill protesters sold to a repressing regime be contradictory to the support of the Arab Spring? Is the contemporary like a flea market to avoid to debating the important topics of today? Can art be in advance of the broken arm, and avoid accident? Is the goal of dOCUMENTA to create a revolution or to entertain? Is dOCUMENTA betterly done than Disney Land? Is it better to watch Fox News for two years or to go to dOCUMENTA for two days? If a curator, curating a contemporary art show about war, forgets to debate about the weapons factories next door, should it be considered as a professional mistake? Is it OK to employ philosophers to promote vodka? Is navigation a threat? Can an art show like dOCUMENTA be dangerous? Thierry Geoffroy / Colonel author of the month Global Art and the Museum @ZKM: " THE NEXT DOCUMENTA SHOULD BE CURATED BY A TANK " Link to Emergency Room Dictionary < /a> "COOLNESS" from the EMERGENCY ROOM DICTIONARY by COLONEL MUSIC Biennalist at dOCUMENTA 13 "TIRED" from the EMERGENCY ROOM DICTIONARY by COLONEL MUSIC Link to " APATHY " (from the Emergency Room Dictionary ) AWARENESS MUSCLE [fr. muscle de la conscience ] In the same sense memory can be trained, an awareness muscle can be developed by an effort. To develop the awareness muscle, the artist has to reduce his gesticulations. When an artist is busy the artist is not very aware the artist is occupied. A daily training is necessary But how to train? Scanning the news in a critical way could be one exercise. Daily debating politics with others could be another. Looking at other point of views usually produces significant improvements. Fighting prejudice is an excellent exercise. Many other forms of training could also produce beneficial effects for the awareness muscle. Continuous and daily training is important. For instance rewinding and slow motioning what has been absorbed getting away the sugar from the propaganda machines talking to everyone excercise comparatif critical run. If not daily trained the awareness muscle can degrade into atrophy To develop the awareness muscle requires will-power Thierry Geoffroy / Colonel. (shrink)

Résumé Quand l’urbanisme naît au tournant du 19 e /20 e siècle, il ne considère pas la ville sans la nature. Certains, comme Ebenezer Howard, pensent que la cité-jardin va devenir le nouveau visage du paysage urbain n’associant que les aspects positifs et de la grande ville et de la campagne… D’autres, hygiénistes et rationalistes, prônent un urbanisme fonctionnel dans lequel « l’espace vert » est constitutif du plan d’ensemble. Ainsi, la nature n’est-elle pas oubliée. Mais de quelle « nature»s’agit-il? (...) Une « nature » extérieure au citadin, comme un ornement ou une une décoration? Une valorisation du cadre bâti et non pas comme la condition même de notre existence d’humain? Ainsi, derrière la prise en compte de la « nature » par les urbanistes trouvons nous des intentions bien différentes, d’une époque à une autre et d’une culture à une autre. La « nature » globalisée, standardisée qui participe dorénavant au marketing urbain, n’est qu’une image, elle n’est plus localisée, cultivée ou encore sauvage, partenaire de notre condition de terrien. Ce sont ces transformations en cours que tente d’examiner Thierry Paquot. (shrink)

Devenir borgne! Difficile de ne pas vivre ce handicap comme un drame. Sans la vision binoculaire et stéréoscopique, le réel semble n'avoir plus d'épaisseur. L'auteur rapporte ce qu'il a éprouvé au cours de sa prise en charge ophtalmologique et interroge en même temps les peintres malvoyants et les philosophes : qu'est-ce que voir? Le handicap visuel permettrait-il de dépasser l'ordinaire de la vision? Pour répondre à ces questions, Monet, Degas, Victor Brauner sont interpellés dans leurs oeuvres ou encore Bruegel et (...) Rembrandt, en même temps que sont convoqués Platon, Descartes, Alain, Merleau-Ponty ou encore James Joyce et William Blake, sans oublier les Évangiles. Les bien-voyants ne se rendent pas compte qu'ils sont condamnés à vivre la tyrannie du réel. Et si les yeux empêchaient de voir en vrai? Le genre humain n'a peut-être pas vocation à voir mais à entrevoir. Dans ces conditions, ne devrait-on pas considérer la malvoyance comme un atout? Ne serait-il pas temps de voir autrement qu'avec les yeux? Peut-être, alors, sentira-t-on la présence de l'Être émerger de la pénombre"--Page 4 of cover. (shrink)

. The effort in providing constructive and predicative meaning to non-constructive modes of reasoning has almost without exception been applied to theories with full classical logic [4]. In this paper we show how to combine unrestricted countable choice, induction on infinite well-founded trees and restricted classical logic in constructively given models. These models are sheaf models over a $\sigma$ -complete Boolean algebra, whose topologies are generated by finite or countable covering relations. By a judicious choice of the Boolean algebra we (...) can directly extract effective content from $\Pi_2^0$ -statements true in the model. All the arguments of the present paper can be formalised in Martin-Löf's constructive type theory with generalised inductive definitions. (shrink)

This study was aimed at explaining how and under what conditions surface similarity leads to the retrieval of an analogous base problem in LTM. Some elements of a theory of the organisation of knowledge in memory are proposed. Two levels of representation are distinguished. The first level represents directly accessible, local surface properties. The second level represents more abstract information pertaining to the category with which each analogous problem can be associated. Some results will be described showing that access to (...) an analogue in LTM based on surface properties is determined by the existence of a similarity at a higher level of abstraction. This is a search-area effect, in that categorical information seems to delimit a memory search space, within which the connection between local surface properties is more likely to be made. (shrink)

ABSTRACT During the first half of the nineteenth century, while Georges Cuvier ruled over natural history and the Muséum d’Histoire Naturelle (MHN) was at its institutional acme, a French banker and industrialist with a Swiss family background, Benjamin Delessert, was developing an important botanical museum in Paris. His private collection included both a rich botanical library and a massive herbarium: the close integration of these two dimensions, together with the magnanimity of Delessert’s patronage, contributed to making this private institution a (...) worthy rival to the powerful and state-funded MHN. Delessert’s museum had the favor of both professional and amateur naturalists. Knowledgeable and dedicated assistants (Antoine Guillemin and Antoine Lasègue) curated the collections. Moreover, Delessert was an intimate friend of the Genevan botanist Augustin-Pyramus de Candolle. Although Delessert’s herbarium followed the Linnaean order, the Delessert Botanical Museum (DBM) contributed to the development of Candolle’s natural system, especially through the publication of costly volumes of engravings, the Icones selectae plantarum rariorum. This essay draws together the main steps in the evolution of Delessert’s collections, stressing the interdependency between books and dried plants. It focuses on the DBM as a case of cooperation between institutional and amateur expertise, private and public collections, and field collectors and cabinet naturalists. (shrink)