Despite claims from prominent scientists that SARS‐CoV‐2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy‐makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual‐use gain‐of‐function research practice of viral (...) serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS‐CoV‐2's distinctive spike‐protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re‐examination of the risks and rewards of dual‐use gain‐of‐function research. (shrink)

The structures of everyday life, where religious identity is constructed, are analysed in the article of Boreyko Yuri Grigorovich «The structures of everyday life in the design of religious identity». Determined that the basis of personal and group religious identity are mental structures, symbolic actions, rituals, language.

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

in D. Dieks (ed.), The Ontology of Spacetime, Vol. 2. Elsevier, forthcoming.

Yuri Balashov sets out major rival views of persistence--endurance, perdurance, and exdurance--in a spacetime framework and proceeds to investigate the implications of Einstein's theory of relativity for the debate about persistence. His overall conclusion--that relativistic considerations favour four-dimensionalism over three-dimensionalism--is hardly surprising. It is, however, anything but trivial. Contrary to a common misconception, there is no straightforward argument from relativity to four-dimensionalism. The issues involved are complex, and the debate is closely entangled with a number of other philosophical disputes, including (...) those about the nature and ontology of time, parts and wholes, material constitution, causation and properties, and vagueness. (shrink)

This commentary suggests that the ongoing malaise of biomedical research results from adopting a doctrine that is incompatible with the principles of creative scientific discovery and thus should be treated as a mental rather than somatic disorder. I overview the progression of the malaise, outline the doctrine and the history of its marriage to science, formulate the diagnosis, justify it by reviewing the symptoms of the malaise, and suggest how to begin to cure the disease.

Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

The chapter "Attracting the People" ("Lai min") of The Book of Lord Shang (Shangjun shu) was composed ca. 255-251 B.C.E. At that point, the Qin leaders were frustrated: despite a series of military victories, Qin was still unable to subjugate its eastern neighbors. The chapter's author suggests that to attain final success, Qin must shift its attention from the battlefield to a demographic balance of power with its rivals. To attract immigrants from the overpopulated states of Han and Wei, Qin (...) should abandon its rigid policies of turning every subject into a tiller-cum-soldier. Instead, the immigrants should be exempted from military service and granted economic privileges. In marked contrast to the rest of The Book of Lord Shang, the author of "Attracting the People" advocates dividing the population into tillers and soldiers. The new awareness of the economic and demographic costs of warfare reflects changes in Qin's military situation after a century of robust expansion and on the eve of its final drive toward the unification of "All-under-Heaven." -/- . (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

Knowledge-how often appears to be more difficult to transmit by testimony than knowledge-that and knowledge-wh. Some philosophers have argued that this difference provides us with an important objection to intellectualism—the view that knowledge-how is a species of knowledge-that. This article defends intellectualism against these testimony-based objections.

This ambitious book looks into the reasons for the exceptional durability of the Chinese empire, which lasted for more than two millennia (221 B.C.E. - 1911 C.E.). Yuri Pines identifies the roots of the empire's longevity in the activities of thinkers of the Warring States period (453-221 B.C.E.), who, in their search for solutions to an ongoing political crisis, developed ideals, values, and perceptions that would become essential for the future imperial polity. In marked distinction to similar empires worldwide, the (...) Chinese empire was envisioned and to a certain extent 'preplanned' long before it came into being. As a result, it was not only a military and administrative construct, but also an intellectual one. Pines makes the argument that it was precisely its ideological appeal that allowed the survival and regeneration of the empire after repeated periods of turmoil. "Envisioning Eternal Empire" presents a panoptic survey of philosophical and social conflicts in Warring States political culture. By examining the extant corpus of preimperial literature, including transmitted texts and manuscripts uncovered at archaeological sites, Pines locates the common ideas of competing thinkers that underlie their ideological controversies. This bold approach allows him to transcend the once fashionable perspective of competing 'schools of thought' and show that beneath the immense pluralism of Warring States thought one may identify common ideological choices that eventually shaped traditional Chinese political culture. The result is a refreshingly novel look at the foundational period in Chinese intellectual history. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

This article discusses the chapter “Objection to Positional Power” (Nan shi 難勢) of Han Feizi 韓非子. It provides a full translation cum analysis of the text and explores systematically the chapter’s structure, rhetoric, and its political message. The discussion, which contextualizes the chapter’s message within broader trends of the Warring States-period political debates, demonstrates that beneath the surface of debates about “positional power” (shi 勢) versus “worth” (xian 賢), the chapter addresses one of the touchiest issues in Chinese political thought: (...) that of the intrinsic weakness of hereditary monarchy. Furthermore, “Objection to Positional Power” also addresses problems of the meritocratic system of rule and elucidates some of the reasons for Han Fei’s dislike of meritocratic discourse. By highlighting some of the chapter’s intellectual gems I hope to attract further attention to the immense richness of Han Feizi as one of the most sophisticated products of China’s political thought. (shrink)

This chapter explores the relationship between knowing-how and skill, as well other success-in-action notions like dispositions and abilities. I offer a new view of knowledge-how which combines elements of both intellectualism and Ryleanism. According to this view, knowing how to perform an action is both a kind of knowing-that (in accord with intellectualism) and a complex multi-track dispositional state (in accord with Ryle’s view of knowing-how). I argue that this new view—what I call practical attitude intellectualism—offers an attractive set of (...) solutions to various puzzles concerning the connections between knowing-how and abilities and skills to perform intentional actions. (shrink)

I examine the issue of persistence over time in the context of the special theory of relativity (SR). The four-dimensional ontology of perduring objects is clearly favored by SR. But it is a different question if and to what extent this ontology is required, and the rival endurantist ontology ruled out, by this theory. In addressing this question, I take the essential idea of endurantism, that objects are wholly present at single moments of time, and argue that it commits one (...) to unacceptable conclusions regarding coexistence, in the context of SR. I then propose and discuss a plausible account of coexistence for perduring objects, which is free of these defects. This leaves the endurantist room for some maneuvers. I consider them and show that they do not really help the endurantist out. She can accommodate the notion of coexistence in the relativistic framework only at the cost of renouncing central endurantist intuitions. (shrink)

The article analyzes the structure and manifestations of everyday life as the sphere of the empirical life of the individual believer and the religious community. Patterns of everyday life are not confined to certain universal conceptual or value systems, as there is no ready-made standards and rules of their formation. Everyday life is intersubjective space of social relations in which religious individuals, communities, institutions self-identified based on form of reproduction of sociality. Religious everyday life determined by ordinary consciousness, practices, social (...) aspects of life in the religious community, which are constituted by communication. The main religious structures of everyday life is mental cut ordinary religious consciousness, religious practice, religious experience, religious communication, religious stereotypes. Everyday life is the sphere of interaction between the social and the transcendental worlds, in which religious practices are an integral social relationships and the objectification of religious experience through the prism of individual membership to a specific religion, a means of inclusion of transcendence in the context of everyday life. Religious practices reflect understanding of a religious individual objects of the supernatural world, which is achieved through social experience, intersubjective interaction, experience of transcendental reality. The everyday life of the believing personality is formed in the dynamics of tradition and innovation, the mechanism of interaction of which affects the space of social existence. It exists within the private and public space and time, differing openness within the life-world. Continuous modification of everyday life, change its fundamental structures is determined by the process of modern social and technical transformation of society. (shrink)

The article explores the semantic potential of social narratives associated with the creation and constitution of the Orthodox Church of Ukraine, which caused a interpretations conflict, marked by conflicting interpretations and differences in meanings that are applied in different contexts. The narrative arranges events in a certain time sequence, accumulates and translates meanings, individual and social experience. The presence of meanings in the interpretation of the narrative depends on the perspective, interpretation horizons and the subject's ability to analyze information and (...) its correct application. The social narrative accumulates a set of stories and messages that are fragmentary and disordered, constructs a coherent plot aimed at finding and defining meanings, and forming social discourse. Social narratives materialized in social structures, orientations, expectations, and stereotypes of their bearers due to everyday modification in the form of simple images, attitudes, and principles. Since each social narrative claims to be exclusive and correct in its own way of understanding events, a clash of narratives and their interpretations is inevitable. A large-scale event determines the modification of social structures, standards, and evaluation criteria, is accompanied by the transformation of everyday life, reveals deep mental layers, and opens up new perspectives. The extraordinary event that was marked by the creation of the Orthodox Church of Ukraine is accompanied by diametrically opposite assessments from the clergy, believers, politicians, experts – from the statement about autocephaly as the only opportunity to achieve unity and recognition of Ukrainian Orthodoxy to the political subtext justification of the new religious organization creation. Church circles represented by representatives of the Ukrainian Orthodox Church of the Moscow Patriarchate claim that the state interferes in the internal Affairs of the Church. The Constitution of the Orthodox Church of Ukraine takes place in the context of the confrontation of two social narratives – the «ukrainian world» and the «russian world». The social narrative «ukrainian world» is based on values rooted in the national soil, but the social narrative «russian world» denies the existence of the Ukrainian nation and the Ukrainian state. Under the patronage of the Russian Orthodox Church, the expression of the ideas of the «russian world» is the Ukrainian Orthodox Church of the Moscow Patriarchate, which enshrines in the minds of believers ideologies about «the common origin of the Ukrainian and Russian peoples», «the common baptismal font», «the unity of the historical space of Holy Rus», «the identity of the East Slavic Orthodox civilization». The Ukrainian Orthodox Church of the Moscow Patriarchate did not support the decision of patriarch Bartholomew to grant autocephaly to the Orthodox Church of Ukraine. Metropolitan Onufriy did not give his blessing to the hierarchs to participate in the Unification Council, which is called «a non-canonical assembly of schismatic groups». The Ukrainian Orthodox Church of the Moscow Patriarchate, according to its primate, has de facto autocephaly, so it is the only canonical local Orthodox Church in Ukraine. In the face of the conflict of public narratives, the Orthodox Church of Ukraine, along with meeting the spiritual needs of believers, contributes to the formation of national identity, the formation of a worldview matrix that will determine the vision of the future development of the country. (shrink)

RaTG13, MP789, and RmYN02 are the strains closest to SARS‐CoV‐2, and their existence came to light only after the start of the pandemic. Their genomes have been used to support a natural origin of SARS‐CoV‐2 but after a close examination all of them exhibit several issues. We specifically address the presence in RmYN02 and closely related RacCSxxx strains of a claimed natural PAA/PVA amino acid insertion at the S1/S2 junction of their spike protein at the same position where the PRRA (...) insertion in SARS‐CoV‐2 has created a polybasic furin cleavage site. We show that RmYN02/RacCSxxx instead of the claimed insertion carry a 6‐nucleotide deletion in the region and that the 12‐nucleotide insertion in SARS‐CoV‐2 remains unique among Sarbecoviruses. Also, our analysis of RaTG13 and RmYN02's metagenomic datasets found unexpected reads which could indicate possible contamination. Because of their importance to inferring SARS‐CoV‐2′s origin, we call for a careful reevaluation of RaTG13, MP789 and RmYN02 sequencing records and assembly methods. (shrink)

Este ensayo plantea una cuestión filosófica perseguida como investigación histórica que desemboca en una explicación sociológica en torno a la medición de la ciencia. Medir, etimológicamente relacionado con una praecisio adquiere su sentido más profundo en una era postontológica para describir las implicaciones culturales de un mundo privado de metafísica. Basado en un relato sucinto del surgimiento del pensamiento bibliométrico enmarcado por el debate historiográfico de principios del siglo XX entre historiadores seriales e historiadores del evento, este ensayo une tanto (...) el significado postontológico como la evidencia histórica en un análisis sociológico de la ciencia y políticas tecnológicas en la Colombia del cambio de siglo que conlleva una transformaciónradical de la universidad como institución social, del estatus del conocimiento en la sociedad contemporánea y de la identidad de nosotros los académicos que habitamos ese espacio. (shrink)

John organized a state lottery and his wife won the main prize. You may feel that the event of her winning wasn’t particularly random, but how would you argue that in a fair court of law? Traditional probability theory does not even have the notion of random events. Algorithmic information theory does, but it is not applicable to real-world scenarios like the lottery one. We attempt to rectify that.

In a paper of 1933 Godel proved that every satisfiable first-order ∀ 2 ∃ * sentence has a finite model. Actually he constructed a finite model in an ingenious and sophisticated way. In this paper we use a simple and straightforward probabilistic argument to establish existence of a finite model of an arbitrary satisfiable ∀ 2 ∃ * sentence.

The set of all words in the alphabet {l, r} forms the full binary tree T. If x ∈ T then xl and xr are the left and the right successors of x respectively. We consider the monadic second-order language of the full binary tree with the two successor relations. This language allows quantification over elements of T and over arbitrary subsets of T. We prove that there is no monadic second-order formula φ * (X, y) such that for every (...) nonempty subset X of T there is a unique y ∈ X that satisfies φ * (X, y) in T. (shrink)

We introduce the class PIO of functions computable in time that is polynomial in max{the length of input, the length of output}, observe that there is no notation system for total PIO functions but there are notation systems for partial PIO functions, and give an algebra of partial PIO functions from binary strings to binary strings.

In the current era of the Sustainable Development Goals, many countries are attempting to strengthen their health system and achieving Universal Health Coverage. The Korean National Health Insurance system functions as a core element of health financing, contributing to achieving UHC by promoting public health and social security through insurance benefits for prevention, diagnosis, treatment, rehabilitation, childbirth, and health promotion. The Republic of Korea achieved 100% NHI coverage of the target population in 1989, 12 years after the introduction of the (...) social insurance system. However, poor coverage of health services and lack of financial protection are major obstacles to achieving UHC. Therefore, the Korean government announced and implemented ‘Moon Jae-in Care’ in August 2017 to enhance the coverage rate of NHI by 70%. First, this study reviews the existing health insurance system in Korea from the perspective of health financing and UHC. Second, it analyses ‘Moon Jae-in Care’, based on the main framework of UHC. Third, it considers the ethical implications of these developments, with focus on the principles of equity, fairness, autonomy, and solidarity. Although the NHI reform is expected to propel Korean health care closer to UHC, many ethical, social, and political issues remain. (shrink)

The author analyses some problems discussed in the article of Vadim Mezhuev. He discusses the ways in which historians deal with their own scientific problems in the light of philosophical problems of sciences. According to Yu. Nikiforov, a philosopher can always talk about the future which is yet to come; a historian sees the future through the present of the processes which she describes. The author argues that a reconstruction of the past is always based on the knowledge of the (...) present. (shrink)

This introduction surveys the biography and major works of Liu Zehua, a leading scholar of China's intellectual history, political thought, and political culture. It explores the impact of Liu Zehua's personal experience, in particular the upheavals of the Cultural Revolution, on his conceptualization of Chinese political culture as subjugated to the overarching principle of monarchism. Liu Zehua's critical engagement with China's past distinguishes him from proponents of revival of traditional values and makes him one of the powerful opponents of cultural (...) conservatives in China. (shrink)

This chapter explores Mencius’s political ideas, particularly his views of the ruler, the men-of-service (or intellectuals, shi 士), and the commoners. It highlights intrinsic tensions in Mencius’s thought, e.g. between his avowed commitment to the monarchic order (in which the intellectuals like himself should act as the ruler’s servitors) and his staunch belief that intellectuals are morally superior to the rulers and should act as their teachers. Another tension was between Mencius’s insistence on the commoners’ primary importance for the polity (...) and his equally strong opposition to their participation in political life. Tensions and frustrations aside, Mencius succeeded to position himself as the most devoted leader of the Warring States-period men-of-service. This ensured him the lasting role as a source of inspiration for the imperial literati. (shrink)

The Spring and Autumn Annals of Master Yan. Translated and annotated by Olivia Milburn. Sinica Leidensia, vol. 128. Leiden: Brill, 2016. Pp. xxx + 485. €161, $193.

This article explores textual, paleographic, and archeological evidence for the “Long Wall” of Qi, arguably one of the earliest long walls erected on Chinese soil. It analyzes the possible dates of the Wall’s constructions, its route, its defensive role, and its relation to military, political, economic, and administrative developments of the Warring States period. I argue that the Long Wall played a significant role in Qi’s military strategy in the fifth and fourth centuries BCE, bolstering its defensive capabilities. In the (...) long term, however, the Wall might have inadvertently hindered Qi’s southward expansion, placing it in a disadvantageous position versus its rivals. (shrink)

In this article author considers the problem of epistemology of historical knowledge. Author doesn't accept the neo-kantianism theory. He makes an attempt to differ the two forms of unitarization of scientific knowledge — theoretization and the principle of holism and, hence, the two forms of the theoretical consideration of history. The author insists that the Marxists approach seems to be the most relevant from this point of view. Thus, he defends the thesis that the idealistic concepts are much vulnerable comparing (...) with the materialistic approaches. (shrink)