Zusammenfassung Childs’ Rekonstruktion der Genealogien wird bestätigt: Der Pfeiler ist wahrscheinlich von Cherẽi und nicht von Cheriga errichtet worden. Die am Ende der Südseite erwähnten Schlachten fanden wahrscheinlich nicht später als 428 v. Chr. statt. Die auf der Ostseite erwähnten Aktionen sind wahrscheinlich nicht später als 424 v. Chr., weil Ertaχssiraza unmittelbar vor einer Aktion des Dynasten Teϑϑiweibi erwähnt wird und daher mit Artaxerxes I. gleichzusetzen ist. In einer zuvor berichteten militärischen Aktion erscheinen Miϑrapata, Aruwãtijesi und die „Triere des Cherẽi“. (...) Am Beginn der Nordseite gibt es einen Sprung bis wahrscheinlich 412/411 v. Chr., als der Satrap Tissaphernes in Kaunos tätig war. Am Ende des Prosatextes ist wahrscheinlich in ]welẽ der Name des Dynasten Ddenewele zu sehen, als „sein Sohn“, d. h. Cherẽis Sohn und Nachfolger. Die griechischen Verse danach rühmen den Sohn des Harpagos, und sein Name sollte nach dem Καρικα γένος zu [Καρ.]ις ergänzt werden, nicht zu [Γεργ]ις. Die ihm zugeschriebene Tötung von sieben arkadischen Hopliten an einem Tag erklärt die sonst kryptische Zahl CII im Feldzug gegen Tlos. Die anschließenden B-lykischen Verse gelten aber Cheriga, und das Nordgedicht mag zu seinen Lebzeiten gedichtet worden sein, weil er hier handelnd auftritt. Der einzige chronologische Fixpunkt ist die Schlacht an der Mykale 428 v. Chr., von der auf der Südseite berichtet wird. Im Westgedicht tritt eine Frau namens Muni an die Stelle des Cheriga, und das könnte seine Frau sein, die nach dem Tod des Cherẽi die Herrschaft übernommen haben könnte. Dieses Bild von der Pfeiler-Chronologie ist vereinbar mit Müselers Chronologie der dynastischen Münzen mit den Namen von Cheriga, Teϑϑiweibi, Cherẽi und Ddenewele. Allerdings können im Rahmen dieses Konzepts andere auf dem Pfeiler vorkommende Dynasten wie Trbbẽnimi, Miϑrapata und Aruwãtijesi nicht mit den gleichnamigen Münzprägern identisch sein, mit der möglichen Ausnahme des Punamuwa. Außerdem ist der Cheriga der Münzen zwar sicher mit dem Cheriga auf dem Pfeiler identisch, aber offenbar nicht mit Cheriga, dem Vater des Erbbina in den Letoon-Inschriften. Doch der Dynast Waχssepddimi auf dem Pfeiler ist möglichwerweise identisch mit dem älteren der beiden Weχssere genannten Dynasten, der im Xanthostal unmittelbar nach der Herrschaft des Kuprlli Münzen prägte. (shrink)

Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains of some proteins are almost invariant in sequence and length, betraying a structural and functional role for amino acids along the entire length of the coiled‐coil. Other coiled‐coils are divergent in sequence, but conserved in length, thereby functioning as molecular spacers. In this capacity, coiled‐coil proteins influence the architecture of organelles such as centrioles and the Golgi, as well as permit the tethering of transport vesicles. (...) Specialized coiled‐coils, such as those found in motor proteins, are capable of propagating conformational changes along their length that regulate cargo binding and motor processivity. Coiled‐coil domains have also been identified in enzymes, where they function as molecular rulers, positioning catalytic activities at fixed distances. Finally, while coiled‐coils have been extensively discussed for their potential to nucleate and scaffold large macromolecular complexes, structural evidence to substantiate this claim is relatively scarce. (shrink)

American Academy of Pediatrics (AAP) and American College of Medical Genetics (ACMG) recently provided two recommendations about predictive genetic testing of children. The Clinical Sequencing Exploratory Research Consortium's Pediatrics Working Group compared these recommendations, focusing on operational and ethical issues specific to decision making for children. Content analysis of the statements addresses two issues: (1) how these recommendations characterize and analyze locus of decision making, as well as the risks and benefits of testing, and (2) whether the guidelines conflict or (...) come to different but compatible conclusions because they consider different testing scenarios. These statements differ in ethically significant ways. AAP/ACMG analyzes risks and benefits using best interests of the child and recommends that, absent ameliorative interventions available during childhood, clinicians should generally decline to order testing. Parents authorize focused tests. ACMG analyzes risks and benefits using the interests of the child and other family members and recommends that sequencing results be examined for additional variants that can lead to ameliorative interventions, regardless of age, which laboratories should report to clinicians who should contextualize the results. Parents must accept additional analysis. The ethical arguments in these statements appear to be in tension with each other. (shrink)

This study on the reception of Cartesianism is the result of a four-year fellowship as assistant-in-training at the Faculty of Philosophy of the University of Groningen. Zie: Preface.

For given Boolean algebras$\mathbb {A}$and$\mathbb {B}$we endow the space$\mathcal {H}(\mathbb {A},\mathbb {B})$of all Boolean homomorphisms from$\mathbb {A}$to$\mathbb {B}$with various topologies and study convergence properties of sequences in$\mathcal {H}(\mathbb {A},\mathbb {B})$. We are in particular interested in the situation when$\mathbb {B}$is a measure algebra as in this case we obtain a natural tool for studying topological convergence properties of sequences of ultrafilters on$\mathbb {A}$in random extensions of the set-theoretical universe. This appears to have strong connections with Dow and Fremlin’s result stating (...) that there are Efimov spaces in the random model. We also investigate relations between topologies on$\mathcal {H}(\mathbb {A},\mathbb {B})$for a Boolean algebra$\mathbb {B}$carrying a strictly positive measure and convergence properties of sequences of measures on$\mathbb {A}$. (shrink)

The soil bacteria rhizobia have the capacity to establish nitrogen‐fixing symbiosis with their leguminous host plants. In most Rhizobium species the genes for nodule development and nitrogen fixation have been localized on large indigenous plasmids that are transmissible, allowing lateral transfer of symbiotic functions. A recent paper reports on the complete sequencing of the symbiotic plasmid pNGR234a from Rhizobium species NGR234(1), revealing not only putative new symbiotic genes but also possible mechanisms for evolution and lateral dispersal of symbiotic nitrogen‐fixing abilities (...) among rhizobia. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 61.3 (2000) 381-395 [Access article in PDF] Minds, Forms, and Spirits: The Nature of Cartesian Disenchantment Han van Ruler What is Descartes's contribution to Enlightenment? Undoubtedly, Cartesian philosophy added to the conflict between philosophical and theological views which divided intellectual life in the Dutch Republic towards the end of its "Golden Age." 1 Although not everyone was as explicit as Lodewijk Meyer, who (...) said that his theological doubts were inspired by Descartes's philosophical method, Cartesianism along with Copernicanism, Socinianism, and Cocceianism played an important part in the growing skepticism towards the authority of Scripture. 2 Apart from Descartes's general method, however, specific Cartesian ideas encouraged a new view towards nature and towards God's role in governing it. In physics and physiology the new philosophy replaced the image of mind working on matter with the image of a self sufficient mechanism. This new causal metaphor led to a typically Cartesian form of "disenchantment." In this article I argue that on account of their approval of a Cartesian theory of causality, even authors with sincere religious motives came close to accepting radical and nearly Spinozistic ideas. I start with disenchantment in a very literal sense: Balthasar Bekker's denial of the activities of devils, angels, and other spirits. A comparison of Bekker's arguments with those of another Cartesian, Arnold Geulincx will, I hope, bring out the nature and importance of what I shall present as [End Page 381] Descartes's "mechanical reduction" in physics. Finally, I argue that the Cartesian separation of mind and body gave rise to a form of disenchantment that reached far beyond contemporary debates. Devils, Ghosts, and God's Omnipotence Balthasar Bekker's classic book The World Bewitched (1691-93) does not so much deal with the practice of sorcery as with its theory. Bekker offers a wide range of theological and philosophical arguments in order to combat the idea that ghosts, devils, and angels influence natural or historical events. In particular Bekker draws some important conclusions from the philosophy of Descartes. Yet it is immediately clear to the reader that the motives for his critique are religious rather than philosophical. 3 The World Bewitched is not written as a scientific assault on superstition. Bekker, at the time serving as a Calvinist minister in Amsterdam, presents his work as a new and perhaps final phase in the perfection of Christianity. For two centuries it had been a goal of the Protestant Reformation to accentuate God's majesty and to establish the idea of His absolute power over creation. Bekker's World again expresses this idea. His denial that ghosts and devils are active in the world is a logical consequence of the belief that there is no room for demigods in nature. Bekker thus adds a final touch to the project of the Reformation. The World Bewitched will testify to the fact "that I return as much of the honor of His Power and Wisdom to the Almighty, as they took from Him who gave it to the Devil. I ban [the Devil] from the World and I bind him in Hell." 4 Removing devils and spirits from nature, Bekker aims to distinguish superstition from true faith. The battle against superstitious beliefs had formed a characteristic element of Protestant tactics. Dutch Calvinists, for instance, took offense at the continuing practices of blessings and incantations. 5 Bekker wanted to go even further. The Protestantization of Christian dogma could only be completed by making everything in nature's course depend on God's unique power and providence. 6 "Science" in our sense of the word was a subsidiary matter. 7 Still, Bekker saw the new scientific theories of his day as useful allies. In particular it was the new philosophy of Descartes that attracted him. Following Descartes, Bekker reasons "that I think, that I will, [End Page 382] [and] that I understand something," without any part of my body being involved in this type of consciousness. Mind and body in fact have nothing in common: My... (shrink)

In set theory without the axiom of choice (AC), we study the relative strength of the principle “No decreasing sequence of cardinals,” that is, “There is no function f on ω such that |f(n+1)|<|f(n)| for all n∈ω” (NDS) with regard to its position in the hierarchy of weak choice principles. We establish the following results: (1) The Boolean prime ideal theorem plus countable choice does not imply NDS in ZF; (2) “Every non-well-orderable set has a well-orderable partition into denumerable (...) sets” (Dℵ0) plus the axiom of choice for well-ordered families of nonempty finite sets does not imply NDS ∨ “The axiom of choice for countable families of nonempty countable sets” in ZFA; and (3) The axiom of choice for well-ordered families of nonempty sets, each of cardinality not greater than or equal to 2ℵ0, does not imply NDS ∨ “countable union theorem” in ZFA. The above results answer corresponding questions left open in works by Howard and Rubin (1998) and Howard and Tachtsis (2016). We also show the following: (4) “Every non-well-orderable set has a well-orderable partition into infinite well-orderable sets” (Dw) is strictly weaker than D ℵ0 in ZFA. This resolves an open problem from Keremedis and Tachtsis (2003). (shrink)

Arnold Geulincx Arnold Geulincx was an early-modern Flemish philosopher who initially taught at Leuven University, but fled the Catholic Low Countries when he was fired there in 1658. He settled at Leiden, in the Protestant North, where he worked under the patronage of the Cartesian Calvinist theologian Abraham Heidanus, and … Continue reading Geulincx, Arnold →.

A negative solution of the problem posed by Maksimova [5] is given. Two sequences of Superintuitionistic logics are axiomatized by using an analogy of the operation.

Although Thomas More’s description of the Utopians’ ‘Epicurean’ position in philosophy nominally coincides with Erasmus’s defence of the Philosophia Christi, More shows no concern for the arguments Erasmus gave in support of this view. Taking its starting point from Erasmus’s depreciations of the body and More’s intellectual as well as physical preoccupations with the bodily sphere, this article presents the theme of the human body and its moral and religious significance as a test case for comparing Erasmus and More. The (...) treatises both men wrote on Christ’s suffering in the Garden of Gethsemane confirm that both authors dealt with the notion of the body in contrasting ways: Erasmus shows a tendency to address the moral-psychological question of mentally conquering the worldly self, whilst More highlights the way in which ordinary facts and physical things may carry spiritual and religious meaning. Paradoxically, Erasmus consistently applied his spiritualized ideal of man to this-worldly moral and social concerns, whereas More focused on the physical domain out of a religious interest in transcendent truths. In line with Giulia Sissa’s thesis, our hypothesis is that More ostensibly appropriated an Erasmian type of idealism in Utopia, but, contrary to Erasmus himself, focused on the exterior form of a virtuous society, rather than on its moral and spiritual preconditions. While Erasmus advocated a mental transformation towards reason, More’s Utopia envisioned what might come of this. (shrink)

Let denote the class of all cardinal sequences of length α associated with compact scattered spaces. Also put If λ is a cardinal and α λ1>>λn−1 and ordinals α0,…,αn−1 such that α=α0++αn−1 and where each .The proofs are based on constructions of universal locally compact scattered spaces.

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

Rapid advancement of technologies continues to revolutionize healthcare foundations and outlook. Technological progress in medicine are not only continuing to improve quality of individual life but also generally improving quality of healthcare services. As a matter of fact, the most significant change in healthcare systems was the shift from standardized, patronizing and rigid physician–patient relationship to more patient-focused, personalized and participatory practice. With this shift came increased attention to the assurance of patient’s right to autonomy. Therefore, this article aims to (...) discuss principal problematic aspects of patient’s right to autonomy hereby the patient’s role in the context of technologies and innovation. It is argued, that one of the effective ways to ensure patient’s right to autonomy is implementation of legal instruments, such as informed consent, advance directives and Ulysses contracts. However, this article also proposes, that with a potential of new technologies and artificial intelligence, these legal instruments need to be reconsidered and transformed in more efficient and eligible model, presenting information in more individualized, appealing and convenient manner. (shrink)

I argue that the rôle for the cerebellar cortex is in the generation of sensory predictions, not motor sequences. This proposal may explain the allometric relationship described in Braitenberg et al.'s target article. I also point out that the parallel beam organisation may have a nontemporal basis.

This essay poses the question of how many rulers are envisaged in Plato’s Statesman. After pointing out that this is a crucial question for issues concerning non-ideal as well as ideal approaches to political rule, the essay focuses on three relevant aspects of rule in the Statesman: the notion of kingly rule, the limitations posed by human nature, and the importance of self-rule. It is shown how each of these dimensions of Plato’s discussion demonstrates the complexity of the question. (...) Particular attention is then given to features inherent to political rule: the need for subordinate functions and a distribution of offices, seen in light of the ends of political rule as helping citizens obtain their potential. It is argued that while the Statesman does not lead to any certain conclusion concerning the number of rulers, and some of its considerations conflict with each other, the text as a whole allows for a fairly broad basis of political rule. (shrink)

We write for the cardinality of the set of finite sequences of a set which is of cardinality. With the Axiom of Choice (), for every infinite cardinal where is the cardinality of the permutations on a set which is of cardinality. In this paper, we show that “ for every cardinal ” is provable in and this is the best possible result in the absence of. Similar results are also obtained for : the cardinality of the set of finite (...) sequences without repetition of a set which is of cardinality. (shrink)

This year marks the five-hundredth anniversary of Thomas More's widely influential book Utopia, and this volume brings together a number of scholars to consider the book, its long afterlife, and specifically its effects on political activists over the centuries. In addition to thorough studies of Utopia itself, and appraisals of More's relationship with Erasmus, the book presents detailed studies of the effect of Utopia on early modern England and the Low Countries, as well as philosophical reflections on ideology and the (...) utopian mind, and much more. (shrink)

Descartes's dualism did not result from Cartesian doubts, Christian beliefs, from a bias against animal nature, or from a conflict of reason and emotion. In fact, Descartes's dualism was the very fruitful product of the mechanistic conception of causality with which the French philosopher sought to replace the souls, qualities and intelligences contemporaries put forward as alternatives for the outdated Aristotelian principles of matter, form and privation. Descartes's naturalistic turn in physiology and physics not only formed the basis for his (...) dualistic metaphysics; it still bears fruit in the work of scientists such as Antonio R. Damasio today. Descartes gave scientists the paradoxical instruction to describe nature without reference to human experience. (shrink)

Inscriptions of Assyrian kings disclose that these rulers maintained and improved the land near the palace. This paper brings together the pictorial versions of what may be described as the “Assyrian royal landscape,” that is, outdoor scenery designed for royal purposes and represented on the stone panels that lined the walls of the palaces at Nimrud, Nineveh, and Dur-Sharrukin. The royal landscapes differ from reign to reign, since they each reflect some aspect of the particular king’s rule. The description (...) and discussion of the individual scenes also take into account the rationale behind their creation. Textual and archaeological data are supportive additions, and the previous studies of other scholars are also considered. The discussion of scenes carved on the stone panels follows in chronological sequence the reigns of four Assyrian kings: Ashurnasirpal II, Sargon II, Sennacherib, and Ashurbanipal. The chronological presentation demonstrates that royal landscape imagery in the sculptural arts progressed as a method of documentation by the Assyrian kings. (shrink)

Beliefs like the Gambler's Fallacy and the Hot Hand have interested cognitive scientists, economists, and philosophers for centuries. We propose that these judgment patterns arise from the observer's mental models of the sequence-generating mechanism, moderated by the strength of belief in an a priori base rate. In six behavioral experiments, participants observed one of three mechanisms generating sequences of eight binary events: a random mechanical device, an intentional goal-directed actor, and a financial market. We systematically manipulated participants’ beliefs about (...) the base rate probabilities at which different outcomes were generated by each mechanism. Participants judged 18 sequences of outcomes produced by a mechanism with either an unknown base rate, a specified distribution of three equiprobable base rates, or a precise, fixed base rate. Six target sequences ended in streaks of between two and seven identical outcomes. The most common predictions for subsequent events were best described as pragmatic belief updating, expressed as an increasingly strong expectation that a streak of identical signals would repeat as the length of that streak increased. The exception to this pattern was for sequences generated by a random mechanical device with a fixed base rate of.50. Under this specific condition, participants exhibited a bias toward reversal of streaks, and this bias was larger when participants were asked to make a dichotomous choice versus a numerical probability rating. We review alternate accounts for the anomalous judgments of sequences and conclude with our favored interpretation that is based on Rabin's version of Tversky & Kahneman's Law of Small Numbers. (shrink)

We give an overview of the role of equicontinuity of sequences of real-valued functions on [0,1] and related notions in classical mathematics, intuitionistic mathematics, Bishop’s constructive mathematics, and Russian recursive mathematics. We then study the logical strength of theorems concerning these notions within the programme of Constructive Reverse Mathematics. It appears that many of these theorems, like a version of Ascoli’s Lemma, are equivalent to fan-theoretic principles.

Arnold Geulincx Arnold Geulincx was an early-modern Flemish philosopher who initially taught at Leuven University, but fled the Catholic Low Countries when he was fired there in 1658. He settled at Leiden, in the Protestant North, where he worked under the patronage of the Cartesian Calvinist theologian Abraham Heidanus, and … Continue reading Geulincx, Arnold →.

Although Descartes’ characterization of the mind has sometimes been seen as too ‘moral’ and too ‘intellectualist’ to serve as a modern notion of consciousness, this article re-establishes the idea that Descartes’ way of doing metaphysics contributed to a novel delineation of the sphere of the mental. Earlier traditions in moral philosophy and religion certainly emphasized both a dualism of mind and body and a contrast between free intellectual activities and forcibly induced passions. Recent scholastic and neo-Stoic philosophical traditions, moreover, drew (...) attention to the disparity between the material and the immaterial, as well as to the possibility of a retreat into the personal realm of one’s own mind. Yet none of these moral and religious assessments of the relation between mind and body were motivated by the purely epistemological interest that we find in Descartes in setting apart a world of consciousness from the world of physics. The present article explains how Descartes made use of specific theological and moral philosophical theories in his own analysis of mental faculties; how he changed the orientation of metaphysics itself in the direction of a phenomenology of the mental; how he never returned to the naive idea of offering a dualist foundation for ethics; and how his mechanicism may have motivated his epistemological transformation of the science of metaphysics. In all these various ways, Descartes inaugurated an understanding of human mental life on the basis of physiological rather than metaphysical considerations, a view of psychology that is related to the experience of human individuals, and a naturalistic characterization of the mind in terms of a domain of consciousness rather than of moral conscience. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and are (...) better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

In [4], Kunen used iterated ultrapowers to show that ifUis a normalκ-complete nontrivial ultrafilter on a cardinalκthenL[U], the class of sets constructive fromU, has only the ultrafilterU∩L[U] and this ultrafilter depends only onκ. In this paper we extend Kunen's methods to arbitrary sequencesUof ultrafilters and obtain generalizations of these results. In particular we answer Problem 1 of Kunen and Paris [5] which asks whether the number of ultrafilters onκcan be intermediate between 1 and 22κ. If there is a normalκ-complete ultrafilterUonκsuch (...) that {α <κ: α is measurable} ∈Uthen there is an inner model with exactly two normal ultrafilters onκ, and ifκis super-compact then there are inner models havingκ+ +,κ+or any cardinal less than or equal toκnormal ultrafilters.These methods also show that several properties ofLwhich had been shown to hold forL[U] also hold forL[U]: using an idea of Silver we show that inL[U] the generalized continuum hypothesis is true, there is a Souslin tree, and there is awell-ordering of the reals. In addition we generalize a result of Kunen to characterize the countaby complete ultrafilters ofL[U]. (shrink)

This article discusses Descartes’s preferred focus on morally and theologically neutral subjects and points out the impact of this focus on the scientific status of theology. It does so by linking Descartes’s method to his transformation of the notion of substance. Descartes’s _Meditations_ centred around epistemological questions rather than non-human intelligences or the life of the mind beyond this world. Likewise, in his early works, Descartes consistently avoided referring to causal operators. Finally, having first redefined the notion of substance in (...) the _Principia,_ Descartes would completely abandon making use of this notion in his later years. Indeed, in contrast to many authors before and after him, Descartes never showed any interest in the long-established metaphysical interpretation of substances as being causal factors of natural change. With God, nature, and mind commonly serving as instances of substantial causality, Descartes’s philosophy had a huge impact on the place of God in science and discreetl. (shrink)

The only maximal extension of the logic of relevant entailment E is the classical logic CL. A logic L ⊆ [E,CL] called pre-maximal if and only if L is a coatom in the interval [E,CL]. We present two denumerable infinite sequences of premaximal extensions of the logic E. Note that for the relevant logic R there exist exactly three pre-maximal logics, i.e. coatoms in the interval [R,CL].