Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. The bidirectional mechanisms that are likely to underlie this extensive comorbidity between migraine and other (...) diseases are manifold. Comorbid pathologies can induce and promote thalamocortical network dysexcitability, multi-organ transient or persistent pro-inflammatory state, and disproportionate energetic needs in a variable combination, which in turn may be causative mechanisms of the activation of an ample defensive system with includes the trigeminovascular system in conjunction with the neuroendocrine hypothalamic system. This strategy is designed to maintain brain homeostasis by regulating homeostatic needs, such as normal subcortico-cortical excitability, energy balance, osmoregulation, and emotional response. In this light, the treatment of migraine should always involves a multidisciplinary approach, aimed at identifying and, if necessary, eliminating possible risk and comorbidity factors. (shrink)

Since Bonaventure never wrote a treatise dedicated to the Eucharist, his extensive treatment in the fourth book of his commentary on Peter Lombard's Sentences, which covers many of the topics that would have comprised such a work, stands as his most extensive discussion. In it the Seraphic Doctor considers, among other things, the symbolism of the Eucharist, its connection to the imagery of the Old Testament, the metaphysics of transubstantiation, and the efficacy of the sacrament in the heart of (...) the believer. The result is a treatment that in many ways parallels the doctrine of Thomas Aquinas, yet is distinctively Bonaventurean. This volume presents a translation of this discussion in its entirety, together with the Latin text of the Quaracchi edition. Professor Johnson's introduction situates this text in the larger development of medieval Eucharistic doctrine and comments extensively on the theology of this set of questions. In addition to explaining dense technical and linguistic issues in the text, the notes key the reader to Bonaventure's rich inheritance of material in the Fathers and in earlier medieval theologians. (shrink)

Prologue 1. To begin with, the first principle from Whom all illumination descends as from the Father of Light, by Whom are given all the best and perfect gifts, the eternal Father do I call upon through His Son, our Lord Jesus Christ, that by the intercession of the most holy Virgin Mary, mother of God Himself and of our Lord, Jesus Christ, and of the blessed Francis, our father and leader, He may enlighten the eyes of our mind to (...) guide our feet into the way of that peace "which surpasses all understanding", which peace our Lord Jesus Christ has announced and given to us; which lesson our father Francis always taught, in all of whose preaching was the annunciation of peace both in the beginning and in the end, wishing for peace in every greeting, yearning for ecstatic peace in every moment of contemplation, as a citizen of that Jerusalem of which that man of peace said, with those that hated peace he was peaceable, "Pray ye for the things that are for the peace of Jerusalem". For he knew that the throne of Solomon was nowise save in peace, since it is written, "His place is in peace and His abode in Sion". 2. Since, then, following the example of the most blessed father Francis, I breathlessly sought this peace, I, a sinner, who have succeeded to the place of that most blessed father after his death, the seventh Minister General of the brothers, though in all ways unworthy--it happened that by the divine will in the thirty-third year after the death of that blessed man I ascended to Mount Alverna as to a quiet place, with the desire of seeking spiritual peace; and staying there, while I meditated on the ascent of the mind to God, amongst other things there occurred that miracle which happened in the same place to the blessed Francis himself, the vision namely of the winged Seraph in the likeness of the Crucified. While looking upon this vision, I immediately saw that it signified the suspension of our father himself in contemplation and the way by which he came to it. 3. For by those six wings are rightly to be understood the six stages of illumination by which the soul, as if by steps or progressive movements, was disposed to pass into peace by ecstatic elevations of Christian wisdom. The way, however, is only through the most burning love of the Crucified, Who so transformed Paul, "caught up into the third heaven", into Christ, that he said, "With Christ I am nailed to the cross, yet I live, now not I, but Christ liveth in me" ; who therefore so absorbed the mind of Francis that his soul was manifest in his flesh and he bore the most holy stigmata of the Passion in his body for two years before his death. Therefore the symbol of the six-winged Seraph signifies the six stages of illumination, which begin with God's creatures and lead up to God, to Whom no one can enter properly save through the Crucified. For he who does not enter by the door but otherwise, he is a thief and a robber. But if anyone does enter by this door, he shall go in and go out and shall find pastures. Because of this John says in his Apocalypse, "Blessed are they that wash their robes in the blood of the Lamb, that they may have a right to the Tree of Life and may enter in by the gates into the City"; as if he were to say that one cannot enter into the heavenly Jerusalem through contemplation unless one enter through the blood of the Lamb as through a gate. (shrink)

The Hackett edition of this classic of medieval philosophy and mysticism--a plan of pilgrimage for the learned Franciscan wishing to reach the apex of the mystical experience--combines the highly regarded Boehner translation with a new introduction by Stephen Brown focusing on St. Francis as a model of the contemplative life, the meaning of the Itinerarium, its place in Bonaventure’s mystical theology, and the plan of the work. Boehner’s Latin Notes, as well as Latin texts from other works of (...) class='Hi'>Bonaventure included in the Franciscan Institute Edition, are rendered here in English, making this the edition of choice for the beginning student. (shrink)

In Wisdom and Initiation in Gabon, Bonaventure Mvé Ondo argues that Fang tales, myths, and legends are components of the foundation of a worldview that sustains and protects a unique, historical Fang identity. The lessons transmitted from generation to generation by these marvelous stories are, Mvé Ondo argues, central to living lives that reflect and perpetuate the eternal truths of the Fang experience.

Le mode de penser constitue depuis des siècles le critère principal qui permet de spécifier une culture, une civilisation, et donc de la distinguer des autres. Une telle logique a conduit tout d'abord à établir des hiérarchies entre elles. Il s'ensuivit un développement sans précédent des cristallisations identitaires et des conflits de tous ordres, qui naissent le plus souvent de la peur et de l'ignorance. En proposant un cadre théorique dans lequel le logocentrisme occidental et l'onto-mythologie africaine peuvent se rencontrer, (...) et même en établissant la conjonction du logos et du muthos, le philosophe Bonaventure Mve Ondo explore ici une voie originale qui permet de sortir des radicalismes actuels, et ouvre au nécessaire dialogue fondateur que préconisaient Léoplod Sédar Senghor et Aimé Césaire. La thèse de Bonaventure Mve Ondo soutenue il y a trente ans et enfin publiée, s'avère aujourd'hui plus prospective que jamais. (shrink)

This paper examines the dynamics between scientific reason and cultural diversity by: a) analyzing the epistemic structure of 'universalism' as conceived by science, both theoretically and through its historical determination; and b) focusing on the situation of science in Africa, presenting its limits and challenges. It calls for a coconstruction of science at an international scale, which represents a key factor of development and cultural transmission, in particular, transmission of scientific scholarship.

This work provides the means for re-establishing the unity of science by interpreting the whole of modern experimental science from the perspective of analogous transfer of the metaphysical principle of unity rather than in terms of efficient causality.

This paper examines the dynamics between scientific reason and cultural diversity by: a) analyzing the epistemic structure of 'universalism' as conceived by science, both theoretically and through its historical determination; and b) focusing on the situation of science in Africa, presenting its limits and challenges. It calls for a coconstruction of science at an international scale, which represents a key factor of development and cultural transmission, in particular, transmission of scientific scholarship.

This paper outlines an account of conditionals, the evidential account, which rests on the idea that a conditional is true just in case its antecedent supports its consequent. As we will show, the evidential account exhibits some distinctive logical features that deserve careful consideration. On the one hand, it departs from the material reading of ‘if then’ exactly in the way we would like it to depart from that reading. On the other, it significantly differs from the non-material accounts which (...) hinge on the Ramsey Test, advocated by Adams, Stalnaker, Lewis, and others. (shrink)

This paper develops a probabilistic analysis of conditionals which hinges on a quantitative measure of evidential support. In order to spell out the interpreta- tion of ‘if’ suggested, we will compare it with two more familiar interpretations, the suppositional interpretation and the strict interpretation, within a formal framework which rests on fairly uncontroversial assumptions. As it will emerge, each of the three interpretations considered exhibits specific logical features that deserve separate consideration.

Epistemologists and philosophers of science have often attempted to express formally the impact of a piece of evidence on the credibility of a hypothesis. In this paper we will focus on the Bayesian approach to evidential support. We will propose a new formal treatment of the notion of degree of confirmation and we will argue that it overcomes some limitations of the currently available approaches on two grounds: (i) a theoretical analysis of the confirmation relation seen as an extension of (...) logical deduction and (ii) an empirical comparison of competing measures in an experimental inquiry concerning inductive reasoning in a probabilistic setting. (shrink)

This paper investigates the logic of reasons. Its aim is to provide an analysis of the sentences of the form ‘p is a reason for q’ that yields a coherent account of their logical properties. The idea that we will develop is that ‘p is a reason for q’ is acceptable just in case a suitably defined relation of incompatibility obtains between p and ¬q. As we will suggest, a theory of reasons based on this idea can solve three challenging (...) puzzles that concern, respectively, contraposing reasons, conflicting reasons, and supererogatory reasons, and opens a new perspective on some classical issues concerning non-deductive inferences. (shrink)

According to the view of conditionals named 'inferentialism', a conditional holds when its consequent can be inferred from its antecedent. This paper identifies some major challenges that inferentialism has to face, and uses them to assess three accounts of conditionals: one is the classical strict account, the other two have recently been proposed by Douven and Rott. As will be shown, none of the three proposals meets all challenges in a fully satisfactory way. We argue through novel formal results that (...) a variation of the evidential account of conditionals suggested by Crupi and Iacona is the most promising candidate to develop inferentialism in a coherent formal framework. (shrink)

Several initiatives by the Government of Uganda, Research Institutes and CGIAR centers have promoted the use of tissue culture banana technology as an effective means of providing clean planting material to reduce the spread of Banana Xanthomonas wilt but its uptake is still low. We examine factors that constrain uptake of tissue culture banana planting materials in central Uganda by considering the cultural context of banana cultivation. Data were collected using eight focus group discussions involving 64 banana farmers and 10 (...) key informant interviews and subjected to thematic analysis. Results showed that banana cultivars in the study communities were important for food, cultural practices and medicine. Cultivars supplied through TC were based on commercial considerations focusing on market value and household income and insufficient attention was given to their cultural importance. Farmers regard banana from TC planting material to be incompatible with their tastes and preferences for traditional food and drinks, culture and medicine. Furthermore, the plantlets are perceived as complicated to use, and farmers report requiring more knowledge and information on how to plant and maintain the plantlets on-farm. In these aspects, TC planting material does not align with cultural values linked to societal welfare. Future efforts aimed at controlling pests and diseases would benefit from more location-specific and holistic approaches that integrate cultural dimensions alongside planting material hygiene, quality and vigor. (shrink)

This paper develops a formal theory of non-monotonic consequence which differs from most extant theories in that it assumes Contraposition as a basic principle of defeasible reasoning. We define a minimal logic that combines Contraposition with three uncontroversial inference rules, and we prove some key results that characterize this logic and its possible extensions.