Results for 'lymphatic'

16 found
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  1.  23
    Lymphatic vasculature: a molecular perspective.Brett Hosking & Taija Makinen - 2007 - Bioessays 29 (12):1192-1202.
    The lymphatic vasculature comprises an intricate network of vessels critical for fluid homeostasis, immune surveillance and fat absorption. Recent studies have provided insights into the developmental processes and molecular mechanisms controlling the formation and remodelling of the lymphatic vessels. These studies have further demonstrated the essential and active role of the lymphatic vessels in various pathological conditions and advanced our understanding of the progression of human diseases, such as inflammation and tumorigenesis. In the context of the latest (...)
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  2.  20
    Granulomatous Inflammation in Tuberculosis and Sarcoidosis: Does the Lymphatic System Contribute to Disease?Karen C. Patterson, Christophe J. Queval & Maximiliano G. Gutierrez - 2019 - Bioessays 41 (11):1900086.
    A striking and unexplained feature of granulomatous inflammation is its anatomical association with the lymphatic system. Accumulating evidence suggests that lymphatic tracks and granulomas may alter the function of each other. The formation of new lymphatics, or lymphangiogenesis, is an adaptive response to tumor formation, infection, and wound healing. Granulomas also may induce lymphangiogenesis which, through a variety of mechanisms, could contribute to disease outcomes in tuberculosis and sarcoidosis. On the other hand, alterations in lymph node function and (...)
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  3.  71
    Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal tanzania.Melissa Parker & Tim Allen - 2013 - Journal of Biosocial Science 45 (4):517-545.
    SummaryThis article documents understandings and responses to mass drug administration for the treatment and prevention of lymphatic filariasis among adults and children in northern coastal Tanzania from 2004 to 2011. Assessment of village-level distribution registers, combined with self-reported drug uptake surveys of adults, participant observation and interviews, revealed that at study sites in Pangani and Muheza districts the uptake of drugs was persistently low. The majority of people living at these highly endemic locations either did not receive or actively (...)
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  4.  22
    Granulomatous Inflammation and the Lymphatic System—Perhaps a New Target for Intervention in Tuberculosis and Sarcoidosis.Jesse Roman & Rafael L. Perez - 2019 - Bioessays 41 (11):1900167.
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  5. Notre Dame Preventing Lymphatic Filariasis in Haiti.Jessica Spiewak - 2010 - Scientia: Undergraduate Research Journal for the Sciences University of Notre Dame 1 (1).
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  6.  20
    A Mathematical Model for the Transmission Dynamics of Lymphatic Filariasis with Intervention Strategies.S. M. Simelane, P. M. Mwamtobe, S. Abelman & J. M. Tchuenche - 2020 - Acta Biotheoretica 68 (3):297-320.
    This manuscript considers the transmission dynamics of lymphatic filariasis with some intervention strategies in place. Unlike previously developed models, our model takes into account both the exposed and infected classes in both the human and mosquito populations, respectively. We also consider vaccinated, treated and recovered humans in the presented model. The global dynamics of the proposed model are completely determined by the basic ( R0{\mathcal {R}}_0 ) and effective reproduction numbers ( Re{\mathcal {R}}_e ). We then use Lyapunov function (...)
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  7.  19
    Retroviruses and lymphatic cancers. Human T‐cell leukemia/lymphoma virus. Edited by R. c. G ALLO, M. E. E SSEX and L. G ROSS. Cold Spring Harbor Laboratory Press. Pp. 391. $50.00 (Outside USA, $60.00). [REVIEW]Donald Metclaf - 1985 - Bioessays 2 (1):42-42.
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  8.  5
    A Brief History of Blood and Lymphatic Vessels.Andreas Bikfalvi - 2017 - Cham: Imprint: Springer.
    This book provides a comprehensive account of vascular biology and pathology and its significance for health and disease. It systematically and chronologically explains how we came to our current understanding of the vasculature and it's function today, and describes in an entertaining way the diverse flaws and turns in science and medicine from the past. It thereby offers a complete and well-studied history on vascular biology and medicine. The book has an easy-to-read style and is written for students as well (...)
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  9.  37
    Endothelial Metabolic Control of Lymphangiogenesis.Pengchun Yu, Guosheng Wu, Heon-Woo Lee & Michael Simons - 2018 - Bioessays 40 (6):1700245.
    Lymphangiogenesis is an important developmental process that is critical to regulation of fluid homeostasis, immune surveillance and response as well as pathogenesis of a number of diseases, among them cancer, inflammation, and heart failure. Specification, formation, and maturation of lymphatic blood vessels involves an interplay between a series of events orchestrated by various transcription factors that determine expression of key genes involved in lymphangiogenesis. These are traditionally thought to be under control of several key growth factors including vascular growth (...)
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  10.  26
    Molecular control of lymphangiogenesis.Megan E. Baldwin, Steven A. Stacker & Marc G. Achen - 2002 - Bioessays 24 (11):1030-1040.
    The lymphatic vasculature plays a critical role in the regulation of body fluid volume and immune function. Extensive research into the molecular mechanisms that control blood vessel growth has led to identification of molecules that also regulate development and growth of the lymphatic vessels. This is generating a great deal of interest in the molecular control of the lymphatics in the context of embryogenesis, lymphatic disorders and tumor metastasis. Studies in animal models carried out over the past (...)
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  11.  34
    Informed Consent among Clinical Trial Participants with Different Cancer Diagnoses.Connie M. Ulrich, Sarah J. Ratcliffe, Camille J. Hochheimer, Qiuping Zhou, Liming Huang, Thomas Gordon, Kathleen Knafl, Therese Richmond, Marilyn M. Schapira, Victoria Miller, Jun J. Mao, Mary Naylor & Christine Grady - 2024 - AJOB Empirical Bioethics 15 (3):165-177.
    Importance Informed consent is essential to ethical, rigorous research and is important to recruitment and retention in cancer trials.Objective To examine cancer clinical trial (CCT) participants’ perceptions of informed consent processes and variations in perceptions by cancer type.Design and Setting and Participants Cross-sectional survey from mixed-methods study at National Cancer Institute–designated Northeast comprehensive cancer center. Open-ended and forced-choice items addressed: (1) enrollment and informed consent experiences and (2) decision-making processes, including risk-benefit assessment. Eligibility: CCT participant with gastro-intestinal or genitourinary, hematologic- (...) malignancies, lung cancer, and breast or gynecological cancer (N = 334).Main Outcome Measures Percentages satisfied with consent process and information provided; and assessing participation’s perceptions of risks/benefits. Multivariable logistic or ordinal regression examined differences by cancer type.Results Most patient-participants felt well informed by the consent process (more than 90% overall and by cancer type) and. most (87.4%) reported that the consent form provided all the information they wanted, although nearly half (44.8%) reported that they read the form somewhat carefully or less. More than half (57.9%) said that talking to research staff (i.e., the consent process) had a greater impact on participation decisions than reading the consent form (2.1%). A third (31.1%) were very sure of joining in research studies before the informed consent process (almost half of lung cancer patients did—47.1%). Most patients personally assessed the risks and benefits before consenting. However, trust in physicians played an important role in the decision to enroll in CCT.Conclusions and Relevance Cancer patients rely less on written features of the informed consent process than on information obtained from the research staff and their own physicians. Research should focus on information and communication strategies that support informed consent from referring physicians, researchers, and others to improve patient risk-benefit assessment and decision-making. (shrink)
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  12.  16
    I am Not Obese. I am Just Fat.Sarah Bramblette - 2014 - Narrative Inquiry in Bioethics 4 (2):85-88.
    In lieu of an abstract, here is a brief excerpt of the content:I am Not Obese. I am Just Fat.Sarah BrambletteMy body mass index classifies me as super morbidly obese, however my overall vital health statistics would indicate otherwise. I celebrated the American Medical Association’s classification of obesity as a disease for several reasons. First, obesity as a disease involves other medical complications of which I have none, so finally perhaps I can say I am not obese, I am just (...)
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  13.  14
    Nijmegen breakage syndrome: consequences of defective DNA double strand break repair.Martin Digweed, André Reis & Karl Sperling - 1999 - Bioessays 21 (8):649-656.
    The autosomal recessive genetic disorder, Nijmegen Breakage Syndrome, is characterised by an excessively high risk for the development of lymphatic tumours and an extreme sensitivity towards ionising radiation. The most likely explanation for these characteristics, a deficiency in the repair of DNA lesions, has been greatly substantiated by the recent cloning of the gene mutated in Nijmegen Breakage Syndrome patients and the analysis of its protein product, nibrin. The direct involvement of this protein in the processing of DNA double (...)
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  14. The intruder.Jean-Luc Nancy, Jeff Fort & Claire Denis - 2024 - New York: Fordham University Press. Translated by Richard Rand & Anna Moschovakis.
    In 1991, Jean-Luc Nancy's heart gave out. In one of the first such procedures in France, a stranger's heart was grafted into his body. Numerous complications followed, including more surgeries and lymphatic cancer. The procedure and illnesses he endured revealed to him, in a more visceral way than most of us ever experience, the strangeness of bodily existence itself and surviving the stranger within him. During this same period, Europe began closing its borders to those seeking refuge from war (...)
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  15. A Storytelling Approach: Insights from the Shambaa.Camillo Lamanna - 2018 - Journal of Medical Humanities 39 (3):377-389.
    Narrative medicine explores the stories that patients tell; this paper, conversely, looks at some of the stories that patients are told. The paper starts by examining the ‘story’ told by the Shambaa people of Tanzania to explain the bubonic plague and contrasts this with the stories told by Ghanaian communities to explain lymphatic filariasis. By harnessing insights from memory studies, these stories’ memorability is claimed to be due to their use mnemonic devices woven into stories. The paper suggests that (...)
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  16.  9
    Endothelial ontogeny and the establishment of vascular heterogeneity.Oliver A. Stone, Bin Zhou, Kristy Red-Horse & Didier Y. R. Stainier - 2021 - Bioessays 43 (7):2100036.
    The establishment of distinct cellular identities was pivotal during the evolution of Metazoa, enabling the emergence of an array of specialized tissues with different functions. In most animals including vertebrates, cell specialization occurs in response to a combination of intrinsic (e.g., cellular ontogeny) and extrinsic (e.g., local environment) factors that drive the acquisition of unique characteristics at the single‐cell level. The first functional organ system to form in vertebrates is the cardiovascular system, which is lined by a network of endothelial (...)
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