In this essay, the hypothesis that biliverdin pigment plays an antioxidant role in the avian eggshell is proposed. Due to its ability to scavenge free radical species and to reduce mutation, biliverdin potentially counteracts the oxidative action of pathogens that penetrate the eggshell and/or protects the shell membrane from oxidation, thus promoting the proven antioxidant and antimicrobial capacities of the shell membrane itself. Additionally, biliverdin may be able to inhibit viral replication in the eggshell due to its (...) ascribed antiviral properties. Moreover, previous results in other taxa leave open the question of whether biliverdin can be absorbed by the embryo from the eggshell and play a role in embryogenesis. These mechanisms of antioxidant action of eggshell biliverdin remain totally unexplored in birds and in other oviparous animals. The main assumptions and predictions of the antioxidant hypothesis are developed, and directions for future research are proposed. (shrink)

Graphical AbstractThe antioxidant hypothesis proposes that the blue-green pigment found in many birds’ eggs provides a direct benefit to the developing embryo through its antioxidant-like properties. Such protection is feasible if the pigment transfers to the eggshell membrane or inside the egg. This newly proposed hypothesis provides a range of intriguing possibilities for future tests.

This paper defends the claim that pragmatic encroachment—the idea that knowledge is sensitive to the practical stakes of believing—can explain a distinctive kind of epistemic injustice: the injustice that occurs when prejudice causes someone to know less than they otherwise would. This encroachment injustice, as we call it, occurs when the threat of being met with prejudice raises the stakes for someone to rely on her belief when acting, by raising the level of evidential support required for knowledge. We explain (...) this notion of encroachment injustice, connect it to the empirical literature on implicit bias, and defend it against important objections. (shrink)

Background While the number of emergency patients worldwide continues to increase, emergency doctors often face moral distress. It hampers the overall efficiency of the emergency department, even leading to a reduction in human resources. Aim This study explored the experience of moral distress among emergency department doctors and analyzed the causes of its occurrence and the strategies for addressing it. Method Purposive and snowball sampling strategies were used in this study. Data were collected through in-depth, semi-structured interviews with 10 doctors (...) working in the emergency department of a tertiary general hospital in southwest China. The interview data underwent processing using the Nvivo 14 software. The data analysis was guided by Colaizzi’s phenomenological analysis method. Study findings This study yielded five themes: (1) imbalance between Limited Medical Resources and High-Quality Treatment Needs; (2) Ineffective Communication with Patients; (3) Rescuing Patients With no prospect of treatment; (4) Challenges in Sustaining Optimal Treatment Measures; and (5) Strategies for Addressing Moral Distress. Conclusion The moral distress faced by emergency doctors stems from various aspects. Clinical management and policymakers can alleviate this distress by enhancing the dissemination of emergency medical knowledge to the general public, improving the social and economic support systems, and strengthening multidisciplinary collaboration and doctors’ communication skills. (shrink)

The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary prior to their transcription. Their expression is regulated both temporally and spatially within this tissue. They thus serve as models both for the regulation of DNA replication and of developmental transcription. The regulatory elements for DNA amplification have been delineated. Their analysis reveals that amplification is mediated by several regulatory regions and initiates at defined origins within the chorion cluster. Proteins involved (...) in amplification are being identified both by mutations affecting amplification and by DNA binding studies. Regulatory elements for temporal as well as spatial control of chorion gene, expression have been characterized, and two candidate transcription factor genes have been cloned. (shrink)

Something has been going wrong on many college campuses in the last few years. Speakers are shouted down. Students and professors say they are walking on eggshells and are afraid to speak honestly. Rates of anxiety, depression, and suicide are rising--on campus as well as nationally. How did this happen? First Amendment expert Greg Lukianoff and social psychologist Jonathan Haidt show how the new problems on campus have their origins in three terrible ideas that have become increasingly woven into American (...) childhood and education: What doesn't kill you makes you weaker; always trust your feelings; and life is a battle between good people and evil people. These three Great Untruths contradict basic psychological principles about well-being and ancient wisdom from many cultures. Embracing these untruths--and the resulting culture of safetyism--interferes with young people's social, emotional, and intellectual development. It makes it harder for them to become autonomous adults who are able to navigate the bumpy road of life. Lukianoff and Haidt investigate the many social trends that have intersected to promote the spread of these untruths. They explore changes in childhood such as the rise of fearful parenting, the decline of unsupervised, child-directed play, and the new world of social media that has engulfed teenagers in the last decade. They examine changes on campus, including the corporatization of universities and the emergence of new ideas about identity and justice. They situate the conflicts on campus within the context of America's rapidly rising political polarization and dysfunction. This is a book for anyone who is confused by what is happening on college campuses today, or has children, or is concerned about the growing inability of Americans to live, work, and cooperate across party lines. (shrink)

Political protests, debates on college campuses, and social media tirades make it seem like everyone is speaking their minds today. Surveys, however, reveal that many people increasingly feel like they're walking on eggshells when communicating in public. Speaking your mind can risk relationships and professional opportunities. It can alienate friends and anger colleagues. Isn't it smarter to just put your head down and keep quiet about controversial topics? In this book, Hrishikesh Joshi offers a novel defense of speaking your mind. (...) He explains that because we are social creatures, we never truly think alone. What we know depends on what our community knows. And by bringing our unique perspectives to bear upon public discourse, we enhance our collective ability to reach the truth on a variety of important matters. Speaking your mind is also important for your own sake. It is essential for developing your own thinking. And it's a core aspect of being intellectually courageous and independent. Joshi argues that such independence is a crucial part of a well-lived life. The book draws from Aristotle, John Stuart Mill, Friedrich Nietzsche, Bertrand Russell, and a range of contemporary thinkers to argue that it's OK to speak your mind. Key Features Shows that we have not just a right but a moral duty to publicly share what we know. Argues that discussing your unique ideas with others is essential for developing as a critical thinker. Explores the value of intellectual honesty and independence in the writings of John Stuart Mill and Friedrich Nietzsche and connects their thinking to contemporary problems. Argues that avoiding cultural blind spots today is important for the fate of future generations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:656 Feminist Studies 43, no. 3. © 2017 by Feminist Studies, Inc. Ghost Story The day our house burned, Mama dumped it in the river. Palms on the shore, finch in place of bruises. A hollowed tusk birthing pockets of gray glowing some kind of holy, salt-spittle and rattling. Carolina Horror Story Sandra, softest face south of the Mason Dixon line, got eggshells under her toes, eyes made of (...) salt and other things too holy to remember. Oil slicks and line breaks spilling out of her mouth, gets called sugar, sugar walkin’ down the street, sugar at high tide, high noon, peeled molasses at the bottom of the barrel, shotgun cool. Sugar’s got a face I can only look at crying, look at human, arranged and harmless. Sugar, sugar what’s wrong, Emily Zhang Emily Zhang 657 air’s so stale it could choke a hurricane? Turns to me like the tide, shoots me through and through with her face, refractin’ all the night’s light. Honey Open up the sky, shaken of its salt. Open up the lip of a run-on sentence, blurry and reeling, the way air turns into breath. Open when the smallest fires become streams of bright dust, swimming pools swelling from bee stings. Open the sweetness out of summer. Open when we dump frogs into bathtubs and the waves set like milk, when our mouths are full of spit and we shuck foam from our hair. Open for the movie theater trips when the sky is setting heavy, for the horror films where girls sound like rabbits and rabbits look like girls. Open with waxwings birthed from dirt, the Band-Aids and yawning trash cans, the cavities. Open for the way the air sticks to us like a hide, the way we feel like wine stains, but wanted. Open in the grocery store produce section when we see the damp crabs clawing each other and we think of womanhood. Open for the girls with lips like copper wiring, fluorescents, double-exposure, for our melting sense of un-worry, our hands always self-corrected. Open when we’re halfway over the fence and the neighbor’s Doberman is trying to bite the meat off our ankles. Open the way a sprinkler head looks like a rotting berry, the way we all fall lightly in love with witches. Open for the radios spilling music slow, elbows on the dashboard, weary elbows, loud elbows. Open for the unholy women throughout history who sat alone on islands where the sky was so blue it burned with borrowed static now lost.... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Jews and Gender: Responses to Otto WeiningerBéla SzabadosJews and Gender: Responses to Otto Weininger, edited by Nancy A. Harrowitz and Barbara Hyams; 341 pp. Philadelphia: Temple University Press, 1995, $54.95 cloth, $24.95 paper.“Every artist has been influenced by others and shows traces of that influence yet his significance for us is nothing but his personality. What he inherits from others can be nothing but eggshells,” said Wittgenstein, listing (...) Weininger as a seminal influence on his work, “a seed out of which his plant grew.” Weininger’s influence fell on other leading cultural figures early this century such as Kraus, Kafka, Freud, Joyce, Lawrence, Canetti, Stein and others. This book aims to retrieve that influence and provide a broad interdisciplinary representation of new critical readings of Weininger’s legacy.The fact and extent of Weininger’s influence seems puzzling: his fame stems from his misogyny and anti-Semitism. In Sex and Character Weininger claims that: humans are bisexual, a mixture of male and female; woman is nothing but sexuality; individuals must choose between the masculine and feminine elements within themselves; sexual abstinence is a precondition of spirit and genius; there can be no justification for sex even for procreation within marriage; furthermore, “the Jew is saturated with femininity and has little sense of good and evil.” How could an author with such odd and odious views exert any influence at all?Yet Weininger was pivotal: his writing erases boundaries between discipline, genre, and nationality, revealing tensions and contradictions in Viennese and Western culture. So many ‘isms’ mark him as a patriarch of the tradition: [End Page 548] essentialism, transcendentalism, dualism, theism, and his belief in a rational self. Yet this is juxtaposed with postmodernist themes: deconstruction of sexual and gender dichotomies, rejection of essentialism concerning individuals, an emphasis on difference and the personal, the ethical primacy of practice over theory. His influence is felt in literature, philosophy, science, history, and because of Jehoshua Sobol’s play, The Soul of a Jew, in theatre.Jews and Gender divides into three parts. The first introduces readers to Weininger research and provides new bibliographic information. To begin with, the editors offer us the necessary background with a concise critical essay on the history of Weininger reception. This is followed by Jacques Le Rider revisiting Weininger scholarship subsequent to the publication of his own book, The Otto Weininger Case. The section ends with Hannelore Rodlauer’s efforts to piece together fragments from Weininger’s education. The second section, “In Context,” focuses on Weininger in the context of his contemporaries. Allan Janik starts off with his examination of the riddle of Weininger’s influence on Wittgenstein. Next, Nancy Harrowitz sketches and discusses affinities between Weininger and his nineteenth-century forerunner Lomboroso. Then Steven Beller explores the surprising question of whether Weininger was a liberal in an ethos when European liberalism exerted immense pressure on Jews to assimilate the whole set of social, religious, national, cultural values of a community. Sander Gilman in turn traces connections between Freud and Weininger on questions of race and gender. In her essay on “Characterology,” Katherine Arens situates Weininger in relation to Austrian “scientific” racism. In his contribution, John Hoberman reflects on Weininger’s critique of Jewish masculinity, locating its source in the stereotypes prevalent in those times.The third section of the volume looks at Weininger and his impact on modern literature. In “A Scientific Image of Woman,” Gisela Brude-Firnau discusses the way in which Weininger’s work can be seen as a contentious response to the women’s movement. Jeffrey Mehlman discerns Weininger in one of Apolinnaire’s major poems, “La Chanson du Malaimé,” where the anger against woman is quirkily actualized as a fury against the Jews. Gerald Stieg goes on to draw affinities between Kafka and Weininger. Then Marilyn Reizbaum, Natania Rosenfeld, and Elfriede Pöder explore in separate essays Weininger’s influence on James Joyce’s Ulysses by probing Bloom’s Jewish self-hatred, the figure of the womanly wandering Jew, and Molly as pure sexuality, respectively. Alberto Cavaglion proceeds to trace the appearance of Weininger’s thought in Italo Svevo’s novel The Confessions of Zeno... (shrink)