Abstract

Although it is a matter of fact that clinical trials and research play a very important role in the scientific and technological development, however, it also gives birth to many ethical problems and dilemmas specially when these research and trials are conducted in developing or resource poor countries. The sponsors and investigators could prefer to perform research in underdeveloped countries where there is lack of basic resources; people are illiterate and are most susceptible to exploitation. These research give birth to many ethical and moral issues. This paper attempts to discuss some of these issues in detail like; potential for exploitation of research participants, standard of care debates, quality of informed consent, therapeutic misconception and conflict of interest issues. All of them lead to the violation of very basic ethical principles of autonomy, beneficence, non-maleficence and justice. Many interventions could be implimented and the guidelines mentioned in this paper could be followed by the research enterprise to make the studies moral and ethical.