Wana Manitpisitkul1, Sabrina Lee2, Matthew Cooper31Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD, USA; 2Solid Organ Transplant Program, University of Utah Health Care, Salt Lake City, UT, USA; 3Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA: Addition of mycophenolate mofetil to calcineurin-based immunosuppressive therapy has led to a significant improvement in graft survival and reduction of acute rejection in renal transplant recipients. However, in clinical practice, MMF dose reduction, interruption, or discontinuation due to hematological (...) and gastrointestinal side-effects occurred in up to 50% of the patients. Large retrospective analyses have demonstrated that patients requiring MMF dose manipulation due to adverse events experienced a higher rate of rejection and graft loss. Enteric-coated mycophenolate sodium was developed with the goal of improving upper GI side-effects. Here, we review the efficacy and safety of EC-MPS in de novo kidney transplant recipient, and in stable renal transplant patients who were converted from MMF. The changes in GI-related adverse events using patient-reported outcome instruments are also reviewed.Keywords: enteric-coated mycophenolate sodium, mycophenolate mofetil, kidney transplant, efficacy, gastrointestinal tolerability. (shrink)

Comparative Political Theory and Cross-Cultural Philosophy explores new forms of philosophizing in the age of globalization by challenging the conventional border between the East and the West, as well as the traditional boundaries among different academic disciplines. This rich investigation demonstrates the importance of cross-cultural thinking in our reading of philosophical texts and explores how cross-cultural thinking transforms our understanding of the traditional philosophical paradigm.

I argue that supervenience is an inadequate device for representing relations between different levels of phenomena. I then provide six criteria that emergent phenomena seem to satisfy. Using examples drawn from macroscopic physics, I suggest that such emergent features may well be quite common in the physical realm.

We present work demonstrating that the nature of an object for our visual system depends on the actions we are programming and on the presence of action relations between stimuli. For example, patients who show visual extinction are more likely to become aware of two objects if the objects fall in appropriate visual locations for a common action. This effect of the action relations between objects is modulated both by the familiarity of the positioning of the objects for action, and (...) by the mere possibility of action (the ‘affordance’) between the objects. In addition, the programming of an action to a part of an object alters the representation of that object, making the ‘part’ into the object selected by the visual system. These results point to object coding being a rather flexible process, affected not only by the perceptual properties of stimuli but also by the relations between these properties and action. We discuss the implications for theories of perception as well as considering why action information, in particular, may be important for perception. (shrink)

Category-specific impairments of object recognition and naming are among the most intriguing disorders in neuropsychology, affecting the retrieval of knowledge about either living or nonliving things. They can give us insight into the nature of our representations of objects: Have we evolved different neural systems for recognizing different categories of object? What kinds of knowledge are important for recognizing particular objects? How does visual similarity within a category influence object recognition and representation? What is the nature of our semantic knowledge (...) about different objects? We review the evidence on category-specific impairments, arguing that deficits even for one class of object cannot be accounted for in terms of a single information processing disorder across all patients; problems arise at contrasting loci in different patients. The same apparent pattern of impairment can be produced by damage to different loci. According to a new processing framework for object recognition and naming, the hierarchical interactive theory, we have a hierarchy of highly interactive stored representations. HIT explains the variety of patients in terms of lesions at different levels of processing and different forms of stored knowledge used both for particular tasks and for particular categories of object. Key Words: category-specific deficits; functional imaging; hierarchical models; interactive activation models; neuropsychology; object recognition; perceptual and functional knowledge. (shrink)

The elements of structural models used in the social sciences are built up from four fundamental assumptions. It is then shown how the central idea of qualitative probabilistic causality follows as a special case of this covariational account. The relationships of both instrumentalism and common cause arguments for scientific realism to these structures is demonstrated. It is concluded that a predictivist argument against a thoroughgoing instrumentalism can be given, and hence why the difference between experimental and non-experimental contexts is important (...) to arguments for scientific realism. (shrink)

This paper complicates, extends, and modifies Pinch and Bijker's original social construction of technology, specifically their concepts of relevant social groups, closure, and stabilization, in order to gain insight into long-term processes of how we use and understand technology. First, this paper identifies four broad categories of relevant social groups in the social construction of technology based on stake holdings and compares them according to their activities, resources, and directionality. Second, the paper discusses the distinctions between closure and stabilization of (...) technological artifacts, introducing temporary closure and structural flexibility as a means of understanding how different technologies can relate to each other. Third, using Rosch's cognitive approach to categorization, the paper suggests structural flexibility as a means of operationalizing stabilization. These reconceptualizations offer researchers a broader scale with which to understand the social construction of technology. (shrink)

We investigate the performance and risk of Socially Responsible Investment (SRI) equity funds in the Australian market and find no significant difference between the returns of SRI and conventional funds. In an extension to prior literature, we examine the impact of the number of positive, negative and total screens funds impose on performance and risk. We find little evidence of positive or negative screening impacting total return, but find weak evidence that funds with more screens overall provide better risk-adjusted performance. (...) Positive screening significantly reduces funds’ risk. However, negative screening significantly increases risk and reduces funds’ abilities to form diversified portfolios. (shrink)

Consciousness is, perhaps, the aspect of our mental lives that is the most perplexing for both psychologists and philosophers. Daniel Dennett has described it as 'both the most obvious and the most mysterious feature of our minds' and attempts at definition often seem to move in circles. Thomas Nagel famously remarked that 'without consciousness the mind-body problem would be much less interesting. With consciousness it seems hopeless.' These observations might suggest that consciousness - indefinable and mysterious - falls outside the (...) scope of rational enquiry, defying both scientific and philosophical investigation. In reality, however, the topic has been a focus of psychological investigation since William James and is increasingly vital in philosophical research. This book illustrates the various, interdisciplinary approaches to the problem, providing both pointers to a solution and a summary of the key positions. (shrink)

We discuss the difficulty of measuring the perceptual experience of colour, supporting Palmer's assertion that neuropsychological disorders of colour processing can be informative in this respect. We point out that some disorders seem to affect the perceptual experience of colour over and above the perceptual processing of colour, providing direct insights into the neural mechanisms supporting perceptual experience.

An introductory level text designed to explain and review basic ideas concerning the role of law in society. Assuming no previous knowledge of the field, the volume examines the theoretical and empirical dimensions of law in society from political, sociological, psychological and philosophical perspectives.

An efficient representation of the environment requires both the selection of a fraction of the information that reaches our senses and the organization of this information into coherent and meaningful elements. Here we discuss the dynamic interplay between selective attention and perceptual organization, important processes that allow us to perceive a seamless, integrated world. Based on evidence from behavioral and neuroimaging studies with normal observers and neuropsychological patients, we examine whether: perceptual grouping constrains visual attention, determining which objects will be (...) selected and be candidates for explicit report; visual attention modulates perceptual grouping, determining how elements are grouped to form meaningful wholes. The data suggest that, whilst not being necessary for at least some forms of perceptual grouping, visual attention can nevertheless modulate grouping. We conclude that selection is dynamically set by bottom-up stimulus factors, top-down knowledge and the allocation of attention to space and within grouped regions of objects. (shrink)

John Hales. A Tolerant Man Living in an Intolerant Age This article focuses upon the seventeenth-century English philosophical theologian, John Hales, who is all too often overlooked or forgotten at the present time. The thought of Hales on the relation of human reason to God’s revelation in Holy Scripture is shown to be remarkably modern in many ways. The article also concludes that Hales’s “Middle Way” of thinking and acting continues to be relevant to Christian churches throughout the world torn (...) as they presently are with discord and dissention. (shrink)

This study examines how ambiguity in corporate objectives affects managers’ choice between opposing sustainability and short-term profit goals. We test this question with an experiment in which we vary whether environmental sustainability is included explicitly as a strategic objective that is used for managers’ performance evaluations. Findings show that managers increase biodegradable production and correspondingly decrease short-term profit when environmental sustainability performance is explicitly incorporated within the company’s strategic objectives. Also, managers in the implicit incorporation group are more likely to (...) decrease their biodegradable production when they learn that their counterparts within the firm have chosen to decrease biodegradable production in other product lines. Further, managers in the explicit incorporation group have greater trust in senior management, and that trust mediates the negative relationship between incorporation ambiguity and the level of biodegradable production. The theoretical and practical implications of this study are discussed. (shrink)

We summarise and respond to the main points made by the commentators on our target article, which concern: whether structural similarity can play a causal role in normal object identification and in neuropsychological deficits for living things, the nature of our structural knowledge of the world, the relations between sensory and functional knowledge of objects, and the nature of our functional knowledge about living things, whether we need to posit a “core” semantic system, arguments that can be marshalled from evidence (...) on functional imaging, the causal mechanisms by which category differences can emerge in object representations, and the nature of our knowledge about categories other than living and nonliving things. We also highlight points raised in our article that seem to be accepted. (shrink)

This introduction to the Journal of Business Research special issue on anti-consumption briefly defines and highlights the importance of anticonsumption research, provides an overview of the latest studies in the area, and suggests an agenda for future research on anti-consumption.

There are two main paradigms for brain-related science, with different implications for brain-focused intervention or advancement. The paradigm of homeostasis (“stability through constancy,” Walter Cannon), originating from laboratory-based experimental physiology pioneered by Claude Bernard, shows that living systems tend to maintain system functionality in the direction of constancy (or similitude). The aim of physiology is elucidate the factors that maintain homeostasis, and therapeutics aim to correct abnormal factor functions. The homeostasis paradigm does not formally recognize influences outside its controlled experimental (...) frames and it is variable in its modelling of neural contributions. The paradigm of allostatic orchestration (PAO) extends the principle of allostasis (“stability through change”) as originally put forth by Peter Sterling. The PAO originates from an evolutionary perspective and recognizes that biological set points change in anticipation of changing environments. The brain is the organ of central command, orchestrating cross-system operations to support optimal behavior at the level of the whole organism. Alternative views of blood pressure regulation and posttraumatic stress disorder illustrate differences between the paradigms. For the PAO, complexities of top-down neural effects and environmental context are foundational (not to be “factored out”), and anticipatory regulation is the principle of their interface. The allostatic state represents the integrated totality of brain-body interactions. Health itself is an allostatic state of optimal anticipatory oscillation, hypothesized to relate to the state of criticality, a mathematical point of poise between phases, on the border between order and disorder (or the “edge of chaos”). Diseases are allostatic states of impaired anticipatory oscillations, demonstrated as rigidifications of set points across the brain and body (disease comorbidity). Conciliation of the paradigms is possible, with “reactive homeostasis” resolved as an illusion stemming from anticipation of environmental monotony. Considerations are presented with respect to implications of the two paradigms for brain-focused intervention or advancement; the hypothesis that the state of criticality is a vehicle for evolutionary processes; concordance with a philosophy of freedom based on ethical individualism as well as self-creativity, non-obsolescence, empowerment, and citizenship; and concluding reflections on the science and ethics of the placebo, and the potential for virtuous cycles of brain-Anthropocene interactions. (shrink)

A broad evolutionary perspective is essential to fully reverse figure and ground in the rationality debate. Humans' evolved psychological architecture was designed to produce inferences that were adaptive, not normatively logical. This perspective points to several predictable sources of errors in modern laboratory reasoning tasks, including inherent, systematic biases in information-processing systems explained by Error Management Theory.

The most perplexing aspect of Galileo's work in physics is without doubt the sharp distinction one can draw between his essentially dynamic studies in such juvenilia as De Motu and the consciously kinematical approach of his later output—particularly the Two New Sciences. Whether one chooses to call this a shift from the “why” of motion to the “how”, or, as I should prefer, a shift from dynamics to kinematics, there can be no denying its existence. The Galileo who wrote that (...) “The present does not seem to be the proper time to investigate the cause of the acceleration of natural motion …” is, on the face of it, a very different man from the one who had earlier written almost an entire treatise on precisely this topic. (shrink)

James K. A. Smith’s Awaiting the King is the most effective popularization of Augustine’s political thought currently available, but its reliance on the work of Oliver O’Donovan obscures uncomfortable elements of Augustine’s thought, and it does not adequately address how the racial and socioeconomic composition of Christian communities is itself formative.